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Browse our Endothelin 1 Proteins (EDN1)

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Endothelin 1 Proteins (EDN1)
On are 21 Endothelin 1 (EDN1) Proteins from 8 different suppliers available. Additionally we are shipping Endothelin 1 Antibodies (262) and Endothelin 1 Kits (115) and many more products for this protein. A total of 422 Endothelin 1 products are currently listed.
EDN, Edn1, ET-1, Et1, fb14d01, HDLCQ7, PPET-1, PPET1, preproET, wu:fb14d01
list all proteins Gene Name GeneID UniProt
EDN1 1906 P05305
EDN1 24323 P22388
EDN1 13614 P22387

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Endothelin 1 Proteins (EDN1) by Origin

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Top referenced Endothelin 1 Proteins

  1. Human Endothelin 1 Protein expressed in Escherichia coli (E. coli) - ABIN1046972 : Itoh, Yanagisawa, Ohkubo, Kimura, Kosaka, Inoue, Ishida, Mitsui, Onda, Fujino: Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: identity of human and porcine endothelin. in FEBS letters 1988 (PubMed)
    Show all 3 references for ABIN1046972

  2. Human Endothelin 1 Protein expressed in Wheat germ - ABIN1352324 : Schildroth, Rettig-Zimmermann, Kalk, Steege, Fähling, Sendeski, Paliege, Lai, Bachmann, Persson, Hocher, Patzak: Endothelin type A and B receptors in the control of afferent and efferent arterioles in mice. in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2011 (PubMed)

More Proteins for Endothelin 1 Interaction Partners

Zebrafish Endothelin 1 (EDN1) interaction partners

  1. Phylogenetic analysis of conserved grhl (show GHRL Proteins)-binding sites in gene regulatory regions identified endothelin-1 (edn1) as a putative direct grhl3 (show GRHL3 Proteins) target gene, and this was confirmed by chromatin precipitation assays in embryos.

  2. EDN1 plays an important role in hepatocellular carcinoma progression by activating the PI3K/AKT pathway and is regulated by miR-1.

  3. Data suggest that edn1/ednraa (show EDNRA Proteins) (endothelin-1/endothelin-1 receptor type A (show EDNRA Proteins)) signaling is involved in acid-base regulation and transepithelial proton secretion via vacuolar proton-translocating ATPase in zebrafish embryonic skin.

  4. These findings point to complexity of regulation by edn1 and hand2 at the earliest stages of pharyngeal arch development, in which control of growth and morphogenesis can be genetically separated.

  5. Endothelin 1 combines with Bone Morphogenetic Proteins to pattern the dorsal-ventral axis of the craniofacial skeleton.

  6. activation of Endothelin-1 signaling in craniofacial patterning

  7. Edn1 from the pharyngeal ectoderm signals through Ednra (show EDNRA Proteins) proteins to direct early dorsoventral patterning of the skeletogenic neural crest.

  8. The role of endothelin-1 and light in the regulation of melanopsins and the clock proteins in an embyronic cell line is reported.

Xenopus laevis Endothelin 1 (EDN1) interaction partners

  1. This is the first report describing the cDNA encoding preproendothelin-1 in an amphibian species.

  2. A new role for et-1 signaling during early neural crest specification is reported.

Human Endothelin 1 (EDN1) interaction partners

  1. Alternatively activated (M2) macrophage phenotype is inducible by endothelin-1 in cultured macrophages.

  2. These findings indicate that TT is a practical and effective strategy to reduce BP and circulating ET-1 concentration and enhance leg blood flow in patients with PAD.

  3. reduced lung levels of PPARgamma (show PPARG Proteins) and increased levels of microRNA-27a (miR (show MLXIP Proteins)-27a), v-ets (show ETS1 Proteins) avian erythroblastosis virus E26 oncogene (show RAB1A Proteins) homolog 1 (ETS1 (show ETS1 Proteins)), endothelin-1 (ET-1), and markers of endothelial dysfunction (platelet/endothelial cell adhesion molecule 1 (show PECAM1 Proteins) and E selectin (show SELE Proteins)).

  4. We show that in young adults, Rho kinase (show ROCK1 Proteins) is an important mediator of the endothelin-1-mediated attenuation of endothelium-dependent and -independent cutaneous vasodilation, and that endothelin-1 does not increase sweating.

  5. ET-1 levels were significantly elevated in patients with chronic stable heart failure with preserved ejection fraction.

  6. Differences were found in the neonatal and maternal expression of leptin (show LEP Proteins), adiponectin (show ADIPOQ Proteins), adropin (show ENHO Proteins), and endothelin-1 in intrauterine growth restricted mothers and neonates compared with a control group.

  7. Nur77 (show NR4A1 Proteins) decreases ET-1 expression by suppressing NF-kappaB (show NFKB1 Proteins) and p38 MAPK (show MAPK14 Proteins).

  8. Increased circulating Edn1 and expression of Ednra (show EDNRA Proteins) in endothelial cells are characteristic of diabetic kidney disease.

  9. Big ET-1 was strongly and independently associated with coronary artery ectasia by multivariate analysis

  10. Leptin (show LEP Proteins) to insulin (show INS Proteins) and adiponectin (show ADIPOQ Proteins) to endothelin ratios are novel derived biomarkers useful for noninvasive diagnostics of initial stages of coronary lesions in patients with coronary artery disease.

Pig (Porcine) Endothelin 1 (EDN1) interaction partners

  1. sub-vasomotor concentration of ET-1 leads to vascular dysfunction by impairing endothelium-dependent NO-mediated dilation via p38 (show MAPK14 Proteins) kinase-mediated production of superoxide from NADPH oxidase (show NOX1 Proteins) following ETA receptor activation

  2. ET1 was lowest in kidneys removed from live pigs, greater in kidneys from pigs with brain death, and greatest in kidneys from pigs with cardiac arrest.

  3. ET-1 contributes to formation of oedema during experimental sepsis by a novel mechanism involving increased HBP (show HEBP1 Proteins) release from neutrophils.

  4. Endothelin-1 expression is upregulated following therapeutic hypothermia after cardiac arrest.

  5. ET-1 produces contraction of the urinary bladder neck muscles via muscular ET(A (show EDNRA Proteins)) receptors coupled to extracellular Ca(2 (show CA2 Proteins)+) entry via VOC (L-type) and non-VOC channels.

  6. Endothelin-1 elevation is not only a conserved phenomenon in a pig traumatic brain injury (TBI (show TBPL1 Proteins)) model, but it is a likely target for understanding the observed enhanced vascular response to TBI (show TBPL1 Proteins).

  7. interleukin-6 (show IL6 Proteins), endothelin ET-1, and apoptotic Bak (show BAK1 Proteins) and Bcl-XL (show BCL2L1 Proteins) genes have roles in small bowel transplantation, in a swine model of ischemia and reperfusion injury

  8. ET-1 elicits a different pattern of Src (show SRC Proteins) family kinase (SFK) activation and might trigger a different pattern of SFK activation from that caused by ATP and UTP.

  9. Compared with the untreated group, the levels of serum ET-1 after acute myocardial infarction and reperfusion were significantly decreased in the Xuefu Zhuyu-treated group.

  10. study suggests a possible role for endothelin-1(resulting from the actions of endothelin-converting enzyme-1 (show ECE1 Proteins)) acting via endothelin receptor A (show EDNRA Proteins) in the control of luteolytic sensitivity in the pig

Cow (Bovine) Endothelin 1 (EDN1) interaction partners

  1. EDN-1 may be involved in the protection of sperm from phagocytosis by polymorphonuclear neutrophils in the bovine oviduct, supporting sperm survival until fertilization

  2. Data suggest that, in Fallopian tubes, endothelins (EDN1, EDN2 (show EDN2 Proteins), EDN3 (show EDN3 Proteins)) and EDN (show RNASE2 Proteins)-converting enzymes (ECE1 (show ECE1 Proteins), ECE2 (show ECE2 Proteins)) are expressed in epithelial cells; EDN (show RNASE2 Proteins) receptors (EDNRA (show EDNRA Proteins), EDNRB (show EDNRB Proteins)) are present in smooth-muscle. Expression of EDN1, EDN2 (show EDN2 Proteins), and ECE2 (show ECE2 Proteins) is highest on day of ovulation. EDN (show RNASE2 Proteins)/ENDR signaling appears to participate Fallopian tube function. These studies were conducted in Holstein cows.

  3. results suggest that ET-1-induced activation of proMMP-2 is mediated via cross-talk between NADPH oxidase (show NOX1 Proteins)-PKCalpha (show PKCa Proteins)-p(38)MAPK (show MAPK1 Proteins) and NFkappaB-MT1MMP (show MMP14 Proteins) signaling pathways along with a marked decrease in TIMP-2 (show TIMP2 Proteins) expression in the cells

  4. We demonstrated that (i) treatment of bovine pulmonary artery smooth muscle cells with ET-1 stimulates cPLA2 (show PLA2G4A Proteins) activity in the cell membrane.

  5. Differential cell-specific and spatiotemporal expression of the EDN1 system and NOS in the bovine utero-placental unit may be associated with regulation of vascular and cellular functions during pregnancy.

  6. Oxidized LDL is a stimulus of ET-1 production in cultured vascular endothelial cells.

  7. Endothelin-1 decreases ethanolamine plasmalogen levels and evokes platelet-activating factor production in brain microvessels

  8. prostaglandin F2alpha, endothelin-1, and angiotensin II may interact with each other in a local positive feedback manner to activate their secretion in the regressing corpus luteum, thus accelerating and completing luteolysis

  9. LOX-1 (show OLR1 Proteins) and CD40 (show CD40 Proteins) synergistically, but through a distinct pathway, work to induce endothelin-1 expression in endothelial cells.

  10. Elevated local expression of ET-1 and Ednra/Ednrb (show EDNRB Proteins) during the peri (show PLIN1 Proteins)-ovulatory period induces the high contractile activity of the oviduct to optimize gamete transport.

Mouse (Murine) Endothelin 1 (EDN1) interaction partners

  1. Taken together, these data indicate that during high-salt feeding, the autocrine actions of ET-1 via upregulation of the ETB (show EDNRB Proteins) receptor are critical for IMCD NO production, facilitating inhibition of ion reabsorption.

  2. reduced lung levels of PPARgamma (show PPARG Proteins) and increased levels of microRNA-27a (miR (show MLXIP Proteins)-27a), v-ets (show ETS1 Proteins) avian erythroblastosis virus E26 oncogene (show RAB1A Proteins) homolog 1 (ETS1 (show ETS1 Proteins)), endothelin-1 (ET-1), and markers of endothelial dysfunction (platelet/endothelial cell adhesion molecule 1 (show PECAM1 Proteins) and E selectin (show SELE Proteins)).

  3. Increased circulating Edn1 and expression of Ednra (show EDNRA Proteins) in endothelial cells are characteristic of diabetic kidney disease-susceptible mice.

  4. Review and Meta-Analysis of ET-1 Transgenic Mice provides robust evidence that global ET-1 overexpression in mice lowers blood pressure in an age-dependent manner. Older ET-1+/+ mice have a somewhat more pronounced reduction of blood pressure.

  5. evidence supports a model in which aldosterone activation of the mineralocorticoid receptor (show NR3C2 Proteins) (MR) results in the MR-hormone complex binding at HRE at -671bp to open chromatin structure around other regulatory elements in the Edn1 gene

  6. Decreased ET-1 levels were associated with greater activation of NLRP3 (show NLRP3 Proteins) and IL-1beta (show IL1B Proteins) in normal glucose. High glucose increased NLRP3 (show NLRP3 Proteins) markers and activation compared to normal and low glucose

  7. evidence supports a model in which aldosterone activation of the mineralocorticoid receptor (show NR3C2 Proteins) (MR) results in the MR-hormone complex binding at HRE at -671bp to open chromatin structure around other regulatory elements in the Edn1 gene

  8. AMPAR-mediated glutamatergic neurotransmission may underlie the mechanism of ET1-ET(A (show EDNRA Proteins))R signaling pathway in the regulation of anxiety.

  9. indicate that endothelin-1 is critical in the development of cerebrovascular and cognitive impairments with experimental cerebral malaria

  10. increased extrarenal vascular ET-1 production in response to HS intake is mediated by increased extracellular osmolarity and plays a critical role in regulating skin storage of Na(+)

Horse (Equine) Endothelin 1 (EDN1) interaction partners

  1. Short-term hyperinsulinaemia leads to increased vascular resistance in the equine digit and increased expression of ET-1 in the laminar tissue.

Rabbit Endothelin 1 (EDN1) interaction partners

  1. Plasma ET-1 levels of rabbits increased significantly in fluorinated groups compared with those in the control group.

  2. Dynamic monitoring and comparison of plasma levels of ET, CGRP, NO, and MDA as well as SOD activity revealed that appropriate intervention of these factors may reduce reperfusion injury

  3. In a saline lavage-induced lung injury model, both circulatory and pulmonary ET-1 levels increased.

  4. Data suggest elevated levels of endothelin-1, as exhibited in cardiovascular diseases, facilitate development of ventricular arrhythmia by steepening action potential duration restitution and by increasing beat-to-beat variability of repolarization.

  5. High levels of ET-1 are closely associated with BBB disruption. ET-1 may play an important role in the pathogenesis of secondary brain injury after ICH (show ACE Proteins).

  6. After subarachnoid hemorrhage, the contractile response to ET-1 was enhanced, and the ET(A (show EDNRA Proteins)) receptor expression was upregulated in the basilar artery.

  7. After acute pulmonary thromboembolism, thrombolytic and anti-inflammatory treatment could decrease acute lung injury induced by ET-1 and NF-kappaB (show NFKB1 Proteins) activation. [endothelin-1; NFKB]

  8. The increase in myocardial distensibility induced by endothelin-1 is absent in heart failure and is dependent on nitric oxide and prostaglandin release.

  9. Endothelin-1 enhances nuclear Ca2 (show CA2 Proteins)+ transients in atrial myocytes through Ins (show INS Proteins)(1,4,5)P3-dependent Ca2 (show CA2 Proteins)+ release from perinuclear Ca2 (show CA2 Proteins)+ stores

  10. The enhancement of gap junction intercellular communication is activated by endothelin-1 via modulating the expression of connexin43 (show GJA1 Proteins), and plays an important role in the pathogenesis of cerebral vasospasm

Endothelin 1 (EDN1) Protein Profile

Protein Summary

The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. This peptide is a potent vasoconstrictor and is produced by vascular endothelial cells. Endothelin 1 also can affect the central nervous system. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with Endothelin 1 (EDN1)

  • endothelin 1 (edn1)
  • endothelin 1 (EDN1)
  • endothelin 1 (edn1-a)
  • endothelin 1 (Edn1)
  • endothelin-1 (ET-1)
  • EDN protein
  • Edn1 protein
  • ET-1 protein
  • Et1 protein
  • fb14d01 protein
  • HDLCQ7 protein
  • PPET-1 protein
  • PPET1 protein
  • preproET protein
  • wu:fb14d01 protein

Protein level used designations for Endothelin 1 Proteins (EDN1)

endothelin-1 , et1 , suc , sucker , endothelin 1 , preproendothelin-1 , ET-1 , PPET1 , gene for endothelin , preproendothelin , Preproendothelin-1 , preproendothelin 1

100144700 Xenopus (Silurana) tropicalis
58032 Danio rerio
462437 Pan troglodytes
100036806 Xenopus laevis
100294653 Ovis aries
1906 Homo sapiens
443498 Ovis aries
24323 Rattus norvegicus
403424 Canis lupus familiaris
396915 Sus scrofa
281137 Bos taurus
13614 Mus musculus
100726197 Cavia porcellus
494214 Felis catus
699982 Macaca mulatta
100034060 Equus caballus
420854 Gallus gallus
100009270 Oryctolagus cuniculus
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