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Study shows that cerebrovascular muscle cells can express endothelin-1 (ET-1). The production of ET-1 in cerebrovascular muscle cells stimulated by oxyhemoglobin occurs partially through the NF-[kappa]B signal pathway.
Plasma ET-1 levels of rabbits increased significantly in fluorinated groups compared with those in the control group.
Dynamic monitoring and comparison of plasma levels of ET, CGRP, NO, and MDA as well as SOD activity revealed that appropriate intervention of these factors may reduce reperfusion injury
In a saline lavage-induced lung injury model, both circulatory and pulmonary ET-1 levels increased.
Data suggest elevated levels of endothelin-1, as exhibited in cardiovascular diseases, facilitate development of ventricular arrhythmia by steepening action potential duration restitution and by increasing beat-to-beat variability of repolarization.
High levels of ET-1 are closely associated with BBB disruption. ET-1 may play an important role in the pathogenesis of secondary brain injury after ICH (show ACE Proteins).
After subarachnoid hemorrhage, the contractile response to ET-1 was enhanced, and the ET(A (show EDNRA Proteins)) receptor expression was upregulated in the basilar artery.
After acute pulmonary thromboembolism, thrombolytic and anti-inflammatory treatment could decrease acute lung injury induced by ET-1 and NF-kappaB (show NFKB1 Proteins) activation. [endothelin-1; NFKB]
The increase in myocardial distensibility induced by endothelin-1 is absent in heart failure and is dependent on nitric oxide and prostaglandin release.
Endothelin-1 enhances nuclear Ca2 (show CA2 Proteins)+ transients in atrial myocytes through Ins (show INS Proteins)(1,4,5)P3-dependent Ca2 (show CA2 Proteins)+ release from perinuclear Ca2 (show CA2 Proteins)+ stores
sub-vasomotor concentration of ET-1 leads to vascular dysfunction by impairing endothelium-dependent NO-mediated dilation via p38 (show MAPK14 Proteins) kinase-mediated production of superoxide from NADPH oxidase (show NOX1 Proteins) following ETA receptor activation
ET1 was lowest in kidneys removed from live pigs, greater in kidneys from pigs with brain death, and greatest in kidneys from pigs with cardiac arrest.
ET-1 contributes to formation of oedema during experimental sepsis by a novel mechanism involving increased HBP (show HEBP1 Proteins) release from neutrophils.
Endothelin-1 expression is upregulated following therapeutic hypothermia after cardiac arrest.
ET-1 produces contraction of the urinary bladder neck muscles via muscular ET(A (show EDNRA Proteins)) receptors coupled to extracellular Ca(2 (show CA2 Proteins)+) entry via VOC (L-type) and non-VOC channels.
Endothelin-1 elevation is not only a conserved phenomenon in a pig traumatic brain injury (TBI) model, but it is a likely target for understanding the observed enhanced vascular response to TBI.
interleukin-6 (show IL6 Proteins), endothelin ET-1, and apoptotic Bak (show BAK1 Proteins) and Bcl-XL (show BCL2L1 Proteins) genes have roles in small bowel transplantation, in a swine model of ischemia and reperfusion injury
ET-1 elicits a different pattern of Src (show SRC Proteins) family kinase (SFK) activation and might trigger a different pattern of SFK activation from that caused by ATP and UTP.
Compared with the untreated group, the levels of serum ET-1 after acute myocardial infarction and reperfusion were significantly decreased in the Xuefu Zhuyu-treated group.
study suggests a possible role for endothelin-1(resulting from the actions of endothelin-converting enzyme-1 (show ECE1 Proteins)) acting via endothelin receptor A (show EDNRA Proteins) in the control of luteolytic sensitivity in the pig
Polymorphic variants of endothelin EDN (show RNASE2 Proteins) (K198N) and endothelin receptor type A (show EDNRA Proteins) genes EDN (show RNASE2 Proteins) RA (C1222T, C70G, G231A) affected ET plasma concentrations. There was no association between the plasma endothelin levels and the risk factors for normal tension glaucoma.
high glucose and free fatty acids reduced NO and increased ET-1 levels induced by acetylcholine through the modulation of intracellular calcium concentrations and endothelial NO synthase phosphorylation, events also reverted by hydroxytyrosol and polyphenol extract.
In both the acute and remission phase of thrombotic thrombocytopenic purpura we found increased CT-proET-1 and VWF (show VWF Proteins) levels, while Factor H (show CFH Proteins) levels decreased compared with healthy controls. In remission, however, the elevated CT-proET-1 levels showed a 22 % decrease when compared with the acute phase.
ET-1 increased NSCLC clonal growth, whereas BQ123, ZD4054, lapatinib or gefitinib inhibited proliferation. The results indicate that ET-1 may regulate NSCLC cellular proliferation in an EGFR (show EGFR Proteins)- and HER2 (show ERBB2 Proteins)-dependent manner
Data indicate that patients with systemic sclerosis (SSc (show CYP11A1 Proteins)) displayed higher serum levels of VEGF (show VEGFA Proteins), endothelin-1 and s-Fractalkine (show CX3CL1 Proteins), and that the s-Fractalkine (show CX3CL1 Proteins) levels positively correlated with CD34 (show CD34 Proteins)(+)CD45 (show PTPRC Proteins)(-) endothelial progenitor cells (EPC (show TCF21 Proteins)) numbers.
Endothelin-1 and its receptors on haemorrhoidal tissue: a potential site for therapeutic intervention
we could provide evidence that established stress-related biomarkers ET-1, MCP-1 (show CCL2 Proteins), CGA (show CGA Proteins) were differentially regulated among patients with AF compared to healthy controls.
Two END1 (show VPS11 Proteins) polymorphisms do not appear to affect the development of hypertension in the Chinese population.
TWEAK (show TNFSF12 Proteins) may stimulate endothelial ET-1 synthesis, through the up-regulation of ECE-1 (show ECE1 Proteins).
ET-1 may be a unique predictor of heart failure prognosis
c-Src tyrosine kinase (show CSK Proteins) mediates high glucose-induced endothelin-1 expression
SIX1 (show SIX1 Proteins) regulates dorsal arch development not only by inducing dorsal Jag1 (show JAG1 Proteins) expression but also by inhibiting endothelin 1 (Edn1) expression in the pharyngeal endoderm of the dorsal arch, thus preventing dorsal EDNRA (show EDNRA Proteins) signaling.
NOX4 (show NOX4 Proteins)-derived reactive oxygen species in general, and possibly superoxide in particular, are involved in flow-stimulated inner medullary collecting duct ET-1 production.
in normal tissues the tandem of serine carboxypeptidases, Scpep1 and CathA likely constitutes an important part of the physiological mechanism responsible for the balanced elimination of heightened levels of ET-1 that otherwise would accumulate in tissues and consequently contribute to development of the hyper-proliferative corneal dystrophy and abnormal skin thickening
Newborn endothelial cells express high levels of ET-1 peptides, rapidly release ET-1 in response to endothelial stimulation, and initiate ET-1-mediated endothelium-dependent constriction
cellular and molecular mechanisms of ET-1 action in periodontitis
Taken together, these data indicate that during high-salt feeding, the autocrine actions of ET-1 via upregulation of the ETB (show EDNRB Proteins) receptor are critical for IMCD NO production, facilitating inhibition of ion reabsorption.
reduced lung levels of PPARgamma (show PPARG Proteins) and increased levels of microRNA-27a (miR (show MLXIP Proteins)-27a), v-ets (show ETS1 Proteins) avian erythroblastosis virus E26 oncogene (show RAB1A Proteins) homolog 1 (ETS1 (show ETS1 Proteins)), endothelin-1 (ET-1), and markers of endothelial dysfunction (platelet/endothelial cell adhesion molecule 1 (show PECAM1 Proteins) and E selectin (show SELE Proteins)).
Increased circulating Edn1 and expression of Ednra (show EDNRA Proteins) in endothelial cells are characteristic of diabetic kidney disease-susceptible mice.
Phylogenetic analysis of conserved grhl (show GHRL Proteins)-binding sites in gene regulatory regions identified endothelin-1 (edn1) as a putative direct grhl3 (show GRHL3 Proteins) target gene, and this was confirmed by chromatin precipitation assays in embryos.
EDN1 plays an important role in hepatocellular carcinoma progression by activating the PI3K/AKT pathway and is regulated by miR-1.
Data suggest that edn1/ednraa (show EDNRA Proteins) (endothelin-1/endothelin-1 receptor type A (show EDNRA Proteins)) signaling is involved in acid-base regulation and transepithelial proton secretion via vacuolar proton-translocating ATPase in zebrafish embryonic skin.
These findings point to complexity of regulation by edn1 and hand2 at the earliest stages of pharyngeal arch development, in which control of growth and morphogenesis can be genetically separated.
Endothelin 1 combines with Bone Morphogenetic Proteins to pattern the dorsal-ventral axis of the craniofacial skeleton.
activation of Endothelin-1 signaling in craniofacial patterning
Edn1 from the pharyngeal ectoderm signals through Ednra (show EDNRA Proteins) proteins to direct early dorsoventral patterning of the skeletogenic neural crest.
The role of endothelin-1 and light in the regulation of melanopsins and the clock proteins in an embyronic cell line is reported.
EDN-1 may be involved in the protection of sperm from phagocytosis by polymorphonuclear neutrophils in the bovine oviduct, supporting sperm survival until fertilization
Data suggest that, in Fallopian tubes, endothelins (EDN1, EDN2 (show EDN2 Proteins), EDN3 (show EDN3 Proteins)) and EDN (show RNASE2 Proteins)-converting enzymes (ECE1 (show ECE1 Proteins), ECE2 (show ECE2 Proteins)) are expressed in epithelial cells; EDN (show RNASE2 Proteins) receptors (EDNRA (show EDNRA Proteins), EDNRB (show EDNRB Proteins)) are present in smooth-muscle. Expression of EDN1, EDN2 (show EDN2 Proteins), and ECE2 (show ECE2 Proteins) is highest on day of ovulation. EDN (show RNASE2 Proteins)/ENDR signaling appears to participate Fallopian tube function. These studies were conducted in Holstein cows.
results suggest that ET-1-induced activation of proMMP-2 is mediated via cross-talk between NADPH oxidase (show NOX1 Proteins)-PKCalpha (show PKCa Proteins)-p(38)MAPK (show MAPK1 Proteins) and NFkappaB-MT1MMP (show MMP14 Proteins) signaling pathways along with a marked decrease in TIMP-2 (show TIMP2 Proteins) expression in the cells
We demonstrated that (i) treatment of bovine pulmonary artery smooth muscle cells with ET-1 stimulates cPLA2 (show PLA2G4A Proteins) activity in the cell membrane.
Differential cell-specific and spatiotemporal expression of the EDN1 system and NOS in the bovine utero-placental unit may be associated with regulation of vascular and cellular functions during pregnancy.
Oxidized LDL is a stimulus of ET-1 production in cultured vascular endothelial cells.
Endothelin-1 decreases ethanolamine plasmalogen levels and evokes platelet-activating factor production in brain microvessels
prostaglandin F2alpha, endothelin-1, and angiotensin II may interact with each other in a local positive feedback manner to activate their secretion in the regressing corpus luteum, thus accelerating and completing luteolysis
LOX-1 (show OLR1 Proteins) and CD40 (show CD40 Proteins) synergistically, but through a distinct pathway, work to induce endothelin-1 expression in endothelial cells.
Elevated local expression of ET-1 and Ednra/Ednrb (show EDNRB Proteins) during the peri (show PLIN1 Proteins)-ovulatory period induces the high contractile activity of the oviduct to optimize gamete transport.
Short-term hyperinsulinaemia leads to increased vascular resistance in the equine digit and increased expression of ET-1 in the laminar tissue.
This is the first report describing the cDNA encoding preproendothelin-1 in an amphibian species.
A new role for et-1 signaling during early neural crest specification is reported.
The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. This peptide is a potent vasoconstrictor and is produced by vascular endothelial cells. Endothelin 1 also can affect the central nervous system. Two transcript variants encoding different isoforms have been found for this gene.
, gene for endothelin
, endothelin 1
, preproendothelin 1
, endothelin 1 L homeolog