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Human Endothelin 1 Protein expressed in Escherichia coli (E. coli) - ABIN1046972
Itoh, Yanagisawa, Ohkubo, Kimura, Kosaka, Inoue, Ishida, Mitsui, Onda, Fujino: Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: identity of human and porcine endothelin. in FEBS letters 1988
Show all 3 references for ABIN1046972
Human Endothelin 1 Protein expressed in Wheat germ - ABIN1352324
Schildroth, Rettig-Zimmermann, Kalk, Steege, Fähling, Sendeski, Paliege, Lai, Bachmann, Persson, Hocher, Patzak: Endothelin type A and B receptors in the control of afferent and efferent arterioles in mice. in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2011
Phylogenetic analysis of conserved grhl (show GHRL Proteins)-binding sites in gene regulatory regions identified endothelin-1 (edn1) as a putative direct grhl3 (show GRHL3 Proteins) target gene, and this was confirmed by chromatin precipitation assays in embryos.
EDN1 plays an important role in hepatocellular carcinoma progression by activating the PI3K/AKT pathway and is regulated by miR-1.
Data suggest that edn1/ednraa (show EDNRA Proteins) (endothelin-1/endothelin-1 receptor type A (show EDNRA Proteins)) signaling is involved in acid-base regulation and transepithelial proton secretion via vacuolar proton-translocating ATPase in zebrafish embryonic skin.
These findings point to complexity of regulation by edn1 and hand2 at the earliest stages of pharyngeal arch development, in which control of growth and morphogenesis can be genetically separated.
Endothelin 1 combines with Bone Morphogenetic Proteins to pattern the dorsal-ventral axis of the craniofacial skeleton.
activation of Endothelin-1 signaling in craniofacial patterning
Edn1 from the pharyngeal ectoderm signals through Ednra (show EDNRA Proteins) proteins to direct early dorsoventral patterning of the skeletogenic neural crest.
The role of endothelin-1 and light in the regulation of melanopsins and the clock proteins in an embyronic cell line is reported.
This is the first report describing the cDNA encoding preproendothelin-1 in an amphibian species.
A new role for et-1 signaling during early neural crest specification is reported.
ET1 gene and ECE-1 expression levels in human umbilical vein endothelial cells and ET-1 expression levels in the cell culture supernatants increased significantly in some experimental groups compared with those in the control group.
Serum and synovial fluid endothelin-1 concentrations are correlated with the development and progression of knee osteoarthritis.
This study demonstrated the pathogenesis mechanism during the development of dementia after ischemic stroke by investigating the relationship between miR (show MLXIP Proteins)-125a and its target ET-1.
Urinary TGF-beta1 (show TGFB1 Proteins) and ET-1 levels were associated with AGT (show AGXT Proteins) level, which likely reflects an early interplay between tissue remodeling and RAAS in obesity-related kidney injury.
High circulating endothelin-1 levels are associated with the development of impaired glucose tolerance and type 2 diabetes in women.
Serum endothelin-1 was elevated in preeclampsia and correlated with severity of illness.
There was no significant difference in serum EDN1 between patients with vasovagal syncope, epilepsy, and controls.
Therefore, despite a clear age-specific role in the regulation of vascular tone, endogenous ET-1, acting through endothelin type A receptors, does not account for the age-related reduction in mean shear rate in the common femoral artery.
In patients with autosomal dominant polycystic kidney disease, urinary ET-1 was inversely associated with eGFR (show EGFR Proteins) and positively correlated with total kidney volume.
Congenital heart disease complicated with pulmonary artery hypertension is associated with increased circulating endothelial cell counts and ET-1 production.
sub-vasomotor concentration of ET-1 leads to vascular dysfunction by impairing endothelium-dependent NO-mediated dilation via p38 (show MAPK14 Proteins) kinase-mediated production of superoxide from NADPH oxidase (show NOX1 Proteins) following ETA receptor activation
ET1 was lowest in kidneys removed from live pigs, greater in kidneys from pigs with brain death, and greatest in kidneys from pigs with cardiac arrest.
ET-1 contributes to formation of oedema during experimental sepsis by a novel mechanism involving increased HBP (show HEBP1 Proteins) release from neutrophils.
Endothelin-1 expression is upregulated following therapeutic hypothermia after cardiac arrest.
ET-1 produces contraction of the urinary bladder neck muscles via muscular ET(A (show EDNRA Proteins)) receptors coupled to extracellular Ca(2 (show CA2 Proteins)+) entry via VOC (L-type) and non-VOC channels.
Endothelin-1 elevation is not only a conserved phenomenon in a pig traumatic brain injury (TBI (show TBPL1 Proteins)) model, but it is a likely target for understanding the observed enhanced vascular response to TBI (show TBPL1 Proteins).
interleukin-6 (show IL6 Proteins), endothelin ET-1, and apoptotic Bak (show BAK1 Proteins) and Bcl-XL (show BCL2L1 Proteins) genes have roles in small bowel transplantation, in a swine model of ischemia and reperfusion injury
ET-1 elicits a different pattern of Src (show SRC Proteins) family kinase (SFK) activation and might trigger a different pattern of SFK activation from that caused by ATP and UTP.
Compared with the untreated group, the levels of serum ET-1 after acute myocardial infarction and reperfusion were significantly decreased in the Xuefu Zhuyu-treated group.
study suggests a possible role for endothelin-1(resulting from the actions of endothelin-converting enzyme-1 (show ECE1 Proteins)) acting via endothelin receptor A (show EDNRA Proteins) in the control of luteolytic sensitivity in the pig
results suggest that ET-1-induced activation of proMMP-2 is mediated via cross-talk between NADPH oxidase (show NOX1 Proteins)-PKCalpha (show PKCa Proteins)-p(38)MAPK (show MAPK1 Proteins) and NFkappaB-MT1MMP (show MMP14 Proteins) signaling pathways along with a marked decrease in TIMP-2 (show TIMP2 Proteins) expression in the cells
We demonstrated that (i) treatment of bovine pulmonary artery smooth muscle cells with ET-1 stimulates cPLA2 (show PLA2G4A Proteins) activity in the cell membrane.
Differential cell-specific and spatiotemporal expression of the EDN1 system and NOS in the bovine utero-placental unit may be associated with regulation of vascular and cellular functions during pregnancy.
Oxidized LDL is a stimulus of ET-1 production in cultured vascular endothelial cells.
Endothelin-1 decreases ethanolamine plasmalogen levels and evokes platelet-activating factor production in brain microvessels
prostaglandin F2alpha, endothelin-1, and angiotensin II may interact with each other in a local positive feedback manner to activate their secretion in the regressing corpus luteum, thus accelerating and completing luteolysis
LOX-1 (show OLR1 Proteins) and CD40 (show CD40 Proteins) synergistically, but through a distinct pathway, work to induce endothelin-1 expression in endothelial cells.
Elevated local expression of ET-1 and Ednra/Ednrb (show EDNRB Proteins) during the peri (show PLIN1 Proteins)-ovulatory period induces the high contractile activity of the oviduct to optimize gamete transport.
Suggest that the activation of a local positive feedback mechanism in the corpus luteum among ET-1, Ang II (show AGT Proteins) and PGF2alpha might play a functional role in the paracrine modulation of luteolytic cascade.
The combined metabolic burden of homocysteine and high glucose stimulates ET-1 synthesis in bovine aortic endothelial cells via a mechanism dependent on the production of mitochondrial ROS (show ROS1 Proteins), but may not be generalisable to all types of endothelial cells.
evidence supports a model in which aldosterone activation of the mineralocorticoid receptor (show NR3C2 Proteins) (MR) results in the MR-hormone complex binding at HRE at -671bp to open chromatin structure around other regulatory elements in the Edn1 gene
Decreased ET-1 levels were associated with greater activation of NLRP3 (show NLRP3 Proteins) and IL-1beta (show IL1B Proteins) in normal glucose. High glucose increased NLRP3 (show NLRP3 Proteins) markers and activation compared to normal and low glucose
AMPAR-mediated glutamatergic neurotransmission may underlie the mechanism of ET1-ET(A (show EDNRA Proteins))R signaling pathway in the regulation of anxiety.
indicate that endothelin-1 is critical in the development of cerebrovascular and cognitive impairments with experimental cerebral malaria
increased extrarenal vascular ET-1 production in response to HS intake is mediated by increased extracellular osmolarity and plays a critical role in regulating skin storage of Na(+)
PPARgamma (show PPARG Proteins) regulates miR (show MLXIP Proteins)-98 to modulate ET-1 expression and pulmonary endothelial cell proliferation in pulmonary hypertension.
these results indicated that I/R induced upregulation of ET1 and ETA in the kidneys, which was, at least in part, dependent on the production of inflammatory cytokines.
we have demonstrated that the expression of ET-1 and IL-25 (show IL25 Proteins) was coordinately upregulated in the lesional keratinocytes of patients with AD and a murine AD model.
The cardiac expression of prepro-endothelin-1 mRNA was increased in 18-week-old obese C57BL/6 mice compared to animals with normal weight. Furthermore, endothelin-1 plasma levels showed an increasing trend.
Short-term hyperinsulinaemia leads to increased vascular resistance in the equine digit and increased expression of ET-1 in the laminar tissue.
Plasma ET-1 levels of rabbits increased significantly in fluorinated groups compared with those in the control group.
Dynamic monitoring and comparison of plasma levels of ET, CGRP, NO, and MDA as well as SOD activity revealed that appropriate intervention of these factors may reduce reperfusion injury
In a saline lavage-induced lung injury model, both circulatory and pulmonary ET-1 levels increased.
Data suggest elevated levels of endothelin-1, as exhibited in cardiovascular diseases, facilitate development of ventricular arrhythmia by steepening action potential duration restitution and by increasing beat-to-beat variability of repolarization.
High levels of ET-1 are closely associated with BBB disruption. ET-1 may play an important role in the pathogenesis of secondary brain injury after ICH (show ACE Proteins).
After subarachnoid hemorrhage, the contractile response to ET-1 was enhanced, and the ET(A (show EDNRA Proteins)) receptor expression was upregulated in the basilar artery.
After acute pulmonary thromboembolism, thrombolytic and anti-inflammatory treatment could decrease acute lung injury induced by ET-1 and NF-kappaB (show NFKB1 Proteins) activation. [endothelin-1; NFKB]
The increase in myocardial distensibility induced by endothelin-1 is absent in heart failure and is dependent on nitric oxide and prostaglandin release.
Endothelin-1 enhances nuclear Ca2 (show CA2 Proteins)+ transients in atrial myocytes through Ins (show INS Proteins)(1,4,5)P3-dependent Ca2 (show CA2 Proteins)+ release from perinuclear Ca2 (show CA2 Proteins)+ stores
The enhancement of gap junction intercellular communication is activated by endothelin-1 via modulating the expression of connexin43 (show GJA1 Proteins), and plays an important role in the pathogenesis of cerebral vasospasm
The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. This peptide is a potent vasoconstrictor and is produced by vascular endothelial cells. Endothelin 1 also can affect the central nervous system. Two transcript variants encoding different isoforms have been found for this gene.
, endothelin 1
, gene for endothelin
, preproendothelin 1