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Normal expression of Reg2 (show FLOT1 Proteins) gene is required for appropriate compensations in pancreatic islet proliferation and expansion in response to obesity and aging.
mReg2 inhibits AIF (show AIFM1 Proteins)-mediated apoptosis by promoting the nuclear presence of Scythe (show BAT3 Proteins) and inducing hsp70 (show HSP70 Proteins).
Investigated the use of Escherichia coli as an expression host for Munc18c. Three N-terminal His-tagged constructs were engineered, two with a tobacco etch virus (TEV) or thrombin (show F2 Proteins) protease cleavage site to enable removal of the fusion tag.
Reg2 (show FLOT1 Proteins) induces glucose-regulated peptide 78 (GRP78 (show HSPA5 Proteins)) expression via the Akt (show AKT1 Proteins)-mTORC1 axis.
PTP1B (show PTPN1 Proteins) is the first known tyrosine phosphatase for Munc18c and a regulator of its phosphorylation and function in adipocytes.
Ectopic expression of syntaxin3 affects behaviors of B16 melanoma by controlling actin dynamics.
Direct stimulation of Reg2 (show FLOT1 Proteins) and Reg3beta genes by glucocorticoids.
Munc18c provides stimulus-specific regulation of GLUT4 (show SLC2A4 Proteins) trafficking, but not FA transporter trafficking
Reg2 (show FLOT1 Proteins), Reg3alpha, and Reg3beta were abundantly expressed in most acinar cells of the pancreas with clear age-dependent and isoform-specific patterns.
The Using 3T3-L1 adipocytes subjected to small int (show TYRO3 Proteins)erfering ribonucleic acid reduction o (show INS Proteins)f Munc18c as a model of (show SLC2A4 Proteins)impaired insulin-stimulated GLUT4 vesicle exocytosis.
Data suggest MUNC18C is required for STX4 (show STX4 Proteins)-mediated invadopodium formation and tumor invasion of extracellular matrix; N-terminal STX4 (show STX4 Proteins) fragment binds to MUNC18C and inhibits interactions of STX4 (show STX4 Proteins) with synaptosome-associated protein 23 (SNAP23 (show SNAP23 Proteins)) and vesicle-associated membrane protein 2 (VAMP2 (show VAMP2 Proteins)). Fibrosarcoma/adenocarcinoma cell lines were used in these studies. (MUNC18C = syntaxin binding protein MUNC18C; STX4 (show STX4 Proteins) = syntaxin 4 (show STX4 Proteins))
In vitro interaction assays indicated that Doc2b (show DOC2B Proteins) is required to bridge the interaction between Munc18c and Munc18-1 (show STXBP1 Proteins) in the macromolecular complex; Munc18c and Munc18-1 (show STXBP1 Proteins) failed to associate in the absence of Doc2b (show DOC2B Proteins)
Munc18c gene expression in human adipose tissue is down-regulated in morbid obesity.
Western Blot data showed decreased expression (p < 0,05) of Munc18c and phospho-PKC Zeta (show PRKCZ Proteins) in polycystic ovary-insulin (show INS Proteins) resistant endometria (PCOSE-IR) with respect to the control.
The identify IR as the first known tyrosine kinase (show TXK Proteins) for Munc18c as part of a new insulin (show INS Proteins)-signaling step in GLUT4 (show SLC2A4 Proteins) vesicle exocytosis.
Calpha (show PRKACA Proteins) activation and phosphorylation of syntaxin 4 (show STX4 Proteins) and Munc18c are required for the cell surface expression of P-selectin (show SELP Proteins) and the consequent binding of neutrophils to endothelial cells.
Munc18-2 (show STXBP2 Proteins) acts as a regulator of primary granule exocytosis, while Munc18-3 may preferentially regulate the fusion of secondary granules
These results indicate that insulin (show INS Proteins) induces dynamic associations between PKCzeta (show PRKCZ Proteins), 80K-H (show PRKCSH Proteins), and munc18c and that 80K-H (show PRKCSH Proteins) may act as a key signaling link between PKCzeta (show PRKCZ Proteins) and munc18c in live cells.
Might act as an inhibitor of spontaneous calcium carbonate precipitation.
, syntaxin-binding protein 3
, syntaxin binding protein 3
, syntaxin-binding protein 3-like
, islet of Langerhans regenerating protein 2
, pancreatic stone protein 2
, pancreatic thread protein 2
, regenerating islet-derived, mouse homolog 2
, platelet Sec1 protein
, protein unc-18 homolog 3
, protein unc-18 homolog C
, syntaxin 4 binding protein
, mammalian homolog of Unc-18c
, unc-18 homolog 3