Browse our MTMR3 Proteins (MTMR3)

Full name:
Myotubularin Related Protein 3 Proteins (MTMR3)
On are 3 Myotubularin Related Protein 3 (MTMR3) Proteins from 2 different suppliers available. Additionally we are shipping MTMR3 Antibodies (9) and many more products for this protein. A total of 13 MTMR3 products are currently listed.
1700092A20Rik, AI255150, AW557713, DKFZp459K2113, FYVE-DSP1, MGC68981, MGC143436, mKIAA0371, ZFYVE10
list all proteins Gene Name GeneID UniProt
MTMR3 8897 Q13615
MTMR3 74302  
Rat MTMR3 MTMR3 305482 Q5PQT2

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Human Myotubularin Related Protein 3 (MTMR3) interaction partners

  1. Data suggest MTMR3 has multiple functions in regulation of autophagy; one mechanism appears to be direct interaction between MTMR3 and mTORC1 (MTOR (show FRAP1 Proteins), mLST8 (show MLST8 Proteins), raptor (show RPTOR Proteins)) which inhibits phosphorylation activity of mTORC1; MTMR3 is localized to Golgi apparatus.

  2. the rs713875 IBD risk polymorphism increases MTMR3 expression, which modulates pattern recognition receptor (PRR (show PVRL1 Proteins))-induced outcomes, including increased induced caspase-1 (show CASP1 Proteins) activation

  3. myotubularin-related protein 3 and myotubularin-related protein 4 may act as a bridge between CEP55 (show CEP55 Proteins) and polo-like kinase 1, ensuring proper CEP55 (show CEP55 Proteins) phosphorylation and regulating CEP55 (show CEP55 Proteins) recruitment to the midbody.

  4. cloning, expression, purification and crystallization of human myotubularin-related protein 3 encompassing the PH-GRAM and the phosphatase catalytic domain are reported

  5. These results indicate that MTMR3 may play an important role in the progression of CRC (show CALR Proteins) and suggest that siRNA mediated silencing of MTMR3 could be an effective tool in CRC (show CALR Proteins) treatment.

  6. Our results suggest that the MTMR3 gene is shared between IgA nephropathy and lupus nephritis in the northern Chinese population, further highlighting the role of autophagy in systemic lupus erythematosus.

  7. Data suggest MTMR3, PIKFYVE (phosphoinositide kinase FYVE), and their product phosphatidylinositol 5-phosphate are involved in activation of RAC1 (rho family small GTP binding protein); this process regulates migration/invasion of carcinoma/sarcoma.

  8. Production of phosphatidylinositol 5-phosphate via PIKfyve (show PIKFYVE Proteins) and MTMR3 regulates cell migration.

  9. MTMR3 belongs to the myotubularin (show MTM1 Proteins) family of phosphoinositides phosphatases

  10. MTMR3 shares similar phosphatase activity and substrate specificity with its homologous proteins MTM1 (show MTM1 Proteins) and MTMR3

MTMR3 Protein Profile

Protein Summary

This gene encodes a member of the myotubularin dual specificity protein phosphatase gene family. The encoded protein is structurally similar to myotubularin but in addition contains a FYVE domain and an N-terminal PH-GRAM domain. The protein can self-associate and also form heteromers with another myotubularin related protein. The protein binds to phosphoinositide lipids through the PH-GRAM domain, and can hydrolyze phosphatidylinositol(3)-phosphate and phosphatidylinositol(3,5)-biphosphate in vitro. The encoded protein has been observed to have a perinuclear, possibly membrane-bound, distribution in cells, but it has also been found free in the cytoplasm. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with MTMR3

  • myotubularin-related protein 3 (mtmr3)
  • myotubularin related protein 3 (MTMR3)
  • myotubularin related protein 3 (mtmr3)
  • myotubularin related protein 3 (Mtmr3)
  • 1700092A20Rik protein
  • AI255150 protein
  • AW557713 protein
  • DKFZp459K2113 protein
  • FYVE-DSP1 protein
  • MGC68981 protein
  • MGC143436 protein
  • mKIAA0371 protein
  • ZFYVE10 protein

Protein level used designations for MTMR3

myotubularin-related protein 3 , myotubularin related protein 3 , myotubularin-related protein 3-like , FYVE (Fab1 YGLO23 Vsp27 EEA1 domain) dual-specificity protein phosphatase , FYVE domain-containing dual specificity protein phosphatase 1 , zinc finger FYVE domain-containing protein 10 , zinc finger, FYVE domain containing 10

379701 Xenopus laevis
417015 Gallus gallus
458748 Pan troglodytes
486349 Canis lupus familiaris
494749 Xenopus laevis
535099 Bos taurus
715214 Macaca mulatta
100030849 Monodelphis domestica
100058825 Equus caballus
100157292 Sus scrofa
100173446 Pongo abelii
100341987 Oryctolagus cuniculus
100386598 Callithrix jacchus
100484172 Ailuropoda melanoleuca
100494490 Xenopus (Silurana) tropicalis
100548510 Meleagris gallopavo
8897 Homo sapiens
74302 Mus musculus
305482 Rattus norvegicus
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