Browse our anti-OCRL (OCRL) Antibodies

On are 64 Oculocerebrorenal Syndrome of Lowe (OCRL) Antibodies from 15 different suppliers available. Additionally we are shipping OCRL Proteins (6) and many more products for this protein. A total of 75 OCRL products are currently listed.
9530014D17Rik, BB143339, INPP5F, LOCR, NPHL2, OCRL, OCRL-1, OCRL1, wu:fi09g03, zgc:152864
list all antibodies Gene Name GeneID UniProt
OCRL 317576  
OCRL 4952 Q01968
OCRL 320634  

Most Popular Reactivities for anti-OCRL (OCRL) Antibodies

anti-Rat (Rattus) OCRL Antibodies:

anti-Human OCRL Antibodies:

anti-Mouse (Murine) OCRL Antibodies:

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More Antibodies against OCRL Interaction Partners

Zebrafish Oculocerebrorenal Syndrome of Lowe (OCRL) interaction partners

  1. OCRL1 is required for renal tubular endocytosis.

  2. Knockdown of OCRL1 in zebrafish caused developmental defects consistent with disruption of ciliary function.

  3. results indicate a novel role for OCRL1 in neural development, and support a model whereby dysregulation of phosphoinositide metabolism and clathrin-mediated membrane traffic leads to the neurological symptoms of Lowe syndrome

Human Oculocerebrorenal Syndrome of Lowe (OCRL) interaction partners

  1. We discuss how studies of OCRL have led to important discoveries about the basic mechanisms of membrane trafficking and describe the key features and limitations of the currently available animal models of Lowe syndrome. Mutations in OCRL can also give rise to a milder pathology, Dent disease 2, which is characterized by renal Fanconi syndrome in the absence of extrarenal pathologies.

  2. A diagnosis of Dent disease was established in 19 boys from 16 families by the presence of loss of function/deleterious mutations in CLCN5 (show CLCN5 Antibodies) or OCRL1.

  3. Depleting or inhibiting OCRL leads to an accumulation of lysosomal PtdIns(4,5)P2, an inhibitor of the calcium channel mucolipin-1 (show MCOLN1 Antibodies) that controls autophagosome-lysosome fusion

  4. Here we show that OCRL1 is part of the membrane-trafficking machinery operating at the trans-Golgi network (TGN (show TG Antibodies))/endosome interface.

  5. Authors propose that the precise spatial and temporal activation of Rab35 (show RAB35 Antibodies) acts as a major switch for OCRL recruitment on newborn endosomes, post-scission PtdIns(4,5)P2 hydrolysis, and subsequent endosomal trafficking.

  6. OCRL mRNA and protein were downregulated in osteoarthritis knee cartilage. OCRL inhibits Rac1 activation in OA.

  7. OCRL-mutated fibroblasts from patients with Dent-2 disease exhibit INPP5B (show INPP5B Antibodies)-independent phenotypic variability relatively to Lowe syndrome cells.

  8. Results indicate that inositol 5-phosphatase OCRL acts as an uncoating factor and that defects in clathrin-mediated endocytosis likely contribute to pathology in patients with OCRL mutations.

  9. The crystal structures of human OCRL in complex with phosphoinositide substrate analogs revealed a membrane interaction patch likely to assist in sequestering substrates from the lipid bilayer.

  10. Implications of OCRL and TRPV4 (show TRPV4 Antibodies) in primary cilia function may also shed light on mechanosensation in other organ systems.

Mouse (Murine) Oculocerebrorenal Syndrome of Lowe (OCRL) interaction partners

  1. These results suggest that the functions of OCRL/INPP5B (show INPP5B Antibodies) and proton-chloride exchange transporter 5 converge on shared mechanisms, the impairment of which has a dramatic effect on proximal tubule endocytosis

  2. OCRL mRNA and protein were downregulated in osteoarthritis knee cartilage. OCRL inhibits Rac1 activation in OA.

  3. Implications of OCRL and TRPV4 (show TRPV4 Antibodies) in primary cilia function may also shed light on mechanosensation in other organ systems.

  4. Bcl10 was required to locally deliver the vesicular OCRL phosphatase that regulates PI(4,5)P(2) and F-actin turnover, both crucial for the completion of phagosome closure.

  5. These results indicate a functional overlap of Ocrl and Inpp5b (show INPP5B Antibodies) in most cell lineages, especially in extraembryonic tissues.

  6. The results indicate that OCRL1 restricts intracellular growth of L. pneumophila and binds to Legionella-containing vacuoles in association with Legionella LpnE.

OCRL Antigen Profile

Antigen Summary

This gene encodes a phosphatase enzyme that is involved in actin polymerization and is found in the trans-Golgi network. Mutations in this gene cause oculocerebrorenal syndrome of Lowe and also Dent disease.

Alternative names and synonyms associated with OCRL

  • oculocerebrorenal syndrome of Lowe (Ocrl) antibody
  • phosphatidylinositol polyphosphate 5-phosphatase (NAEGRDRAFT_58601) antibody
  • oculocerebrorenal syndrome of Lowe (OCRL) antibody
  • oculocerebrorenal syndrome of Lowe (ocrl) antibody
  • 9530014D17Rik antibody
  • BB143339 antibody
  • INPP5F antibody
  • LOCR antibody
  • NPHL2 antibody
  • OCRL antibody
  • OCRL-1 antibody
  • OCRL1 antibody
  • wu:fi09g03 antibody
  • zgc:152864 antibody

Protein level used designations for OCRL

inositol polyphosphate 5-phosphatase OCRL-1 , phosphatidylinositol polyphosphate 5-phosphatase , phosphatidylinositol polyphosphate 5-phosphotase , oculocerebrorenal syndrome of Lowe , phosphatidylinositol polyphosphate 5-phosphatase-like , inositol polyphosphate 5-phosphatase OCRL-1-like , Lowe oculocerebrorenal syndrome protein

317576 Rattus norvegicus
8851947 Naegleria gruberi strain NEG-M
422136 Gallus gallus
492123 Canis lupus familiaris
535844 Bos taurus
702345 Macaca mulatta
777716 Danio rerio
100021521 Monodelphis domestica
100059144 Equus caballus
100087165 Ornithorhynchus anatinus
100125214 Xenopus (Silurana) tropicalis
100172875 Pongo abelii
100346052 Oryctolagus cuniculus
100415106 Callithrix jacchus
100476961 Ailuropoda melanoleuca
100524726 Sus scrofa
100543414 Meleagris gallopavo
100563751 Anolis carolinensis
100603753 Nomascus leucogenys
4952 Homo sapiens
320634 Mus musculus
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