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expression of PLA2s (show PLA2G2A Proteins)-IIE and -V correlates with the development of calcification as well as the expression of pro-osteogenic molecules in human aortic valves
sPLA(2 (show PLA2G2A Proteins)) -IIE regulates lipolysis in adipocytes, likely through the ERK (show EPHB2 Proteins)/HSL (show LIPE Proteins) signaling pathway
Single-nucleotide polymorphism in PLA2G2E gene is associated with ulcerative colitis.
promotes stimulus-induced arachidonic acid release and prostaglandin (PG) production similar to those elicited by HSPG (show HSPG2 Proteins)-dependent sPLA(2 (show PLA2G2A Proteins))s, suggesting that this enzyme plays a role in the inflammatory process.
two skin sPLA2s (show PLA2G2D Proteins), hair follicular sPLA2-IIE and epidermal sPLA2-IIF (show PLA2G2F Proteins), play non-redundant roles in distinct compartments of mouse skin, underscoring the functional diversity of multiple sPLA2s (show PLA2G2D Proteins) in the coordinated regulation of skin homeostasis and diseases.
PLA2G2E altered minor lipoprotein phospholipids, phosphatidylserine and phosphatidylethanolamine, and moderately facilitated lipid accumulation in adipose tissue and liver.
PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Has a preference for arachidonic-containing phospholipids.
phospholipase A2, group IIE
, group IIE secretory phospholipase A2
, phosphatidylcholine 2-acylhydrolase 2E
, GIIE sPLA2