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Human Monoclonal PLEK Primary Antibody for IF, IP - ABIN968010
Abrams, Wu, Zhao, Belmonte, White, Brass: Pleckstrin inhibits phosphoinositide hydrolysis initiated by G-protein-coupled and growth factor receptors. A role for pleckstrin's PH domains. in The Journal of biological chemistry 1995
Show all 4 Pubmed References
Human Polyclonal PLEK Primary Antibody for ELISA, WB - ABIN250083
Hunter, Mackintosh, Hers: Protein kinase C-mediated phosphorylation and activation of PDE3A regulate cAMP levels in human platelets. in The Journal of biological chemistry 2009
Show all 2 Pubmed References
Only one gene, pleckstrin , was significantly overexpressed in periodontitis,cardiovascular disease, rheumatoid arthritis and ulcerative colitis , implicating this gene as an important networking link between these chronic inflammatory diseases
These findings reveal a novel role of the PLD1-pleckstrin homology domain as a positive regulator of endocytosis and provide a link between PLD1 and HIF-1alpha (show HIF1A Antibodies) in the EGFR (show EGFR Antibodies) endocytosis pathway.
crystallization and preliminary X-ray diffraction analysis of the first 2 domains of pleckstrin (NPHDEP); work demonstrates that NPHDEP behaves as a monomer in solution and suggests that all 3 pleckstrin domains contribute to the dimerization interface
Here they show that the PH domain from Bcr-Abl (show ABL1 Antibodies) binds a number of proteins involved in vital cellular processes in leukemogenesis.
A pleckstrin homology domain located in G protein-coupled receptor kinase-2 (GRK2 (show ADRBK1 Antibodies)) residue 548 to 660 plays a significant role in mediating interaction between protein kinase C beta 1 (show PRKCB Antibodies) and GRK2 (show ADRBK1 Antibodies).
The human pleckstrin-1 solution nuclear magnetic resonance structure of the C-terminal pleckstrin homology domain was reported.
Proteins beta3 integrin (show ITGB3 Antibodies), Vav3 (show VAV3 Antibodies), Plekhm1 (show PLEKHM1 Antibodies), and Src (show SRC Antibodies), implicated in attachment defects, had normal exon sequences in a new type of osteopetrosis (show CSF1 Antibodies).
Idirect associations between plek and actin through 17 beta-hydroxysteroid dehydrogenase 4 (show HSD17B4 Antibodies), alpha-actinin (show ACTN1 Antibodies), moesin (show MSN Antibodies), radixin (show RDX Antibodies) and factor XIIIA (show F13A1 Antibodies), is proposed.
Targeting of the pleckstrin homology domain of AKT (show AKT1 Antibodies) was studied in cancer treatment in mouse models.
pleckstrin regulates the fusion of granules to the cell membrane and is an essential component of PKC-mediated exocytosis in platelets
Major protein kinase C substrate of platelets.
, platelet 47 kDa protein