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anti-Mouse (Murine) TEP1 Antibodies:
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Collectively, these findings provide a mechanistic account of how Rac1-dependent membrane raft localization regulates differential activation of distinct phosphoinositide 3-kinase isoforms and offer insight into why PTEN-deficient cancers depend on p110beta.
SHP2 (show PTPN11 Antibodies) and PTEN (show PTEN Antibodies) deficiencies were detected in liver cancer patients with poor prognosis. These data depict a mechanism of hepato-oncogenesis and suggest a potential therapeutic strategy.
Mechanistically, ligation of alpha8beta1 by the milk protein Mfge8 (show MFGE8 Antibodies) reduces antral smooth muscle contractile force by preventing RhoA (show RHOA Antibodies) activation through a PTEN (show PTEN Antibodies)-dependent mechanism.
We have found a prospective targeted therapy for PTEN (show PTEN Antibodies)-deficient tumors, with efficacy in vitro and in vivo in tumors derived from different tissues. This is based upon the changes in glutamine (show GFPT1 Antibodies) metabolism, DNA replication, and DNA damage response which are consequences of inactivation of PTEN (show PTEN Antibodies).
Suggest a role for PI(3,4)P2 in the phenotype caused by loss-of-function mutations or deletions in PTEN (show PTEN Antibodies) in breast/prostate tumor cells.
embryonic myogenic progenitors lacking the phosphatase and tensin homolog (Pten (show PTEN Antibodies)) exhibit enhanced proliferation and differentiation, resulting in muscle hypertrophy.
PTEN (show PTEN Antibodies) loss in E-cadherin (show CDH1 Antibodies)-deficient mouse mammary epithelial cells rescues apoptosis and results in development of classical invasive lobular carcinoma.
Pten (show PTEN Antibodies) modulates the hematopoietic stem cells response to inflammatory cytokines.
PTEN (show PTEN Antibodies) counteracts FBXL2 (show FBXL2 Antibodies) to promote IP3R3 (show ITPR3 Antibodies)- and Ca(2 (show CA2 Antibodies)+)-mediated apoptosis limiting tumour growth
Theca cell-selective Pten (show PTEN Antibodies) mutation (tPtenMT) in mice resulted in increases in PDK1 (show PDPK1 Antibodies) and Akt (show AKT1 Antibodies) phosphorylation, indicating an over-activation of PI3K signaling in the ovaries.
The current results suggested that genetic variants at TEP1 (show PTEN Antibodies) SNPs rs1760893 and rs1713423 may be associated significantly with increased risk of stomach cancer.
TEP1 (show PTEN Antibodies) Polymorphisms are not associated with Hepatocellular Carcinoma in Thai Patients with Chronic Hepatitis B Virus Infection.
These data suggest that genetic variations in the TEP1 (show PTEN Antibodies) gene may be biomarkers for risk of PCa (show FLVCR1 Antibodies) and BCR (show BCR Antibodies) after RP.
8 common SNPs in telomerase reverse transcriptase (TERT (show TERT Antibodies)) and telomerase-associated protein 1 (TEP1) were genotyped.
the protein levels of MVP (show MVP Antibodies), TEP1 (show PTEN Antibodies) and vPARP (show PARP4 Antibodies) are actually increased in the highergrade tumors suggesting existence of post-transcriptional regulation of vault component production.
TP1 (show RPLP2 Antibodies) expression did not change after cisplatin exposure for 72 hours.
TEP1 (show PTEN Antibodies), hTR (show F2R Antibodies), hsp90 (show HSP90 Antibodies), p23, and dyskerin (show DKC1 Antibodies) remained at high and unchanged levels throughout up- or down regulation of telomerase activity.
TEP1 (show PTEN Antibodies), TOPOIIalpha, and HSP90 (show HSP90 Antibodies) interact directly with BLM in vitro and modulate its helicase activity on telomere-like DNA substrates but not on non-telomeric substrates.
This gene product is a component of the ribonucleoprotein complex responsible for telomerase activity which catalyzes the addition of new telomeres on the chromosome ends. The telomerase-associated proteins are conserved from ciliates to humans.
mutated in multiple advanced cancers 1
, phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
, phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
, protein tyrosine phosphatase and tensin-like protein
, phosphatase and tensin homolog deleted on chromosome ten
, telomerase protein component 1
, telomerase protein 1
, p80 telomerase homolog
, telomerase-associated protein 1
, p80 homolog
, TROVE domain family, member 1