TEP1 antibody (N-Term)

Catalog No. ABIN5541415

Product Details anti-TEP1 Antibody

Target: TEP1 (Telomerase-Associated Protein 1 (TEP1))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TEP1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: Species: Human, Mouse and Rat.

Purification: Immunoaffinity Chromatography.

Immunogen: Synthetic Peptide corresponding to 20 Amino Acid peptide from near the amino terminus of human TP1.

Application Details

Application Notes: Immunohistochemistry on Paraffin Sections (5 μg/mL). Western Blot.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Phosphate Buffered Saline PBS containing 0.02 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Dilute only prior to immediate use. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for TEP1

Target: TEP1 (Telomerase-Associated Protein 1 (TEP1))

Alternative Name: tep1,tlp1 (TEP1 Products)

Background: Telomerase is an RNA-dependent DNA polymerase that uses an RNA component to add telomeric repeat sequences at the ends of chromosomes. Besides the RNA component which serves as the template that specifies the telomeric repeat, the telomerase complex contains a reverse transcriptase protein (TRT) and various accessory proteins including the telomerase-associated protein 1 (TEP1). Telomerase activity is low in most somatic cells, causing the gradual shortening of telomeres which can ultimately lead to telomere fusion and cell death. High levels of telomerase activity are widely seen in cancerous cells and while recent experiments have suggested that telomerase may be a viable target in cancer therapy, expression levels of TEP1 do not correlate with malignancy. At least two isoforms of TP1 are known to exist.

UniProt: Q99973

Pathways: Inositol Metabolic Process, Synaptic Membrane, Regulation of Cell Size, Autophagy, Platelet-derived growth Factor Receptor Signaling, Signaling of Hepatocyte Growth Factor Receptor