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PTEN counteracts FBXL2 (show FBXL2 ELISA Kits) to promote IP3R3 (show ITPR3 ELISA Kits)- and Ca(2 (show CA2 ELISA Kits)+)-mediated apoptosis limiting tumour growth
Theca cell-selective Pten mutation (tPtenMT) in mice resulted in increases in PDK1 (show PDPK1 ELISA Kits) and Akt (show AKT1 ELISA Kits) phosphorylation, indicating an over-activation of PI3K signaling in the ovaries.
We further demonstrate that loss of one allele of PTEN is sufficient to shift isoform dependency from p110alpha (show PIK3CA ELISA Kits) to p110beta in vivo. These results provide insight into the molecular mechanism by which ErbB2 (show ERBB2 ELISA Kits)-positive breast cancer escapes p110alpha (show PIK3CA ELISA Kits) inhibition.
Low PTEN expression is associated with Prostate Cancer Progression.
Findings indicate that the ovary is highly resistant to tumorigenic changes due to selective global or granulosa cells-specific Pten disruption and rising FSH (show BRD2 ELISA Kits) levels.
The results identify a novel miR (show MLXIP ELISA Kits)-682/PTEN/NF-kappaB (show NFKB1 ELISA Kits) p65 (show NFkBP65 ELISA Kits) signaling pathway in intestinal epithelial cells injury induced by ischemia-reperfusion that could be targeted for therapy.
This is the first report of a viral-Cre mediated Trp53/Pten mouse model of undifferentiated pleomorphic sarcoma. The bioluminescence imaging feature, along with high penetrance of the model and its immunological characteristics, makes it suited for pre-clinical studies of soft tissue sarcoma
miR (show MLXIP ELISA Kits)-214 regulates renal cell hypertrophy and matrix protein expression by directly acting on PTEN and modulating the PRAS40 (show AKT1S1 ELISA Kits)/tuberin (show TSC2 ELISA Kits) and mTORC1 axis in response to high glucose.
loss of Pten, which in cones results in less robust mTORC1 activation when compared with loss of Tsc1 (show TSC1 ELISA Kits), still affords long-term cone survival.
Transgenic mice overexpressing PSGR in the prostate were reported to develop an acute inflammatory response followed by emergence of low grade prostatic intraepithelial neoplasia, whereas mice with compound PSGR overexpression and loss of PTEN exhibited accelerated formation of invasive prostate adenocarcinoma. (Review)
The current results suggested that genetic variants at TEP1 SNPs rs1760893 and rs1713423 may be associated significantly with increased risk of stomach cancer.
TEP1 Polymorphisms are not associated with Hepatocellular Carcinoma in Thai Patients with Chronic Hepatitis B Virus Infection.
These data suggest that genetic variations in the TEP1 gene may be biomarkers for risk of PCa (show FLVCR1 ELISA Kits) and BCR (show BCR ELISA Kits) after RP.
8 common SNPs in telomerase reverse transcriptase (TERT (show TERT ELISA Kits)) and telomerase-associated protein 1 (TEP1) were genotyped.
the protein levels of MVP (show MVP ELISA Kits), TEP1 and vPARP (show PARP4 ELISA Kits) are actually increased in the highergrade tumors suggesting existence of post-transcriptional regulation of vault component production.
TP1 (show RPLP2 ELISA Kits) expression did not change after cisplatin exposure for 72 hours.
TEP1, hTR (show F2R ELISA Kits), hsp90 (show HSP90 ELISA Kits), p23, and dyskerin (show DKC1 ELISA Kits) remained at high and unchanged levels throughout up- or down regulation of telomerase activity.
TEP1, TOPOIIalpha, and HSP90 (show HSP90 ELISA Kits) interact directly with BLM in vitro and modulate its helicase activity on telomere-like DNA substrates but not on non-telomeric substrates.
This gene product is a component of the ribonucleoprotein complex responsible for telomerase activity which catalyzes the addition of new telomeres on the chromosome ends. The telomerase-associated proteins are conserved from ciliates to humans.
mutated in multiple advanced cancers 1
, phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
, phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
, protein tyrosine phosphatase and tensin-like protein
, phosphatase and tensin homolog deleted on chromosome ten
, telomerase protein component 1
, telomerase protein 1
, p80 telomerase homolog
, telomerase-associated protein 1
, p80 homolog
, TROVE domain family, member 1