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results showed a significant correlation between IFNGR1- T-56CSNP and Nontuberculous mycobacteria infection among studied populations
Data suggest IFNG (show IFNG Proteins) plays various roles in dynamics of inflammation in subjects with underlying autoimmunity modeled as "canonical" and "non-canonical" pathways; in canonical pathway, IFNG (show IFNG Proteins) dimerizes and binds to IFNGR1 in IFNGR1/IFNGR2 (show IFNGR2 Proteins) hetero-multimer; STAT (show STAT1 Proteins) transcription factors are involved in non-canonical pathway. (IFNG (show IFNG Proteins) = interferon gamma (show IFNG Proteins); IFNGR = IFNG (show IFNG Proteins) receptor; STAT (show STAT1 Proteins) = signal transducers and activators of transcription)
The study did not provide enough powerful evidence to identify a significant association between IFNGR1 -56C/T polymorphism and tuberculosis susceptibility (meta-analysis).
All patients tested were positive for mycobacteria; one was heterozygous for the IFNGR1 exon 5 single-nucleotide-missense substitution
The deletion of IFNGR1 causes complete IFN-gammaR1 deficiency. Despite the deletion ending very close to the IL22RA2 (show IL22RA2 Proteins) gene, it does not appear to affect IL22RA2 (show IL22RA2 Proteins) transcription.
A significant association of IFN-gammaR1 and P2X7 (show P2RX7 Proteins) genes polymorphisms with risk of developing TB in Iranian population.
Mendelian susceptibility to mycobacteria due to a partial dominant mutation of the interferon gamma receptor 1 gene.
Targeted deep sequencing identifies rare loss-of-function variants in IFNGR1 for risk of atopic dermatitis complicated by eczema herpeticum
Statistical analyses revealed that four genetic variants in IFNGR1 were marginally associated with the risk of Tuberculosis (P = 0.02-0.04), while other single nucleotide polymorphisms in IFNGR1 and IFNGR2 (show IFNGR2 Proteins) did not exhibit any associations
Uniformly low expression of IFN and IFNGR1 in post Kala-azar dermal leishmaniasis skin biopsies could explain parasite persistence and is consistent with prior demonstration of genetic association with IFNGR1 polymorphisms.
These findings suggest that IFNGR1 signaling plays a pivotal role in placental pathology and subsequent adverse pregnancy outcomes during severe malaria. Our findings may increase our understanding of how disease aggravation occurs during malaria during pregnancy.
Down regulation of macrophage IFNGR1 resists infection by Listeria monocytogenes.
Marginal zone macrophage population loss is dependent on interferon gamma (show IFNG Proteins) receptor but independent of T cells or tumor necrosis factor alpha receptor (show TNFRSF1A Proteins) 1 signaling pathways.
These results suggest that pulmonary C-fibers affect IFNGR1 expression by inducing IFN-alpha (show IFNA Proteins) to regulate IFN-gamma (show IFNG Proteins)-mediated airway inflammation and airway hyperresponsiveness.
data define a novel B cell-intrinsic IFN-gammaR signaling pathway specific to Spt (show AGXT Proteins)-GC development and autoimmunity.
These data offer direct evidence that tumor cell loss of the IFNGR1 gene, which results in loss of IFN-g (show IFNG Proteins) signaling, leads to resistance to anti-CTLA-4 (show CTLA4 Proteins) therapy.
These data indicate that both GKO and GRKO mice fail to develop an IFN-gamma (show IFNG Proteins)-mediated antiviral response, but differ in regulation of the inflammatory response to infection.
IFN-gamma (show IFNG Proteins) Ralpha is a key determinant of CD8 (show CD8A Proteins)+ T cell-mediated tumor elimination or tumor escape and relapse in FVB mouse.
Data indicate that prolonged IFNgammaR-/- dendritic cell survival promotes CD4 (show CD4 Proteins) T cell expansion.
These data suggest that type I IFN stimulation induces a rapid recruitment of a repressive Egr3 (show EGR3 Proteins)/Nab1 (show NAB1 Proteins) complex that silences transcription from the ifngr1 promoter.
analysis of mir (show MYLIP Proteins)-378 and of the interferon gamma receptor 1 protein at different stages of luteal development showed that mir (show MYLIP Proteins)-378 decreased the expression of interferon gamma receptor 1 protein but not the mRNA
SNPs in IFNG (show IFNG Proteins), IFNGR1 and R2, IL22 (show IL22 Proteins), and IL22RA1 (show IL22RA1 Proteins) were analyzed for an association to Estimated breeding values for somatic cell score in Canadian Holstein bulls; no significant associations were found.
The receptor complex for Ifn-gamma2 includes cytokine receptor (show LEPR Proteins) family B (Crfb)6 together with Crfb13 and Crfb17.
This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection.
AVP, type 2
, CD119 antigen
, IFN-gamma receptor 1
, antiviral protein, type 2
, immune interferon receptor 1
, interferon-gamma receptor alpha chain
, INF-g receptor
, interferon-gamma receptor 1
, interferon gamma receptor 1