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silencing of IL1B (show IL1B ELISA Kits) plus dexamethasone-induced DUSP1 (show DUSP1 ELISA Kits) significantly reduced IRF1 expression. IL1B (show IL1B ELISA Kits)-induced expression of CXCL10 (show CXCL10 ELISA Kits) was largely insensitive to dexamethasone, whereas other DUSP1 (show DUSP1 ELISA Kits)-enhanced, IRF1-dependent mRNAs showed various degrees of repression.
Inflammation-driven IRF1 and NF-kappaB (show NFKB1 ELISA Kits) activity promotes ERVK reactivation.
MiR (show MLXIP ELISA Kits)-23a downregulates the expression of IRF-1 in HCC (show FAM126A ELISA Kits) cells.
the interactions of IRF1, IFN-beta (show IFNB1 ELISA Kits) and IRF5 (show IRF5 ELISA Kits) are involved in the M1 polarization of macrophages and have antitumor functions.
rs56288038 (C/G) in IRF-1 3'UTR (show UTS2R ELISA Kits) acted as a promotion factor in gastric cancer development through enhancing the regulatory role of miR (show MLXIP ELISA Kits)-502-5p in IRF-1 expression.
An IRF-1 shorter splicing transcript has been identified in acute promyelocytic leukemia (show PML ELISA Kits) cells dispalying similar transactivation activity to the full length transcript.
Data suggest that interferon beta (IFN-beta (show IFNB1 ELISA Kits)) might be involved in modulating the expressions of interferon regulatory factor 1 (IRF1) and interferon regulatory factor-5 (show IRF5 ELISA Kits) protein (IRF5 (show IRF5 ELISA Kits)) as well as maintaining the M1 polarization status and its function.
IRF1 upregulation in fetal membranes and myometrium after term labor indicates a proinflammatory role for IRF1 in human parturition. IRF1 is involved in TLR- and cytokine-mediated signaling in human myometrium.
5AZ had a protective effect after MI by potentiation of IRF1 sumoylation and is suggested as a novel therapeutic intervention for cardiac repair.
IRF1 is a transcriptional regulator of IRG1 in human macrophages.
Given these results, porcine IRF1 plays potential roles in cellular antiviral responses against swine viruses.
In a healthy swine model, elevated levels of endothelial IRF-1 were also observed within atherosusceptible regions of the aorta by Western blot analysis and immunohistochemistry, implicating arterial hemodynamics in the regulation of IRF-1 expression.
The results suggested that the porcine IRF1 gene is strong candidate gene for these immune traits in pig.
IRF-1 and interferon-alpha (show IFNA ELISA Kits) with interferon-beta (show IFNB1 ELISA Kits) cooperate to control acute gammaherpesvirus infection.
this study shows that binding motifs for the transcription factors STAT1 (show STAT1 ELISA Kits) and IRF1 are associated with robust and IL-4 (show IL4 ELISA Kits)-resistant responses to IFN-gamma (show IFNG ELISA Kits) in macrophages
direct the expression of a set of genes, the IRF8 (show IRF8 ELISA Kits)/IRF1 regulome, that play critical roles in host inflammatory and antimicrobial defenses in mouse models of neuroinflammation and of pulmonary tuberculosis, respectively
couples synthesis of miR (show MLXIP ELISA Kits)-342-5p to the antiviral interferon (show IFNA ELISA Kits) response
The gammaherpesvirus-driven germinal center expansion was exaggerated and lost its transient nature in the absence of interferon-regulatory factor 1 (IRF-1), a transcription factor with antiviral and tumor suppressor functions.
IRF1 is required for IRF8 (show IRF8 ELISA Kits)-induced gene expression in microglia.
in addition to regulating the enterocyte metabolic switch, Blimp1 functions as a gatekeeper in opposition to Irf1 to prevent premature activation of the MHC class I pathway in villus epithelium to maintain tolerance in the neonatal intestine.
Although treatment with IFN-gamma (show IFNG ELISA Kits) strongly induced the activation of STAT1 (show STAT1 ELISA Kits) as a transcriptional activator, its target molecule, IRF1, was not clearly produced in Lmp2 (show PSMB9 ELISA Kits)-deficient uterine smooth muscle cells.
found that the effect of PGC-1alpha (show PPARGC1A ELISA Kits) on repressing IRF-1 expression and activity is facilitated by the reduction in phosphorylation of STAT1 (show STAT1 ELISA Kits) at position 727 (S727P), an essential transcriptional activator of IRF-1
IRF1 encodes interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse it has been shown to be required for double-stranded RNA induction of these genes. IRF1 also functions as a transcription activator of genes induced by interferons alpha, beta, and gamma. Further, IRF1 has been shown to play roles in regulating apoptosis and tumor-suppressoion.
interferon regulatory factor 1
, interferon regulatory factor 11
, interferon responsive factor 1