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Following spring viremia of carp (show ANKRD1 ELISA Kits) virus infection, DrIFNPhi1/3 and DrIRF1/3/7 transcripts are significantly induced in zebrafish tissues, which correlates with the replication of spring viremia of carp (show ANKRD1 ELISA Kits) virus. data provide evidence that fish and mammals have evolved a similar IRF (show TRIM63 ELISA Kits)-dependent regulatory mechanism fine-tuning IFN gene activation.
HNP1 (show DEFA1 ELISA Kits) upregulation of cytokine expression in pDCs was inhibited by blockade of NF-kappaB (show NFKB1 ELISA Kits) activation or knockdown of IRF1, demonstrating the importance of these two signaling events in HNP1 (show DEFA1 ELISA Kits)-induced pDC (show PNKD ELISA Kits) activation.
Data show that the Japanese encephalitis virus (JEV)-induced expression of miR (show MLXIP ELISA Kits)-301a led to inhibition of the production of the transcription factor IFN regulatory factor 1 (IRF1) and the signaling protein suppressor of cytokine signaling 5 (SOCS5 (show SOCS5 ELISA Kits)).
A comprehensive mass spectrometric analysis identified interferon regulatory factor 1 (IRF1) as a key transcription factor in growth arrest of LNCaP-mTOR (show FRAP1 ELISA Kits).
IFN regulatory factor 1 effectively inhibits hepatitis E virus replication through the activation of the JAK (show JAK3 ELISA Kits)-STAT (show STAT1 ELISA Kits) pathway
B. abortus lipoproteins via IL-6 (show IL6 ELISA Kits) inhibit the expression of IFN regulatory factor 1 (IRF-1), a critical regulatory transcription factor for CIITA (show CIITA ELISA Kits) induction.
STAT1 (show STAT1 ELISA Kits) and IRF1 collaborate to induce interferon-gamma (show IFNG ELISA Kits) stimulated genes (ISGs), but the extent to which they act alone or together is unclear.This study provides strong evidence for widespread cooperation between STAT1 (show STAT1 ELISA Kits) and IRF1 at ISGs, and suggests that in silico predictions reliably predict the effect of nucleotide variants on binding in vivo.
aimed to determine the role of Treg cells and IRF-1 in MDS (show PAFAH1B1 ELISA Kits)
Tat (show TAT ELISA Kits) exploited the cellular HDM2 (human double minute 2 protein (show MDM2 ELISA Kits)) ubiquitin ligase to accelerate IRF-1 proteasome-mediated degradation, resulting in a quenching of IRF-1 transcriptional activity during HIV-1 infection.
Leading to a STAT1 (show STAT1 ELISA Kits)-IRF1 controlled upregulation of TLR3 (show TLR3 ELISA Kits) expression in macrophages.
Regulatory elements for both IRF-1 (-1019 to -1016) and CREB (show CREB1 ELISA Kits) (-1198 to -1195), specific to the distal THBS1 (show THBS1 ELISA Kits) promoter, were required for leptin (show LEP ELISA Kits)-induced TSP-1 (show THBS1 ELISA Kits) transcription.
Given these results, porcine IRF1 plays potential roles in cellular antiviral responses against swine viruses.
In a healthy swine model, elevated levels of endothelial IRF-1 were also observed within atherosusceptible regions of the aorta by Western blot analysis and immunohistochemistry, implicating arterial hemodynamics in the regulation of IRF-1 expression.
The results suggested that the porcine IRF1 gene is strong candidate gene for these immune traits in pig.
Results indicate IRF-1 is one of the key transcriptional factors for the prevention of neointimal formation involving angiotensin II type 2 receptors.
Data show that HCFC2 (show HCFC2 ELISA Kits) is a critical component of the IRF1 and IRF2 (show IRF2 ELISA Kits) transcriptional machinery that regulates Tlr3 (show TLR3 ELISA Kits) gene expression.
Our studies uncovered the critical role of two transcription factors, IRF1 and BATF, in preparing the chromatin landscape for induction of the Tr1 gene network in response to IL-27 signaling, where BATF acted as a pioneer factor and prepared the genomic landscape for the binding of additional transcription factors that define the Tr1 lineage.
IRF-1 and interferon-alpha (show IFNA ELISA Kits) with interferon-beta (show IFNB1 ELISA Kits) cooperate to control acute gammaherpesvirus infection.
this study shows that binding motifs for the transcription factors STAT1 (show STAT1 ELISA Kits) and IRF1 are associated with robust and IL-4 (show IL4 ELISA Kits)-resistant responses to IFN-gamma (show IFNG ELISA Kits) in macrophages
5AZ had a protective effect after MI by potentiation of IRF1 sumoylation and is suggested as a novel therapeutic intervention for cardiac repair.
direct the expression of a set of genes, the IRF8 (show IRF8 ELISA Kits)/IRF1 regulome, that play critical roles in host inflammatory and antimicrobial defenses in mouse models of neuroinflammation and of pulmonary tuberculosis, respectively
couples synthesis of miR (show MLXIP ELISA Kits)-342-5p to the antiviral interferon (show IFNA ELISA Kits) response
The gammaherpesvirus-driven germinal center expansion was exaggerated and lost its transient nature in the absence of interferon-regulatory factor 1 (IRF-1), a transcription factor with antiviral and tumor suppressor functions.
IRF1 encodes interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse it has been shown to be required for double-stranded RNA induction of these genes. IRF1 also functions as a transcription activator of genes induced by interferons alpha, beta, and gamma. Further, IRF1 has been shown to play roles in regulating apoptosis and tumor-suppressoion.
interferon regulatory factor 1
, interferon regulatory factor 11
, interferon responsive factor 1