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Human IRF1 Protein expressed in Wheat germ - ABIN1308073
Liu, Khachigian et al.: Histone deacetylase-1 is enriched at the platelet-derived growth factor-D promoter in response to interleukin-1beta and forms a cytokine-inducible gene-silencing complex with NF-kappab p65 and ... in The Journal of biological chemistry 2009
MiR (show MLXIP Proteins)-23a downregulates the expression of IRF-1 in HCC (show FAM126A Proteins) cells.
the interactions of IRF1, IFN-beta (show IFNB1 Proteins) and IRF5 (show IRF5 Proteins) are involved in the M1 polarization of macrophages and have antitumor functions.
rs56288038 (C/G) in IRF-1 3'UTR acted as a promotion factor in gastric cancer development through enhancing the regulatory role of miR (show MLXIP Proteins)-502-5p in IRF-1 expression.
An IRF-1 shorter splicing transcript has been identified in acute promyelocytic leukemia (show PML Proteins) cells dispalying similar transactivation activity to the full length transcript.
Data suggest that interferon beta (IFN-beta (show IFNB1 Proteins)) might be involved in modulating the expressions of interferon regulatory factor 1 (IRF1) and interferon regulatory factor-5 (show IRF5 Proteins) protein (IRF5 (show IRF5 Proteins)) as well as maintaining the M1 polarization status and its function.
IRF1 upregulation in fetal membranes and myometrium after term labor indicates a proinflammatory role for IRF1 in human parturition. IRF1 is involved in TLR- and cytokine-mediated signaling in human myometrium.
5AZ had a protective effect after MI by potentiation of IRF1 sumoylation and is suggested as a novel therapeutic intervention for cardiac repair.
IRF1 is a transcriptional regulator of IRG1 in human macrophages.
Data show that ectopic expression of interferon regulatory factor 1 (IRF-1) reduces NF-kappa B (show NFKB1 Proteins) activity and suppresses TNF receptor-associated factor 2 (TRAF2 (show TRAF2 Proteins)) and inhibitor of apoptosis 1 (show BIRC2 Proteins) protein (cIAP1 (show BIRC2 Proteins)) expression in breast cancer cells.
Gene expression meta-analysis reveals immune response convergence on the IFNgamma-STAT1 (show STAT1 Proteins)-IRF1 axis and adaptive immune resistance mechanisms in lymphoma
Given these results, porcine IRF1 plays potential roles in cellular antiviral responses against swine viruses.
In a healthy swine model, elevated levels of endothelial IRF-1 were also observed within atherosusceptible regions of the aorta by Western blot analysis and immunohistochemistry, implicating arterial hemodynamics in the regulation of IRF-1 expression.
The results suggested that the porcine IRF1 gene is strong candidate gene for these immune traits in pig.
direct the expression of a set of genes, the IRF8 (show IRF8 Proteins)/IRF1 regulome, that play critical roles in host inflammatory and antimicrobial defenses in mouse models of neuroinflammation and of pulmonary tuberculosis, respectively
couples synthesis of miR (show MLXIP Proteins)-342-5p to the antiviral interferon (show IFNA Proteins) response
The gammaherpesvirus-driven germinal center expansion was exaggerated and lost its transient nature in the absence of interferon-regulatory factor 1 (IRF-1), a transcription factor with antiviral and tumor suppressor functions.
IRF1 is required for IRF8 (show IRF8 Proteins)-induced gene expression in microglia.
in addition to regulating the enterocyte metabolic switch, Blimp1 functions as a gatekeeper in opposition to Irf1 to prevent premature activation of the MHC class I pathway in villus epithelium to maintain tolerance in the neonatal intestine.
Although treatment with IFN-gamma (show IFNG Proteins) strongly induced the activation of STAT1 (show STAT1 Proteins) as a transcriptional activator, its target molecule, IRF1, was not clearly produced in Lmp2 (show PSMB9 Proteins)-deficient uterine smooth muscle cells.
found that the effect of PGC-1alpha on repressing IRF-1 expression and activity is facilitated by the reduction in phosphorylation of STAT1 (show STAT1 Proteins) at position 727 (S727P), an essential transcriptional activator of IRF-1
translocates into the nucleus and acts on the 3'UTR region of the IL-4 (show IL4 Proteins) gene, thus inhibiting its transcription in Th2 cells during Listeria infection
these results underline the role of Batf2/Irf1 in inducing inflammatory responses in M. tuberculosis infection.
IRF1 encodes interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse it has been shown to be required for double-stranded RNA induction of these genes. IRF1 also functions as a transcription activator of genes induced by interferons alpha, beta, and gamma. Further, IRF1 has been shown to play roles in regulating apoptosis and tumor-suppressoion.
interferon regulatory factor 1
, interferon regulatory factor 11
, interferon responsive factor 1