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Human IRF1 Protein expressed in Wheat germ - ABIN1308073
Liu, Khachigian et al.: Histone deacetylase-1 is enriched at the platelet-derived growth factor-D promoter in response to interleukin-1beta and forms a cytokine-inducible gene-silencing complex with NF-kappab p65 and ... in The Journal of biological chemistry 2009
Following spring viremia of carp (show ANKRD1 Proteins) virus infection, DrIFNPhi1/3 and DrIRF1/3/7 transcripts are significantly induced in zebrafish tissues, which correlates with the replication of spring viremia of carp (show ANKRD1 Proteins) virus. data provide evidence that fish and mammals have evolved a similar IRF (show TRIM63 Proteins)-dependent regulatory mechanism fine-tuning IFN gene activation.
A comprehensive mass spectrometric analysis identified interferon regulatory factor 1 (IRF1) as a key transcription factor in growth arrest of LNCaP-mTOR (show FRAP1 Proteins).
IFN regulatory factor 1 effectively inhibits hepatitis E virus replication through the activation of the JAK (show JAK3 Proteins)-STAT (show STAT1 Proteins) pathway
B. abortus lipoproteins via IL-6 (show IL6 Proteins) inhibit the expression of IFN regulatory factor 1 (IRF-1), a critical regulatory transcription factor for CIITA (show CIITA Proteins) induction.
STAT1 (show STAT1 Proteins) and IRF1 collaborate to induce interferon-gamma (show IFNG Proteins) stimulated genes (ISGs), but the extent to which they act alone or together is unclear.This study provides strong evidence for widespread cooperation between STAT1 (show STAT1 Proteins) and IRF1 at ISGs, and suggests that in silico predictions reliably predict the effect of nucleotide variants on binding in vivo.
aimed to determine the role of Treg cells and IRF-1 in MDS (show PAFAH1B1 Proteins)
Tat (show TAT Proteins) exploited the cellular HDM2 (human double minute 2 protein (show MDM2 Proteins)) ubiquitin ligase to accelerate IRF-1 proteasome-mediated degradation, resulting in a quenching of IRF-1 transcriptional activity during HIV-1 infection.
Leading to a STAT1 (show STAT1 Proteins)-IRF1 controlled upregulation of TLR3 (show TLR3 Proteins) expression in macrophages.
Regulatory elements for both IRF-1 (-1019 to -1016) and CREB (show CREB1 Proteins) (-1198 to -1195), specific to the distal THBS1 (show THBS1 Proteins) promoter, were required for leptin (show LEP Proteins)-induced TSP-1 (show THBS1 Proteins) transcription.
silencing of IL1B (show IL1B Proteins) plus dexamethasone-induced DUSP1 (show DUSP1 Proteins) significantly reduced IRF1 expression. IL1B (show IL1B Proteins)-induced expression of CXCL10 (show CXCL10 Proteins) was largely insensitive to dexamethasone, whereas other DUSP1 (show DUSP1 Proteins)-enhanced, IRF1-dependent mRNAs showed various degrees of repression.
Inflammation-driven IRF1 and NF-kappaB (show NFKB1 Proteins) activity promotes ERVK reactivation.
Given these results, porcine IRF1 plays potential roles in cellular antiviral responses against swine viruses.
In a healthy swine model, elevated levels of endothelial IRF-1 were also observed within atherosusceptible regions of the aorta by Western blot analysis and immunohistochemistry, implicating arterial hemodynamics in the regulation of IRF-1 expression.
The results suggested that the porcine IRF1 gene is strong candidate gene for these immune traits in pig.
Our studies uncovered the critical role of two transcription factors, IRF1 and BATF, in preparing the chromatin landscape for induction of the Tr1 gene network in response to IL-27 signaling, where BATF acted as a pioneer factor and prepared the genomic landscape for the binding of additional transcription factors that define the Tr1 lineage.
IRF-1 and interferon-alpha (show IFNA Proteins) with interferon-beta (show IFNB1 Proteins) cooperate to control acute gammaherpesvirus infection.
this study shows that binding motifs for the transcription factors STAT1 (show STAT1 Proteins) and IRF1 are associated with robust and IL-4 (show IL4 Proteins)-resistant responses to IFN-gamma (show IFNG Proteins) in macrophages
5AZ had a protective effect after MI by potentiation of IRF1 sumoylation and is suggested as a novel therapeutic intervention for cardiac repair.
direct the expression of a set of genes, the IRF8 (show IRF8 Proteins)/IRF1 regulome, that play critical roles in host inflammatory and antimicrobial defenses in mouse models of neuroinflammation and of pulmonary tuberculosis, respectively
couples synthesis of miR (show MLXIP Proteins)-342-5p to the antiviral interferon (show IFNA Proteins) response
The gammaherpesvirus-driven germinal center expansion was exaggerated and lost its transient nature in the absence of interferon-regulatory factor 1 (IRF-1), a transcription factor with antiviral and tumor suppressor functions.
IRF1 is required for IRF8 (show IRF8 Proteins)-induced gene expression in microglia.
in addition to regulating the enterocyte metabolic switch, Blimp1 functions as a gatekeeper in opposition to Irf1 to prevent premature activation of the MHC class I pathway in villus epithelium to maintain tolerance in the neonatal intestine.
Although treatment with IFN-gamma (show IFNG Proteins) strongly induced the activation of STAT1 (show STAT1 Proteins) as a transcriptional activator, its target molecule, IRF1, was not clearly produced in Lmp2 (show PSMB9 Proteins)-deficient uterine smooth muscle cells.
IRF1 encodes interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse it has been shown to be required for double-stranded RNA induction of these genes. IRF1 also functions as a transcription activator of genes induced by interferons alpha, beta, and gamma. Further, IRF1 has been shown to play roles in regulating apoptosis and tumor-suppressoion.
interferon regulatory factor 1
, interferon regulatory factor 11
, interferon responsive factor 1