Browse our IRF1 Proteins (IRF1)

Full name:
Interferon Regulatory Factor 1 Proteins (IRF1)
On are 22 Interferon Regulatory Factor 1 (IRF1) Proteins from 10 different suppliers available. Additionally we are shipping IRF1 Antibodies (138) and IRF1 Kits (17) and many more products for this protein. A total of 188 IRF1 products are currently listed.
AU020929, Irf-1, IRF1, irf11, MAR, zgc:103566, zgc:136945
list all proteins Gene Name GeneID UniProt
IRF1 3659 P10914
IRF1 16362 P15314
IRF1 24508 P23570

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IRF1 Proteins (IRF1) by Origin

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Top referenced IRF1 Proteins

  1. Human IRF1 Protein expressed in Escherichia coli (E. coli) - ABIN666692 : Hochhaus, Yan, Willer, Hehlmann, Gordon, Goldman, Melo: Expression of interferon regulatory factor (IRF) genes and response to interferon-alpha in chronic myeloid leukaemia. in Leukemia 1997 (PubMed)
    Show all 2 references for 666692

  2. Human IRF1 Protein expressed in Wheat germ - ABIN1308073 : Liu, Khachigian et al.: Histone deacetylase-1 is enriched at the platelet-derived growth factor-D promoter in response to interleukin-1beta and forms a cytokine-inducible gene-silencing complex with NF-kappab p65 and ... in The Journal of biological chemistry 2009 (PubMed)

More Proteins for IRF1 Interaction Partners

Zebrafish Interferon Regulatory Factor 1 (IRF1) interaction partners

  1. Following spring viremia of carp (show ANKRD1 Proteins) virus infection, DrIFNPhi1/3 and DrIRF1/3/7 transcripts are significantly induced in zebrafish tissues, which correlates with the replication of spring viremia of carp (show ANKRD1 Proteins) virus. data provide evidence that fish and mammals have evolved a similar IRF (show TRIM63 Proteins)-dependent regulatory mechanism fine-tuning IFN gene activation.

Human Interferon Regulatory Factor 1 (IRF1) interaction partners

  1. IFN regulatory factor 1 effectively inhibits hepatitis E virus replication through the activation of the JAK (show JAK3 Proteins)-STAT (show STAT1 Proteins) pathway

  2. B. abortus lipoproteins via IL-6 (show IL6 Proteins) inhibit the expression of IFN regulatory factor 1 (IRF-1), a critical regulatory transcription factor for CIITA (show CIITA Proteins) induction.

  3. STAT1 (show STAT1 Proteins) and IRF1 collaborate to induce interferon-gamma (show IFNG Proteins) stimulated genes (ISGs), but the extent to which they act alone or together is unclear.This study provides strong evidence for widespread cooperation between STAT1 (show STAT1 Proteins) and IRF1 at ISGs, and suggests that in silico predictions reliably predict the effect of nucleotide variants on binding in vivo.

  4. aimed to determine the role of Treg cells and IRF-1 in MDS (show PAFAH1B1 Proteins)

  5. Tat (show TAT Proteins) exploited the cellular HDM2 (human double minute 2 protein (show MDM2 Proteins)) ubiquitin ligase to accelerate IRF-1 proteasome-mediated degradation, resulting in a quenching of IRF-1 transcriptional activity during HIV-1 infection.

  6. Leading to a STAT1 (show STAT1 Proteins)-IRF1 controlled upregulation of TLR3 (show TLR3 Proteins) expression in macrophages.

  7. Regulatory elements for both IRF-1 (-1019 to -1016) and CREB (show CREB1 Proteins) (-1198 to -1195), specific to the distal THBS1 (show THBS1 Proteins) promoter, were required for leptin (show LEP Proteins)-induced TSP-1 (show THBS1 Proteins) transcription.

  8. silencing of IL1B (show IL1B Proteins) plus dexamethasone-induced DUSP1 (show DUSP1 Proteins) significantly reduced IRF1 expression. IL1B (show IL1B Proteins)-induced expression of CXCL10 (show CXCL10 Proteins) was largely insensitive to dexamethasone, whereas other DUSP1 (show DUSP1 Proteins)-enhanced, IRF1-dependent mRNAs showed various degrees of repression.

  9. Inflammation-driven IRF1 and NF-kappaB (show NFKB1 Proteins) activity promotes ERVK reactivation.

  10. MiR (show MLXIP Proteins)-23a downregulates the expression of IRF-1 in HCC (show FAM126A Proteins) cells.

Pig (Porcine) Interferon Regulatory Factor 1 (IRF1) interaction partners

  1. Given these results, porcine IRF1 plays potential roles in cellular antiviral responses against swine viruses.

  2. In a healthy swine model, elevated levels of endothelial IRF-1 were also observed within atherosusceptible regions of the aorta by Western blot analysis and immunohistochemistry, implicating arterial hemodynamics in the regulation of IRF-1 expression.

  3. The results suggested that the porcine IRF1 gene is strong candidate gene for these immune traits in pig.

Mouse (Murine) Interferon Regulatory Factor 1 (IRF1) interaction partners

  1. Our studies uncovered the critical role of two transcription factors, IRF1 and BATF, in preparing the chromatin landscape for induction of the Tr1 gene network in response to IL-27 signaling, where BATF acted as a pioneer factor and prepared the genomic landscape for the binding of additional transcription factors that define the Tr1 lineage.

  2. IRF-1 and interferon-alpha (show IFNA Proteins) with interferon-beta (show IFNB1 Proteins) cooperate to control acute gammaherpesvirus infection.

  3. this study shows that binding motifs for the transcription factors STAT1 (show STAT1 Proteins) and IRF1 are associated with robust and IL-4 (show IL4 Proteins)-resistant responses to IFN-gamma (show IFNG Proteins) in macrophages

  4. 5AZ had a protective effect after MI by potentiation of IRF1 sumoylation and is suggested as a novel therapeutic intervention for cardiac repair.

  5. direct the expression of a set of genes, the IRF8 (show IRF8 Proteins)/IRF1 regulome, that play critical roles in host inflammatory and antimicrobial defenses in mouse models of neuroinflammation and of pulmonary tuberculosis, respectively

  6. couples synthesis of miR (show MLXIP Proteins)-342-5p to the antiviral interferon (show IFNA Proteins) response

  7. The gammaherpesvirus-driven germinal center expansion was exaggerated and lost its transient nature in the absence of interferon-regulatory factor 1 (IRF-1), a transcription factor with antiviral and tumor suppressor functions.

  8. IRF1 is required for IRF8 (show IRF8 Proteins)-induced gene expression in microglia.

  9. in addition to regulating the enterocyte metabolic switch, Blimp1 functions as a gatekeeper in opposition to Irf1 to prevent premature activation of the MHC class I pathway in villus epithelium to maintain tolerance in the neonatal intestine.

  10. Although treatment with IFN-gamma (show IFNG Proteins) strongly induced the activation of STAT1 (show STAT1 Proteins) as a transcriptional activator, its target molecule, IRF1, was not clearly produced in Lmp2 (show PSMB9 Proteins)-deficient uterine smooth muscle cells.

IRF1 Protein Profile

Protein Summary

IRF1 encodes interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse it has been shown to be required for double-stranded RNA induction of these genes. IRF1 also functions as a transcription activator of genes induced by interferons alpha, beta, and gamma. Further, IRF1 has been shown to play roles in regulating apoptosis and tumor-suppressoion.

Alternative names and synonyms associated with IRF1

  • interferon regulatory factor 1 (IRF1)
  • interferon regulatory factor 1a (irf1a)
  • interferon regulatory factor 1b (irf1b)
  • interferon regulatory factor 1 (Irf1)
  • AU020929 protein
  • Irf-1 protein
  • IRF1 protein
  • irf11 protein
  • MAR protein
  • zgc:103566 protein
  • zgc:136945 protein

Protein level used designations for IRF1

interferon regulatory factor 1 , interferon regulatory factor 11 , IRF-1 , interferon responsive factor 1

443136 Ovis aries
678604 Danio rerio
792160 Danio rerio
396384 Gallus gallus
3659 Homo sapiens
481500 Canis lupus familiaris
396611 Sus scrofa
789216 Bos taurus
16362 Mus musculus
24508 Rattus norvegicus
100328724 Oryctolagus cuniculus
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