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Browse our SMAD7 Proteins (SMAD7)

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SMAD, Mothers Against DPP Homolog 7 Proteins (SMAD7)
On are 5 SMAD, Mothers Against DPP Homolog 7 (SMAD7) Proteins from 4 different suppliers available. Additionally we are shipping SMAD7 Antibodies (87) and SMAD7 Kits (35) and many more products for this protein. A total of 133 SMAD7 products are currently listed.
CRCS3, madh7, MADH8, Smad7a, Smad10, xsmad7
list all proteins Gene Name GeneID UniProt
SMAD7 4092 O15105
SMAD7 17131 O35253
SMAD7 81516 O88406

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SMAD7 Proteins (SMAD7) by Origin

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Human SMAD, Mothers Against DPP Homolog 7 (SMAD7) interaction partners

  1. SMAD7 overexpression might represent a mechanism limiting TGF-beta (show TGFB1 Proteins)-mediated fibrogenesis in human hepatic diseases; therefore, SMAD7 induction likely represents a candidate for novel therapeutic approaches.

  2. Data show that protein kinase (show CDK7 Proteins) LKB1 (show STK11 Proteins) physically interacts with BMP type I receptors and requires Smad7 protein to promote downregulation of the receptor.

  3. study suggested that TGF-beta1/Smad3/smad7 is a major pathway which plays an important role in the regulation of the IUA and specific inhibitor of Smad3 (SIS3) may provide a new therapeutic strategy for IUA.

  4. Study founds the levels of CYLD (show CYLD Proteins) and SMAD7 significantly decreased in oral squamous cell carcinoma (OSSC) cells and proposes a model that CYLD (show CYLD Proteins) suppresses OSCC metastases through SMAD7. Downregulation of CYLD (show CYLD Proteins) appears to directly contribute to the distal metastases of primary OSCC and subsequently poor prognosis.

  5. Data indicate that, in irritable bowel disease, high Smad7 contributes to sustain detrimental immune responses and knockdown of this molecule can help attenuate the ongoing mucosal inflammation in patients with such disorders

  6. Suggest that greater tumor associated macrophage density, strong Hexim1 (show HEXIM1 Proteins) expression, strong SMAD2 (show SMAD2 Proteins) expression, and mild SMAD7 expression play important roles in the progression of prostate adenocarcinoma.

  7. Results showed that SMAD7 was up-regulated in hepatocellular carcinoma tissues and was found to be the target of UPF1 (show UPF1 Proteins).

  8. The expression of Smad7 increased.

  9. MiR (show MLXIP Proteins)-185-3p and miR (show MLXIP Proteins)-324-3p can modulate NPC (show NPC1 Proteins) cell growth and apoptosis, at least partly through targeting SMAD7.

  10. Meta-analysis showed that for SMAD7 gene, rs4939827 and rs4464148 are risk factors for colorectal cancer (CRC (show CALR Proteins)) among Caucasians whereas rs12953717 could elevate the susceptibility to CRC (show CALR Proteins) in both Caucasians and Asians.

Mouse (Murine) SMAD, Mothers Against DPP Homolog 7 (SMAD7) interaction partners

  1. results indicate that miR (show MLXIP Proteins)-195a-5p inhibits MTEC1 proliferation, at least in part, via down-regulation of Smad7

  2. Data indicate that, in irritable bowel disease, high Smad7 contributes to sustain detrimental immune responses and knockdown of this molecule can help attenuate the ongoing mucosal inflammation in patients with such disorders

  3. Hic-5 (show TGFB1I1 Proteins) deficiency attenuates the activation of hepatic stellate cells and liver fibrosis though reducing the TGF-beta (show TGFB1 Proteins)/Smad2 (show SMAD2 Proteins) signaling by upregulation of Smad7

  4. Data show that microRNA miR (show MLXIP Proteins)-21 was significantly upregulated by bone morphogenetic protein 9 (BMP9 (show GDF2 Proteins)) during the osteogenesis the multilineage cells (MMCs) by suppressing Smad7 protein.

  5. Genetic disruption of Smad7 impairs skeletal muscle growth and regeneration

  6. The present study also identified for the first time, to the best of our knowledge, the promotion of osteogenic differentiation and mineralization by miR (show MLXIP Proteins)-21, by repressing the expression of Smad7.

  7. Overexpression of Smad7 in human HaCaT keratinocyte cells and mouse skin tissues elevated EGF receptor (EGFR (show EGFR Proteins)) activity by impairing ligand-induced ubiquitination and degradation of activated receptor, which is induced by the E3 ubiquitin ligase (show MUL1 Proteins) c-Cbl (show CBL Proteins).

  8. Smad7 signaling is repressed by the active form of vitamin D, 1,25-dihydroxyvitamin D3, which also activates ERK (show EPHB2 Proteins) to inhibit the differentiation of an inflammatory T helper cell subset and suppress experimental autoimmune encephalomyelitis

  9. Study identified miR-367 as a negative regulator of Smad7 expression in pancreatic cancer cells by directly targeting its 3'-UTR.

  10. TGF-beta (show TGFB1 Proteins) dependent modulation of neurogenesis in aged S7DeltaEx1 animals abrogates the cell-intrinsic hyperproliferative properties

Xenopus laevis SMAD, Mothers Against DPP Homolog 7 (SMAD7) interaction partners

  1. cTid1 can bind to other members of the Smad (show SMAD1 Proteins) family and that highest binding activity occurs with the negative regulatory Smad7, through the conserved MH2 (show SCN4A Proteins) domain

  2. Smad7 has a role in Xenopus mesodermal and neural induction

Pig (Porcine) SMAD, Mothers Against DPP Homolog 7 (SMAD7) interaction partners

  1. SMAD7 plays a potentially important role in mammalian prenatal skeletal muscle development and is a candidate gene for promoting greater weaning weight in pig breeding.

  2. MiR (show MYLIP Proteins)-92a inhibits porcine ovarian granulosa cell apoptosis by targeting Smad7 gene

Cow (Bovine) SMAD, Mothers Against DPP Homolog 7 (SMAD7) interaction partners

  1. a detailed computational model for TGF-beta (show TGFB1 Proteins) signalling that incorporates elements of previous models together with crosstalking between Smad1 (show SMAD1 Proteins)/5/8 and Smad2 (show SMAD2 Proteins)/3 channels through a negative feedback loop dependent on Smad7.

  2. Results suggest that myostatin (show MSTN Proteins) auto-regulates its gene expression through a Smad7 dependent mechanism in myogenic cells.

SMAD7 Protein Profile

Protein Summary

The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with SMAD7

  • SMAD family member 7 (SMAD7)
  • SMAD family member 7 (Smad7)
  • SMAD family member 7 (smad7)
  • CRCS3 protein
  • madh7 protein
  • MADH8 protein
  • Smad7a protein
  • Smad10 protein
  • xsmad7 protein

Protein level used designations for SMAD7

MAD (mothers against decapentaplegic, Drosophila) homolog 7 , MAD homolog 8 , Mothers against decapentaplegic, drosophila, homolog of, 7 , SMAD, mothers against DPP homolog 7 , hSMAD7 , mothers against DPP homolog 8 , mothers against decapentaplegic homolog 7 , MAD homolog 7 , SMAD 7 , madh8 , mothers against DPP homolog 7 , mothers against decapentaplegic homolog 8 , MAD, mothers against decapentaplegic homolog 7 , mothers against DPP 7 , mothers against decapentaplegic-like protein 7 , SMAD family member 7

4092 Homo sapiens
17131 Mus musculus
81516 Rattus norvegicus
490570 Canis lupus familiaris
394331 Xenopus laevis
455411 Pan troglodytes
100717293 Cavia porcellus
100521305 Sus scrofa
535916 Bos taurus
429683 Gallus gallus
443160 Ovis aries
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