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Browse our SMAD7 Proteins (SMAD7)

Full name:
SMAD, Mothers Against DPP Homolog 7 Proteins (SMAD7)
On www.antibodies-online.com are 5 SMAD, Mothers Against DPP Homolog 7 (SMAD7) Proteins from 4 different suppliers available. Additionally we are shipping SMAD7 Antibodies (87) and SMAD7 Kits (44) and many more products for this protein. A total of 142 SMAD7 products are currently listed.
Synonyms:
CRCS3, madh7, MADH8, Smad7a, Smad10, xsmad7
list all proteins Gene Name GeneID UniProt
SMAD7 4092 O15105
SMAD7 17131 O35253
SMAD7 81516 O88406

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SMAD7 Proteins (SMAD7) by Origin

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Human SMAD, Mothers Against DPP Homolog 7 (SMAD7) interaction partners

  1. Results showed that SMAD7 was up-regulated in hepatocellular carcinoma tissues and was found to be the target of UPF1 (show UPF1 Proteins).

  2. The expression of Smad7 increased.

  3. MiR (show MLXIP Proteins)-185-3p and miR (show MLXIP Proteins)-324-3p can modulate NPC (show NPC1 Proteins) cell growth and apoptosis, at least partly through targeting SMAD7.

  4. Meta-analysis showed that for SMAD7 gene, rs4939827 and rs4464148 are risk factors for colorectal cancer (CRC (show CALR Proteins)) among Caucasians whereas rs12953717 could elevate the susceptibility to CRC (show CALR Proteins) in both Caucasians and Asians.

  5. The decrease in miR-195 led to an increase in Smad7 expression and corresponding up-regulation of p65 and the AP-1 (activator protein 1) pathway, which might explain the mechanism of steroid resistance in ulcerative colitis patients

  6. TGF-beta (show TGFB1 Proteins)/Smad (show SMAD1 Proteins) signalling pathway and VEGF-A (show VEGFA Proteins) participate in the pathogenesis of sarcoidosis.

  7. Increased miR-16 (show GDE1 Proteins) expression promotes liver fibrosis through downregulation of HGF (show HGF Proteins) and Smad7 in hepatitis C patients.

  8. miR (show MLXIP Proteins)-181a promotes TGF-beta (show TGFB1 Proteins)-mediated epithelial-to-mesenchymal transition via repression of Smad7.

  9. Results suggest that Itch is a positive regulator of the TGF-beta (show TGFB1 Proteins)-mediated Smad (show SMAD1 Proteins) signaling pathway via Smad7 ubiquitination and protein degradation.

  10. Overexpression of Smad7 in human HaCaT keratinocyte cells and mouse skin tissues elevated EGF receptor (EGFR (show EGFR Proteins)) activity by impairing ligand-induced ubiquitination and degradation of activated receptor, which is induced by the E3 ubiquitin ligase (show MUL1 Proteins) c-Cbl (show CBL Proteins).

Mouse (Murine) SMAD, Mothers Against DPP Homolog 7 (SMAD7) interaction partners

  1. Hic-5 (show TGFB1I1 Proteins) deficiency attenuates the activation of hepatic stellate cells and liver fibrosis though reducing the TGF-beta (show TGFB1 Proteins)/Smad2 (show SMAD2 Proteins) signaling by upregulation of Smad7

  2. Data show that microRNA miR (show MLXIP Proteins)-21 was significantly upregulated by bone morphogenetic protein 9 (BMP9 (show GDF2 Proteins)) during the osteogenesis the multilineage cells (MMCs) by suppressing Smad7 protein.

  3. Genetic disruption of Smad7 impairs skeletal muscle growth and regeneration

  4. The present study also identified for the first time, to the best of our knowledge, the promotion of osteogenic differentiation and mineralization by miR (show MLXIP Proteins)-21, by repressing the expression of Smad7.

  5. Overexpression of Smad7 in human HaCaT keratinocyte cells and mouse skin tissues elevated EGF receptor (EGFR (show EGFR Proteins)) activity by impairing ligand-induced ubiquitination and degradation of activated receptor, which is induced by the E3 ubiquitin ligase (show MUL1 Proteins) c-Cbl (show CBL Proteins).

  6. Smad7 signaling is repressed by the active form of vitamin D, 1,25-dihydroxyvitamin D3, which also activates ERK (show EPHB2 Proteins) to inhibit the differentiation of an inflammatory T helper cell subset and suppress experimental autoimmune encephalomyelitis

  7. Study identified miR-367 as a negative regulator of Smad7 expression in pancreatic cancer cells by directly targeting its 3'-UTR.

  8. TGF-beta (show TGFB1 Proteins) dependent modulation of neurogenesis in aged S7DeltaEx1 animals abrogates the cell-intrinsic hyperproliferative properties

  9. The results indicate that partial loss of Smad7 function in mice leads to compromised bone formation and enhanced bone resorption. Thus, Smad7 is acknowledged as a novel key regulator between osteogenesis and osteoclastogenesis.

  10. Suggest novel role of leptin (show LEP Proteins)-NADPH oxidase (show NOX1 Proteins) induction of miR21 as a key regulator of TGF-beta (show TGFB1 Proteins) signaling and fibrogenesis in experimental and human NASH (show SAMSN1 Proteins).

Xenopus laevis SMAD, Mothers Against DPP Homolog 7 (SMAD7) interaction partners

  1. cTid1 can bind to other members of the Smad (show SMAD1 Proteins) family and that highest binding activity occurs with the negative regulatory Smad7, through the conserved MH2 (show SCN4A Proteins) domain

  2. Smad7 has a role in Xenopus mesodermal and neural induction

Pig (Porcine) SMAD, Mothers Against DPP Homolog 7 (SMAD7) interaction partners

  1. MiR (show MYLIP Proteins)-92a inhibits porcine ovarian granulosa cell apoptosis by targeting Smad7 gene

Cow (Bovine) SMAD, Mothers Against DPP Homolog 7 (SMAD7) interaction partners

  1. a detailed computational model for TGF-beta (show TGFB1 Proteins) signalling that incorporates elements of previous models together with crosstalking between Smad1 (show SMAD1 Proteins)/5/8 and Smad2 (show SMAD2 Proteins)/3 channels through a negative feedback loop dependent on Smad7.

  2. Results suggest that myostatin (show MSTN Proteins) auto-regulates its gene expression through a Smad7 dependent mechanism in myogenic cells.

SMAD7 Protein Profile

Protein Summary

The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with SMAD7

  • SMAD family member 7 (SMAD7)
  • SMAD family member 7 (Smad7)
  • SMAD family member 7 (smad7)
  • CRCS3 protein
  • madh7 protein
  • MADH8 protein
  • Smad7a protein
  • Smad10 protein
  • xsmad7 protein

Protein level used designations for SMAD7

MAD (mothers against decapentaplegic, Drosophila) homolog 7 , MAD homolog 8 , Mothers against decapentaplegic, drosophila, homolog of, 7 , SMAD, mothers against DPP homolog 7 , hSMAD7 , mothers against DPP homolog 8 , mothers against decapentaplegic homolog 7 , MAD homolog 7 , SMAD 7 , madh8 , mothers against DPP homolog 7 , mothers against decapentaplegic homolog 8 , MAD, mothers against decapentaplegic homolog 7 , mothers against DPP 7 , mothers against decapentaplegic-like protein 7 , SMAD family member 7

GENE ID SPECIES
4092 Homo sapiens
17131 Mus musculus
81516 Rattus norvegicus
490570 Canis lupus familiaris
394331 Xenopus laevis
455411 Pan troglodytes
100717293 Cavia porcellus
100521305 Sus scrofa
535916 Bos taurus
429683 Gallus gallus
443160 Ovis aries
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