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In conclusion, our study demonstrated that COL1A2 (show COL1A2 Proteins)-AS1 (show PTGDR Proteins)/miR (show MLXIP Proteins)-21/Smad (show SMAD1 Proteins) pathway plays an important role in inhibiting hypertrophic scar formation, and suggested this novel pathway may be a new target for hypertrophic scar treatment.
Our data revealed the SMAD7 loci is associated with hepatocellular carcinoma susceptibility and its clinicopathologic development.
Smad7 expression in necrotizing enterocolitis macrophages interrupts TGF-beta (show TGFB1 Proteins) signaling and promotes NF-kappaB (show NFKB1 Proteins)-mediated inflammatory signaling in these cells through increased expression of IKK-beta (show IKBKB Proteins)
SMAD7 gene and specifically the allele C could be protective for colorectal cancer (CRC (show CALR Proteins)). An independent protective association was also observed between high adherence Mediterranean diet pattern and CRC (show CALR Proteins) risk.
Smad7 inhibition diminishes interaction of PKR (show PKLR Proteins) with protein kinase inhibitor p58 (p58 (show DNAJC3 Proteins)(IPK)).
Smad7 regulates TGF-beta1 (show TGFB1 Proteins) signaling via a negative feedback loop and mediates the interaction between TGF-beta1 (show TGFB1 Proteins) and other signaling pathways; suggesting that Smad7 over expression may have therapeutic potential in ALL.
Missense variant in smad7 gene is associated with colorectal cancer.
ASPP2 (show TP53BP2 Proteins) suppresses invasion, peritoneal dissemination and TGF-beta1 (show TGFB1 Proteins)-induced EMT (show ITK Proteins) by inhibiting Smad7 degradation mediated by ITCH in gastric cancer cells.
Transforming Growth Factor beta inhibitor peptide P144 downregulates SKI (show SKI Proteins) and an upregulates SMAD7 at both transcriptional and translational levels in glioblastoma cell lines.
The inverse correlation between Smad7 and AhR (show AHR Proteins) expression helps to propagate inflammatory signals in the gut (show GUSB Proteins) in Crohn's disease.
a heterozygous deletion of SMAD7 results in an increased proliferation of Muller cell progenitors in the central retina at postnatal day 4, the time window when Muller cells differentiate in the mouse retina; this in turn results in a thickened retina and inner nuclear layer and a higher number of differentiated Muller cells in the more developed retina
changes were associated with increased expression of the antifibrotic protein Smad7 and higher levels of sphingosine in Sphk2 (show SPHK2 Proteins)(-/-) unilateral ureteral obstruction kidneys
Smad7 plays a protective role in acute kidney injury by preventing tubular epithelial cells from the G1 cell cycle arrest.
study reports an alternately-spliced form of Smad7, Smad7Delta, that is induced by TGF-beta (show TGFB1 Proteins) and CLIC4 (show CLIC4 Proteins), is a dominant inhibitor of Smad7 and enhances TGF-beta (show TGFB1 Proteins) signaling
Pancreatic depletion of SMAD7 resulted in age-dependent increases in beta cell dysfunction with accelerated glucose intolerance, followed by overt diabetes.
results indicate that miR (show MLXIP Proteins)-181a-5p promotes 3T3-L1 preadipocyte differentiation and adipogenesis through regulating TGFbeta (show TGFB1 Proteins)/Smad (show SMAD1 Proteins) and Wnt (show WNT2 Proteins) signaling pathway by directly targeting Smad7 and Tcf7l2 (show TCF7L2 Proteins)
microRNA-497 modulates breast cancer cell proliferation, invasion, and survival by targeting SMAD7.
results indicate that miR (show MLXIP Proteins)-195a-5p inhibits MTEC1 proliferation, at least in part, via down-regulation of Smad7
Data indicate that, in irritable bowel disease, high Smad7 contributes to sustain detrimental immune responses and knockdown of this molecule can help attenuate the ongoing mucosal inflammation in patients with such disorders
Tril (show TRIL Proteins) is a novel component of a Bmp-Gata2 (show GATA2 Proteins) positive-feedback loop that plays an essential role in hematopoietic specification, by targeting Smad7 for degradation.
cTid1 can bind to other members of the Smad (show SMAD1 Proteins) family and that highest binding activity occurs with the negative regulatory Smad7, through the conserved MH2 (show SCN4A Proteins) domain
Smad7 has a role in Xenopus mesodermal and neural induction
SMAD7 plays a potentially important role in mammalian prenatal skeletal muscle development and is a candidate gene for promoting greater weaning weight in pig breeding.
MiR (show MYLIP Proteins)-92a inhibits porcine ovarian granulosa cell apoptosis by targeting Smad7 gene
a detailed computational model for TGF-beta (show TGFB1 Proteins) signalling that incorporates elements of previous models together with crosstalking between Smad1 (show SMAD1 Proteins)/5/8 and Smad2 (show SMAD2 Proteins)/3 channels through a negative feedback loop dependent on Smad7.
Results suggest that myostatin (show MSTN Proteins) auto-regulates its gene expression through a Smad7 dependent mechanism in myogenic cells.
The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene.
MAD (mothers against decapentaplegic, Drosophila) homolog 7
, MAD homolog 8
, Mothers against decapentaplegic, drosophila, homolog of, 7
, SMAD, mothers against DPP homolog 7
, mothers against DPP homolog 8
, mothers against decapentaplegic homolog 7
, MAD homolog 7
, SMAD 7
, mothers against DPP homolog 7
, mothers against decapentaplegic homolog 8
, MAD, mothers against decapentaplegic homolog 7
, mothers against DPP 7
, mothers against decapentaplegic-like protein 7
, SMAD family member 7