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anti-Rat (Rattus) KDM3A Antibodies:
anti-Human KDM3A Antibodies:
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Human Polyclonal KDM3A Primary Antibody for IP, WB - ABIN262232
Javierre, Rodriguez-Ubreva, Al-Shahrour, Corominas, Graña, Ciudad, Agirre, Pisano, Valencia, Roman-Gomez, Calasanz, Prosper, Esteller, Gonzalez-Sarmiento, Ballestar: Long-range epigenetic silencing associates with deregulation of Ikaros targets in colorectal cancer cells. in Molecular cancer research : MCR 2011
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Human Monoclonal KDM3A Primary Antibody for IHC, ELISA - ABIN969228
Nagase, Ishikawa, Suyama, Kikuno, Miyajima, Tanaka, Kotani, Nomura, Ohara: Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. in DNA research : an international journal for rapid publication of reports on genes and genomes 1999
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Human Monoclonal KDM3A Primary Antibody for ICC, ELISA - ABIN969229
Beausoleil, Jedrychowski, Schwartz, Elias, Villén, Li, Cohn, Cantley, Gygi: Large-scale characterization of HeLa cell nuclear phosphoproteins. in Proceedings of the National Academy of Sciences of the United States of America 2004
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Human Polyclonal KDM3A Primary Antibody for ICC, IF - ABIN4332049
Kuroki, Matoba, Akiyoshi, Matsumura, Miyachi, Mise, Abe, Ogura, Wilhelm, Koopman, Nozaki, Kanai, Shinkai, Tachibana: Epigenetic regulation of mouse sex determination by the histone demethylase Jmjd1a. in Science (New York, N.Y.) 2013
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Cow (Bovine) Polyclonal KDM3A Primary Antibody for IHC, WB - ABIN2777661
Katoh, Katoh: Identification and characterization of TRIP8 gene in silico. in International journal of molecular medicine 2003
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The histone H3 (show HIST3H3 Antibodies) lysine 9 demethylase (show MBD2 Antibodies) KDM3A facilitates the Xenopus Neurog2 (show NEUROG2 Antibodies) chromatin accessibility during neuronal transcription. Loss-of-function analyses reveal that KDM3A is not required for the transition of naive ectoderm to neural progenitor cells but is essential for primary neuron formation.
Authors show that KDM3A regulates MCAM (show MCAM Antibodies) expression both through a direct mechanism, involving modulation of H3K9 methylation at the MCAM (show MCAM Antibodies) promoter, and an indirect mechanism, via the Ets1 (show ETS1 Antibodies) transcription factor.
JMJD1A promotes urinary bladder cancer progression by enhancing glycolysis through coactivation of HIF1alpha (show HIF1A Antibodies).
depletion of KDM3A was capable of reactivating mutated p53 (show TP53 Antibodies) to induce the expression of pro-apoptotic genes in breast cancer with mutant p53 (show TP53 Antibodies). KDM3A knockdown also potently inhibited tumorigenic potentials of breast cancer stem-like cells and rendered them sensitive to apoptosis induced by chemotherapeutic drugs.
our findings reveal a novel mechanism by which KDM3A promotes ovarian CSCs, proliferation and chemoresistance and thus, highlights the significance of KDM3A as a novel therapeutic target for resistant ovarian cancer.
a critical role for JMJD1A in regulating proliferation and survival of prostate cancer cells by controlling c-Myc (show MYC Antibodies) expression at transcriptional and post-translational levels
deficient expression of JMJD1A/JMJD1A might be reflecting and/or contributing to round spermatid maturation arrest
JMJD1A could promote non-small cell lung cancer tumorigenesis
Study identified KDM3A an H3K9me2 demethylase (show MBD2 Antibodies), as responsible for the H3K9me2 reduction and critical for breast tumor transformation.
JMJD1A-MALAT1-MAPK (show MAPK1 Antibodies) signaling might participate in the JMJD1A-induced cell proliferation of gastric cancer.
These results indicate that the KDM3A-KLF2 (show KLF2 Antibodies)-IRF4 (show IRF4 Antibodies) pathway plays an essential role in multiple myeloma cell survival and homing to the bone marrow, and therefore represents a therapeutic target.
Histone demethylases KDM3A, KDM4A (show KDM4A Antibodies), and KDM4C (show KDM4C Antibodies) were expressed before and after embryonic genome activation, whereas KDM5B (show KDM5B Antibodies) was mainly expressed during the blastocyst period.
JMJD1A is phosphorylated at S265 by protein kinase A (PKA), and this is pivotal to activate the beta1-adrenergic receptor gene (Adrb1 (show ADRB1 Antibodies)) and downstream targets including Ucp1 (show UCP1 Antibodies) in brown adipocytes.
Kdm3a localizes to cytoplasmic structures of maturing spermatids affected in Kdm3a mutant mice, which in turn display altered fractionation of beta-actin (show ACTB Antibodies) and gamma-tubulin (show TUBG1 Antibodies).
Results show that Jmjd1a was not essential for stem cell self-renewal but played a crucial role as a tumor suppressor.
Despite these differences in rats, genetic knockout of Kdm3a in mice resulted in no dramatic effect on immune system development and activation or EAE susceptibility and severity
Jmjd1a directly and positively controls Sry (show SRY Antibodies) expression by regulating H3K9me2 marks. These studies reveal a pivotal role of histone demethylation in mammalian sex determination.
Exposing cells to either chemical or cellular sources of (*)NO resulted in a significant increase in dimethyl Lys (show LYZ Antibodies)-9 on histone 3 (H3K9me2), the preferred substrate for KDM3A.
the Jmjd1a-controlled epigenetic histone modifications are crucial for Crem (show CREM Antibodies)-regulated gene expression and spermatogenesis
TSGA may modulate the function of ER71 (show ETV2 Antibodies) and thereby affect spermatogenesis as well as embryonic development
Jmjd1a might be a critical signaling molecule underlying the maintenance of pluripotency in mouse embryonic stem cells
Jmjd1a demethylates H3K9Me2 at the promoter regions of Tcl1 (show TCL1A Antibodies), Tcfcp2l1 (show TFCP2L1 Antibodies), and Zfp57 (show ZFP57 Antibodies) and positively regulates the expression of these pluripotency-associated genes.
This gene encodes a zinc finger protein that contains a jumonji domain and may play a role in hormone-dependent transcriptional activation. Alternative splicing results in multiple transcript variants.
lysine (K)-specific demethylase 3A
, jumonji domain containing 1A
, lysine-specific demethylase 3A-like
, jmjC domain-containing histone demethylation protein 2A
, jumonji domain-containing protein 1A-B
, lysine-specific demethylase 3A-B
, jumonji domain-containing protein 1A
, lysine-specific demethylase 3A
, jumonji C domain-containing histone demethylase 2A
, jumonji domain containing 1
, testis-specific protein A
, testis specific gene A
, probable zinc finger protein
, testis-specific gene A protein
, zinc finger protein TSGA