Browse our anti-Histone-Lysine N-Methyltransferase MLL4 (MLL4) Antibodies

Full name:
anti-Histone-Lysine N-Methyltransferase MLL4 Antibodies (MLL4)
On www.antibodies-online.com are 24 Histone-Lysine N-Methyltransferase MLL4 (MLL4) Antibodies from 13 different suppliers available. Additionally we are shipping Histone-Lysine N-Methyltransferase MLL4 Kits (10) and many more products for this protein. A total of 38 Histone-Lysine N-Methyltransferase MLL4 products are currently listed.
Synonyms:
2610014H22Rik, ALR, BC032281, BC058659, C430014K11Rik, HRX2, KMT2B, mKIAA0304, MLL1B, Mll2, Mll4, RGD1308331, TRX2, Wbp7
list all antibodies Gene Name GeneID UniProt
MLL4 9757 Q9UMN6
MLL4 361543  
MLL4 75410 O08550

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Top referenced anti-Histone-Lysine N-Methyltransferase MLL4 Antibodies

  1. Cow (Bovine) Polyclonal MLL4 Primary Antibody for WB - ABIN2778080 : FitzGerald, Diaz: MLL2: A new mammalian member of the trx/MLL family of genes. in Genomics 1999 (PubMed)

  2. Human Polyclonal MLL4 Primary Antibody for IHC, ELISA - ABIN184881 : Huntsman, Chin, Muleris, Batley, Collins, Wiedemann, Aparicio, Caldas: MLL2, the second human homolog of the Drosophila trithorax gene, maps to 19q13.1 and is amplified in solid tumor cell lines. in Oncogene 2000 (PubMed)

More Antibodies against Histone-Lysine N-Methyltransferase MLL4 Interaction Partners

Human Histone-Lysine N-Methyltransferase MLL4 (MLL4) interaction partners

  1. The crucial role of KMT2B (show MLL2 Antibodies) in the physiological control of voluntary movement.

  2. MLL4 mutation along with BRCA1 mutation confers chemoresistance in breast cancer.

  3. Results show that KMT2B (show MLL2 Antibodies) interacts with ERalpha (show ESR1 Antibodies) to bind the ERalpha (show ESR1 Antibodies)-binding sites of IL-20 (show IL20 Antibodies) and other ERalpha (show ESR1 Antibodies) target genes with H3K4 modifications suggesting an important role for KMT2B (show MLL2 Antibodies) in the epigenetic transcriptional regulation of cytokine IL-20 (show IL20 Antibodies), and other ERalpha (show ESR1 Antibodies)-responsive genes, in breast cancer cells.

  4. findings thus establish generalized dystonia as the human phenotype associated with haploinsufficiency of KMT2B (show MLL2 Antibodies); moreover, we provide evidence for a causative role of disordered histone modification, chromatin states, and transcriptional deregulation in dystonia pathogenesis

  5. The results explain how the MLL (show MLL Antibodies) SET domains of MLL1 and MLL4 (show MLL2 Antibodies) are able to add multiple methyl groups to the target histone H3 (show HIST3H3 Antibodies) lysine.

  6. The Aven (show AVEN Antibodies) RGG/RG motif bound G4 structures within the coding regions of the MLL1 and MLL4 (show MLL2 Antibodies) mRNAs increasing their polysomal association and translation, resulting in the induction of transcription of leukemic genes.

  7. We propose that MLL3 and MLL4 (show MLL2 Antibodies) are broadly required for controlling MAFA (show KLRG1 Antibodies) and MAFB (show MAFB Antibodies) transactivation during development and postnatally.

  8. HBV-MLL4 (show MLL2 Antibodies) integration occurred frequently in Chinese HCC (show FAM126A Antibodies) patients, representing a unique molecular segment for HCC (show FAM126A Antibodies) with HBV infection

  9. Chromosomal translocation in a pediatric undifferentiated spindle cell sarcoma have characterized this alteration to show rearrangement of the MLL4 (show MLL2 Antibodies) and GPS2 (show GPS2 Antibodies) genes, resulting in fusion gene MLL4 (show MLL2 Antibodies)-GPS2 (show GPS2 Antibodies), the expression of which promotes independent growth.

  10. KMT2B (show MLL2 Antibodies) transgene mediates hippocampal histone 3 lysine 4 di- and trimethylation and is a critical player for memory formation.

Mouse (Murine) Histone-Lysine N-Methyltransferase MLL4 (MLL4) interaction partners

  1. UTX (show KDM6A Antibodies)-MLL4-p300 (show NOTCH1 Antibodies) transcriptional regulatory network establishing an "active enhancer landscape" and defines a detailed mechanism for the joint deposition of H3K4me1 and H3K27ac.

  2. MLL4 deficiency compromised the development of regulatory T cells (Treg cells) and resulted in a substantial decrease in monomethylated H3K4 (H3K4me1) and chromatin interaction at putative gene enhancers, a considerable portion of which were not direct targets of MLL4 but were enhancers that interacted with MLL4-bound sites.

  3. Study shows the contribution of MLL2's methyltransferase and CXXC domain in the trimethylation of H3K4 in embryonic stem cells and find that while it trimethylates H3K4 at both bivalent gene promoters and non-TSS (show RPL38 Antibodies) elements, it regulates transcription at a limited number of genes including those required for primordial germ cell specification.

  4. While H3K4me1 partially supports H3K27ac at active enhancers, it is largely dispensable for transcription. By contrast, Mll3/4 proteins themselves are required for enhancer Pol II loading, eRNA synthesis, and gene expression.

  5. Data from MLL4/KMT2D (show MLL2 Antibodies) enzyme-dead knockin ES cells and mice indicate that the enzymatic activity of H3K4 methyltransferase MLL4 is required for its protein stability.

  6. Although enhancer priming by H3K4me1/2 methyltransferase MLL4/KMT2D (show MLL2 Antibodies) is dispensable for cell-identity maintenance, it controls cell fate transition by orchestrating p300 (show NOTCH1 Antibodies)-mediated enhancer activation

  7. KMT2D (show MLL2 Antibodies) is essential for regulating cardiac gene expression during heart development primarily via H3K4 di-methylation

  8. MLL2 interacts with RNA polymerase II (RNAPII) and RECQL5, and, although MLL2 mutated cells have normal overall H3K4me levels in genes, nucleosomes in the immediate vicinity of RNAPII are hypomethylated.

  9. MLL4 (KMT2D) is a major H3K4 mono- and di-methyltransferase with partial functional redundancy with MLL3 (KMT2C) in mouse and human cells. MLL4 is enriched on enhancers and is required for enhancer activation, cell-type-specific gene expression and cell differentiation.

  10. The results reveal a critical role for Mll2 in proliferation and cardiac lineage differentiation of mouse ESCs (show NR2E3 Antibodies), and provide novel molecular insight into the mechanisms of cardiac development and disease.

Histone-Lysine N-Methyltransferase MLL4 (MLL4) Antigen Profile

Antigen Summary

This gene encodes a protein which contains multiple domains including a CXXC zinc finger, three PHD zinc fingers, two FY-rich domains, and a SET (suppressor of variegation, enhancer of zeste, and trithorax) domain. The SET domain is a conserved C-terminal domain that characterizes proteins of the MLL (mixed-lineage leukemia) family. This gene is ubiquitously expressed in adult tissues. It is also amplified in solid tumor cell lines, and may be involved in human cancer. Two alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene, however, the full length nature of the shorter transcript is not known.

Alternative names and synonyms associated with Histone-Lysine N-Methyltransferase MLL4 (MLL4)

  • lysine (K)-specific methyltransferase 2B (KMT2B) antibody
  • lysine (K)-specific methyltransferase 2B (Kmt2b) antibody
  • lysine (K)-specific methyltransferase 2D (Kmt2d) antibody
  • myeloid/lymphoid or mixed-lineage leukemia 4 (MLL4) antibody
  • myeloid/lymphoid or mixed-lineage leukemia 4 (LOC100353483) antibody
  • 2610014H22Rik antibody
  • ALR antibody
  • BC032281 antibody
  • BC058659 antibody
  • C430014K11Rik antibody
  • HRX2 antibody
  • KMT2B antibody
  • mKIAA0304 antibody
  • MLL1B antibody
  • Mll2 antibody
  • Mll4 antibody
  • RGD1308331 antibody
  • TRX2 antibody
  • Wbp7 antibody

Protein level used designations for MLL4

KMT2D , WBP-7 , WW domain binding protein 7 , WW domain-binding protein 7 , histone-lysine N-methyltransferase 2B , histone-lysine N-methyltransferase MLL4 , lysine N-methyltransferase 2B , lysine N-methyltransferase 2D , mixed lineage leukemia gene homolog 2 , myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 4 , myeloid/lymphoid or mixed-lineage leukemia 4 , myeloid/lymphoid or mixed-lineage leukemia protein 4 , trithorax homolog 2 , trithorax homologue 2 , mixed lineage leukemia 2 , myeloid/lymphoid or mixed-lineage leukemia protein 4 homolog , ALL1-related protein , histone-lysine N-methyltransferase 2D , histone-lysine N-methyltransferase MLL2 , myeloid/lymphoid or mixed-lineage leukemia 2 , myeloid/lymphoid or mixed-lineage leukemia protein 2

GENE ID SPECIES
9757 Homo sapiens
361543 Rattus norvegicus
75410 Mus musculus
381022 Mus musculus
100688666 Canis lupus familiaris
100353483 Oryctolagus cuniculus
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