MLL4 antibody (N-Term)

Catalog No. ABIN2778080

The Rabbit Polyclonal anti-MLL4 antibody (ABIN2778080) specifically detects MLL4 in WB. The antibody is reactive with Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit and Saccharomyces cerevisiae samples.

Quick Overview for MLL4 antibody (N-Term) (ABIN2778080)

Target: MLL4 (Histone-Lysine N-Methyltransferase MLL4 (MLL4))

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MLL4 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MLL4 Antibody

Binding Specificity: N-Term

Purpose: MLL4 Antibody - N-terminal region

Sequence: WAGPRVQRGR GRGRGRGWGP SRGCVPEEES SDGESDEEEF QGFHSDEDVA

Predicted Reactivity: Cow: 92%, Dog: 85%, Guinea Pig: 92%, Horse: 83%, Human: 100%, Mouse: 92%, Rabbit: 92%, Rat: 92%, Yeast: 91%

Characteristics: This is a rabbit polyclonal antibody against MLL4. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human MLL4

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8102627

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for MLL4

Target: MLL4 (Histone-Lysine N-Methyltransferase MLL4 (MLL4))

Alternative Name: MLL4

Background:

Background Information: MLL4 a protein which contains multiple domains including a CXXC zinc finger, three PHD zinc fingers, two FY-rich domains, and a SET (suppressor of variegation, enhancer of zeste, and trithorax) domain. The SET domain is a conserved C-terminal domain that characterizes proteins of the MLL (mixed-lineage leukemia) family. MLL4 is ubiquitously expressed in adult tissues. It is also amplified in solid tumor cell lines, and may be involved in human cancer

Gene Name: Myeloid/lymphoid or mixed-lineage leukemia 4

Alternative Symbols: HRX2, MLL2, MLL4, TRX2, WBP7, DYT28, MLL1B, WBP-7, CXXC10

Protein Name: Histone-lysine N-methyltransferase MLL4

Molecular Weight: 64kDa

Gene ID: 9757

UniProt: Q9UMN6

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Warburg Effect