Browse our Nuclear Receptor Coactivator 3 Proteins (NCOA3)

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Nuclear Receptor Coactivator 3 Proteins (NCOA3)
On are 5 Nuclear Receptor Coactivator 3 (NCOA3) Proteins from 3 different suppliers available. Additionally we are shipping Nuclear Receptor Coactivator 3 Antibodies (155) and Nuclear Receptor Coactivator 3 Kits (11) and many more products for this protein. A total of 174 Nuclear Receptor Coactivator 3 products are currently listed.
2010305B15Rik, actr, aib-1, aib1, AW321064, bHLHe42, cagh16, ctg26, kat13b, NCOA3, p/Cip, pcip, rac3, src-3, src3, tnrc14, tnrc16, tram-1, Tram1, xSRC-3
list all proteins Gene Name GeneID UniProt
NCOA3 8202 Q9Y6Q9
NCOA3 17979  
NCOA3 84584  

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Nuclear Receptor Coactivator 3 Proteins (NCOA3) by Origin

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Human Nuclear Receptor Coactivator 3 (NCOA3) interaction partners

  1. Data (including data from studies of hydrogen-deuterium exchange coupled to mass spectrometry in presence of denaturants) suggest that, for peptide fragments of human ACTR and mouse Crebbp (show CREBBP Proteins) representing disordered interaction domains, exchange rates are changed dramatically by high concentrations of denaturants guanidinium chloride or urea. (ACTR = activator of thyroid and retinoid receptor; Crebbp (show CREBBP Proteins) = CREB binding protein (show CREBBP Proteins))

  2. Data suggest that steroid receptor (show ESR2 Proteins) coactivators (NCOA1 (show NCOA1 Proteins), NCOA2 (show NCOA2 Proteins), NCOA3) are over-expressed in a number of hormone-dependent cancers where they promote tumor growth, invasion, metastasis, and chemo-resistance; with their multiple roles in cancer, steroid receptor (show ESR2 Proteins) coactivators are promising targets for development of antineoplastic agents that can interfere with their function. [REVIEW]

  3. Here, we reported the novel finding that depletion of SRC-3 enhanced sensitivity of breast and lung cancer cells to HDAC (show HDAC3 Proteins) inhibitors (SAHA and romidepsin). In contrast, overexpression of SRC-3 decreased SAHA-induced cancer cell apoptosis. Furthermore, we found that SRC-3 inhibitor bufalin increased cancer cell apoptosis induced by HDAC (show HDAC3 Proteins) inhibitors. The combination of bufalin and SAHA was particular efficient in attenuating

  4. Altered expression of AIB1 may play a role in adenomyosis development and treatment outcome with levonorgestrel-releasing intrauterine system.

  5. The oncogenic transcription factor AIB1 has a novel role in the regulation of polyribosome recruitment and formation of the translational complex. Combinatorial therapies targeting IGF signaling and mRNA translation in AIB1 expressing breast cancers may have clinical benefit and warrants further investigation

  6. Total SRC3 is selectively found at enhancer regions.

  7. The transcriptional coactivator SRC-3.

  8. The aim of this study was to investigate the expression of AIB1 in human esophageal squamous cell carcinoma and its correlation with Ki67 (show MKI67 Proteins) expression.

  9. NCOA3 polymorphisms might influence the risk of dyslipidemia and serum lipid levels in Chinese Han population.

  10. miR (show MLXIP Proteins)-137 has a role in targeting p160 (show MSH6 Proteins) steroid receptor (show ESR2 Proteins) coactivators SRC1 (show SRC Proteins), SRC2 (show NCOA2 Proteins), and SRC3 and inhibits cell proliferation

Mouse (Murine) Nuclear Receptor Coactivator 3 (NCOA3) interaction partners

  1. Findings indicate that the Gata6 (show GATA6 Proteins) promoter is activated by Esrrb in association with Ncoa3, and Dax1 (show NR0B1 Proteins) inhibited activities of Esrrb and Ncoa3, resulting maintenance of the undifferentiated status of embryonic stem (ES) cells.

  2. SRC-1 (show NCOA1 Proteins)/3 are required for cardiomyocyte proliferation and differentiation at earlier developmental stages, and their dysfunction causes NCC (show SLC12A3 Proteins)-like abnormalities in the hearts of newborn and adult mice.

  3. AIB1 promotes gastric cancer cell proliferation, survival and invasiveness through modulating major signaling pathways such as ErbB (show EGFR Proteins) and Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathways. Findings suggest that AIB1 plays an important role in the pathogenesis of gastric cancer.

  4. SRC-3 is a target for inhibiting aggressive prostate cancer containing neuroendocrine tumor cells.

  5. Impaired hematopoiesis and delayed thrombopoietic recovery following sublethal irradiation in SRC3 knockout mice.

  6. The p/CIP gene regulatory network identifies various feed-forward modules including one in which p/CIP activates members of the extended pluripotency network, demonstrating that p/CIP is a component of this extended network.

  7. Loss of SRC3 also shows sex differences in anxiety and exploratory behaviors.

  8. IRS1 (show IRS1 Proteins) levels are significantly increased in mouse cell lines representing fat and muscle lineages with p/CIP and SRC-1 (show NCOA1 Proteins) deletions and in white adipose tissue and skeletal muscle of knockout mice.

  9. Data show that knockdown of nuclear receptor coactivator 3 (Ncoa3) not only compromises the expression of pluripotency markers but also impairs in vitro and in vivo differentiation potential of embryonic stem cells.

  10. Ncoa3, an essential coactivator, is required to mediate Esrrb function in embryonic stem cells.

Nuclear Receptor Coactivator 3 (NCOA3) Protein Profile

Protein Summary

The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein.

Alternative names and synonyms associated with Nuclear Receptor Coactivator 3 (NCOA3)

  • nuclear receptor coactivator 3 (NCOA3)
  • nuclear receptor coactivator 3 (Ncoa3)
  • nuclear receptor coactivator 3 (ncoa3)
  • 2010305B15Rik protein
  • actr protein
  • aib-1 protein
  • aib1 protein
  • AW321064 protein
  • bHLHe42 protein
  • cagh16 protein
  • ctg26 protein
  • kat13b protein
  • NCOA3 protein
  • p/Cip protein
  • pcip protein
  • rac3 protein
  • src-3 protein
  • src3 protein
  • tnrc14 protein
  • tnrc16 protein
  • tram-1 protein
  • Tram1 protein
  • xSRC-3 protein

Protein level used designations for NCOA3

nuclear receptor coactivator 3 , CBP-interacting protein , amplified in breast cancer 1 protein , class E basic helix-loop-helix protein 42 , receptor-associated coactivator 3 , steroid receptor coactivator protein 3 , thyroid hormone receptor activator molecule 1 , steroid receptor coactivator 3 , AIB-1 , NCoA-3 , RAC-3 , SRC-3 , amplified in breast cancer-1 protein homolog , retinoid X receptor-interacting coactivator xSRC-3

705431 Macaca mulatta
8202 Homo sapiens
100135659 Sus scrofa
17979 Mus musculus
485915 Canis lupus familiaris
523707 Bos taurus
84584 Rattus norvegicus
398021 Xenopus laevis
419208 Gallus gallus
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