Browse our PARK7 Proteins (PARK7)

Full name:
Parkinson Protein 7 Proteins (PARK7)
On www.antibodies-online.com are 29 Parkinson Protein 7 (PARK7) Proteins from 14 different suppliers available. Additionally we are shipping PARK7 Antibodies (265) and PARK7 Kits (23) and many more products for this protein. A total of 327 PARK7 products are currently listed.
Synonyms:
CAP1, DJ-1, DJ1, SP22, zgc:103725
list all proteins Gene Name GeneID UniProt
PARK7 57320 Q99LX0
PARK7 11315 Q99497
PARK7 117287 O88767

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PARK7 Proteins (PARK7) by Origin

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Top referenced PARK7 Proteins

  1. Human PARK7 Protein expressed in Escherichia coli (E. coli) - ABIN667043 : Choi, Sullards, Olzmann, Rees, Weintraub, Bostwick, Gearing, Levey, Chin, Li: Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases. in The Journal of biological chemistry 2006 (PubMed)
    Show all 2 references for 667043

More Proteins for PARK7 Interaction Partners

Zebrafish Parkinson Protein 7 (PARK7) interaction partners

  1. Melatonin, added together with MPTP (show PTPN2 Proteins) or added once MPTP (show PTPN2 Proteins) was removed, prevented and recovered, respectively, the parkinsonian phenotype once it was established, restoring gene expression and normal function of the parkin (show PARK2 Proteins)/PINK1 (show PINK1 Proteins)/DJ-1/MUL1 loop and also the normal motor activity of the embryos.

  2. These studies show that zDJ-1 is very similar to human DJ-1 and is evolutionarily conserved and expressed in dopaminergic neurons.

Mouse (Murine) Parkinson Protein 7 (PARK7) interaction partners

  1. These results indicate that up-regulation of GH in the lungs of DJ-1 KO mice may enhance the malignancy of B16F10 cells and nodule formation in pulmonary metastasis of melanoma.

  2. DJ-1 is a powerful regulator of reactive oxygen species production as well as NHE1 (show SLC9A1 Proteins) expression and activity in CD4 (show CD4 Proteins)(+) T cells.

  3. DJ-1 deficiency negatively regulates liver progenitor cells (LPC (show PCSK7 Proteins)) proliferation by impairing the formation of LPC (show PCSK7 Proteins)-associated fibrosis and inflammatory niches.

  4. regulation of reactive oxygen species (ROS (show ROS1 Proteins)) and of the antioxidant protein (show PRDX3 Proteins) DJ-1 (PARK-7), which increases with cancer progression and acts to lessen oxidative damage to malignant cells, in relationship with systemic mastocytosis severity, was examined.

  5. Our data strengthen previous findings regarding DJ-1 diverse pathways and indicate that DJ-1 is part of a concerted and complex cellular response to OS

  6. Our data demonstrates that the activation of DJ-1 in response to myocardial I/R injury protects the heart by regulating the SUMOylation status of Drp1 and attenuating excessive mitochondrial fission.

  7. DJ-1(-/-) astrocytes may provide decreased neuroprotection to surrounding neurons due to alterations in pro-inflammatory mediator expression

  8. Loss of DJ-1 impairs antioxidant response by altered glutamine and serine metabolism.

  9. To verify our finding, we provide evidence that the protein expression of Parkinson protein 7, including new protein synthesis, is sensitive to mTORC1 inhibition

  10. These observations reveal an unexpected differential role of DJ-1 in the development of nTregs and iTregs.

Human Parkinson Protein 7 (PARK7) interaction partners

  1. DJ-1 deficiency negatively regulates liver progenitor cells (LPC (show PCSK7 Proteins)) proliferation by impairing the formation of LPC (show PCSK7 Proteins)-associated fibrosis and inflammatory niches.

  2. Downregulation of DJ-1 using DJ-1-siRNA in H69AR cells sensitized cancer cells to chemotherapeutic drugs through increasing drug-induced cell apoptosis accompanied with G0-G1 phase arrest. These findings suggest DJ-1 may serve as a potential biomarker for chemoresistance and prognostic factor for patients with small-cell lung cancer (SCLC).

  3. regulation of reactive oxygen species (ROS (show ROS1 Proteins)) and of the antioxidant protein (show PRDX3 Proteins) DJ-1 (PARK-7), which increases with cancer progression and acts to lessen oxidative damage to malignant cells, in relationship with systemic mastocytosis severity, was examined.

  4. DJ-1 was highly expressed in the early stage of lung cancer, and its expression was significantly decreased after metastasis. Therefore, DJ-1 may be a potential biomarker for the early diagnosis and monitoring of lung cancer metastasis

  5. DJ-1 overexpression can restore the impaired Nrf2 (show GABPA Proteins) pathway, leading to Alveolar type II cell protection in heavy smokers.

  6. DJ-1 serum levels seem to be correlated with worsening of the endometrial cancer grade and histotype, making it a reliable tool in the preoperative decision-making process.

  7. DJ-1 family deglycases repair proteins from glycation by glyoxals. Contradictory results suggested that this activity resulted from a Tris artefact. We show here that DJ-1 behaves indeed as a bona fide deglycase.

  8. ELISA-based detection of flotillin 2 (show FLOT2 Proteins) and PARK7 showed that the combination of these proteins was able to distinguish prostate cancer patients and healthy controls with 68% sensitivity and 93% specificity

  9. Furthermore, SIRT1 (show SIRT1 Proteins) activity was reduced in DJ-1-knockout cells, and this reduced activity was restored by re-introduction of wild-type DJ-1 but not of C106-mutant DJ-1 into DJ-1-knockout cells. It is first report showing direct connection of DJ-1 with SIRT1 (show SIRT1 Proteins).

  10. DJ-1 is necessary for 20C-mediated protection against rotenone-induced oxidative damage, at least in part, by activating PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) signaling, and subsequently enhancing the nuclear accumulation of Nrf2 (show GABPA Proteins).

Pig (Porcine) Parkinson Protein 7 (PARK7) interaction partners

  1. The PARK7 gene was demonstrated to be located on porcine chromosome 6

PARK7 Protein Profile

Protein Summary

The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene.

Alternative names and synonyms associated with PARK7

  • parkinson disease (autosomal recessive, early onset) 7 (park7)
  • Parkinson disease (autosomal recessive, early onset) 7 (PARK7)
  • Parkinson disease (autosomal recessive, early onset) 7 (Park7)
  • parkinson protein 7 (PARK7)
  • parkinson protein 7 (Park7)
  • CAP1 protein
  • DJ-1 protein
  • DJ1 protein
  • SP22 protein
  • zgc:103725 protein

Protein level used designations for Parkinson Protein 7 Proteins (PARK7)

DJ-1 protein , parkinson disease protein 7 homolog , protein DJ-1 , zDJ-1 , Parkinson disease 7 , RNA-binding protein regulatory subunit , Parkinson disease (autosomal recessive, early onset) 7 , oncogene DJ1 , contraception-associated protein 1 , fertility protein SP22

GENE ID SPECIES
449674 Danio rerio
395277 Gallus gallus
57320 Mus musculus
11315 Homo sapiens
511268 Bos taurus
117287 Rattus norvegicus
479595 Canis lupus familiaris
780404 Sus scrofa
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