PARK7/DJ1 Protein (His tag)

Catalog No. ABIN7197282

Product Details

Target: PARK7/DJ1 (PARK7) (Parkinson Protein 7 (PARK7))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This PARK7/DJ1 protein is labelled with His tag.

Purpose: Recombinant Human PARK7/DJ-1 Protein (His Tag)

Sequence: Met 1-Asp 189

Characteristics: A DNA sequence encoding the human PARK7 (Q99497-1) (Met 1-Asp 189) was fused with a polyhistidine tag at the C-terminus.

Purity: > 95 % as determined by reducing SDS-PAGE.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM Tris, 150 mM NaCl, 3 mM DTT, 5 % glycerol, pH 8.0

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: PARK7/DJ1 (PARK7) (Parkinson Protein 7 (PARK7))

Alternative Name: PARK7/DJ-1 (PARK7 Products)

Synonyms: DJ-1 Protein, DJ1 Protein, CAP1 Protein, Dj1 Protein, SP22 Protein, dj1 Protein, zgc:103725 Protein, park7b Protein, park7 Protein, park7a Protein, Parkinsonism associated deglycase Protein, Parkinson disease (autosomal recessive, early onset) 7 Protein, parkinson protein 7 Protein, parkinson protein 7 S homeolog Protein, parkinson protein 7 L homeolog Protein, PARK7 Protein, Park7 Protein, park7 Protein, park7.S Protein, park7.L Protein

Background:

Background: Parkinson's disease locus DJ-1 (PARK7) is a differentially expressed transcript. DJ-1 plays a physiologic role in protection of erythroid cells from oxidant damage, a function unmasked in the context of oxidative stress. PARK7 belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Mutations in the DJ-1 gene are associated with rare forms of autosomal recessive early-onset Parkinson's disease (PD). DJ-1/p53 interactions contribute to apoptosis resistance in clonal myeloid cells and may serve as a prognostic marker in patients with myelodysplastic syndromes (MDS). DJ-1 regulates redox signaling kinase pathways and acts as a transcriptional regulator of antioxidative gene batteries. Therefore, DJ-1 is an important redox-reactive signaling intermediate controlling oxidative stress after ischemia, upon neuroinflammation, and during age-related neurodegenerative processes. Augmenting DJ-1 activity might provide novel approaches to treating chronic neurodegenerative illnesses such as Parkinson's disease and acute damage such as stroke.

Synonym: DJ-1,DJ1,HEL-S-67p

Molecular Weight: 21.3 kDa

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Proton Transport