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results thus demonstrate that the catalytic activity of GCN5 (show KAT2A Proteins) is stimulated by subunits of the ADA2a (show TADA2A Proteins)- or ADA2b (show TADA2B Proteins)-containing HAT (show MGEA5 Proteins) modules and is further increased by incorporation of the distinct HAT (show MGEA5 Proteins) modules in the ATAC (show XCL1 Proteins) or SAGA holo-complexes
PCAF (show KAT2B Proteins) and ADA3 regulate Bid (show BID Proteins) processing via PACS2 (show PACS2 Proteins), to modulate the mitochondrial cell death pathway in response to hGrzB.
Cytoplasmic localization of alteration/deficiency in activation 3 (ADA3) predicts poor clinical outcome in breast cancer patients.
Expression of the interacting proteins altered expression of an hADA3-regulated reporter gene, suggesting functional consequences for the interactions.
a critical role of Ada3 in embryogenesis and cell cycle progression as an essential component of HAT complex.
hADA3 interacts directly with RARalpha (show RARA Proteins) in a hormone-dependent manner and this interaction contributes to RARalpha (show RARA Proteins) transactivation
Data identify hADA3, human homologue of the yeast transcriptional coactivator yADA3, as a novel human papillomavirus oncoprotein E6-interacting protein and a target of E6-induced degradation.
Results demonstrate that human papilloma virus 16 E6 oncoprotein inhibits the RXR(alpha)-mediated transactivation of target genes, implying that perturbation of RXR-mediated transactivation by E6 could contribute to HPV oncogenesis.
results demonstrate that transcriptional adaptor ADA3 protein directly binds to human estrogen receptor alpha (show ESR1 Proteins) and beta and enhances the transcription of estrogen receptor (show ESR1 Proteins)-responsive genes
human Ada3 has an essential role in p53 (show TP53 Proteins) acetylation
demonstrate a novel ADA3 interaction with CENP-B (show CENPB Proteins)-centromere that may account for its previously known function in mitosis
The loss of Ada3 led to enhanced chromosomal aberrations, such as chromosome breaks, fragments, deletions and translocations, which further increased upon DNA damage.
Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. In addition, it associates with the tumor suppressor protein p53 and is required for full activity of p53 and p53-mediated apoptosis. At least four alternatively spliced variants have been found for this gene, but the full-length nature of some variants has not been determined.
transcriptional adaptor 3
, transcriptional adapter 3-like
, ADA3 homolog B
, ADA3-like protein B
, Transcriptional adapter 3-like B
, transcriptional adapter 3-B
, ADA3 homolog
, ADA3-like protein
, transcriptional adapter 3