Browse our anti-ube3a (ube3a) Antibodies

Full name:
anti-Ubiquitin Protein Ligase E3A Antibodies (ube3a)
On are 97 Ubiquitin Protein Ligase E3A (ube3a) Antibodies from 21 different suppliers available. Additionally we are shipping ube3a Kits (16) and ube3a Proteins (8) and many more products for this protein. A total of 128 ube3a products are currently listed.
4732496B02, 5830462N02Rik, A130086L21Rik, ANCR, As, CG6190, das, DDBDRAFT_0188760, DDBDRAFT_0302447, DDB_0188760, DDB_0302447, DKFZp459N106, Dmel\\CG6190, dube3a, E6-AP, EPVE6AP, Hpve6a, im:7140733, MGC69536, mKIAA4216, ube3a, UME3A, zgc:92173
list all antibodies Gene Name GeneID UniProt
ube3a 7337 Q05086
ube3a 22215  
ube3a 361585  

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Top referenced anti-ube3a Antibodies

  1. Human Polyclonal ube3a Primary Antibody for IP, WB - ABIN153040 : Jiang, Sahoo, Michaelis, Bercovich, Bressler, Kashork, Liu, Shaffer, Schroer, Stockton, Spielman, Stevenson, Beaudet: A mixed epigenetic/genetic model for oligogenic inheritance of autism with a limited role for UBE3A. in American journal of medical genetics. Part A 2004 (PubMed)
    Show all 8 references for 153040

  2. Human Polyclonal ube3a Primary Antibody for FACS, IF - ABIN388925 : Be, Hong, Wei, Androphy, Chen, Baleja: Solution structure determination and mutational analysis of the papillomavirus E6 interacting peptide of E6AP. in Biochemistry 2001 (PubMed)
    Show all 5 references for 388925

  3. Human Polyclonal ube3a Primary Antibody for EIA, IHC (p) - ABIN357571 : Kleijnen, Shih, Zhou, Kumar, Soccio, Kedersha, Gill, Howley: The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome. in Molecular cell 2000 (PubMed)
    Show all 5 references for 357571

  4. Human Monoclonal ube3a Primary Antibody for IF, WB - ABIN393616 : Zaaroor-Regev, de Bie, Scheffner, Noy, Shemer, Heled, Stein, Pikarsky, Ciechanover: Regulation of the polycomb protein Ring1B by self-ubiquitination or by E6-AP may have implications to the pathogenesis of Angelman syndrome. in Proceedings of the National Academy of Sciences of the United States of America 2010 (PubMed)
    Show all 5 references for 393616

  5. Human Monoclonal ube3a Primary Antibody for IF, WB - ABIN968525 : Matsuura, Sutcliffe, Fang, Galjaard, Jiang, Benton, Rommens, Beaudet: De novo truncating mutations in E6-AP ubiquitin-protein ligase gene (UBE3A) in Angelman syndrome. in Nature genetics 1997 (PubMed)
    Show all 2 references for 968525

  6. Human Polyclonal ube3a Primary Antibody for WB - ABIN153039 : Sato, Stryker: Genomic imprinting of experience-dependent cortical plasticity by the ubiquitin ligase gene Ube3a. in Proceedings of the National Academy of Sciences of the United States of America 2010 (PubMed)

  7. Human Monoclonal ube3a Primary Antibody for IF, IHC (p) - ABIN563326 : Underbrink, Howie, Bedard, Koop, Galloway: E6 proteins from multiple human betapapillomavirus types degrade Bak and protect keratinocytes from apoptosis after UVB irradiation. in Journal of virology 2008 (PubMed)

  8. Human Monoclonal ube3a Primary Antibody for IF, IHC (p) - ABIN2477024 : Wolyniec, Shortt, de Stanchina, Levav-Cohen, Alsheich-Bartok, Louria-Hayon, Corneille, Kumar, Woods, Opat, Johnstone, Scott, Segal, Pandolfi, Fox, Strasser, Jiang, Lowe, Haupt, Haupt: E6AP ubiquitin ligase regulates PML-induced senescence in Myc-driven lymphomagenesis. in Blood 2012 (PubMed)

  9. Cow (Bovine) Polyclonal ube3a Primary Antibody for WB - ABIN2775648 : Bedard, Underbrink, Howie, Galloway: The E6 oncoproteins from human betapapillomaviruses differentially activate telomerase through an E6AP-dependent mechanism and prolong the lifespan of primary keratinocytes. in Journal of virology 2008 (PubMed)

More Antibodies against ube3a Interaction Partners

Fruit Fly (Drosophila melanogaster) Ubiquitin Protein Ligase E3A (ube3a) interaction partners

  1. Negative regulation of Tkv by Ube3a was conserved in mammalian cells. These results reveal a critical role for Ube3a in regulating NMJ synapse development by repressing BMP (show TGFb Antibodies) signaling. This study sheds new light onto the neuronal functions of UBE3A and provides novel perspectives for understanding the pathogenesis of UBE3A-associated disorders.

  2. Data indicate that E3 ligase called ube3 (dube3a) is required for brain development as mutants have defective mushroom bodies.

  3. Rpn10 is targeted for degradation by Ube3a.

  4. In Drosophila melanogaster the human homologue ube3a regulates the actin cytoskeleton and neuronal homeostasis.

  5. MeCP2 and E6AP play a role in the transcriptional control of common target gene expression.

  6. Ube3a regulates serotonin and dopamine synthesis in the fly brain by increasing GTP cyclohydrolase I (show GCH1 Antibodies) activity.

  7. dube3a null mutants appear normal externally, but display abnormal locomotive behavior and circadian rhythms, and defective long-term memory; overexpression in the nervous system caused locomotion defects, dependent on the ubiquitin ligase activity

  8. Overexpression of dUBE3A decreased dendritic branching.

Human Ubiquitin Protein Ligase E3A (ube3a) interaction partners

  1. study has broad implications for human disorders associated with UBE3A gain or loss of function and suggests that dysfunctional UBE3A might affect additional proteins and pathways that are sensitive to proteasome activity

  2. We found that KD of E6AP attenuates cancer cell growth by promoting cellular senescence in vivo, which correlates with restoration of tumor suppression by PML (show PML Antibodies).

  3. HCV core protein inhibits E6AP expression via DNA methylation to protect itself from ubiquitin-dependent proteasomal degradation and stimulate virus propagation.

  4. E6AP suppresses breast cancer metastasis by regulating actin cytoskeleton remodeling through the control of ECT2 (show ECT2 Antibodies) and Rho GTPase (show RACGAP1 Antibodies) activity.

  5. Dube3a is neither imprinted nor preferentially expressed from the maternal allele in fly neurons.

  6. The ubiquitylation of beta-catenin (show CTNNB1 Antibodies) by E6AP was dependent on its E3 ubiquitin ligase (show MUL1 Antibodies) activity, but it was proteasome-independent and did not require HPV16-E6.

  7. All patients with Angelman syndrome based on a deletion had epilepsy. Epilepsy was present in 3/4 children with UBE3A mutation. Laughter-induced postural muscle tone loss occurred only among deletion cases

  8. The results of Trans-well and cell scratch tests showed that when ANCR expression was decreased, the invasion and migration abilities of SW620 cells significantly declined (both P < 0.05). In conclusion, these results suggest that lncRNA-ANCR could influence the invasion and migration of CRC (show CALR Antibodies) cells by specifically binding to EZH2 (show EZH2 Antibodies).

  9. There were total 55 molecularly confirmed Angelman syndrome(AS) between January 1995 to September 2015 for review. 65.5% of them were caused by maternal microdeletion, 10.9% by paternal uniparental disomy, 3.6% by imprinting center defect and 14.5% by UBE3A gene mutation

  10. The observation of Dup15q syndrome in individuals with maternally but not paternally inherited duplications of chromosome 15q11-q13, suggest that UBE3A drives the Angelman syndrome phenotype in this disorder. (Review)

Mouse (Murine) Ubiquitin Protein Ligase E3A (ube3a) interaction partners

  1. Our findings suggest that UBE3A may act locally to regulate individual synapses while also mediating global, neuronwide influences through the regulation of gene transcription

  2. treatment of topotecan, a brain-penetrating topoisomerase 1 (show TOP1 Antibodies) inhibitor, to HD transgenic mouse considerably improved its motor behavioural abnormalities. Finally, we show that topotecan treatment to HD mouse not only inhibits the expression of transgenic mutant huntingtin (show HTT Antibodies), but also at the same time induces the expression of Ube3a

  3. We report that mice with maternally-inherited deletions of Ube3a that models Angelman syndrome show an increased social preference/interaction.

  4. increasing UBE3A in the nucleus downregulates the glutamatergic synapse organizer Cbln1 (show CBLN1 Antibodies), which is needed for sociability in mice

  5. Based on our findings, we propose that imprinting of UBE3A does not function to reduce the dosage of UBE3A in neurons but rather to regulate some other, as yet unknown, aspect of gene expression or protein function

  6. the role of UBE3A is investigated in neurite contact guidance during neuronal development, is reported.

  7. Results substantiate GABAergic Ube3a loss as the principal cause of circuit hyperexcitability in Angelman syndrome mice, lending insight into ictogenic mechanisms in AS.

  8. Loss of Ube3a from tyrosine hydroxylase (show TH Antibodies)-expressing neurons impairs mesoaccumbal, non-canonical GABA co-release and enhances reward-seeking behaviour measured by optical self-stimulation.

  9. Results suggest that the phenotypes observed in Angelman syndrome mice may be modulated by factors independent of Ube3a genotype

  10. UBE3A dampens ERK (show EPHB2 Antibodies) pathway signalling in HPV E6 transformed HeLa cells

Pig (Porcine) Ubiquitin Protein Ligase E3A (ube3a) interaction partners

  1. In the skeletal muscle of neonate pigs, both NECD (show NDN Antibodies) and SNRPN (show SNRPN Antibodies) were maternally imprinted, while UBE3A was not imprinted.

ube3a Antigen Profile

Antigen Summary

This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined.

Alternative names and synonyms associated with ube3a

  • Ubiquitin protein ligase E3A (Ube3a) antibody
  • ubiquitin protein ligase E3A (UBE3A) antibody
  • ubiquitin-protein ligase E3A (ube3a) antibody
  • ubiquitin protein ligase E3A (ube3a) antibody
  • ubiquitin protein ligase E3A (human papilloma virus E6-associated protein, Angelman syndrome) (ube3a) antibody
  • ubiquitin protein ligase E3A (Eint_040430) antibody
  • ubiquitin protein ligase E3A (Ube3a) antibody
  • 4732496B02 antibody
  • 5830462N02Rik antibody
  • A130086L21Rik antibody
  • ANCR antibody
  • As antibody
  • CG6190 antibody
  • das antibody
  • DDBDRAFT_0188760 antibody
  • DDBDRAFT_0302447 antibody
  • DDB_0188760 antibody
  • DDB_0302447 antibody
  • DKFZp459N106 antibody
  • Dmel\\CG6190 antibody
  • dube3a antibody
  • E6-AP antibody
  • EPVE6AP antibody
  • Hpve6a antibody
  • im:7140733 antibody
  • MGC69536 antibody
  • mKIAA4216 antibody
  • ube3a antibody
  • UME3A antibody
  • zgc:92173 antibody

Protein level used designations for ube3a

ubiquitin protein ligase E3A , CG6190-PA , Ube3a-PA , drosophila angelman syndrome , angelman syndrome , ubiquitin protein ligase E3A (human papilloma virus E6-associated protein, Angelman syndrome) , ubiquitin-protein ligase E3A , ubiquitin-protein ligase E3A-like , CTCL tumor antigen se37-2 , E6AP ubiquitin-protein ligase , human papilloma virus E6-associated protein , human papillomavirus E6-associated protein , oncogenic protein-associated protein E6-AP , renal carcinoma antigen NY-REN-54 , E6-AP ubiquitin protein ligase , ubiquitin conjugating enzyme E3A

39266 Drosophila melanogaster
453269 Pan troglodytes
479010 Canis lupus familiaris
8627519 Dictyostelium discoideum AX4
100173699 Pongo abelii
100194730 Salmo salar
407881 Xenopus (Silurana) tropicalis
9699096 Encephalitozoon intestinalis ATCC 50506
100050725 Equus caballus
100385816 Callithrix jacchus
100438681 Pongo abelii
7337 Homo sapiens
22215 Mus musculus
792398 Danio rerio
533136 Bos taurus
361585 Rattus norvegicus
100522589 Sus scrofa
418686 Gallus gallus
100342825 Oryctolagus cuniculus
100730511 Cavia porcellus
380385 Xenopus laevis
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