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Results found that EDD was consistent with GOLPH3 (show GOLPH3 ELISA Kits) expression and also promoted the EMT (show ITK ELISA Kits) process and activated Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signaling in epithelial ovarian cancer.
UBR5 directly binds to the tumor suppressor esophageal cancer-related gene 4, increasing its ubiquitination to reducing the protein stability of ECRG4 (show C2orf40 ELISA Kits) to promote colorectal cancer progression.
Wnt (show WNT2 ELISA Kits)-dependent inactivation of the Groucho/TLE co-repressor by the HECT E3 ubiquitin ligase Hyd/UBR5 is a key prerequisite that enables Armadillo/beta-catenin to activate transcription.
UBR5 downregulates proapoptotic MOAP-1 (show MOAP1 ELISA Kits) and suggest that UBR5 can confer cisplatin resistance in ovarian cancer.
Data suggest that UBR5 down-regulates levels of TRAF3 (show TRAF3 ELISA Kits), a key component of Toll (show TLR4 ELISA Kits)-like receptor signaling, via the miRNA pathway; p90RSK (show RPS6KA1 ELISA Kits) is an upstream regulator of UBR5; p90RSK (show RPS6KA1 ELISA Kits) phosphorylates UBR5 as required for translational repression of TRAF3 (show TRAF3 ELISA Kits) mRNA. (UBR5 = ubiquitin protein ligase E3 component n-recognin 5 protein; TRAF3 (show TRAF3 ELISA Kits) = TNF receptor-associated factor 3 (show TRAF3 ELISA Kits); p90RSK (show RPS6KA1 ELISA Kits) = 90 kDa ribosomal protein S6 (show RPS6 ELISA Kits) kinase (show RPS6KB1 ELISA Kits))
Data show that ubiquitin protein ligase E3 component n-recognin 5 protein (UBR5) bound the tumor suppressor gastrokine 1 (GKN1 (show GKN1 ELISA Kits)) and increased its ubiquitination to reduce the protein stability of GKN1 (show GKN1 ELISA Kits).
Findings unveil UBR5 as a novel and critical regulator of tumor growth, metastasis, and immune response in triple negative breast cancer.
Study highlights many functional biological role of UBR5 especially in cancer where it seems to be a key regulator of cell signaling. [review]
Colony-formation assays and soft agar assays show that gain of function of TIP60 or depletion of EDD1 in HPV-positive cervical cancer cells significantly inhibits cell growth in vitro
Human herpesvirus-6 U14 induces cell cycle arrest in G2/M phase by associating with a cellular protein, EDD.
Hence, while loss of UBR5 perturbed Hedgehog (show SHH ELISA Kits) signalling in the developing limb, there were no obvious morphological defects.
UBR5-mediated ATMIN ubiquitination is a vital event for ATM (show ATM ELISA Kits) pathway selection and activation in response to DNA damage
a novel function of RIP1 (show RALBP1 ELISA Kits) kinase involving its interaction with EDD to regulate JNK (show MAPK8 ELISA Kits) activation and TNFalpha (show TNF ELISA Kits) production.
Silencing Edd1 with shRNA in mouse embryonic stem cells significantly suppressed their growth.
The SCF (show KITLG ELISA Kits) E3 ligase complex containing Fbxo40 (show FBXO40 ELISA Kits) directly ubiquitinates IRS1 (show IRS1 ELISA Kits), and this activity is enhanced by increased tyrosine phosphorylation of IRS1 (show IRS1 ELISA Kits).
Through the PABC domain, EDD participates in miRNA silencing by recruiting downstream effectors.
UBR5 can attenuate myocardin (show MYOCD ELISA Kits) protein degradation resulting in increased myocardin (show MYOCD ELISA Kits) protein expression without affecting myocardin (show MYOCD ELISA Kits) mRNA expression.
Results suggest that Edd has an essential role in extraembryonic development.
This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation.
E3 identified by differential display
, E3 ubiquitin protein ligase, HECT domain containing, 1
, E3 ubiquitin-protein ligase UBR5
, E3 ubiquitin-protein ligase, HECT domain-containing 1
, hyperplastic discs protein homolog
, progestin induced protein
, progestin-induced protein
, ubiquitin-protein ligase
, extraembryonic development