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Human Cardiotrophin 1 ELISA Kit for Sandwich ELISA - ABIN411375
Pennica, Swanson, Shaw, Kuang, Gray, Beatty, Wood: Human cardiotrophin-1: protein and gene structure, biological and binding activities, and chromosomal localization. in Cytokine 1997
Rat (Rattus) Cardiotrophin 1 ELISA Kit for Sandwich ELISA - ABIN368063
López-Andrés, Rousseau, Akhtar, Calvier, Iñigo, Labat, Zhao, Cruickshank, Díez, Zannad, Lacolley, Rossignol: Cardiotrophin 1 is involved in cardiac, vascular, and renal fibrosis and dysfunction. in Hypertension 2012
This paper will review many aspects of CT-1 physiological role in several organs and discuss data for consideration in therapeutic approaches.
biliary epithelium-derived CT-1 may exert a profibrogenic potential in PCLD (show PRKCSH ELISA Kits).
Data show that cardiotrophin-1 is positively related to brachial-ankle pulse-wave velocity (baPWV) independent of traditional cardiometabolic risk factors for arterial stiffness.
this study, even though preliminary and awaiting further confirmation by independent replication, provides first evidence that common genetic variation in CTF1 could contribute to insulin (show INS ELISA Kits) sensitivity in humans.
Study correlates CT-1 levels with ambulatory and central BP, as well as with pulse wave velocity in patients with essential hypertension.
CT-1 is differentially induced in the myocardium of infants with congenital cardiac defects depending on hypoxemia, and may mediate myocardial hypertrophy and dysfunction.
Subjects with impaired glucose tolerance (IGT) and newly diagnosed diabetes (NDD) have significantly higher CT-1 concentrations than those with normal glucose tolerance. IGT and NDD are positively associated with CT-1 concentrations.
exaggerated cardiomyocyte production of cardiotrophin-1 in response to increased left ventricular end-diastolic stress may contribute to fibrosis through stimulation of fibroblasts in heart failure of hypertensive origin.
A reduction in serum CT-1 levels after a WL program.
CT-1 induces the proteolytic potential in human aortic endothelial cells by upregulating MMP-1 (show MMP1 ELISA Kits) expression.
Nuclear translocation of CT-1 regulates cardiomyogenesis of ES cells and involves calcium, NO, ROS (show ROS1 ELISA Kits) as well as CT-1 regulated signaling pathways.
Data suggest that Ctf1 up-regulates lipolysis in white adipocytes via 1) induction of perilipin, 2) activation of hormone sensitive lipase (via phosphorylation by PKA), and 3) inactivation of adipose triglyceride lipase (via up-regulation of G0S2).
Cardiotrophin-1 (CT-1) is a hepatoprotective cytokine that modulates fat and glucose metabolism. Here we analyzed the changes in hepatic fat stores induced by recombinant CT-1 and its therapeutic potential in non-alcoholic fatty liver disease.
The transgenic expression of CTF1 brought about a marked improvement on cognitive functioning in the APPswe/PS1dE9 transgenic mouse model of Alzheimer's disease.
CT-1 improves beta cell function and survival, and protects mice against STZ-induced diabetes
CT-1 may be a major regulator of arterial stiffness with a major impact on the aging process.
Hypoxia increased cardiotrophin-1 levels in cardiac cells through a direct regulation of CT-1 promoter by HIF-1alpha (show HIF1A ELISA Kits), protecting cells from apoptosis.
Data suggest a key role for CT-1 in cardiac remodeling induced by aldosterone independent of changes in blood pressure levels.
We conclude that CT-1 is a master regulator of fat and glucose metabolism with potential applications for treatment of obesity and insulin (show INS ELISA Kits) resistance.
Treatment of embryoid bodies grown from pluripotent murine embryonic stem (ES) cells with cardiotrophin 1 significantly stimulated cardiomyogenesis and increased nuclear expression of the proliferation marker Ki-67 (show MKI67 ELISA Kits).
CT1 (show SLC6A8 ELISA Kits) decreases cell death through a mechanism related to Stat3 (show STAT3 ELISA Kits) and Akt (show AKT1 ELISA Kits) phosphorylation and activation of calpastatin (show CAST ELISA Kits) in D-galactosamine-treated hepatocytes.
The protein encoded by this gene is a secreted cytokine that induces cardiac myocyte hypertrophy in vitro. It has been shown to bind and activate the ILST/gp130 receoptor. Two transcript variants encoding different isoforms have been found for this gene.
, cardiophin 1