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The dizygotic twins presented here carry a compound heterozygous variant in the HTR7 gene. No other coding sequence abnormalities (CNVs and SVs) were observed in their fully sequenced genomes consistent with either dominant or recessive inheritance. This provides a first suggestive genetic link between the 5-HT7 receptor and autism spectrum disorder in patients.
Placental expression of HTR7 was significantly increased in women with pre-eclampsia compared to controls.
PTP1B (show PTPN1 Proteins) directly regulates STAT5 (show STAT5A Proteins) phosphorylation and its activation via the cAMP/PKA pathway downstream of the 5-HT7 receptor is involved in the suppression of beta-casein (show CSN2 Proteins) expression in MCF-12A cells
Study shows that HTR7 variants are not related to the overall improvement in schizophrenia symptoms following perospirone or aripiprazole treatment
Study demonstrated that binding of clozapine or olanzapine to the 5-HT7 receptor leads to antagonist-mediated lysosomal degradation by exposing key residues in the C-terminal tail that interact with GASP-1 (show GPRASP1 Proteins)
This is a review of literature about how 5-HT7 receptor has been implicated in cognitive disturbances, sleep and circadian rhythmicity disorders, anxiety and depression
Genetic variations in HTR7 serotonin receptor (show HTR1B Proteins) contribute to the predisposition for alcohol dependence.
There is a cross-reactivity between 5-HT7 and 5-HT1A (show HTR1A Proteins) receptors and in this review they are shown to have a role in depressive disorders.
Serotonin skews human macrophage polarization through HTR2B and HTR7.
the expression of 5-HT7 receptors in brain tissues was higher in the epilepsy group compared with the nonepileptic group; the results suggested that 5-HT7 receptors participate in the pathogenesis of temporal lobe epilepsy
5-HT(7)Dro activity is essential for normal courtship and mating behaviors in the fly
this study shows that 5-HT7 is expressed in the liver in vivo and in vitro in CCl4-induced damage, and that 5-HT7 receptor agonist but not the antagonist shows hepatoprotective effect against liver fibrosis
5-HT6 (show HTR6 Proteins)/7 receptor antagonist ADN (show CFD Proteins)-1184 displays anxiolytic-like activity in animal models of anxiety which employed punished stimuli.
results indicate that there is a crucial role for 5-HT7R-Cdc42 (show CDC42 Proteins)-mediated signaling in the regulation of dendritic cell morphology and motility, suggesting that 5-HT7R could be a new target for treatment of a variety of inflammatory and immune disorders.
5-HT7 is required for multiple actions of serotonin in the mammary glands.
Activation of HTR7 promoted opening of the ion channel TRPA1 (show TRPA1 Proteins), which in turn triggered itch behaviors. Acute itch triggered by serotonin or a selective serotonin reuptake inhibitor required both HTR7 and TRPA1 (show TRPA1 Proteins), as did development of atopic dermatitis.
It indicated that Correlation between nAChalpha4-, 5-HT1A- and 5-HT7-containing receptors and latencies on day 16 may point to a probable link in extinction mechanisms.
Blockade of 5-HT7R Results in Increased Severity of Chronic DSS (show PMP22 Proteins)-induced Colitis.
These results indicate that 5-HT (show DDC Proteins) receptors are functionally expressed in a subpopulation of substantia gelatinosa neurons of the and activation of 5-HT (show DDC Proteins) receptors plays an important role in modulating orofacial nociceptive processing.
The results provide evidence that lurasidone can act as a 5-HT7 receptor antagonist and provide a possible explanation for its antidepressant effect.
Colitis severity was significantly lower in 5-HT7(-/-) mice.
The 5-HT7 receptor seem to be particularly involved in antigen-induced airway hyperresponsiveness(AI-AHR (show AHR Proteins)) to ACh (show FGFR3 Proteins) in guinea-pigs.
excitatory 5-HT(2A) and inhibitory 5-HT(7) are present in the uterus of non-pregnant pigs. Endogenous 5-HT (show DDC Proteins) containing cells are mainly present in uterine glands of the pig
The neurotransmitter, serotonin, is thought to play a role in various cognitive and behavioral functions. The serotonin receptor encoded by this gene belongs to the superfamily of G protein-coupled receptors and the gene is a candidate locus for involvement in autistic disorder and other neuropsychiatric disorders. Three splice variants have been identified which encode proteins that differ in the length of their carboxy terminal ends.
, 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)
, 5-hydroxytryptamine receptor 7
, serotonin receptor
, serotonin receptor 1
, serotonin receptor 7
, 5-HT7-like serotonin receptor
, high affinity serotonin receptor (5HT7)
, 5-hydroxytryptamine7 receptor
, 5-HT receptor 7a
, serotonin 5-hydroxytryptamine 7-a receptor
, hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)