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These results suggest that endometrial and conceptus IFNAR1 (show IFNAR1 Proteins) and IFNAR2 may mediate the action of type I IFNs during the implantation period for the establishment and maintenance of pregnancy in pigs.
The genomic structure of porcine IFNAR2 gene consists of nine exons and eight introns and mRNA expression was detected in all tissues examined
We found that STAT-1 (show STAT1 Proteins)(-/-) MRL lpr (show FAS Proteins) m, but not IRF-9 (show IRF9 Proteins)(-/-) or IFNAR-2(-/-) mice, developed interstitial nephritis characterized by infiltration with RORgammat-positive lymphocytes, macrophages, and eosinophils.
mTORC2 (show CRTC2 Proteins) has a central role in IFNgamma signaling and type II IFN responses
In this study, we elucidate the in vivo importance of the soluble type I IFNAR (show IFNAR1 Proteins), soluble (s)IFNAR2a
In this study we have characterized the Stat2 (show STAT2 Proteins)-IFNaR2 interaction and examined its role in IFNalpha signaling
studies reveal that a single conserved IFNAR2 tyrosine, Y(510), plays a critical role in directing the IFN-I-dependent activation of STAT1 (show STAT1 Proteins) and STAT2 (show STAT2 Proteins), both in murine fibroblasts and macrophages
The local transgenic expression of GM-CSF (show CSF2 Proteins) in the stomach overrides any possible modulatory effects of IFNAR2 on experimental autoimmune gastritis development.
Data show that that DC, especially the CD8alpha(+) subset, from type I IFN receptor knock out (IFNAR (show IFNAR1 Proteins) KO) mice, display a reduced turnover rate when compared with DC from WT mice.
ability of L. pneumophila to induce IFN-I expression was found to be dependent on IRF-3 (show IRF3 Proteins), but not NF-kappaB (show NFKB1 Proteins). Secreted IFN-Is then in turn suppress the intracellular replication of L. pneumophila
the level of IFNAR1, IFNAR2, and CCR5 mRNA expression was found to be significantly lower in the responders than nonresponders.Our results highlighted the significance of IFNAR and CCR5 genes in multiple sclerosis risk and the response to IFN-b therapy.
this study shows that the surface expression levels of the common IFN-alpha (show IFNA Proteins)/beta receptor subunit 2 (show CCT2 Proteins) are significantly higher on plasmacytoid dendritic cells from females in comparison to males
A very small percentage of the pancreatic tumors showed strong expression of the IFNAR (show IFNAR1 Proteins)-2c.
Data suggest IFNA2 (interferon (show IFNA Proteins), alpha 2) binding to extracellular domain of IFNAR1 (show IFNAR1 Proteins) or IFNAR2 promotes proximity between intracellular domains; signaling depends on duration of activation/affinity of binding rather than specific conformational changes.
The expression of IFNAR1 (show IFNAR1 Proteins), IFNgammaR1 and ribovarin transporters were significantly impaired in chronic liver disease and cirrhotic livers.
Lack of expression of functional IFNAR2 does not seem to be the major cause of interferon (show IFNA Proteins) resistance in hepatitis C virus patients receiving standard interferon (show IFNA Proteins) therapy.
Dimerization of IFNAR1 (show IFNAR1 Proteins) and IFNAR2 and the limiting role of IFNAR1 (show IFNAR1 Proteins) binding affinity in complex assembly is modulated by USP18 (show USP18 Proteins).
Therefore, this study associated, for the first time, in a large panel of pancreatic cancer cell lines the effects of IFN-alpha (show IFNA Proteins)/-beta with the expression of type-I IFN receptors.
Results suggest that oxidative stress play an important role in the regulation of type I interferon (show IFNA Proteins) receptors IFNAR1 (show IFNAR1 Proteins) and IFNAR2 in chronic hepatitis B virus (HBV) infection.
The effects of two functional polymorphisms, type I interferon receptor 2 gene (IFNAR2)-F8S and interleukin-10 receptor subunit beta (show IL10RB Proteins) gene (IL10RB (show IL10RB Proteins))-K47E, on chronic hepatitis B virus (HBV) infection, were investigated.
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene.
interferon alpha/beta receptor 2
, interferon receptor 2
, IFN-alpha/beta receptor 2
, interferon receptor 2c
, interferon-alpha/beta receptor 2
, type I interferon alpha/beta receptor 2a
, type I interferon receptor 2
, IFN-alpha binding protein
, human interferon alpha/beta receptor
, interferon alpha binding protein
, interferon-alpha/beta receptor beta chain
, interferon, beta; receptor
, interferon alpha/beta receptor-2