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IFNAR2 Protein (Interferon alpha/beta Receptor 2) (AA 27-243) (His tag)

IFNAR2 Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
Catalog No. ABIN2181252
$318.46
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  • Target See all IFNAR2 Proteins
    IFNAR2 (Interferon alpha/beta Receptor 2 (IFNAR2))
    Protein Type
    Recombinant
    Protein Characteristics
    AA 27-243
    Origin
    • 9
    • 5
    • 1
    • 1
    Human
    Source
    • 5
    • 3
    • 3
    • 3
    • 1
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This IFNAR2 protein is labelled with His tag.
    Sequence
    AA 27-243
    Characteristics
    This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 25.6 kDa. The protein migrates as 40-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
    Purity
    >95 % as determined by SDS-PAGE.
    Sterility
    0.22 μm filtered
    Endotoxin Level
    Less than 1.0 EU per μg by the LAL method.
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4
    Handling Advice
    Please avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
  • Target
    IFNAR2 (Interferon alpha/beta Receptor 2 (IFNAR2))
    Alternative Name
    IFNAR2 (IFNAR2 Products)
    Synonyms
    AI747302, Ifnar-2, IFN-R, IFN-alpha-REC, IFNABR, IFNARB, IFN-R-2, IFNBR, interferon alpha and beta receptor subunit 2, interferon (alpha and beta) receptor 2, IFNAR2, Ifnar2
    Background
    Interferon alpha/beta receptor 2 (IFNAR2) is also known as IFN-alpha binding protein, IFN-alpha/beta receptor 2, Type I interferon receptor 2, IFNABR and IFNARB, which is a single-pass type I membrane protein and belongs to the type II cytokine receptor family. IFNAR2 can associate with IFNAR1 to form the type I interferon receptor. IFNAR2 is a receptor for interferons alpha and beta.IFNAR2 involves in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 of IFNAR2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 of IFNAR2 is a potent inhibitor of type I IFN receptor activity.Genetic variations in IFNAR2 influence susceptibility to hepatitis B virus (HBV) infection.
    Molecular Weight
    25.8 kDa
    NCBI Accession
    NP_997467
    Pathways
    JAK-STAT Signaling, Hepatitis C
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