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anti-Rat (Rattus) IL12RB1 Antibodies:
anti-Human IL12RB1 Antibodies:
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Mouse (Murine) Monoclonal IL12RB1 Primary Antibody for FACS - ABIN2689093
Chua, Wilkinson, Presky, Gubler: Cloning and characterization of a mouse IL-12 receptor-beta component. in Journal of immunology (Baltimore, Md. : 1950) 1995
Show all 8 Pubmed References
Human Monoclonal IL12RB1 Primary Antibody for FACS - ABIN4896781
Fieschi, Bosticardo, de Beaucoudrey, Boisson-Dupuis, Feinberg, Santos, Bustamante, Levy, Candotti, Casanova: A novel form of complete IL-12/IL-23 receptor beta1 deficiency with cell surface-expressed nonfunctional receptors. in Blood 2004
Show all 3 Pubmed References
Human Monoclonal IL12RB1 Primary Antibody for FACS - ABIN4896782
Hodge, Ziesmer, Yang, Secreto, Gertz, Novak, Ansell: IL-21 in the bone marrow microenvironment contributes to IgM secretion and proliferation of malignant cells in Waldenstrom macroglobulinemia. in Blood 2012
Show all 3 Pubmed References
Human Monoclonal IL12RB1 Primary Antibody for FM, FACS - ABIN2689092
Presky, Minetti, Gillessen, Wilkinson, Wu, Gubler, Chizzonite, Gately: Analysis of the multiple interactions between IL-12 and the high affinity IL-12 receptor complex. in Journal of immunology (Baltimore, Md. : 1950) 1998
Show all 2 Pubmed References
Human Monoclonal IL12RB1 Primary Antibody for FACS - ABIN2689091
Wu, Warrier, Carvajal, Chua, Minetti, Chizzonite, Mongini, Stern, Gubler, Presky, Gately: Biological function and distribution of human interleukin-12 receptor beta chain. in European journal of immunology 1996
Show all 2 Pubmed References
Human Monoclonal IL12RB1 Primary Antibody for CyTOF, FACS - ABIN4899834
Ebert, Mehta: Human intestinal intraepithelial lymphocytes keep TNF alpha levels low by cell uptake and feedback inhibition of transcription. in Cellular immunology 2006
Mouse (Murine) Polyclonal IL12RB1 Primary Antibody for IHC (fro), IF (p) - ABIN747863
Terayama, Yoshimoto, Hirai, Naito, Qu, Hatayama, Hayashi, Mitobe, Furusawa, Mizoguchi, Kezuka, Goto, Suyama, Moriyama, Sakabe, Itoh: Contribution of IL-12/IL-35 common subunit p35 to maintaining the testicular immune privilege. in PLoS ONE 2014
Four SNPs in IFNGR2 (show IFNGR2 Antibodies), IL12RB1, IL12RB2 (show IL12RB2 Antibodies), and IL23R (show IL23R Antibodies) were found to be associated with the MAP infection status of the resource population.
Polymorphisms of IFNG (show IFNG Antibodies), IL12B (show IL12B Antibodies) and IL12RB1 genes in paracoccidioidomycosis Brazilian patients do not affect the susceptibility or resistance to the disease.
The results of this case-control study suggest that IL-12A (show IL12A Antibodies), IL-12B (show IL12B Antibodies), IL12RB1, IL12RB2 (show IL12RB2 Antibodies) and IL23R (show IL23R Antibodies) make no genetic contribution to the susceptibility of Takayasu arteritis in Chinese populations
Truncated IL12rbeta1/Fc is a novel fusion protein for specific binding multiple forms of p40 subunit to exert potent anti-inflammatory effects.
the introduction of RNA-DNA differences into an individual's IL12RB1 mRNA repertoire is a novel determinant of IL12 (show IL12A Antibodies)/23 sensitivity.
we describe cosegregation of a heterozygous germline defect in IL12RB1 and gastric cancer development in a family with IL-12Rbeta1 deficiency
individual variability in IL12RB1 function is introduced at the epigenetic, genomic polymorphism, and mRNA splicing levels [review]
Early coupled up-regulation of IL12RB1 in CD8 (show CD8A Antibodies)+ central memory and effector T cells result in better clinical outcomes in liver transplant recipients.
Genetic variations of IL-12B (show IL12B Antibodies), IL-12Rbeta1, IL-12Rbeta2 in Behcet's disease and VKH syndrome.
The IL-23 (show IL23A Antibodies)/IL-23R (show IL23R Antibodies)/IL-12Rbeta1 complex formation does not follow the classical "site I-II-III" architectural paradigm.
SNP rs2305743 in IL12RB1 was associated with systemic sclerosis.
the data support a model wherein IL12Rbeta1DeltaTM is a secreted product of il12rb1 that promotes resistance to M. tuberculosis infection by potentiating T(H) cells response to IL-12 (show IL12A Antibodies).
Although they share a common subunit, IL-23 (show IL23A Antibodies) and IL-12 (show IL12A Antibodies) receptors are not expressed on the same cell populations.
IL12RB1 is essential for human resistance to Mycobacterium tuberculosis infection
IL-12p40 is induced rapidly in response to Francisella tularensis LVS and is required for DC migration through an IL-12Rbeta1-IL-12(p40 (show IL12B Antibodies))2 dependent mechanism.
IL-12Rbeta1DeltaTM represents a novel regulator of IL12Rbeta1-dependent dendritic cell function and of the immune response to Mycobacterium tuberculosis.
IL-12R beta 1 deficiency results in decreased viral replication and inflammation following coxsackievirus B3-induced myocarditis, decreasing IL-1 beta (show IL1B Antibodies) and IL-18 (show IL18 Antibodies) in the heart.
The binding domain in the IL-12 receptor beta 1 cytoplasmic region has been mapped to sphingosine kinase 2 (show SPHK2 Antibodies).
Expression of the IL-12 (show IL12A Antibodies) beta 1 receptor is upregulated in both microglia and splenic macrophages.
IL-12 receptor beta 1 subunit plays an essential role in the activation and differentiation of Th1-type myelin oligodendrocyte glycoprotein (MOG)-specific autoreactive T cells in vivo.
IL-12 receptor beta 1 (Rbeta1) mediates IL-12 p40 (show IL12B Antibodies) homodimer (p80 (show COIL Antibodies))-dependent macrophage chemotaxis and inhibition of the p80 (show COIL Antibodies)-Rbeta1 interaction, a novel anti-inflammatory strategy to manipulate inflammation associated with respiratory viral infection.
The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The lack of expression of this gene was found to result in the immunodeficiency of patients with severe mycobacterial and Salmonella infections. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
interleukin-12 receptor subunit beta-1
, interleukin 12 receptor, beta 1
, IL12 receptor beta 1 subunit
, interleukin-12 receptor subunit beta-1-like
, IL-12 receptor beta component
, IL-12 receptor subunit beta-1
, IL-12R subunit beta-1
, interleukin-12 receptor beta-1 chain
, Interleukin-12 receptor beta-1 chain precursor (IL-12R-beta1) (Interleukin-12 receptor beta) (IL-12 receptor beta component)