IL12RB1 antibody (AA 420-470)

Catalog No. ABIN747863

There is 1 publication for this product available. The Rabbit Polyclonal anti-IL12RB1 antibody is suitable to detect IL12RB1 in samples from Mouse. It has been validated for WB, IF (cc), IF (p), IHC (fro) and IHC (p).

Quick Overview for IL12RB1 antibody (AA 420-470) (ABIN747863)

Target: IL12RB1 (Interleukin 12 Receptor beta 1 (IL12RB1))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL12RB1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-IL12RB1 Antibody

Binding Specificity: AA 420-470

Purpose: IL12RB1 Polyclonal Antibody

Cross-Reactivity: Mouse

Predicted Reactivity: Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from mouse IL-12RB1

Isotype: IgG

Application Details

Application Notes: WB(1:300-5000),

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-IL12RB1 antibody (ABIN747863)

Terayama, Yoshimoto, Hirai, Naito, Qu, Hatayama, Hayashi, Mitobe, Furusawa, Mizoguchi, Kezuka, Goto, Suyama, Moriyama, Sakabe, Itoh: "Contribution of IL-12/IL-35 common subunit p35 to maintaining the testicular immune privilege." in: PLoS ONE, Vol. 9, Issue 4, pp. e96120, (2014) (PubMed).

Target Details for IL12RB1

Target: IL12RB1 (Interleukin 12 Receptor beta 1 (IL12RB1))

Alternative Name: Il-12rb1/Cd212

Background:

Synonyms: CD212, IL-12R[b], Interleukin-12 receptor subunit beta-1, IL-12 receptor subunit beta-1, IL-12R subunit beta-1, IL-12R-beta-1, IL-12 receptor beta component, Il12rb1, Il12rb

Background: Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.

Gene ID: 16161

UniProt: Q60837

Pathways: JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation