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Four SNPs in IFNGR2, IL12RB1, IL12RB2 (show IL12RB2 ELISA Kits), and IL23R (show IL23R ELISA Kits) were found to be associated with the MAP infection status of the resource population.
Truncated IL12rbeta1/Fc is a novel fusion protein for specific binding multiple forms of p40 subunit to exert potent anti-inflammatory effects.
the introduction of RNA-DNA differences into an individual's IL12RB1 mRNA repertoire is a novel determinant of IL12 (show IL12A ELISA Kits)/23 sensitivity.
we describe cosegregation of a heterozygous germline defect in IL12RB1 and gastric cancer development in a family with IL-12Rbeta1 deficiency
individual variability in IL12RB1 function is introduced at the epigenetic, genomic polymorphism, and mRNA splicing levels [review]
Early coupled up-regulation of IL12RB1 in CD8 (show CD8A ELISA Kits)+ central memory and effector T cells result in better clinical outcomes in liver transplant recipients.
Genetic variations of IL-12B (show IL12B ELISA Kits), IL-12Rbeta1, IL-12Rbeta2 in Behcet's disease and VKH syndrome.
The IL-23 (show IL23A ELISA Kits)/IL-23R (show IL23R ELISA Kits)/IL-12Rbeta1 complex formation does not follow the classical "site I-II-III" architectural paradigm.
SNP rs2305743 in IL12RB1 was associated with systemic sclerosis.
A review of the molecular genetics of all known IL12RB1 mutations and variants.
IL12Rbeta1 expression is lacking on CD8 (show CD8A ELISA Kits)+ T and natural killer (NK) cell surface in a 33-year-old patient with Mycobacterium tilburgii infection.
the data support a model wherein IL12Rbeta1DeltaTM is a secreted product of il12rb1 that promotes resistance to M. tuberculosis infection by potentiating T(H) cells response to IL-12 (show IL12A ELISA Kits).
Although they share a common subunit, IL-23 (show IL23A ELISA Kits) and IL-12 (show IL12A ELISA Kits) receptors are not expressed on the same cell populations.
IL12RB1 is essential for human resistance to Mycobacterium tuberculosis infection
IL-12p40 is induced rapidly in response to Francisella tularensis LVS and is required for DC migration through an IL-12Rbeta1-IL-12(p40 (show IL12B ELISA Kits))2 dependent mechanism.
IL-12Rbeta1DeltaTM represents a novel regulator of IL12Rbeta1-dependent dendritic cell function and of the immune response to Mycobacterium tuberculosis.
IL-12R beta 1 deficiency results in decreased viral replication and inflammation following coxsackievirus B3-induced myocarditis, decreasing IL-1 beta (show IL1B ELISA Kits) and IL-18 (show IL18 ELISA Kits) in the heart.
The binding domain in the IL-12 receptor beta 1 cytoplasmic region has been mapped to sphingosine kinase 2 (show SPHK2 ELISA Kits).
Expression of the IL-12 (show IL12A ELISA Kits) beta 1 receptor is upregulated in both microglia and splenic macrophages.
IL-12 receptor beta 1 subunit plays an essential role in the activation and differentiation of Th1 (show HAND1 ELISA Kits)-type myelin oligodendrocyte glycoprotein (MOG (show MOG ELISA Kits))-specific autoreactive T cells in vivo.
IL-12 receptor beta 1 (Rbeta1) mediates IL-12 p40 (show IL12B ELISA Kits) homodimer (p80 (show COIL ELISA Kits))-dependent macrophage chemotaxis and inhibition of the p80 (show COIL ELISA Kits)-Rbeta1 interaction, a novel anti-inflammatory strategy to manipulate inflammation associated with respiratory viral infection.
The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The lack of expression of this gene was found to result in the immunodeficiency of patients with severe mycobacterial and Salmonella infections. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
interleukin-12 receptor subunit beta-1
, interleukin 12 receptor, beta 1
, IL12 receptor beta 1 subunit
, interleukin-12 receptor subunit beta-1-like
, IL-12 receptor beta component
, IL-12 receptor subunit beta-1
, IL-12R subunit beta-1
, interleukin-12 receptor beta-1 chain
, Interleukin-12 receptor beta-1 chain precursor (IL-12R-beta1) (Interleukin-12 receptor beta) (IL-12 receptor beta component)