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Browse our IL12RB2 Proteins (IL12RB2)

Full name:
Interleukin 12 Receptor, beta 2 Proteins (IL12RB2)
On are 20 Interleukin 12 Receptor, beta 2 (IL12RB2) Proteins from 6 different suppliers available. Additionally we are shipping IL12RB2 Antibodies (87) and IL12RB2 Kits (9) and many more products for this protein. A total of 121 IL12RB2 products are currently listed.
A930027I18Rik, Ifnm, IL-12RB2, IL12RB2
list all proteins Gene Name GeneID UniProt
IL12RB2 16162 P97378
Rat IL12RB2 IL12RB2 171334  
IL12RB2 3595 Q99665

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IL12RB2 Proteins (IL12RB2) by Origin

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Top referenced IL12RB2 Proteins

  1. Mouse (Murine) IL12RB2 Protein expressed in Human Cells - ABIN2007318 : Rogge, Barberis-Maino, Biffi, Passini, Presky, Gubler, Sinigaglia: Selective expression of an interleukin-12 receptor component by human T helper 1 cells. in The Journal of experimental medicine 1997 (PubMed)
    Show all 3 references for ABIN2007318

More Proteins for IL12RB2 Interaction Partners

Mouse (Murine) Interleukin 12 Receptor, beta 2 (IL12RB2) interaction partners

  1. These results provide a new pathway of Th1 (show HAND1 Proteins) response regulation where IL-12 (show IL12A Proteins) secreted by dendritic cellss is consumed by a sub-population of IL-12Rbeta2-expressing Treg cells.

  2. in neonatal mice, IL-12 (show IL12A Proteins) uses IL-12Rbeta2 to counter IL-13Ralpha1 expression in addition to promoting Th1 (show HAND1 Proteins) differentiation

  3. Data indicate that delayed induction of the IL-12Rbeta2 receptor component after STAT1 (show STAT1 Proteins) activation helped ensure that Treg cells do not readily complete STAT4 (show STAT4 Proteins)-dependent Th1 (show HAND1 Proteins) cell development and lose their ability to suppress effector T cell proliferation.

  4. Signaling through the IL-35 receptor required the transcription factors STAT1 (show STAT1 Proteins) and STAT4 (show STAT4 Proteins).

  5. Data show that T(H)1 differentiation was impaired in Il2 (show IL2 Proteins)(-/-) T cells but was restored by IL-12Rbeta2 expression.

  6. gamma rays cause a decrease in IFN-gamma (show IFNG Proteins), IL-12p70, IL-12 (show IL12A Proteins) receptor beta2, and STAT4 (show STAT4 Proteins) and an increase in IL-4 (show IL4 Proteins) in natural killer cells

  7. Freshly isolated ex vivo T helper (Th)17 cells display restricted expression from Il12rb2 due to the presence of repressive chromatin remodeling.

  8. T-bet mediates STAT1 (show STAT1 Proteins)-dependent processes of T(H)1 development, including the induction of IL-12Rbeta2.

  9. NO activates soluble guanylyl cyclase, leading to the up-regulation of cGMP, which selectively induces the expression of IL-12 (show IL12A Proteins) receptor beta2.

  10. Contrary to the expectation that the absence of IL-12RB2 would protect from experimental autoimmune encephalitis, IL-12RB2-deficient mice develop earlier and more severe disease, with extensive demyelination and central nervous system inflammation.

Human Interleukin 12 Receptor, beta 2 (IL12RB2) interaction partners

  1. IL12RB2 polymorphisms correlate with risk of lung adenocarcinoma.

  2. The effects of rs3762315 and rs3762316 single nucleotide polymorphisms in 5' flanking region on IL12RB2 transcription

  3. Estrogen receptor beta 2 (show ESR2 Proteins) regulates IL12RB2 expression via p38 MAPK (show MAPK14 Proteins) signaling and inhibits non-small-cell lung cancer proliferation and invasion.

  4. IL12RB2 polymorphism is associated with systemic lupus erythematosus in the Chinese population.

  5. Genetic variations of IL-12B (show IL12B Proteins), IL-12Rbeta1, IL-12Rbeta2 in Behcet's disease and VKH syndrome.

  6. results suggest the rs924080 risk A allele does not affect baseline expression of IL-12RB2, IL-23R (show IL23R Proteins), IFN-gamma (show IFNG Proteins) and TNF-alpha (show TNF Proteins) but enhances IL-23R (show IL23R Proteins) and TNF-alpha (show TNF Proteins) expression capacity in response to LPS (show IRF6 Proteins) stimulation; the A allele appears to enhance baseline IL-6 (show IL6 Proteins) production

  7. a differential regulation pattern for genes solely expressed in Th17 cells (IL17A (show IL17A Proteins) and CCL20 (show CCL20 Proteins)) compared to genes expressed in both Th17 and Th1 (show TH1L Proteins) cells (IL23R (show IL23R Proteins) and IL12RB2), where high levels of promoter methylation are correlated to near zero

  8. Polymorphisms present in the promoter region of IL12RB2 may not be associated with susceptibility to leprosy or its clinical forms.

  9. Data indicate that four of the IL-12Rbeta2 variants, N271Y, R313G, A604V and L808R showed reduced IL-12 (show IL12A Proteins) responses compared to the wild type variant.

  10. Association of IL12RB2 rs6679356 polymorphism with the age of type 1 diabetes mellitus onset suggests that this gene plays a role in defining the time of disease onset.

Cow (Bovine) Interleukin 12 Receptor, beta 2 (IL12RB2) interaction partners

  1. Four SNPs in IFNGR2 (show IFNGR2 Proteins), IL12RB1 (show IL12RB1 Proteins), IL12RB2, and IL23R (show IL23R Proteins) were found to be associated with the MAP infection status of the resource population.

IL12RB2 Protein Profile

Protein Summary

The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene.

Alternative names and synonyms associated with IL12RB2

  • interleukin 12 receptor, beta 2 (IL12RB2)
  • interleukin 12 receptor, beta 2 (Il12rb2)
  • A930027I18Rik protein
  • Ifnm protein
  • IL-12RB2 protein
  • IL12RB2 protein

Protein level used designations for IL12RB2

interleukin 12 receptor, beta 2 , interleukin 12 receptor beta-2 , interleukin-12 receptor subunit beta-2 , interleukin-12 receptor subunit beta-2-like , IL-12 receptor subunit beta-2 , IL-12R subunit beta-2 , IL-12R-beta-2 , interferon response to microorganisms , interleukin-12 receptor beta-2 chain , IL-12RB2 , interleukin-12 receptor beta 2 , IL-12 receptor beta-2

469348 Pan troglodytes
489550 Canis lupus familiaris
700677 Macaca mulatta
100393796 Callithrix jacchus
100456779 Pongo abelii
100582797 Nomascus leucogenys
16162 Mus musculus
171334 Rattus norvegicus
3595 Homo sapiens
424705 Gallus gallus
397178 Sus scrofa
282452 Bos taurus
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