Browse our IL12RB2 Proteins (IL12RB2)

Full name:
Interleukin 12 Receptor, beta 2 Proteins (IL12RB2)
On are 20 Interleukin 12 Receptor, beta 2 (IL12RB2) Proteins from 6 different suppliers available. Additionally we are shipping IL12RB2 Antibodies (87) and IL12RB2 Kits (9) and many more products for this protein. A total of 122 IL12RB2 products are currently listed.
A930027I18Rik, Ifnm, IL-12RB2, IL12RB2
list all proteins Gene Name GeneID UniProt
IL12RB2 16162 P97378
Rat IL12RB2 IL12RB2 171334  
IL12RB2 3595 Q99665

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IL12RB2 Proteins (IL12RB2) by Origin

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Top referenced IL12RB2 Proteins

  1. Mouse (Murine) IL12RB2 Protein expressed in Human Cells - ABIN2007318 : Rogge, Barberis-Maino, Biffi, Passini, Presky, Gubler, Sinigaglia: Selective expression of an interleukin-12 receptor component by human T helper 1 cells. in The Journal of experimental medicine 1997 (PubMed)
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More Proteins for IL12RB2 Interaction Partners

Mouse (Murine) Interleukin 12 Receptor, beta 2 (IL12RB2) interaction partners

  1. These results provide a new pathway of Th1 (show HAND1 Proteins) response regulation where IL-12 (show IL12A Proteins) secreted by dendritic cellss is consumed by a sub-population of IL-12Rbeta2-expressing Treg cells.

  2. in neonatal mice, IL-12 (show IL12A Proteins) uses IL-12Rbeta2 to counter IL-13Ralpha1 expression in addition to promoting Th1 (show HAND1 Proteins) differentiation

  3. Data indicate that delayed induction of the IL-12Rbeta2 receptor component after STAT1 (show STAT1 Proteins) activation helped ensure that Treg cells do not readily complete STAT4 (show STAT4 Proteins)-dependent Th1 (show HAND1 Proteins) cell development and lose their ability to suppress effector T cell proliferation.

  4. Signaling through the IL-35 receptor required the transcription factors STAT1 (show STAT1 Proteins) and STAT4 (show STAT4 Proteins).

  5. Data show that T(H)1 differentiation was impaired in Il2 (show IL2 Proteins)(-/-) T cells but was restored by IL-12Rbeta2 expression.

  6. gamma rays cause a decrease in IFN-gamma (show IFNG Proteins), IL-12p70, IL-12 (show IL12A Proteins) receptor beta2, and STAT4 (show STAT4 Proteins) and an increase in IL-4 (show IL4 Proteins) in natural killer cells

  7. Freshly isolated ex vivo T helper (Th)17 cells display restricted expression from Il12rb2 due to the presence of repressive chromatin remodeling.

  8. T-bet mediates STAT1 (show STAT1 Proteins)-dependent processes of T(H)1 development, including the induction of IL-12Rbeta2.

  9. NO activates soluble guanylyl cyclase, leading to the up-regulation of cGMP, which selectively induces the expression of IL-12 (show IL12A Proteins) receptor beta2.

  10. Contrary to the expectation that the absence of IL-12RB2 would protect from experimental autoimmune encephalitis, IL-12RB2-deficient mice develop earlier and more severe disease, with extensive demyelination and central nervous system inflammation.

Human Interleukin 12 Receptor, beta 2 (IL12RB2) interaction partners

  1. this study identified susceptibility single nucleotide polymorphisms in IL12RB2 with Behcet's disease in Han Chinese

  2. In ankylosing spondylitis, conditional analysis identified rs11209032 as the probable causal single-nucleotide polymorphism within a 1.14 kb putative enhancer between IL23R (show IL23R Proteins) and IL12RB2. The rs11209032 single-nucleotide polymorphism downstream of IL23R (show IL23R Proteins) forms part of an enhancer, allelic variation of which may influence Th1 (show TH1L Proteins)-cell numbers.

  3. The results of this case-control study suggest that IL-12A (show IL12A Proteins), IL-12B (show IL12B Proteins), IL12RB1 (show IL12RB1 Proteins), IL12RB2 and IL23R (show IL23R Proteins) make no genetic contribution to the susceptibility of Takayasu arteritis in Chinese populations

  4. study confirmed the relationship of IL12RB2 polymorphisms with primary biliary cholangitis (PBC (show DLAT Proteins)) susceptibility; provided evidence that IL12RB2 polymorphisms are associated with liver cirrhosis and an increased concentration of disease-specific anti-mitochondrial antibodies in sera of PBC (show DLAT Proteins) patients

  5. this study shows that single nucleotide polymorphisms of the IL23R-IL12RB2 region are associated with Behcet's disease in a Northern Chinese Han population

  6. IL12RB2 polymorphisms correlate with risk of lung adenocarcinoma.

  7. The effects of rs3762315 and rs3762316 single nucleotide polymorphisms in 5' flanking region on IL12RB2 transcription

  8. Estrogen receptor beta 2 (show ESR2 Proteins) regulates IL12RB2 expression via p38 MAPK (show MAPK14 Proteins) signaling and inhibits non-small-cell lung cancer proliferation and invasion.

  9. IL12RB2 polymorphism is associated with systemic lupus erythematosus in the Chinese population.

  10. Genetic variations of IL-12B (show IL12B Proteins), IL-12Rbeta1, IL-12Rbeta2 in Behcet's disease and VKH syndrome.

Cow (Bovine) Interleukin 12 Receptor, beta 2 (IL12RB2) interaction partners

  1. Four SNPs in IFNGR2 (show IFNGR2 Proteins), IL12RB1 (show IL12RB1 Proteins), IL12RB2, and IL23R (show IL23R Proteins) were found to be associated with the MAP infection status of the resource population.

IL12RB2 Protein Profile

Protein Summary

The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene.

Alternative names and synonyms associated with IL12RB2

  • interleukin 12 receptor, beta 2 (IL12RB2)
  • interleukin 12 receptor, beta 2 (Il12rb2)
  • A930027I18Rik protein
  • Ifnm protein
  • IL-12RB2 protein
  • IL12RB2 protein

Protein level used designations for IL12RB2

interleukin 12 receptor, beta 2 , interleukin 12 receptor beta-2 , interleukin-12 receptor subunit beta-2 , interleukin-12 receptor subunit beta-2-like , IL-12 receptor subunit beta-2 , IL-12R subunit beta-2 , IL-12R-beta-2 , interferon response to microorganisms , interleukin-12 receptor beta-2 chain , IL-12RB2 , interleukin-12 receptor beta 2 , IL-12 receptor beta-2

469348 Pan troglodytes
489550 Canis lupus familiaris
700677 Macaca mulatta
100393796 Callithrix jacchus
100456779 Pongo abelii
100582797 Nomascus leucogenys
16162 Mus musculus
171334 Rattus norvegicus
3595 Homo sapiens
424705 Gallus gallus
397178 Sus scrofa
282452 Bos taurus
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