IL12B Proteins
(Interleukin 12 beta (IL12B))
This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008].
| Catalog no. | Product | Reactivity | Host / Clonality | Application | Price & lead time |
|---|---|---|---|---|---|
| IL12B Protein (AA 23-328) (His tag) | Cynomolgus | HEK-293 Cells |
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$522.92
View price
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| IL12B Protein (AA 23-328) (His tag) | Human | HEK-293 Cells |
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$728.58
View price
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| IL12B Protein (AA 23-328) (His tag) | Human | Baculovirus infected Insect Cells |
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$676.92
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| IL12B Protein (AA 23-328, full length) (His tag) | Human | Mammalian Cells |
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$404.89
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| IL12B Protein (AA 229-328) (GST tag) | Human | Wheat germ |
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$475.39
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| IL12B Protein (AA 23-335) (His tag) | Mouse | HEK-293 Cells |
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$307.73
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| IL12B Protein (AA 23-335) (His tag) | Mouse | Mammalian Cells |
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$535.66
View price
|
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| IL12B Protein (AA 23-328) (His tag) | Human | Mammalian Cells |
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$535.66
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| IL12B Protein (AA 23-328) (His tag) | Human | Escherichia coli (E. coli) |
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$478.03
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|
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| IL12B Protein (AA 23-328) (His tag) | Human | HEK-293 Cells |
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$220.55
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| IL12B Protein (His tag) | Mouse | HEK-293 Cells |
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$489.50
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| IL12B Protein (His tag) | Human | HEK-293 Cells |
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$2,293.50
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|
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| IL12B Protein | Mouse | HEK-293 Cells |
|
$533.50
View price
|
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| IL12B Protein (His tag) | Mouse | Escherichia coli (E. coli) |
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$297.95
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| IL12B Protein | Human | Hi-5 Cells |
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$1,067.25
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| IL12B Protein (AA 23-335) (His tag) | Mouse | Mammalian Cells |
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$520.18
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| IL12B Protein (AA 23-328) | Human | Mammalian Cells |
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$520.18
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| IL12B Protein (AA 23-329) (His tag) | Dog | Escherichia coli (E. coli) |
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$833.93
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| IL12B Protein (AA 23-327) (His tag) | Cow | Escherichia coli (E. coli) |
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$862.97
View price
|
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| IL12B Protein (AA 30-320) (His tag) | Human | Escherichia coli (E. coli) |
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$879.00
View price
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Protein
- SDS (SDS-PAGE: Validation image available)
- ELISA (ELISA: Validation image available)
- SEC-HPLC (Size-exclusion chromatography-High Pressure Liquid Chromatography: Validation image available)
- Origin
- Cynomolgus
- Host
- HEK-293 Cells
- Protein Type
- Recombinant
- Purity
- > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC
- Biological Activity
- Active
Catalog No. ABIN7275395
$522.92
Plus shipping costs $50.00
100 μg
(More quantities available)
Shipping to:
United States
Delivery in 11 to 14 Business Days
Protein
- SDS (SDS-PAGE: Validation image available)
- AM (Affinity Measurement: Listed application)
- ADA (Antibody Drug Assay: Listed application)
- IA (Immunoassay: Listed application)
- ScA (Screening Assay: Listed application)
- Origin
- Human
- Host
- HEK-293 Cells
- Protein Type
- Recombinant
- Purity
- The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
Catalog No. ABIN7491195
$728.58
Plus shipping costs $50.00
100 μg
(More quantities available)
Shipping to:
United States
Delivery in 12 to 15 Business Days
Protein
- SDS (SDS-PAGE: Listed application)
- Origin
- Human
- Host
- Baculovirus infected Insect Cells
- Protein Type
- Recombinant
- Purity
- > 90 %
Catalog No. ABIN1098598
$676.92
Plus shipping costs $50.00, if applicable $20.00 dry ice
50 μg
(More quantities available)
Shipping to:
United States
Delivery in 15 to 21 Business Days
Protein
- SDS (SDS-PAGE: Validation image available)
- Origin
- Human
- Host
- Mammalian Cells
- Protein Type
- Recombinant
- Purity
- Greater than 95 % as determined by SDS-PAGE.
Catalog No. ABIN8118615
$404.89
Plus shipping costs $50.00
100 μg
(More quantities available)
Shipping to:
United States
Delivery in 23 to 40 Business Days
Protein
- AP (Affinity Purification: Listed application)
- AA (Antibody Array: Listed application)
- ELISA (ELISA: Listed application)
- WB (Western Blotting: Listed application)
- Origin
- Human
- Host
- Wheat germ
- Protein Type
- Recombinant
Catalog No. ABIN1307678
$475.39
Plus shipping costs $50.00, if applicable $20.00 dry ice
10 μg
(More quantities available)
Shipping to:
United States
Delivery in 11 to 14 Business Days
Protein
- WB (Western Blotting: Validation image available)
- Origin
- Mouse
- Host
- HEK-293 Cells
- Protein Type
- Recombinant
- Purity
- > 95 % as determined by reducing SDS-PAGE.
Catalog No. ABIN7320572
$307.73
Plus shipping costs $50.00
50 μg
(More quantities available)
Shipping to:
United States
Delivery in 11 to 15 Business Days
Protein
- WB (Western Blotting: Listed application)
- SDS (SDS-PAGE: Listed application)
- Imm (Immunogen: Listed application)
- ELISA (ELISA: Listed application)
- AcA (Activity Assay: Listed application)
- Origin
- Mouse
- Host
- Mammalian Cells
- Protein Type
- Recombinant
- Purity
- >90 % as determined by SDS-PAGE.
- Biological Activity
- Active
Catalog No. ABIN7678517
$535.66
Plus shipping costs $50.00
100 μg
(More quantities available)
Shipping to:
United States
Delivery in 12 to 15 Business Days
Protein
- WB (Western Blotting: Listed application)
- SDS (SDS-PAGE: Listed application)
- Imm (Immunogen: Listed application)
- ELISA (ELISA: Listed application)
- AcA (Activity Assay: Listed application)
- Origin
- Human
- Host
- Mammalian Cells
- Protein Type
- Recombinant
- Purity
- >90 % as determined by SDS-PAGE.
- Biological Activity
- Active
Catalog No. ABIN7678476
$535.66
Plus shipping costs $50.00
100 μg
(More quantities available)
Shipping to:
United States
Delivery in 12 to 15 Business Days
Protein
- WB (Western Blotting: Listed application)
- PC (Positive Control: Listed application)
- Origin
- Human
- Host
- Escherichia coli (E. coli)
- Protein Type
- Recombinant
- Purity
- > 95 %
Catalog No. ABIN1000983
$478.03
Plus shipping costs $50.00
10 μg
Shipping to:
United States
Delivery in 2 to 4 Business Days
Protein
- Origin
- Human
- Host
- HEK-293 Cells
- Protein Type
- Recombinant
Catalog No. ABIN7889195
$220.55
Plus shipping costs $50.00
10 μg
Shipping to:
United States
Delivery in 4 to 5 Business Days
Protein
- Origin
- Mouse
- Host
- HEK-293 Cells
- Protein Type
- Recombinant
- Purity
- > 97 % by SDS-PAGE.
- Biological Activity
- Active
Catalog No. ABIN7536163
$489.50
Plus shipping costs $50.00
100 μg
(More quantities available)
Shipping to:
United States
Delivery in 7 to 10 Business Days
Protein
- Origin
- Human
- Host
- HEK-293 Cells
- Protein Type
- Recombinant
- Purity
- > 95 % by SDS-PAGE.
- Biological Activity
- Active
Catalog No. ABIN7535173
$2,293.50
Plus shipping costs $50.00
1 mg
(More quantities available)
Shipping to:
United States
Delivery in 7 to 10 Business Days
Protein
- Origin
- Mouse
- Host
- HEK-293 Cells
- Protein Type
- Recombinant
- Purity
- > 92 % by SDS-PAGE.
- Biological Activity
- Active
Catalog No. ABIN7536177
$533.50
Plus shipping costs $50.00
100 μg
(More quantities available)
Shipping to:
United States
Delivery in 7 to 10 Business Days
Protein
- WB (Western Blotting: Listed application)
- Origin
- Mouse
- Host
- Escherichia coli (E. coli)
- Protein Type
- Recombinant
- Purity
- >98 %
- Biological Activity
- Active
Catalog No. ABIN7884446
$297.95
Plus shipping costs $50.00
5 μg
Shipping to:
United States
Delivery in 10 to 15 Business Days
Protein
- SDS (SDS-PAGE: Listed application)
- Origin
- Human
- Host
- Hi-5 Cells
- Protein Type
- Recombinant
- Purity
- > 90 % pure
Catalog No. ABIN2129951
$1,067.25
Plus shipping costs $50.00
50 μg
Shipping to:
United States
Delivery in 9 to 12 Business Days
Protein
- WB (Western Blotting: Listed application)
- ELISA (ELISA: Listed application)
- Origin
- Mouse
- Host
- Mammalian Cells
- Protein Type
- Recombinant
- Purity
- Greater than 95 % as determined by SDS-PAGE.
Catalog No. ABIN7706678
$520.18
Plus shipping costs $50.00
50 μg
(More quantities available)
Shipping to:
United States
Delivery in 15 to 20 Business Days
Protein
- WB (Western Blotting: Listed application)
- ELISA (ELISA: Listed application)
- Origin
- Human
- Host
- Mammalian Cells
- Protein Type
- Recombinant
- Purity
- Greater than 90 % as determined by SDS-PAGE.
Catalog No. ABIN7706322
$520.18
Plus shipping costs $50.00
50 μg
(More quantities available)
Shipping to:
United States
Delivery in 15 to 20 Business Days
Protein
- WB (Western Blotting: Listed application)
- SDS (SDS-PAGE: Listed application)
- Imm (Immunogen: Listed application)
- PC (Positive Control: Listed application)
- Origin
- Dog
- Host
- Escherichia coli (E. coli)
- Protein Type
- Recombinant
- Purity
- > 97 %
Catalog No. ABIN7387481
$833.93
Plus shipping costs $50.00
100 μg
(More quantities available)
Shipping to:
United States
Delivery in 13 to 17 Business Days
Protein
- WB (Western Blotting: Listed application)
- SDS (SDS-PAGE: Listed application)
- Imm (Immunogen: Listed application)
- PC (Positive Control: Listed application)
- Origin
- Cow
- Host
- Escherichia coli (E. coli)
- Protein Type
- Recombinant
- Purity
- > 97 %
Catalog No. ABIN7387478
$862.97
Plus shipping costs $50.00
100 μg
(More quantities available)
Shipping to:
United States
Delivery in 13 to 17 Business Days
Protein
- WB (Western Blotting: Listed application)
- SDS (SDS-PAGE: Listed application)
- Imm (Immunogen: Listed application)
- PC (Positive Control: Listed application)
- Origin
- Human
- Host
- Escherichia coli (E. coli)
- Protein Type
- Recombinant
- Purity
- > 97 %
Catalog No. ABIN7387499
$879.00
Plus shipping costs $50.00
100 μg
(More quantities available)
Shipping to:
United States
Delivery in 13 to 17 Business Days
Latest Publications for our IL12B Proteins
: "Mycobacterium tuberculosis suppresses innate immunity by coopting the host ubiquitin system." in: Nature immunology, Vol. 16, Issue 3, pp. 237-45, (2015) (PubMed).
: "Complete primary structure, chromosomal localisation, and definition of polymorphisms of the gene encoding the human interleukin-12 p40 subunit." in: Genes and immunity, Vol. 1, Issue 8, pp. 515-20, (2001) (PubMed).
: "Detection of intracytoplasmic cytokine using flow cytometry and directly conjugated anti-cytokine antibodies." in: Journal of immunological methods, Vol. 188, Issue 1, pp. 117-28, (1996) (PubMed).
: "Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 154, Issue 1, pp. 116-27, (1995) (PubMed).
: "Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells." in: The Journal of experimental medicine, Vol. 178, Issue 3, pp. 1041-8, (1993) (PubMed).
: "Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells." in: The Journal of experimental medicine, Vol. 176, Issue 5, pp. 1387-98, (1992) (PubMed).
: "Cloning and expression of murine IL-12." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 148, Issue 11, pp. 3433-40, (1992) (PubMed).
: "Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 146, Issue 9, pp. 3074-81, (1991) (PubMed).
: "Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 88, Issue 10, pp. 4143-7, (1991) (PubMed).
: "Complete primary structure, chromosomal localisation, and definition of polymorphisms of the gene encoding the human interleukin-12 p40 subunit." in: Genes and immunity, Vol. 1, Issue 8, pp. 515-20, (2001) (PubMed).
: "Detection of intracytoplasmic cytokine using flow cytometry and directly conjugated anti-cytokine antibodies." in: Journal of immunological methods, Vol. 188, Issue 1, pp. 117-28, (1996) (PubMed).
: "Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 154, Issue 1, pp. 116-27, (1995) (PubMed).
: "Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells." in: The Journal of experimental medicine, Vol. 178, Issue 3, pp. 1041-8, (1993) (PubMed).
: "Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells." in: The Journal of experimental medicine, Vol. 176, Issue 5, pp. 1387-98, (1992) (PubMed).
: "Cloning and expression of murine IL-12." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 148, Issue 11, pp. 3433-40, (1992) (PubMed).
: "Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 146, Issue 9, pp. 3074-81, (1991) (PubMed).
: "Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 88, Issue 10, pp. 4143-7, (1991) (PubMed).
Aliases for IL12B Proteins
interleukin 12B (IL12B) Proteinsinterleukin 12b (Il12b) Proteins
interleukin 12B (Il12b) Proteins
interleukin 12Ba (il12ba) Proteins
CLMF Proteins
CLMF2 Proteins
CLMF p40 Proteins
IL-12 Proteins
IL-12 p40 Proteins
IL-12.p40 Proteins
IL-12B Proteins
Il-12b Proteins
Il-12p40 Proteins
IL-12p40 Proteins
Il12 Proteins
il12b Proteins
IL12B Proteins
Il12p40 Proteins
IL12p40 Proteins
il12p40.b Proteins
NKSF Proteins
NKSF2 Proteins
p40 Proteins
zgc:152789 Proteins
Did you look for something else?
- IL12A Proteins
- IL12 Proteins
- IL11RA Proteins
- IL10RB Proteins
- IL-9 Proteins
- IL-8 Proteins
- IL-7 Proteins
- IL-6 Receptor Proteins
- IL-6 Proteins
- IL-5 Proteins
- IL-4 Proteins
- IL-37 Proteins
- IL-34 Proteins
- IL-33 Proteins
- IL-32 alpha Proteins
- IL-31 Proteins
- IL-3 Proteins
- IL-27 Proteins
- IL-26 Proteins
- IL-25 Proteins
- IL12RB1 Proteins
- IL12RB2 Proteins
- IL13 Receptor alpha 1 Proteins
- IL13RA2 Proteins
- IL15RA Proteins
- IL16 Proteins
- IL17 Receptor B Proteins
- IL17B Proteins
- IL17C Proteins
- IL17D Proteins
- IL17F Proteins
- IL17RA Proteins
- IL17RC Proteins
- IL17RD Proteins
- IL17RE Proteins
- IL18BP Proteins
- IL18R1 Proteins
- IL18RAP Proteins
- IL1A Proteins
- IL1F10 Proteins
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