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anti-Mouse (Murine) IL15 Antibodies:
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Human Monoclonal IL15 Primary Antibody for Func, ICC - ABIN2665113
Armitage, Macduff, Eisenman, Paxton, Grabstein: IL-15 has stimulatory activity for the induction of B cell proliferation and differentiation. in Journal of immunology (Baltimore, Md. : 1950) 1995
Show all 9 references for ABIN2665113
Human Monoclonal IL15 Primary Antibody for FACS - ABIN2660775
Bouchard, Ratthé, Girard: Interleukin-15 delays human neutrophil apoptosis by intracellular events and not via extracellular factors: role of Mcl-1 and decreased activity of caspase-3 and caspase-8. in Journal of leukocyte biology 2004
Show all 9 references for ABIN2660775
Mouse (Murine) Monoclonal IL15 Primary Antibody for Func - ABIN1449229
Shih, Kurman: Molecular basis of gestational trophoblastic diseases. in Current molecular medicine 2002
Show all 4 references for ABIN1449229
Human Monoclonal IL15 Primary Antibody for Func - ABIN1107803
Bernard, Harb, Mortier, Quéméner, Meloen, Vermot-Desroches, Wijdeness, van Dijken, Grötzinger, Slootstra, Plet, Jacques: Identification of an interleukin-15alpha receptor-binding site on human interleukin-15. in The Journal of biological chemistry 2004
Show all 4 references for ABIN1107803
Mouse (Murine) Polyclonal IL15 Primary Antibody for EIA, WB - ABIN181593
Miyazaki, Ishikawa, Shimizu, Ubagai, Edelstein, Yamaguchi: Gr-1high polymorphonuclear leukocytes and NK cells act via IL-15 to clear intracellular Haemophilus influenzae in experimental murine peritonitis and pneumonia. in Journal of immunology (Baltimore, Md. : 1950) 2007
T cells in chimpanzees infected with human immunodeficiency virus express surface interleukin-15.
CD3 (show CD3 Antibodies)(-) CD8 (show CD8A Antibodies)(+) NK cells play a vital role in controlling HIV-1 infection by producing high levels of IFN-gamma (show IFNG Antibodies), and that IL-15 elicits IFN-gamma (show IFNG Antibodies) production in this subpopulation of NK cells in HIV-1-infected chimpanzees. [Il-15, CD8 (show CD8A Antibodies) antigen, IFN-gamma (show IFNG Antibodies)]
Muscle FNDC5 (show FNDC5 Antibodies) mRNA expression and irisin (show FNDC5 Antibodies) release are not IL-15-dependent in mice.
Virtual memory T cells develop and mediate bystander protective immunity in an IL-15-dependent manner.
Impaired delivery of IL-15 to CD4 (show CD4 Antibodies)+ T cells in the colon downmodulates Foxp3 (show FOXP3 Antibodies) expression and enhances RORgammat expression. CD4 (show CD4 Antibodies)+ T cells deprived of IL-15 trigger IBD characterized by production of pro-inflammatory cytokines and accumulation of Th1 (show HAND1 Antibodies)/Th17 cells.
Most (86%) IL15 in serum resides in the free state, with a minor proportion (14%) residing in complex with IL15Ralpha. Results suggest that IL15 is released as a free molecule by an unknown mechanism rather than via cleavage of membrane-bound IL15/IL15Ralpha.
IL-15 may influence mononuclear phagocytes subsets in the gut (show GUSB Antibodies) in a novel way that alters the frequency of lamina propria Th17 cells.
Downregulation of STAT3 (show STAT3 Antibodies) phosphorylation enhances tumoricidal effect of IL-15-activated dendritic cell against doxorubicin-resistant lymphoma and leukemia via TNF-alpha (show TNF Antibodies).
Exercise-stimulated interleukin-15 is controlled by AMPK (show PRKAA1 Antibodies) and regulates skin metabolism and aging.
IL-15 specifically down-regulates RARB (show RARB Antibodies) expression, and RARB (show RARB Antibodies) may play a protective role in lung injury caused by smoking or viral infections.
Hair follicle expression of IL-15 was required for CD8+ skin-resident memory T (TRM) cells to exert tropism for the epidermis.
High levels of IL-15 can promote tumor destruction and reduce metastasis in breast cancer via effects on NK1.1 positive cells.
results demonstrated the relative functional deficiencies of alpha-GalCer induced UCB iNKT cells, which can be ameliorated by IL-15
Protein, mRNA, and serum expression levels of MMP-7 (show MMP7 Antibodies) and IL-15 in patients with osteoarthritis were all significantly increased in osteoarthritis patients compared with the control group.
Common gamma-chain (show IL2RG Antibodies) cytokines IL-2 (show IL2 Antibodies), IL-7 (show IL7 Antibodies), and IL-15 prevent differentiation of naive T cells in vitro and limit activation of primed T cells in the absence of antigenic stimulus, which can contribute to the formation of cytokine imbalance.
Studeis indicate that expression of interleukin-15 (IL-15) in tissues promotes T helper 1 cell-mediated immunity.
These findings demonstrate a novel mechanism to attenuate IL-15-dependent NK cell proliferation and suggest that inhibitory NK cell receptors contribute to NK cell homeostasis.
IL15 was expressed primarily in the suprabulb of the hair follicle.
IL-15-derived dendritic cells elicited greater antigen-specific, primary and secondary CD8 (show CD8A Antibodies) and CD4 (show CD4 Antibodies) T-cell responses than did IL-4 (show IL4 Antibodies)-derived ones
Myokine IL-15 regulates the crosstalk of co-cultured porcine skeletal muscle satellite cells and preadipocytes.
results demonstrate that porcine reproductive and respiratory syndrome virus (PRRSV)infection could induce IL-15 production in macrophages/dendritic cells; data further show that upregulation of IL-15 by PRRSV requires PKC (show FYN Antibodies) and NF-kappaB (show NFKB1 Antibodies) pathways
IFN-gamma (show IFNG Antibodies) targets the adipocyte to induce IL-15 expression, thus indicating a possible role for the adipocyte in the regulation of T-cell function and muscle metabolism during the innate immune response
When induced by IFN-gamma (show IFNG Antibodies) or other inflammatory mediators, IL-15 may be a significant homeorhetic factor that mobilizes and directs energy away from the adipocyte to other cells during the acute phase of the inflammatory response.
Increased function and survival of IL-15-transduced dendritic cells are mediated by up-regulation of IL-15Ralpha and Bcl-2 (show BCL2 Antibodies).
IL 15 generates a dramatic expansion of short-lived memory CD8 (show CD8A Antibodies) T cells and natural killer in immunocompetent macaques and has long-term effects on the balance of CD4 (show CD4 Antibodies)(+) and CD8 (show CD8A Antibodies)(+) T cells.
These data suggest that therapeutic use of IL-15 in the setting of antiretroviral therapy might facilitate specific restoration of the CD4 (show CD4 Antibodies) + T cell compartment.
IL-15 secretion significantly correlates with the up-regulated expression of CD4 (show CD4 Antibodies) on memory CD4 (show CD4 Antibodies) T cells that is associated with increased permissiveness to simian immunodeficiency virus infection.
The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported.