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anti-Human IL21 Antibodies:
anti-Mouse (Murine) IL21 Antibodies:
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Human Polyclonal IL21 Primary Antibody for ICC, IF - ABIN315232
Liu, Xia, Wu, Wu, Tang, Chen, Xu, Cong, Xu, Liu: Anti-tumour necrosis factor therapy enhances mucosal healing through down-regulation of interleukin-21 expression and T helper type 17 cell infiltration in Crohn's disease. in Clinical and experimental immunology 2013
Show all 5 Pubmed References
Human Polyclonal IL21 Primary Antibody for ICC, ELISA - ABIN1002621
Asao, Okuyama, Kumaki, Ishii, Tsuchiya, Foster, Sugamura: Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex. in Journal of immunology (Baltimore, Md. : 1950) 2001
Show all 3 Pubmed References
Mouse (Murine) Monoclonal IL21 Primary Antibody for FACS - ABIN4896832
Carrier, Whitters, Miyashiro, LaBranche, Ramon, Benoit, Ryan, Keegan, Guay, Douhan, Collins, Dunussi-Joannopoulos, Medley: Enhanced GITR/GITRL interactions augment IL-27 expression and induce IL-10-producing Tr-1 like cells. in European journal of immunology 2012
Show all 2 Pubmed References
Mouse (Murine) Monoclonal IL21 Primary Antibody for FACS - ABIN4896831
Hondowicz, Batheja, Metzgar, Caton, Erikson: ICOS expression by effector T cells influences the ability of regulatory T cells to inhibit anti-chromatin B cell responses in recipient mice. in Journal of autoimmunity 2010
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Human Monoclonal IL21 Primary Antibody for ELISA - ABIN2689755
Leonard, Spolski: Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation. in Nature reviews. Immunology 2005
Show all 2 Pubmed References
Human Monoclonal IL21 Primary Antibody for ELISA - ABIN2689754
Sivakumar, Foster, Clegg: Interleukin-21 is a T-helper cytokine that regulates humoral immunity and cell-mediated anti-tumour responses. in Immunology 2004
Show all 2 Pubmed References
Human Monoclonal IL21 Primary Antibody for ICC, IF - ABIN4324913
Chen, Xiao, Lao, Wei, Liu, Zeng, Wang, Ouyang, Chen, Chan, Shi, Zheng, Kuang: Polarization of Tissue-Resident TFH-Like Cells in Human Hepatoma Bridges Innate Monocyte Inflammation and M2b Macrophage Polarization. in Cancer discovery 2016
Human Polyclonal IL21 Primary Antibody for IF (p), IHC (p) - ABIN748133
Guan, Wang, Meng, Shi, Jiang, Xiao, Shi, Xu, Zhang: Increased IL-21/IL-21R expression and its proinflammatory effects in autoimmune thyroid disease. in Cytokine 2015
Mouse (Murine) Monoclonal IL21 Primary Antibody for CyTOF, FACS - ABIN4899869
Pot, Jin, Awasthi, Liu, Lai, Madan, Sharpe, Karp, Miaw, Ho, Kuchroo: Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells. in Journal of immunology (Baltimore, Md. : 1950) 2009
Mouse (Murine) Monoclonal IL21 Primary Antibody for FACS - ABIN4896826
Lee, Rigby, Zotos, Tsai, Kawamoto, Marshall, Ramiscal, Chan, Gatto, Brink, Yu, Fagarasan, Tarlinton, Cunningham, Vinuesa: B cell priming for extrafollicular antibody responses requires Bcl-6 expression by T cells. in The Journal of experimental medicine 2011
Report efficient retroviral vector transduction of primary human natural killer cells that were stimulated by a combination of IL-2 (show IL2 Antibodies) and engineered K562 cells expressing membrane-bound IL-21 (show IL17C Antibodies) for cancer immunotherapy.
IL21 (show IL17C Antibodies) reduction in osteosarcoma patients due to PD-1 (show PDCD1 Antibodies) and pd-L1 (show CD274 Antibodies) mediated follicular helper T cells suppression.
this study shows that induction of IL-21 (show IL17C Antibodies) in T follicular helper cells is an indicator of influenza vaccine response in a HIV-infected pediatric cohort
IL-21 (show IL17C Antibodies) levels in rheumatoid arthritis synovial fluid were associated with matrix metalloproteinase (MMP)-1 (show MMP1 Antibodies) and MMP-3 (show MMP3 Antibodies).
the elevated level of IL-2 (show IL2 Antibodies)+ and IL-21 (show IL17C Antibodies)+ T cells and a positive correlation between IL-21 (show IL17C Antibodies)+ cells with clinical activity index in ulcerative colitis patients may contribute to the pathogenesis of disease.
these results demonstrate a novel function for IL-21 (show IL17C Antibodies) in tuning NK and CD4 (show CD4 Antibodies)+ T cell interactions promoting a specific expansion of central memory lymphocytes
Combined IL-21 (show IL17C Antibodies)-primed polyclonal CTL plus CTLA4 (show CTLA4 Antibodies) blockade controls refractory metastatic melanoma in a patient
Our work suggests that IL-21 (show IL17C Antibodies) regulates megakaryocyte development and platelet homeostasis. Thus, IL-21 (show IL17C Antibodies) may link immune responses to physiological or pathological platelet-dependent processes.
this study shows that Th17/Treg imbalance and increased IL-21 (show IL17C Antibodies) are associated with liver injury in patients with chronic HBV infection
The findings of the current study indicate an association between IL-21 (show IL17C Antibodies)+TFH cells and disease activity. IL-21 (show IL17C Antibodies)+TFH levels may prove to be a useful marker of disease activity in OA patients.
IL-6 (show IL6 Antibodies) is identified as a master regulator of IL-21 in effector CD8 (show CD8A Antibodies)(+) T cells.
Our work suggests that IL-21 regulates megakaryocyte development and platelet homeostasis. Thus, IL-21 may link immune responses to physiological or pathological platelet-dependent processes.
we identify novel distal regulatory elements in the mouse Il21 locus and demonstrate a dynamic long-range chromatin interaction between the Il21 promoter and these regulatory elements, which contributes to the regulated expression of IL-21
this study shows that IL-21 acts as a potent inhibitor of a IL-17A (show IL17A Antibodies)-producing T-cell subset during Mycobacterium bovis Bacillus infection
IL-21 may play an important role in the pathogenesis of SSc (show CYP11A1 Antibodies) as a Th17 effector cytokine, and IL-21 may induce the differentiation of Th17 cells in the BLM-induced systemic sclerosis mouse model via Il21R (show IL21R Antibodies).
The data of this study suggested that an increase in astrocyte-derived IL-21 expression in hippocampal subregions following KA-induced seizures may have potent regulatory effects on epileptogenesis.
this study reveals a context-dependent role for IL-21 in sustaining effector phenotype CD8 (show CD8A Antibodies) T cells and influencing their migratory properties, accumulation, and functions.
Dysregulated development of IL-17 (show IL17A Antibodies)- and IL-21-expressing follicular helper T cells and increased germinal center formation in the absence of RORgammat.
results demonstrate that, in the setting of lupus-like CD4 (show CD4 Antibodies) T cell-driven B cell hyperactivity, IL-21 signaling on Ag-specific donor CD8 (show CD8A Antibodies) T cells is critical for CTL effector maturation whereas a lack of IL-21R (show IL21R Antibodies) downregulates CTL responses that would otherwise limit B cell hyperactivity and autoantibody production
Gene expression analyses of angioimmunoblastic T-cell lymphoma (AITL), showed that essentially all cases expressed elevated levels of transcripts for IL21, IL21R (show IL21R Antibodies), and a series of genes associated with TFH cell development and function.
The results revealed that the peak expression of IL6 (show IL6 Antibodies) and 21 was on DPV 28 which correlated well with the FMDV antibody titer and plummeted to the prevaccination titer level by 60 DPV.
This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
, interleukin-21 isoform