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Mouse (Murine) IL21 ELISA Kit for Sandwich ELISA - ABIN1672800
Nurieva, Yang, Martinez, Zhang, Panopoulos, Ma, Schluns, Tian, Watowich, Jetten, Dong: Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. in Nature 2007
Show all 4 references for ABIN1672800
Human IL21 ELISA Kit for Sandwich ELISA - ABIN417214
Li, Rauniyar, Yin, Hu, Ouyang, Xiao, Yang: Serum IL-21 levels decrease with glucocorticoid treatment in myasthenia gravis. in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2014
Show all 2 references for ABIN417214
HCV infection increased the frequency of CD4 (show CD4 ELISA Kits)+CXCR5 (show CXCR5 ELISA Kits)+ T cells and decreased the frequency of CD27 (show CD27 ELISA Kits)+IgG+ B cells. CD4 (show CD4 ELISA Kits)+CXCR5 (show CXCR5 ELISA Kits)+ T cells activated CD27 (show CD27 ELISA Kits)+IgG+ B cells via the secretion of IL-21 (show IL17C ELISA Kits).
IL-21 (show IL17C ELISA Kits) exerts major effects on B-cell activation (show BLNK ELISA Kits) and differentiation or apoptosis during humoral immune responses, and also affects different subtypes of T cells. (Review)
The results suggest that IL-21 (show IL17C ELISA Kits) promotes migration and invasion of Rheumatoid arthritis-Fibroblast-like synoviocytes. Therefore, therapeutic strategies targeting IL-21 (show IL17C ELISA Kits) might be effective for the treatment of Rheumatoid arthritis.
IL-12 (show IL12A ELISA Kits) induced the generation of IL-21 (show IL17C ELISA Kits)- and IFN-gamma (show IFNG ELISA Kits)-co-expressing poly-functional CD4 (show CD4 ELISA Kits)+ T cells from human naive CD4 (show CD4 ELISA Kits)+ T cells.
IL-21 (show IL17C ELISA Kits) expression is promoted by MEKK4 (show MAP3K4 ELISA Kits) in malignant T cells and is associated with progression risk in cutaneous T-cell lymphoma
Human IL-21 (show IL17C ELISA Kits)+IFN-gamma (show IFNG ELISA Kits)+CD4 (show CD4 ELISA Kits)+ T cells in nasal polyps are regulated by IL-12 (show IL12A ELISA Kits).
CD3(+)TCRvbeta11(+) NKT cells from a local site of M. tuberculosis infection produce IL-21, express CXCR5 and CD40L, help B cells to secrete IgG and IgA, and may participate in local immune responses against M. tuberculosis infection.
IL-21 (show IL17C ELISA Kits) protein was higher in serum and mRNA and protein were higher in disc tissue of patients with lumbar disc herniation compared to controls.
both IL-21 (show IL17C ELISA Kits) rs907715 and rs2221903 polymorphisms may be associated with systemic lupus erythematosus susceptibility (meta-analysis)
all Ifng (show IFNG ELISA Kits)+ T cells produced IL-21 (show IL17C ELISA Kits), but only a small percentage of highly proliferative Ifng (show IFNG ELISA Kits)+ T cells maintained a T-bethi phenotype
this study reveals a context-dependent role for IL-21 in sustaining effector phenotype CD8 (show CD8A ELISA Kits) T cells and influencing their migratory properties, accumulation, and functions.
Dysregulated development of IL-17 (show IL17A ELISA Kits)- and IL-21-expressing follicular helper T cells and increased germinal center formation in the absence of RORgammat.
results demonstrate that, in the setting of lupus-like CD4 (show CD4 ELISA Kits) T cell-driven B cell hyperactivity, IL-21 signaling on Ag-specific donor CD8 (show CD8A ELISA Kits) T cells is critical for CTL effector maturation whereas a lack of IL-21R (show IL21R ELISA Kits) downregulates CTL responses that would otherwise limit B cell hyperactivity and autoantibody production
Gene expression analyses of angioimmunoblastic T-cell lymphoma (AITL), showed that essentially all cases expressed elevated levels of transcripts for IL21, IL21R (show IL21R ELISA Kits), and a series of genes associated with TFH cell development and function.
IL-21 from microbiota-specific Th17 and/or Tfh cells contributes to robust intestinal IgA levels by enhancing IgA(+) CSR, IgA production and B-cell trafficking into the intestine.
this report demonstrates a critical role for IL-21 in the generation of a primary effector CD8 (show CD8A ELISA Kits) T cell response to an infectious disease model.
IL-21 drives the activation and expansion of a novel population of IL-13 (show IL13 ELISA Kits)-producing Tc2 (show TCN2 ELISA Kits) cells, which serve as a critical link between inflammation and fibrosis.
these findings underscore the important collaboration between IL-4 (show IL4 ELISA Kits) and IL-21 in shaping T-dependent B cells antibody responses.
IL-21-mediated signaling supports generation and stabilization of pathogenic Th17 cells and development of spontaneous autoimmunity.
In vivo treatment with IL-21 results in complete mantle cell lymphoma regression in syngeneic mice via natural killer - and T-cell-dependent mechanisms.
The results revealed that the peak expression of IL6 (show IL6 ELISA Kits) and 21 was on DPV 28 which correlated well with the FMDV antibody titer and plummeted to the prevaccination titer level by 60 DPV.
This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
, interleukin-21 isoform