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Data show that the let-7c/miR (show MLXIP ELISA Kits)-99a/miR (show MLXIP ELISA Kits)-125b cluster controlled tumorigenesis by targeting IL-6 (show IL6 ELISA Kits), IL-6R and IGF1R (show IGF1R ELISA Kits).
Our results argued that increased expression of sIL6R from myeloid cells and subsequent c-Maf (show MAF ELISA Kits) induction were adverse events for counteracting tumor-specific Th1 (show TH1L ELISA Kits) generation. Overall, this work provides a mechanistic rationale for sIL6R targeting to improve the efficacy of T-cell-mediated cancer immunotherapy
These results demonstrate a novel physiologic role for a disintegrin and metalloprotease 17 (show ADAM17 ELISA Kits) in regulating murine IL-6 (show IL6 ELISA Kits) signals during inflammatory processes.
this study show that soluble IL-6R is infiltrating from the circulation in an ADAM17 (show ADAM17 ELISA Kits)-independent process and is involved in the controlled resolution of an acute inflammatory episode
the sIL (show PMEL ELISA Kits)-6R/p28 (show PSMD10 ELISA Kits) fusion protein (FP) upregulated IFN-lambda1 expression by increasing the binding abilities of c-Fos and activating transcription factor 1 (show AFT1 ELISA Kits) to the IFN-lambda1 promoter via the p38 MAPK (show MAPK14 ELISA Kits) signaling pathway; results demonstrate the important role of sIL (show PMEL ELISA Kits)-6R/p28 (show PSMD10 ELISA Kits) FP in mediating virus-induced type III IFN production
Thus, trans-signaling of IL-6 (show IL6 ELISA Kits) can only occur via sIL (show PMEL ELISA Kits)-6R, but not sCD5 (show SCD5 ELISA Kits).
The here presented data demonstrate that miR (show MLXIP ELISA Kits)-451 may function as a potential suppressor of tumor growth, migration and angiogenesis in osteosarcoma via down-regulating IL 6R.
DNA hypomethylation of IL-6 (show IL6 ELISA Kits) gene measured in blood leukocytes was associated with increased risk of ischemic heart disease.
minor allele, with the difference eliminated upon addition of tocilizumab. In conclusion, there is evidence that neutrophils may be an important source of sIL (show PMEL ELISA Kits)-6R in the lungs, and the Asp358Ala variant may have pro-inflammatory effects in lung cells.d However, we were unable to identify evidence for aisease
TNF (show TNF ELISA Kits)/IL-6 (show IL6 ELISA Kits) generated osteoclasts in vitro that resorbed mineralized tissue through a pathway dependent on IL-6R, NFATc1 (show NFATC1 ELISA Kits), DNAX-activation protein 12 (show TYROBP ELISA Kits), and cell proliferation
C2C12 myotubes possesses a mechanism for regulating IL-6R and gp130 (show LRPPRC PLURAL_@12091@) expression following lipoic acid treatment or heat shock.
Interleukin-6 receptor alpha (show IL6R ELISA Kits) may have a role in skin lesions in a murine model of systemic lupus erythematosus
findings identify TRAF3 (show TRAF3 ELISA Kits) and PTPN22 (show PTPN22 ELISA Kits) as inhibitors of IL-6R signaling in B cells and reveal a previously uncharacterized role for TRAF3 (show TRAF3 ELISA Kits) in the regulation of plasma cell differentiation
Data show that blockade of interleukin-6 receptor (show IL6R ELISA Kits) by an anti-IL-6R antibody can augment the anti-arthritic effect of glucocorticoids (GCs (show UGCG ELISA Kits)) and inhibit the bone loss they cause.
established that endogenous IL-6R of both human and murine origin is shed by ADAM17 (show ADAM17 ELISA Kits) in an induced manner, whereas constitutive release of endogenous IL-6R is largely mediated by ADAM10 (show ADAM10 ELISA Kits)
Increased expression of the Th17-IL-6R/pSTAT3/BATF/RorgammaT-axis in the tumoural region of adenocarcinoma as compared to squamous cell carcinoma of the lung
When endogenously released IL-6 (show IL6 ELISA Kits) binds to Il-6Ralpha (show IL6R ELISA Kits) in brain the effect is pyrogenic.
metastasizing cancer cells induced higher MDSCs infiltration and prompted them to secret exaggerated IL-6 (show IL6 ELISA Kits) as well as soluble IL-6Ra (show IL6R ELISA Kits), which, in turn, triggered a persistent increase of pSTAT3 in tumor cells.
Cellular senescence or EGFR (show EGFR ELISA Kits) signaling induces Interleukin 6 receptor (show IL6R ELISA Kits) expression controlled by mTOR (show FRAP1 ELISA Kits).
This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.
IL-6 receptor subunit alpha
, IL-6R 1
, IL-6R subunit alpha
, interleukin 6 receptor, alpha
, interleukin-6 receptor subunit alpha
, CD126 antigen
, membrane glycoprotein 80
, IL-6 receptor alpha chain