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No significant association between IL6R (show IL6R ELISA Kits) rs2228145 and dementia.
we evaluated anti-IL-6 (show IL6 ELISA Kits) receptor antibody treatment of cancer-related anemia in an IL-6 (show IL6 ELISA Kits)-producing human lung cancer xenograft model.We demonstrated that inhibition of the IL-6 (show IL6 ELISA Kits) signaling pathway by MR16-1 treatment resulted in significant recovery of iron-deficiency anemia and alleviation of cancer-related symptoms
Data suggest domains D1-D3, which contain cytokine binding module, determine which cytokine can activate interleukin-6 (show IL6 ELISA Kits) or interleukin-11 (show IL11 ELISA Kits) alpha-receptor subunits; stalk, transmembrane, or intracellular regions do not participate in ligand selectivity.
Anti-IL-6R antibody prevented the early loss of intrahepatic islet grafts mediated by HMGB1 (show HMGB1 ELISA Kits)-induced immune activation after islet transplantation.
While prior studies have found an association between PDE4D (show PDE4D ELISA Kits) and IL6R (show IL6R ELISA Kits) polymorphisms and ischemic stroke, the results of this study suggest that this association may be different in a hypertensive population.
Authors identified miR (show MLXIP ELISA Kits)-125a as a direct regulator of IL-6R, and the genotype of rs12976445 might be a novel predictor of the development of DN in DM.
This is the first study to investigate the effects of functional two polymorphisms on IL-6 (show IL6 ELISA Kits) and IL-6R genes in a pediatric patient group with AA risk.
results provide evidence that two IL6R gene polymorphisms rs2228145 C and rs12083537 G are associated with poor lung function in patients with asthma. Furthermore, the rs2228145 A-C variant is associated with levels of sIL-6R and IgE.
miR (show MLXIP ELISA Kits)-125a-5p directly targets IL-6R and STAT3 (show STAT3 ELISA Kits) expression in HEK (show EPHA3 ELISA Kits)-293T cells.
findings identify TRAF3 (show TRAF3 ELISA Kits) and PTPN22 (show PTPN22 ELISA Kits) as inhibitors of IL-6R signaling in B cells and reveal a previously uncharacterized role for TRAF3 (show TRAF3 ELISA Kits) in the regulation of plasma cell differentiation
Data show that blockade of interleukin-6 receptor (show IL6R ELISA Kits) by an anti-IL-6R antibody can augment the anti-arthritic effect of glucocorticoids (GCs (show UGCG ELISA Kits)) and inhibit the bone loss they cause.
established that endogenous IL-6R of both human and murine origin is shed by ADAM17 (show ADAM17 ELISA Kits) in an induced manner, whereas constitutive release of endogenous IL-6R is largely mediated by ADAM10 (show ADAM10 ELISA Kits)
Increased expression of the Th17-IL-6R/pSTAT3/BATF/RorgammaT-axis in the tumoural region of adenocarcinoma as compared to squamous cell carcinoma of the lung
When endogenously released IL-6 (show IL6 ELISA Kits) binds to Il-6Ralpha (show IL6R ELISA Kits) in brain the effect is pyrogenic.
metastasizing cancer cells induced higher MDSCs infiltration and prompted them to secret exaggerated IL-6 (show IL6 ELISA Kits) as well as soluble IL-6Ra (show IL6R ELISA Kits), which, in turn, triggered a persistent increase of pSTAT3 in tumor cells.
Cellular senescence or EGFR (show EGFR ELISA Kits) signaling induces Interleukin 6 receptor (show IL6R ELISA Kits) expression controlled by mTOR (show FRAP1 ELISA Kits).
IL-6Ralpha (show IL6R ELISA Kits) deficiency activates PP-1alpha and Mule expression, resulting in increased Mcl-1 (show MCL1 ELISA Kits) turnover and protection against HCC (show FAM126A ELISA Kits) development.
identify the transcription factor Twist1 (show TWIST1 ELISA Kits) as a component of a STAT3 (show STAT3 ELISA Kits)-induced feedback loop that controls IL-6 (show IL6 ELISA Kits) signals by directly repressing Il6ra (show IL6R ELISA Kits).
a dual role of the IL-6R stalk region in IL-6 (show IL6 ELISA Kits) signaling.
This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.
IL-6 receptor subunit alpha
, IL-6R 1
, IL-6R subunit alpha
, interleukin 6 receptor, alpha
, interleukin-6 receptor subunit alpha
, CD126 antigen
, membrane glycoprotein 80
, IL-6 receptor alpha chain