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Human IL9 Protein expressed in Escherichia coli (E. coli) - ABIN2667544
Jäger, Dardalhon, Sobel, Bettelli, Kuchroo: Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes. in Journal of immunology (Baltimore, Md. : 1950) 2009
Show all 7 references for ABIN2667544
Human IL9 Protein expressed in Insect Cells - ABIN2666759
Mock, Krall, Kozak, Nesbitt, McBride, Renauld, Van Snick: IL9 maps to mouse chromosome 13 and human chromosome 5. in Immunogenetics 1990
Show all 7 references for ABIN2666759
Mouse (Murine) IL9 Protein expressed in Insect Cells - ABIN2666534
Sismanopoulos, Delivanis, Alysandratos, Angelidou, Vasiadi, Therianou, Theoharides: IL-9 induces VEGF secretion from human mast cells and IL-9/IL-9 receptor genes are overexpressed in atopic dermatitis. in PLoS ONE 2012
Show all 6 references for ABIN2666534
Human IL9 Protein expressed in Baculovirus infected Insect Cells - ABIN2004832
Lejeune, Demoulin, Renauld et al.: Interleukin 9 induces expression of three cytokine signal inhibitors: cytokine-inducible SH2-containing protein, suppressor of cytokine signalling (SOCS)-2 and SOCS-3, but only SOCS-3 overexpression ... in The Biochemical journal 2001
Human IL9 Protein expressed in Escherichia coli (E. coli) - ABIN2681467
Kelleher, Bean, Clark, Leung, Yang-Feng, Chen, Lin, Luo, Yang: Human interleukin-9: genomic sequence, chromosomal location, and sequences essential for its expression in human T-cell leukemia virus (HTLV)-I-transformed human T cells. in Blood 1991
Group 2 innate lymphoid cells utilize the IRF4 (show IRF4 Proteins)-IL-9 module to coordinate epithelial cell maintenance of lung homeostasis.
Our results suggest that The Th9/IL-9 is involved in the pathogenesis of UC.
IL-9 exerted pro-atherosclerotic effects in ApoE (show APOE Proteins)-/- mice at least partially by inducing VCAM-1 (show VCAM1 Proteins) expression, which mediated inflammatory cell infiltration into atherosclerotic lesions.
IL-9 is dispensable for mucosal mast cell development but is necessary for their effective expansion to promote intestinal mastocytosis and susceptibility to experimental food allergy in an IL-9-dependent autocrine manner.
IL-9 production following chlamydial lung infection is redundant for host defense against the intracellular bacteria
IL-25 (show IL25 Proteins)-stimulated dendritic cells rapidly induced mediators, such as the chemokine (show CCL1 Proteins) CCL17 (show CCL17 Proteins), which, in turn, attracted IL-9-producing T cells
Data show that the expression of interleukin-9 (IL-9) was higher, but interleukin-10 (IL-10 (show IL10 Proteins)) was lower in asthma group, and that Th9 cells might play an important role in the pathogenesis of asthma.
TH9 cells are a major source of IL-9 in models of allergic inflammation and play an important role in mast cell accumulation and activation.
IRF4 (show IRF4 Proteins) binds to the promoters of IL1b (show IL1B Proteins) and IL9, suggesting that tick-derived sialostatin L suppresses mast cell-derived IL-9 preferentially by inhibiting IRF4 (show IRF4 Proteins).
these data identify TL1A (show TNFSF15 Proteins)-DR3 (show TNFRSF25 Proteins) interactions as a novel pathway that promotes Th9 differentiation and pathogenicity. TL1A (show TNFSF15 Proteins) may be a potential therapeutic target in diseases dependent on IL-9.
IL-9 serum leves are elevated in patients with systemic lupus erythematosus, rheumatoid arthritis and systemic sclerosis but their clinical significance is unknown. [review]
Th9 cell numbers and IL-9 levels are correlated with OA patient symptoms and joint functionality
IL-9 is functionally active, and is a pro-growth/survival factor for the localized pathologic T cells in the synovium of inflammatory arthritis.
Asthmatic children showed an increase in plasma Il9 levels post Mycoplasma pneumoniae infection.
Interleukin-9 Is Associated with Elevated Anti-Double-Stranded DNA Antibodies in Lupus-Prone Mice
Data demonstrated increased serum levels of IL-9 in systemic lupus erythematosus and rheumatoid arthritis patients but no association with clinical and laboratory parameters was found.
show the regulation of the IL-9-STIM1 (show STIM1 Proteins)-ERK (show EPHB2 Proteins)-IL-8 (show IL8 Proteins) axis in keratinocyte, and how the axis might play an important role in the pathophysiology of atopic dermatitis
association between IL-9 and diabetic kidney disease was complex as it was reduced in diabetes mellitus, but it was of normal levels in those with diabetic kidney disease
The results provide evidence that IL-9 is predominantly involved in the pathogenesis of ulcerative colitis suggesting that targeting IL-9 might become a therapeutic option for patients with UC.
Serum IL-9 is closely related to several clinical features, such as age, B symptoms and local lymph node involvement. It can also be an independent prognostic factor for extranodal NK/T-cell lymphoma, which suggests a role for IL-9 in disease pathogenesis
The protein encoded by this gene is a cytokine that acts as a regulator of a variety of hematopoietic cells. This cytokine stimulates cell proliferation and prevents apoptosis. It functions through the interleukin 9 receptor (IL9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes. The gene encoding this cytokine has been identified as a candidate gene for asthma. Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness.
, T-cell growth factor P40
, cytokine P40
, T-cell growth factor p40
, homolog of mouse T cell and mast cell growth factor 40
, p40 T-cell and mast cell growth factor
, p40 cytokine