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impact of IL-6 on the Th9/Th17 balance depending on the predominant cytokine milieu; data suggest that the IL-6-mediated reduction of Th2-related IL-4 leads to a decline of the Th9 immune response and allows Th17 differentiation
the results of this study indicate that environmental cues dictate the instability of the Th9 phenotype, and they suggest approaches to enhance Th9 activity in beneficial immune responses
The germinal center development of memory B cells is promoted by follicular helpter T cell-derived IL-9.
In mice, the absence of IL-9 impaired ILC2 proliferation and activation of regulatory T (Treg) cells, and resulted in chronic arthritis with excessive cartilage destruction and bone loss.
These data indicate that IL-9 is an essential regulator of megakaryopoiesis and a promising therapeutic agent for treatment of thrombocytopenia such as CIT (show CIT Proteins).
Findings indicate that interleukin-17 (IL-17 (show IL17A Proteins)) inhibits the formation of malignant pleural effusion (MPE) and improves the survival of MPE via an interleukin-9 (IL-9)-dependent mechanism.
Group 2 innate lymphoid cells utilize the IRF4 (show IRF4 Proteins)-IL-9 module to coordinate epithelial cell maintenance of lung homeostasis.
Our results suggest that The Th9/IL-9 is involved in the pathogenesis of UC.
IL-9 exerted pro-atherosclerotic effects in ApoE (show APOE Proteins)-/- mice at least partially by inducing VCAM-1 (show VCAM1 Proteins) expression, which mediated inflammatory cell infiltration into atherosclerotic lesions.
IL-9 is dispensable for mucosal mast cell development but is necessary for their effective expansion to promote intestinal mastocytosis and susceptibility to experimental food allergy in an IL-9-dependent autocrine manner.
TL1A (show TNFSF15 Proteins) differentially induces expression of TH17 effector cytokines IL-17 (show IL17A Proteins), -9, and -22 and provides a potential target for therapeutic intervention in TH17-driven chronic inflammatory diseases.
Expression of IL-9 remarkably increases in peripheral blood and liver tissues in patients with primary biliary cirrhosis
IL-9 promotes proliferation and metastasis in pancreatic cancer cells; this effect may partly involve regulation of the miR-200a/b-catenin axis.
in PsA patients gammadelta T cells activation is driven prevalently by IL-9/IL-9R interaction, and not only by IL-23/IL-23R. Together these findings indicate gammadelta T cells and IL-9 as new players in the pathogenesis of PsA.
Th9 cells produce IL9 that may participate in pathogenesis of Takayasu's arteritis
IL-9 serum leves are elevated in patients with systemic lupus erythematosus, rheumatoid arthritis and systemic sclerosis but their clinical significance is unknown. [review]
Th9 cell numbers and IL-9 levels are correlated with OA patient symptoms and joint functionality
IL-9 is functionally active, and is a pro-growth/survival factor for the localized pathologic T cells in the synovium of inflammatory arthritis.
Asthmatic children showed an increase in plasma Il9 levels post Mycoplasma pneumoniae infection.
The protein encoded by this gene is a cytokine that acts as a regulator of a variety of hematopoietic cells. This cytokine stimulates cell proliferation and prevents apoptosis. It functions through the interleukin 9 receptor (IL9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes. The gene encoding this cytokine has been identified as a candidate gene for asthma. Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness.
, T-cell growth factor P40
, cytokine P40
, T-cell growth factor p40
, homolog of mouse T cell and mast cell growth factor 40
, p40 T-cell and mast cell growth factor
, p40 cytokine