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Of two Jak2 paralogues present in zebrafish, Jak2a but not Jak2b is involved in the intracellular transmission of the Ifn-gamma (show IFNG Proteins) signal.
JAK2 is a direct BCL6 (show BCL6 Proteins) target gene; BCL6 (show BCL6 Proteins) bound to the JAK2 promoter
a concentration of tissue factor pathway inhibitor (show TFPI Proteins) was significantly lower in patients with essential thrombocythemia with JAK2 V617F mutation as compared with patients without the mutation
Upregulation of JAK2 is associated with chemotherapy response in pancreatic cancer.
Xinqin exerts the anti-allergic effect by modulating mast cell-mediated allergic responses by down-regulating JAK2/STAT5 (show STAT5A Proteins) signaling pathway.
Myeloproliferative neoplasms are strong risk factors for splanchnic vein thrombosis. European studies have identified the low prevalence of CALR (show CALR Proteins) somatic mutations in JAK2. The first outside of Europe study, in Australia, confirms that CALR (show CALR Proteins) mutations are rare in patients with splanchnic vein thrombosis.
CALR (show CALR Proteins)- and JAK2-mutated MPNs are broadly similar in terms of the quantity, frequency and spectrum of co-occurring mutations and therefore observed biological differences are likely to not be heavily influenced by the nature and quantity of co-mutated genes.
The family with JAK2 G571S mutations reported here teaches us that 1 germline JAK2 mutation may hide a somatic CALR (show CALR Proteins) mutation, and that, in this case, the phenotype (thrombocytosis) and disease (essential thrombocythemia [ET]) are likely due to the somatic CALR (show CALR Proteins) mutation. This highlights the complexity of making the diagnosis of ET (vs. HT) in a familial context.
Demonstration of ASXL1 (show ASXL1 Proteins) mutation, a putative tumor suppressor gene, represents an important molecular abnormality in CML (show BCR Proteins). Authors also showed that concomitant detection of BCR-ABL (show ABL1 Proteins) and JAK2V617F mutations has a relatively high incidence in Iranian patients.
This study demonstrated that several JAK2 SNPs confer susceptibility to PV and ET. Rs12342421 and rs10758677 were the SNPs most significantly associated with Polycythemia Vera (show IGF2BP3 Proteins) and Essential Thrombocythemia.
Differential expression of LGALS1 (show LGALS1 Proteins) and/or LGALS3 (show LGALS3 Proteins) in patients with myeloproliferative neoplasm (MPN (show PRSS27 Proteins)) is linked with JAK2 V617F status mutation in these diseases and state of cell differentiation.
At the molecular level, administration of liraglutide induced the expression of PDX-1 (show PDX1 Proteins), MafA (show MAFA Proteins), p-JAK2 and p-Stat3 (show STAT3 Proteins) in high-fat diet-induced diabetes model to relatively normal levels.
this study shows that resokaempferol inhibits the inflammatory response in activated macrophages by blocking the activation of the JAK2 pathway
Data show that protein tyrosine phosphatase 1B (PTP1B (show PTPN1 Proteins))-deficiency enhanced JAK2-STAT3 (show STAT3 Proteins) signaling in hypothalamic microglia and attenuated inflammation.
JAK1 (show JAK1 Proteins), JAK2, and JAK3 (show JAK3 Proteins) are involved in stimulation of functional activity of mesenchymal progenitor cells by fibroblast growth factor.
JAK (show JAK3 Proteins) mediated signaling is involved in the differentiation and proliferation of mesenchymal progenitor cells.
IL-3 (show IL-3 Proteins) signaling does not contribute to Jak2 V617F myeloproliferative neoplasm pathogenesis.
Fos-zippered GHR (show GHR Proteins) tails and Jak2, both purified from baculovirus-infected insect cells, interacted via box1 with a binding affinity of approximately 40nM.
Single agent BMS-911543 Jak2 inhibitor has distinct inhibitory effects on STAT5 (show STAT5A Proteins) signaling in genetically engineered mice with pancreatic ductal carcinomas.
JAK2 plays a critical role in brown adipose tissue function and adaptive thermogenesis
The critical role of Jak2 in mediating prolactin (show PRL Proteins)-induced luminal maturation of mammary epithelial cells.
nitration of JAK2 may act as an inhibitory counterpart to phosphorylation activation, reflecting a very localized break on the progression of GH signal transduction processes spanning JAK (show JAK3 Proteins)-STAT (show STAT1 Proteins)-AKT (show AKT1 Proteins) interactions
Janus kinase 2 (JAK2) gene polymorphism is a potential marker for milk production traits in cattle
Results indicate that SNPs in STAT5A (show STAT5A Proteins) and JAK2 genes were associated with somatic cell count and score in milk and cytokines but none of the SNP was associated with milk production traits suggesting an important role in immunity.
Methionine promoted casein synthesis, and this may be mediated by enhanced intracellular substrate availability and by activating JAK2-STAT5 (show STAT5A Proteins) and mTOR (show FRAP1 Proteins) signaling pathways.
SNPs in JAK2 and STAT5B (show STAT5B Proteins) are associated with mastitis susceptibility in Chinese Holstein cattle
Localized changes in the state of nitration of regulatory phosphorylation domains of JAK2 in caveoLAE during inflammation suggest a unique mechanism through which discrete signal transduction switching might occur in the liver
This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis.
, PTK JAK2b
, protein tyrosine kinase JAK2b
, tyrosine-protein kinase JAK2
, Janus kinase 2 (a protein tyrosine kinase)
, tyrosine kinase