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Of two Jak2 paralogues present in zebrafish, Jak2a but not Jak2b is involved in the intracellular transmission of the Ifn-gamma (show IFNG Proteins) signal.
Results suggest that lymphoproliferative and myeloproliferative neoplasms may coexist, although the pathogenetic mechanism of coexisting hematologic requires further investigation. Data indicate that JAK2 V617F and CALR (show CALR Proteins) mutations are not mutually exclusive and the actual frequency of simultaneous JAK2 V617F and CALR (show CALR Proteins) mutations is unknown.
analysis identified five patients (29 %) with the JAK2 p.V617F mutation
Huaier aqueous extract inhibited JAK2/STAT3 (show STAT3 Proteins) and MAPK (show MAPK1 Proteins) signaling pathways.
Fragment analysis is an accurate and sensitive method for the detection of CALR (show CALR Proteins) indels. The novel 9 bp deletion is likely a germline variant. Consequence of coexisting JAK2 V617F and CALR (show CALR Proteins) mutations requires careful interpretation.
High JAK2 expression is associated with chronic myeloid leukemia (show BCL11A Proteins).
identification of a higher frequency of co-existing JAK2 exon-12 or MPL (show MPL Proteins) exon-10 mutations in patients with myeloproliferative neoplasms with a low JAK2V617F allelic burden compared to those with a higher allelic burden.
JAK2 can serve as a valuable negative prognostic factor and a potential therapeutic target in nasopharyngeal carcinoma
The findings of this study indicate that the JAK2 V617F mutation is correlated with the incidence of thrombosis in patients with myeloproliferative neoplasms.
The Janus kinase 2 V617F mutation was detected in 78 patients.
Thrombocytosis and STAT5 (show STAT5A Proteins) activation in chronic myelogenous leukaemia are not consistently associated with CALR (show CALR Proteins) exon 9 or JAK2 V617F mutation.
JAK1 (show JAK1 Proteins), JAK2, and JAK3 (show JAK3 Proteins) are involved in stimulation of functional activity of mesenchymal progenitor cells by fibroblast growth factor.
JAK (show JAK3 Proteins) mediated signaling is involved in the differentiation and proliferation of mesenchymal progenitor cells.
IL-3 (show IL-3 Proteins) signaling does not contribute to Jak2 V617F myeloproliferative neoplasm pathogenesis.
Fos-zippered GHR (show GHR Proteins) tails and Jak2, both purified from baculovirus-infected insect cells, interacted via box1 with a binding affinity of approximately 40nM.
Single agent BMS-911543 Jak2 inhibitor has distinct inhibitory effects on STAT5 (show STAT5A Proteins) signaling in genetically engineered mice with pancreatic ductal carcinomas.
JAK2 plays a critical role in brown adipose tissue function and adaptive thermogenesis
The critical role of Jak2 in mediating prolactin (show PRL Proteins)-induced luminal maturation of mammary epithelial cells.
JAK1 (show JAK1 Proteins)/JAK2 inhibition of graft-versus-host disease was associated with the modulation of chemokine receptor (show CCR1 Proteins) expression, which may have been one factor in the reduced infiltration of donor T cells in graft-versus-host disease target organs.
Findings indicate that CD24(+) antigen (show CD24 Proteins) cells play a role in tumor migration and metastasis and support Janus kinase 2 protein (JAK2) as a therapeutic target in ovarian cancer.
JAK2(V617I) resulted in cytokine hyperresponsiveness without constitutive activation in the absence of ligand, whereas JAK2(V617F) resulted in constitutive activation
nitration of JAK2 may act as an inhibitory counterpart to phosphorylation activation, reflecting a very localized break on the progression of GH signal transduction processes spanning JAK (show JAK3 Proteins)-STAT (show STAT1 Proteins)-AKT (show AKT1 Proteins) interactions
Janus kinase 2 (JAK2) gene polymorphism is a potential marker for milk production traits in cattle
Results indicate that SNPs in STAT5A (show STAT5A Proteins) and JAK2 genes were associated with somatic cell count and score in milk and cytokines but none of the SNP was associated with milk production traits suggesting an important role in immunity.
Methionine promoted casein synthesis, and this may be mediated by enhanced intracellular substrate availability and by activating JAK2-STAT5 (show STAT5A Proteins) and mTOR (show FRAP1 Proteins) signaling pathways.
SNPs in JAK2 and STAT5B (show STAT5B Proteins) are associated with mastitis susceptibility in Chinese Holstein cattle
Localized changes in the state of nitration of regulatory phosphorylation domains of JAK2 in caveoLAE during inflammation suggest a unique mechanism through which discrete signal transduction switching might occur in the liver
This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis.
, PTK JAK2b
, protein tyrosine kinase JAK2b
, tyrosine-protein kinase JAK2
, Janus kinase 2 (a protein tyrosine kinase)
, tyrosine kinase