Browse our JAK2 Proteins (JAK2)

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Janus Kinase 2 Proteins (JAK2)
On are 25 Janus Kinase 2 (JAK2) Proteins from 9 different suppliers available. Additionally we are shipping JAK2 Antibodies (280) and JAK2 Kits (30) and many more products for this protein. A total of 349 JAK2 products are currently listed.
AI504024, C81284, Fd17, JAK-2, jak2, JAK2bCA, JTK10, THCYT3
list all proteins Gene Name GeneID UniProt
JAK2 3717 O60674
JAK2 16452 Q62120
JAK2 24514 Q62689

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JAK2 Proteins (JAK2) by Origin

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More Proteins for JAK2 Interaction Partners

Zebrafish Janus Kinase 2 (JAK2) interaction partners

  1. Of two Jak2 paralogues present in zebrafish, Jak2a but not Jak2b is involved in the intracellular transmission of the Ifn-gamma (show IFNG Proteins) signal.

Human Janus Kinase 2 (JAK2) interaction partners

  1. C-CALR (show CALR Proteins) in response to Ca2 (show CA2 Proteins)+ undergoes conformational changes that trigger its function to export GR from the nucleus, resetting the stress response of normal erythroid cells. Impairment of this function in JAK2V617F-positive erythroid cells maintains EPO-R (show EPOR Proteins) signaling in proliferation mode, contributing to erythrocytosis in PV.

  2. BRM (show SMARCA2 Proteins) could activate JAK2/STAT3 (show STAT3 Proteins) pathway to promote pancreatic cancer growth and chemoresistance.

  3. Regulation of platelet-activating factor-mediated PTP1B activation by a Janus kinase 2/ calpain pathway has been reported.

  4. Multiple myeloma cells over express JAK1 (show JAK1 Proteins)/2 and suggest combined chemotherapy with ruxolitinib, bortezomib and lenalidomide to inhibit JAK (show JAK3 Proteins)/STAT (show STAT1 Proteins) pathway.

  5. Molecular interactions of EphA4 (show EPHA4 Proteins), growth hormone receptor (show GHR Proteins), Jak2, and STAT5B (show STAT5B Proteins) have been described.

  6. Peritoneal membrane dysfunction in long-term peritoneal dialysis patients may result from IL-6 (show IL6 Proteins) promotion of epithelial-to-mesenchymal transition of human peritoneal mesothelial cells possibly through the JAK2/STAT3 (show STAT3 Proteins) signaling pathway.

  7. Mutation inactivating JAK2 gene is associated with Breast Cancer Metastasis.

  8. mechanical load upregulates expression of Runx2 (show RUNX2 Proteins) gene via potentiation of PC1 (show PCSK1 Proteins)-JAK2/STAT3 (show STAT3 Proteins) signaling axis, culminating to possibly control osteoblastic differentiation and ultimately bone formation.

  9. blocking the ERRalpha (show ESRRA Proteins)-controlled mitochondrial program largely inhibits the PLA2R1 (show PLA2R1 Proteins)-induced tumor-suppressive response. Together, our data document ERRalpha (show ESRRA Proteins) and its mitochondrial program as downstream effectors of the PLA2R1 (show PLA2R1 Proteins)-JAK2 pathway leading to oncosuppression.

  10. JAK2 was overexpressed in Epstein Barr virus-associated gastric adenocarcinoma.

Mouse (Murine) Janus Kinase 2 (JAK2) interaction partners

  1. these findings demonstrate that expression of Hmga2 cooperates with Jak2(V617F) in the pathogenesis of Mmyelofibrosis.

  2. Study shows that Jak2 with V617F mutation induces murine model for myeloproliferative neoplasm.

  3. results suggest that loss of Ezh2 (show EZH2 Proteins) cooperates with Jak2V617F in the development of myelofibrosis in Jak2V617F

  4. JAK2-V617F-expressing mice treated with an Ezh2 (show EZH2 Proteins) inhibitor showed higher platelet counts than vehicle controls. Our data support the proposed tumor suppressor function of EZH2 (show EZH2 Proteins)

  5. findings demonstrate that clinically relevant doses of the JAK1 (show JAK1 Proteins)/2 inhibitor ruxolitinib suppresses the harmful consequences of macrophage overactivation characterizing Hemophagocytic lymphohistiocytosis in 2 murine models.

  6. JAK2 has a role in hepatocarcinogenesis through regulating critical inflammatory pathways

  7. Data show that CUZD1 (show CUZD1 Proteins) interacts with a complex containing JAK1 (show JAK1 Proteins)/JAK2 and STAT5 (show STAT5A Proteins), downstream transducers of prolactin (show PRL Proteins) signaling in the mammary gland.

  8. The results showed that AG490 inhibited (p)-JAK2 and RANKL (show TNFSF11 Proteins) expression.

  9. these results have revealed that phosphorylation of Tyr (show TYR Proteins)-343, Tyr (show TYR Proteins)-460, and Tyr (show TYR Proteins)-464 in EpoR (show EPOR Proteins) underlies JAK2 V617F mutant-induced tumorigenesis.

  10. this study shows that ampelopsin reduces inflammatory response of microglial cells through inhibition of JAK2-STAT3 (show STAT3 Proteins) signaling

Pig (Porcine) Janus Kinase 2 (JAK2) interaction partners

  1. nitration of JAK2 may act as an inhibitory counterpart to phosphorylation activation, reflecting a very localized break on the progression of GH signal transduction processes spanning JAK (show JAK3 Proteins)-STAT (show STAT1 Proteins)-AKT (show AKT1 Proteins) interactions

Cow (Bovine) Janus Kinase 2 (JAK2) interaction partners

  1. Janus kinase 2 (JAK2) gene polymorphism is a potential marker for milk production traits in cattle

  2. Results indicate that SNPs in STAT5A (show STAT5A Proteins) and JAK2 genes were associated with somatic cell count and score in milk and cytokines but none of the SNP was associated with milk production traits suggesting an important role in immunity.

  3. Methionine promoted casein synthesis, and this may be mediated by enhanced intracellular substrate availability and by activating JAK2-STAT5 (show STAT5A Proteins) and mTOR (show FRAP1 Proteins) signaling pathways.

  4. SNPs in JAK2 and STAT5B (show STAT5B Proteins) are associated with mastitis susceptibility in Chinese Holstein cattle

  5. Localized changes in the state of nitration of regulatory phosphorylation domains of JAK2 in caveoLAE during inflammation suggest a unique mechanism through which discrete signal transduction switching might occur in the liver

JAK2 Protein Profile

Protein Summary

This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis.

Alternative names and synonyms associated with JAK2

  • Janus kinase 2b (jak2b)
  • Janus kinase 2 (JAK2)
  • Janus kinase 2 (Jak2)
  • tyrosine-protein kinase JAK2-like (LOC100051487)
  • AI504024 protein
  • C81284 protein
  • Fd17 protein
  • JAK-2 protein
  • jak2 protein
  • JAK2bCA protein
  • JTK10 protein
  • THCYT3 protein

Protein level used designations for Janus Kinase 2 Proteins (JAK2)

Jak2b kinase , PTK JAK2b , protein tyrosine kinase JAK2b , tyrosine-protein kinase JAK2 , JAK-2 , Janus kinase 2 (a protein tyrosine kinase) , tyrosine kinase

30298 Danio rerio
3717 Homo sapiens
16452 Mus musculus
24514 Rattus norvegicus
374199 Gallus gallus
484185 Canis lupus familiaris
397201 Sus scrofa
525246 Bos taurus
464979 Pan troglodytes
100172517 Pongo abelii
100051487 Equus caballus
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