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Browse our JAK2 Proteins (JAK2)

Full name:
Janus Kinase 2 Proteins (JAK2)
On are 18 Janus Kinase 2 (JAK2) Proteins from 8 different suppliers available. Additionally we are shipping JAK2 Antibodies (265) and JAK2 Kits (22) and many more products for this protein. A total of 318 JAK2 products are currently listed.
AI504024, C81284, Fd17, JAK-2, jak2, JAK2bCA, JTK10, THCYT3
list all proteins Gene Name GeneID UniProt
JAK2 3717 O60674
JAK2 16452 Q62120
JAK2 24514 Q62689

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JAK2 Proteins (JAK2) by Origin

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More Proteins for JAK2 Interaction Partners

Zebrafish Janus Kinase 2 (JAK2) interaction partners

  1. Of two Jak2 paralogues present in zebrafish, Jak2a but not Jak2b is involved in the intracellular transmission of the Ifn-gamma (show IFNG Proteins) signal.

Human Janus Kinase 2 (JAK2) interaction partners

  1. Studies indicate that a genetic classification of primary fibrosis (PMF (show PRB1 Proteins)) by calreticulin (CALR (show CALR Proteins)) and JAK2V617F (JAK2)mutations carried significant prognostic relevance.

  2. study investigated the presence of JAK2 (V617F) mutation in Egyptian patients with myeloproliferative disorders; results are concordant with international published results for detection of this mutation; JAK2 mutation may be also present in disorders other than MPDs (show DPM1 Proteins) such as; different hypercoagulable states

  3. A heterozygous intronic JAK2 variant was found in familial cases diagnosed with gastric lymphoma and Hodgkin lymphoma.

  4. Case Report: refractory arterial insufficiency associated with JAK2-positive essential thrombocythaemia.

  5. Correlation analysis between JAK2 V617F allele burden and other parameters in patients with Philadelphia negative myeloproliferative neoplasms revealed statistical significant correlation with age, HB, HCT, PLT, UA, LDH, and splenic diameter but insignificant correlation with WBCs and PAH.

  6. A positive correlation of JAK2 V617F mutation was established.

  7. JAK2V617F and CALR (show CALR Proteins) positive patients might have a different phenotype.

  8. Mutation status of JAK2, CALR (show CALR Proteins), and MPL (show MPL Proteins) in essential thrombocythemia and primary myelofibrosis defines clinical outcome.

  9. Data show that the expressions of p-JAK2 protein and p-STAT3 (show STAT3 Proteins) protein were down-regulated after treated with Interferon-beta (IFN-beta (show IFNB1 Proteins)) combined with all-trans retinoic acid (ATRA) on HepG2 cells, especially the combination of IFN-beta (show IFNB1 Proteins) and ATRA.

  10. JAK2 amplification is a potential biomarker for JAK2 dependence.

Mouse (Murine) Janus Kinase 2 (JAK2) interaction partners

  1. IL-3 (show Il3 Proteins) signaling does not contribute to Jak2 V617F myeloproliferative neoplasm pathogenesis.

  2. Fos-zippered GHR (show GHR Proteins) tails and Jak2, both purified from baculovirus-infected insect cells, interacted via box1 with a binding affinity of approximately 40nM.

  3. Single agent BMS-911543 Jak2 inhibitor has distinct inhibitory effects on STAT5 (show STAT5A Proteins) signaling in genetically engineered mice with pancreatic ductal carcinomas.

  4. JAK2 plays a critical role in brown adipose tissue function and adaptive thermogenesis

  5. The critical role of Jak2 in mediating prolactin (show PRL Proteins)-induced luminal maturation of mammary epithelial cells.

  6. JAK1 (show JAK1 Proteins)/JAK2 inhibition of graft-versus-host disease was associated with the modulation of chemokine receptor (show CCR1 Proteins) expression, which may have been one factor in the reduced infiltration of donor T cells in graft-versus-host disease target organs.

  7. Findings indicate that CD24(+) antigen (show CD24 Proteins) cells play a role in tumor migration and metastasis and support Janus kinase 2 protein (JAK2) as a therapeutic target in ovarian cancer.

  8. JAK2(V617I) resulted in cytokine hyperresponsiveness without constitutive activation in the absence of ligand, whereas JAK2(V617F) resulted in constitutive activation

  9. The pro-inflammatory cytokine, interferon-gamma (show IFNG Proteins) may contribute to diarrhea associated with intestinal inflammation in part through regulation of the epithelial aquaporin-1 (show AQP1 Proteins) water channel (show AQP4 Proteins) via a non-classical JAK (show JAK3 Proteins)/STAT (show STAT1 Proteins) receptor signalling pathway.

  10. JAK2 participates in the signalling, regulating the voltage-gated K(+) channel (show KCND3 Proteins) KCNA3 (show KCNA3 Proteins).

Pig (Porcine) Janus Kinase 2 (JAK2) interaction partners

  1. nitration of JAK2 may act as an inhibitory counterpart to phosphorylation activation, reflecting a very localized break on the progression of GH signal transduction processes spanning JAK (show JAK3 Proteins)-STAT (show STAT1 Proteins)-AKT (show AKT1 Proteins) interactions

Cow (Bovine) Janus Kinase 2 (JAK2) interaction partners

  1. Janus kinase 2 (JAK2) gene polymorphism is a potential marker for milk production traits in cattle

  2. Results indicate that SNPs in STAT5A (show STAT5A Proteins) and JAK2 genes were associated with somatic cell count and score in milk and cytokines but none of the SNP was associated with milk production traits suggesting an important role in immunity.

  3. Methionine promoted casein synthesis, and this may be mediated by enhanced intracellular substrate availability and by activating JAK2-STAT5 (show STAT5A Proteins) and mTOR (show FRAP1 Proteins) signaling pathways.

  4. SNPs in JAK2 and STAT5B (show STAT5B Proteins) are associated with mastitis susceptibility in Chinese Holstein cattle

  5. Localized changes in the state of nitration of regulatory phosphorylation domains of JAK2 in caveoLAE during inflammation suggest a unique mechanism through which discrete signal transduction switching might occur in the liver

JAK2 Protein Profile

Protein Summary

This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis.

Alternative names and synonyms associated with JAK2

  • Janus kinase 2b (jak2b)
  • Janus kinase 2 (JAK2)
  • Janus kinase 2 (Jak2)
  • tyrosine-protein kinase JAK2-like (LOC100051487)
  • AI504024 protein
  • C81284 protein
  • Fd17 protein
  • JAK-2 protein
  • jak2 protein
  • JAK2bCA protein
  • JTK10 protein
  • THCYT3 protein

Protein level used designations for Janus Kinase 2 Proteins (JAK2)

Jak2b kinase , PTK JAK2b , protein tyrosine kinase JAK2b , tyrosine-protein kinase JAK2 , JAK-2 , Janus kinase 2 (a protein tyrosine kinase) , tyrosine kinase

30298 Danio rerio
3717 Homo sapiens
16452 Mus musculus
24514 Rattus norvegicus
374199 Gallus gallus
484185 Canis lupus familiaris
397201 Sus scrofa
525246 Bos taurus
464979 Pan troglodytes
100172517 Pongo abelii
100051487 Equus caballus
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