Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all synonyms
Select your origin of interest
Of two Jak2 paralogues present in zebrafish, Jak2a but not Jak2b is involved in the intracellular transmission of the Ifn-gamma (show IFNG Proteins) signal.
Mutation status of JAK2, CALR (show CALR Proteins), and MPL (show MPL Proteins) in essential thrombocythemia and primary myelofibrosis defines clinical outcome.
Data show that the expressions of p-JAK2 protein and p-STAT3 (show STAT3 Proteins) protein were down-regulated after treated with Interferon-beta (IFN-beta (show IFNB1 Proteins)) combined with all-trans retinoic acid (ATRA) on HepG2 cells, especially the combination of IFN-beta (show IFNB1 Proteins) and ATRA.
JAK2 amplification is a potential biomarker for JAK2 dependence.
High JAK2 expression is associated with osteosarcoma.
smallest amplified 9p24.1 region was restricted to the JAK2-PDL1/2-RANBP6 interval. In the next step, we screened 200 cases of classical Hodgkin lymphoma by interphase FISH and identified PDL1/2 rearrangement (CIITA- and IGH-negative) in four cases (2%), what is a novel finding. Forty (25%) cases revealed high level amplification of 9p24.1
The results of this study underscore the importance of screening peripheral blood for the JAK2 p.V617F mutation in the initial evaluation of patients with suspected MPNs or during a workup for thrombophilia.
results reveal a mechanism whereby JAK2 inhibition overcomes acquired resistance to EGFR (show EGFR Proteins) inhibitors and support the use of combination therapy with JAK (show JAK3 Proteins) and EGFR (show EGFR Proteins) inhibitors for the treatment of EGFR (show EGFR Proteins)-dependent NSCLC.
Hyperactivated JAK2 is associated with Inflammatory and Invasive Ductal Breast Cancers.
Foot-and-mouth disease virus VP3 interacted with JAK1 (show JAK1 Proteins)/2, degraded JAK1 (show JAK1 Proteins), and inhibited the tyrosine phosphorylation, dimerization and nuclear accumulation of STAT1 (show STAT1 Proteins).
Anagrelide proved effective among all molecular subsets, indicating that JAK2/CALR (show CALR Proteins)/MPL (show MPL Proteins) mutational status does not seem to represent a major determinant of choice of cytoreductive treatment among essential thrombocythemia therapies.
IL-3 (show Il3 Proteins) signaling does not contribute to Jak2 V617F myeloproliferative neoplasm pathogenesis.
Fos-zippered GHR (show GHR Proteins) tails and Jak2, both purified from baculovirus-infected insect cells, interacted via box1 with a binding affinity of approximately 40nM.
Single agent BMS-911543 Jak2 inhibitor has distinct inhibitory effects on STAT5 (show STAT5A Proteins) signaling in genetically engineered mice with pancreatic ductal carcinomas.
JAK2 plays a critical role in brown adipose tissue function and adaptive thermogenesis
The critical role of Jak2 in mediating prolactin (show PRL Proteins)-induced luminal maturation of mammary epithelial cells.
JAK1 (show JAK1 Proteins)/JAK2 inhibition of graft-versus-host disease was associated with the modulation of chemokine receptor (show CCR1 Proteins) expression, which may have been one factor in the reduced infiltration of donor T cells in graft-versus-host disease target organs.
Findings indicate that CD24(+) antigen (show CD24 Proteins) cells play a role in tumor migration and metastasis and support Janus kinase 2 protein (JAK2) as a therapeutic target in ovarian cancer.
JAK2(V617I) resulted in cytokine hyperresponsiveness without constitutive activation in the absence of ligand, whereas JAK2(V617F) resulted in constitutive activation
The pro-inflammatory cytokine, interferon-gamma (show IFNG Proteins) may contribute to diarrhea associated with intestinal inflammation in part through regulation of the epithelial aquaporin-1 (show AQP1 Proteins) water channel (show AQP4 Proteins) via a non-classical JAK (show JAK3 Proteins)/STAT (show STAT1 Proteins) receptor signalling pathway.
JAK2 participates in the signalling, regulating the voltage-gated K(+) channel (show KCND3 Proteins) KCNA3 (show KCNA3 Proteins).
nitration of JAK2 may act as an inhibitory counterpart to phosphorylation activation, reflecting a very localized break on the progression of GH signal transduction processes spanning JAK (show JAK3 Proteins)-STAT (show STAT1 Proteins)-AKT (show AKT1 Proteins) interactions
Janus kinase 2 (JAK2) gene polymorphism is a potential marker for milk production traits in cattle
Results indicate that SNPs in STAT5A (show STAT5A Proteins) and JAK2 genes were associated with somatic cell count and score in milk and cytokines but none of the SNP was associated with milk production traits suggesting an important role in immunity.
Methionine promoted casein synthesis, and this may be mediated by enhanced intracellular substrate availability and by activating JAK2-STAT5 (show STAT5A Proteins) and mTOR (show FRAP1 Proteins) signaling pathways.
SNPs in JAK2 and STAT5B (show STAT5B Proteins) are associated with mastitis susceptibility in Chinese Holstein cattle
Localized changes in the state of nitration of regulatory phosphorylation domains of JAK2 in caveoLAE during inflammation suggest a unique mechanism through which discrete signal transduction switching might occur in the liver
This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis.
, PTK JAK2b
, protein tyrosine kinase JAK2b
, tyrosine-protein kinase JAK2
, Janus kinase 2 (a protein tyrosine kinase)
, tyrosine kinase