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Of two Jak2 paralogues present in zebrafish, Jak2a but not Jak2b is involved in the intracellular transmission of the Ifn-gamma (show IFNG Proteins) signal.
Data suggest that combining PIM (show PIM1 Proteins) and JAK2 kinase inhibitors may offer a more efficacious therapeutic approach for myeloproliferative neoplasms (MPNs) over JAK2 inhibitor mono-therapy.
Letter: Interleukin-22 (show IL22 Proteins) inhibits tazarotene-induced gene 3 expression in keratinocytes via MAPK (show MAPK1 Proteins)-ERK1/2 and JAK2/STAT3 (show STAT3 Proteins) signaling.
Data indicate the role of tropomyosin-related kinase-B (TrkB (show NTRK2 Proteins)) in activation of the interleukin-6 (show IL6 Proteins)/Janus kinase 2/STAT3 (show STAT3 Proteins) transcription factor and PI3 kinase (show PIK3CA Proteins)/c-AKT (show AKT1 Proteins) proto-oncogene (show RAB1A Proteins) protein pathway in breast cancer.
the JAK2(V617F) mutation in Jordanian patients with Philadelphia chromosome-negative myeloproliferative neoplasms, is identified.
JAK-2 V617F Mutation is associated with Essential Thrombocythemia.
Co-existence of JAK2 V617F and CALR (show CALR Proteins) mutations in primary myelofibrosis
The transduction of hematopoietic stem cells with mJAK2 increased their proliferation capacity in EPO (show EPO Proteins)-free culture conditions.
we demonstrate that like other kinases JAK2 is prone to develop resistant mutations against ATP site inhibitors, but targeting the substrate-binding site prevents the selection of resistant mutations.
by molecular docking analysis and tumor sphere assay we discover that curcumin was able to inhibit JAK2 activity and reduce tumor spheres via inhibiting the JAK2/STAT3 (show STAT3 Proteins) signaling pathway
we conclude that the JAK2-STAT3 (show STAT3 Proteins) pathway promotes the development of paclitaxel resistance via upregulating the expression of prosurvival and antiapoptotic genes.
The critical role of Jak2 in mediating prolactin (show PRL Proteins)-induced luminal maturation of mammary epithelial cells.
JAK1 (show JAK1 Proteins)/JAK2 inhibition of graft-versus-host disease was associated with the modulation of chemokine receptor (show CCR1 Proteins) expression, which may have been one factor in the reduced infiltration of donor T cells in graft-versus-host disease target organs.
Findings indicate that CD24(+) antigen (show CD24 Proteins) cells play a role in tumor migration and metastasis and support Janus kinase 2 protein (JAK2) as a therapeutic target in ovarian cancer.
JAK2(V617I) resulted in cytokine hyperresponsiveness without constitutive activation in the absence of ligand, whereas JAK2(V617F) resulted in constitutive activation
The pro-inflammatory cytokine, interferon-gamma (show IFNG Proteins) may contribute to diarrhea associated with intestinal inflammation in part through regulation of the epithelial aquaporin-1 (show AQP1 Proteins) water channel (show AQP4 Proteins) via a non-classical JAK (show JAK3 Proteins)/STAT (show STAT1 Proteins) receptor signalling pathway.
JAK2 participates in the signalling, regulating the voltage-gated K(+) channel (show KCND3 Proteins) KCNA3 (show KCNA3 Proteins).
PRDX6 (show PRDX6 Proteins) promotes lung tumor development via its mediated and CCL5 (show CCL5 Proteins)-associated activation of the JAK2/STAT3 (show STAT3 Proteins) pathway.
The data support an important role of LIF (show LIF Proteins)-JAK2-STAT3 (show STAT3 Proteins) regulation in the development of colonic adenocarcinoma-related cachexia.
Studied the liver-specific role of PTP1B (show PTPN1 Proteins) in GH signaling; found under 48-hour fasting GH-resistant conditions, GH stimulation in vivo led to a robust stimulation of the JAK (show JAK3 Proteins)-STAT (show STAT1 Proteins) signalling pathway.
HDAC2 (show HDAC2 Proteins) might be a downstream effector of Jak2 to mediate cardiac hypertrophic response by pressure overload or Ang-II (show AGT Proteins).
nitration of JAK2 may act as an inhibitory counterpart to phosphorylation activation, reflecting a very localized break on the progression of GH signal transduction processes spanning JAK (show JAK3 Proteins)-STAT (show STAT1 Proteins)-AKT (show AKT1 Proteins) interactions
Janus kinase 2 (JAK2) gene polymorphism is a potential marker for milk production traits in cattle
Results indicate that SNPs in STAT5A (show STAT5A Proteins) and JAK2 genes were associated with somatic cell count and score in milk and cytokines but none of the SNP was associated with milk production traits suggesting an important role in immunity.
Methionine promoted casein synthesis, and this may be mediated by enhanced intracellular substrate availability and by activating JAK2-STAT5 (show STAT5A Proteins) and mTOR (show FRAP1 Proteins) signaling pathways.
SNPs in JAK2 and STAT5B (show STAT5B Proteins) are associated with mastitis susceptibility in Chinese Holstein cattle
Localized changes in the state of nitration of regulatory phosphorylation domains of JAK2 in caveoLAE during inflammation suggest a unique mechanism through which discrete signal transduction switching might occur in the liver
This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis.
, PTK JAK2b
, protein tyrosine kinase JAK2b
, tyrosine-protein kinase JAK2
, Janus kinase 2 (a protein tyrosine kinase)
, tyrosine kinase