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Of two Jak2 paralogues present in zebrafish, Jak2a but not Jak2b is involved in the intracellular transmission of the Ifn-gamma (show IFNG Proteins) signal.
Studies indicate that a genetic classification of primary fibrosis (PMF (show PRB1 Proteins)) by calreticulin (CALR (show CALR Proteins)) and JAK2V617F (JAK2)mutations carried significant prognostic relevance.
study investigated the presence of JAK2 (V617F) mutation in Egyptian patients with myeloproliferative disorders; results are concordant with international published results for detection of this mutation; JAK2 mutation may be also present in disorders other than MPDs (show DPM1 Proteins) such as; different hypercoagulable states
A heterozygous intronic JAK2 variant was found in familial cases diagnosed with gastric lymphoma and Hodgkin lymphoma.
Case Report: refractory arterial insufficiency associated with JAK2-positive essential thrombocythaemia.
Correlation analysis between JAK2 V617F allele burden and other parameters in patients with Philadelphia negative myeloproliferative neoplasms revealed statistical significant correlation with age, HB, HCT, PLT, UA, LDH, and splenic diameter but insignificant correlation with WBCs and PAH.
A positive correlation of JAK2 V617F mutation was established.
JAK2V617F and CALR (show CALR Proteins) positive patients might have a different phenotype.
Mutation status of JAK2, CALR (show CALR Proteins), and MPL (show MPL Proteins) in essential thrombocythemia and primary myelofibrosis defines clinical outcome.
Data show that the expressions of p-JAK2 protein and p-STAT3 (show STAT3 Proteins) protein were down-regulated after treated with Interferon-beta (IFN-beta (show IFNB1 Proteins)) combined with all-trans retinoic acid (ATRA) on HepG2 cells, especially the combination of IFN-beta (show IFNB1 Proteins) and ATRA.
JAK2 amplification is a potential biomarker for JAK2 dependence.
IL-3 (show Il3 Proteins) signaling does not contribute to Jak2 V617F myeloproliferative neoplasm pathogenesis.
Fos-zippered GHR (show GHR Proteins) tails and Jak2, both purified from baculovirus-infected insect cells, interacted via box1 with a binding affinity of approximately 40nM.
Single agent BMS-911543 Jak2 inhibitor has distinct inhibitory effects on STAT5 (show STAT5A Proteins) signaling in genetically engineered mice with pancreatic ductal carcinomas.
JAK2 plays a critical role in brown adipose tissue function and adaptive thermogenesis
The critical role of Jak2 in mediating prolactin (show PRL Proteins)-induced luminal maturation of mammary epithelial cells.
JAK1 (show JAK1 Proteins)/JAK2 inhibition of graft-versus-host disease was associated with the modulation of chemokine receptor (show CCR1 Proteins) expression, which may have been one factor in the reduced infiltration of donor T cells in graft-versus-host disease target organs.
Findings indicate that CD24(+) antigen (show CD24 Proteins) cells play a role in tumor migration and metastasis and support Janus kinase 2 protein (JAK2) as a therapeutic target in ovarian cancer.
JAK2(V617I) resulted in cytokine hyperresponsiveness without constitutive activation in the absence of ligand, whereas JAK2(V617F) resulted in constitutive activation
The pro-inflammatory cytokine, interferon-gamma (show IFNG Proteins) may contribute to diarrhea associated with intestinal inflammation in part through regulation of the epithelial aquaporin-1 (show AQP1 Proteins) water channel (show AQP4 Proteins) via a non-classical JAK (show JAK3 Proteins)/STAT (show STAT1 Proteins) receptor signalling pathway.
JAK2 participates in the signalling, regulating the voltage-gated K(+) channel (show KCND3 Proteins) KCNA3 (show KCNA3 Proteins).
nitration of JAK2 may act as an inhibitory counterpart to phosphorylation activation, reflecting a very localized break on the progression of GH signal transduction processes spanning JAK (show JAK3 Proteins)-STAT (show STAT1 Proteins)-AKT (show AKT1 Proteins) interactions
Janus kinase 2 (JAK2) gene polymorphism is a potential marker for milk production traits in cattle
Results indicate that SNPs in STAT5A (show STAT5A Proteins) and JAK2 genes were associated with somatic cell count and score in milk and cytokines but none of the SNP was associated with milk production traits suggesting an important role in immunity.
Methionine promoted casein synthesis, and this may be mediated by enhanced intracellular substrate availability and by activating JAK2-STAT5 (show STAT5A Proteins) and mTOR (show FRAP1 Proteins) signaling pathways.
SNPs in JAK2 and STAT5B (show STAT5B Proteins) are associated with mastitis susceptibility in Chinese Holstein cattle
Localized changes in the state of nitration of regulatory phosphorylation domains of JAK2 in caveoLAE during inflammation suggest a unique mechanism through which discrete signal transduction switching might occur in the liver
This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis.
, PTK JAK2b
, protein tyrosine kinase JAK2b
, tyrosine-protein kinase JAK2
, Janus kinase 2 (a protein tyrosine kinase)
, tyrosine kinase