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Of two Jak2 paralogues present in zebrafish, Jak2a but not Jak2b is involved in the intracellular transmission of the Ifn-gamma (show IFNG Proteins) signal.
Higher hematologic parameters including counts of WBC, RBC (show CACNA1C Proteins), and PLT (show NAAA Proteins) are closely associated with JAK2V617F mutation and its burden in Ph-negative MPNs; importantly, PT-INR (show INSR Proteins), APTT are also related to JAK2V617F mutation and allele burden.
Alterated IQGAP1/Rho GTPase (show RACGAP1 Proteins) signaling in myeloproliferative neoplasm erythrocytes is dependent on JAK2/CALR (show CALR Proteins) mutational status.
primary cells from a patient with KRAS-mutant juvenile myelomonocytic leukemia displayed reduced colony formation in response to JAK2 inhibition
The results showed that AG490 inhibited (p)-JAK2 and RANKL (show TNFSF11 Proteins) expression.
the accumulation of reactive oxygen species (ROS (show ROS1 Proteins)) in cells expressing JAK2V617F compromises the NHE-1 (show SLC9A1 Proteins)/Bcl-xL (show BCL2L1 Proteins) deamidation pathway by repressing NHE-1 (show SLC9A1 Proteins) upregulation in response to DNA damage. hematopoietic stem cells (HSCs), FOXO3A (show FOXO3 Proteins) is largely localized within the nuclei despite the presence of JAK2V617F mutation, suggesting that JAK2-FOXO (show FOXO3 Proteins) signaling has a different effect on progenitors compared with stem cells.
Overexpression of Msi2 (show MSI2 Proteins) significantly increased and silencing of Msi2 (show MSI2 Proteins) reduced the phosphorylation of JAK2 and its downstream effecter STAT3 (show STAT3 Proteins).
our data elucidate that knockdown of HOXD-AS1 (show PTGDR Proteins) dramatically suppresses gastric cancer cell growth by inactivating the Janus kinase 2/signal transducer and activator of transcription 3 (show STAT3 Proteins) pathway in vitro and in vivo, contributing to a better understanding of gastric cancer pathogenesis and providing a possible theoretical foundation for long non-coding RNA-directed diagnosis and therapy against this disease.
Germline variation in the JAK2 gene was associated with survival in patients with castration-resistant prostate cancer
TERT (show TERT Proteins) rs2736100 A>C SNP and JAK2 46/1 haplotype significantly contribute to the occurrence of JAK2 V617F and CALR (show CALR Proteins) mutated myeloproliferative neoplasms
this study shows that Korean patients with psoriasis show a strong association for JAK2 single nucleotide polymorphism
JAK2 has a role in hepatocarcinogenesis through regulating critical inflammatory pathways
Data show that CUZD1 (show CUZD1 Proteins) interacts with a complex containing JAK1 (show JAK1 Proteins)/JAK2 and STAT5 (show STAT5A Proteins), downstream transducers of prolactin (show PRL Proteins) signaling in the mammary gland.
these results have revealed that phosphorylation of Tyr (show TYR Proteins)-343, Tyr (show TYR Proteins)-460, and Tyr (show TYR Proteins)-464 in EpoR (show EPOR Proteins) underlies JAK2 V617F mutant-induced tumorigenesis.
this study shows that ampelopsin reduces inflammatory response of microglial cells through inhibition of JAK2-STAT3 (show STAT3 Proteins) signaling
At the molecular level, administration of liraglutide induced the expression of PDX-1 (show PDX1 Proteins), MafA (show MAFA Proteins), p-JAK2 and p-Stat3 (show STAT3 Proteins) in high-fat diet-induced diabetes model to relatively normal levels.
this study shows that resokaempferol inhibits the inflammatory response in activated macrophages by blocking the activation of the JAK2 pathway
Data show that protein tyrosine phosphatase 1B (PTP1B (show PTPN1 Proteins))-deficiency enhanced JAK2-STAT3 (show STAT3 Proteins) signaling in hypothalamic microglia and attenuated inflammation.
JAK1 (show JAK1 Proteins), JAK2, and JAK3 (show JAK3 Proteins) are involved in stimulation of functional activity of mesenchymal progenitor cells by fibroblast growth factor.
JAK (show JAK3 Proteins) mediated signaling is involved in the differentiation and proliferation of mesenchymal progenitor cells.
nitration of JAK2 may act as an inhibitory counterpart to phosphorylation activation, reflecting a very localized break on the progression of GH signal transduction processes spanning JAK (show JAK3 Proteins)-STAT (show STAT1 Proteins)-AKT (show AKT1 Proteins) interactions
Janus kinase 2 (JAK2) gene polymorphism is a potential marker for milk production traits in cattle
Results indicate that SNPs in STAT5A (show STAT5A Proteins) and JAK2 genes were associated with somatic cell count and score in milk and cytokines but none of the SNP was associated with milk production traits suggesting an important role in immunity.
Methionine promoted casein synthesis, and this may be mediated by enhanced intracellular substrate availability and by activating JAK2-STAT5 (show STAT5A Proteins) and mTOR (show FRAP1 Proteins) signaling pathways.
SNPs in JAK2 and STAT5B (show STAT5B Proteins) are associated with mastitis susceptibility in Chinese Holstein cattle
Localized changes in the state of nitration of regulatory phosphorylation domains of JAK2 in caveoLAE during inflammation suggest a unique mechanism through which discrete signal transduction switching might occur in the liver
This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis.
, PTK JAK2b
, protein tyrosine kinase JAK2b
, tyrosine-protein kinase JAK2
, Janus kinase 2 (a protein tyrosine kinase)
, tyrosine kinase