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Browse our anti-MPL (MPL) Antibodies

Full name:
anti-Myeloproliferative Leukemia Virus Oncogene Antibodies (MPL)
On www.antibodies-online.com are 63 Myeloproliferative Leukemia Virus Oncogene (MPL) Antibodies from 12 different suppliers available. Additionally we are shipping MPL Proteins (21) and MPL Kits (2) and many more products for this protein. A total of 89 MPL products are currently listed.
Synonyms:
C-MPL, c-mpl-I, c-mpl-II, CD110, hlb219, MPL, MPLV, THCYT2, TPO-R, TPOR
list all antibodies Gene Name GeneID UniProt
MPL 4352 P40238
MPL 17480 Q08351
MPL 366455  

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Most Popular Reactivities for anti-MPL (MPL) Antibodies

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anti-Human MPL Antibodies:

anti-Mouse (Murine) MPL Antibodies:

anti-Rat (Rattus) MPL Antibodies:

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Top referenced anti-MPL Antibodies

  1. Human Monoclonal MPL Primary Antibody for FACS, WB - ABIN967682 : Broudy, Lin, Fox, Taga, Saito, Kaushansky: Thrombopoietin stimulates colony-forming unit-megakaryocyte proliferation and megakaryocyte maturation independently of cytokines that signal through the gp130 receptor subunit. in Blood 1996 (PubMed)
    Show all 4 references for ABIN967682

  2. Human Monoclonal MPL Primary Antibody for EIA, FACS - ABIN1105749 : Raposo, Sousa, Kirsch, Cardoso, Belsley, de Matos Gomes, Fonseca: Synthesis and characterization of dicyanovinyl-substituted thienylpyrroles as new nonlinear optical chromophores. in Organic letters 2006 (PubMed)
    Show all 2 references for ABIN1105749

  3. Human Monoclonal MPL Primary Antibody for FACS, ELISA - ABIN969542 : Marty, Chaligné, Lacout, Constantinescu, Vainchenker, Villeval: Ligand-independent thrombopoietin mutant receptor requires cell surface localization for endogenous activity. in The Journal of biological chemistry 2009 (PubMed)
    Show all 2 references for ABIN969542

More Antibodies against MPL Interaction Partners

Human Myeloproliferative Leukemia Virus Oncogene (MPL) interaction partners

  1. identification of a higher frequency of co-existing JAK2 (show JAK2 Antibodies) exon-12 or MPL exon-10 mutations in patients with myeloproliferative neoplasms with a low JAK2V617F allelic burden compared to those with a higher allelic burden.

  2. A newborn girl with congenitcal amegakaryocytic thrombocytopenia had a homozygous missense Trp154-to- Arg mutation in exon 4 of c-MPL. The same heterozygote mutation was detected in her mother, father, and 2 siblings.

  3. Mutation status of JAK2 (show JAK2 Antibodies), CALR (show CALR Antibodies), and MPL in essential thrombocythemia and primary myelofibrosis defines clinical outcome.

  4. Normal FLT3 (show FLT3 Antibodies) and negative expression of CD34 (show CD34 Antibodies) and cMPL may predict a longer overall survival in aute myeloid leukemia (show BCL11A Antibodies).

  5. we show that the positive charge of the CALR (show CALR Antibodies) mutant C-terminus is necessary to transform hematopoietic cells by enabling binding between mutant CALR (show CALR Antibodies) and the thrombopoietin receptor MPL.

  6. Anagrelide proved effective among all molecular subsets, indicating that JAK2 (show JAK2 Antibodies)/CALR (show CALR Antibodies)/MPL mutational status does not seem to represent a major determinant of choice of cytoreductive treatment among essential thrombocythemia therapies.

  7. In essential thrombocythemia, MPL mutations might be associated with a higher risk of fibrotic transformation and the presence of JAK2 (show JAK2 Antibodies)/MPL mutations with higher risk of thrombosis.

  8. PARP-1 (show PARP1 Antibodies) has an important role in the progression of acute myeloid leukemia (show BCL11A Antibodies) by suppressing the myeloproliferative leukemia virus oncogene

  9. mutant CALR (show CALR Antibodies) promotes myeloproliferative neoplasm development by activating c-MPL and its downstream pathway.

  10. Thrombopoietin receptor activation by myeloproliferative neoplasm associated calreticulin (show CALR Antibodies) mutants.

Mouse (Murine) Myeloproliferative Leukemia Virus Oncogene (MPL) interaction partners

  1. C-Mpl is expressed on osteoblasts and osteoclasts and is important in regulating skeletal homeostasis.

  2. CALR (show CALR Antibodies) mutants are sufficient to induce thrombocytosis through MPL activation.

  3. Thrombopoietin receptor activation by myeloproliferative neoplasm associated calreticulin (show CALR Antibodies) mutants.

  4. The interaction between Mpl and Atp5d (show ATP5D Antibodies) was confirmed by the yeast two-hybrid system, mammalian two-hybrid assay, pull-down experiment, and co-immunoprecipitation study in vivo and in vitro.

  5. Mouse prenatal platelet-forming lineages share a core transcriptional program but divergent dependence on MPL.

  6. MERIT40 (show BABAM1 Antibodies) deficiency triggers hypersensitivity to Tpo (show THPO Antibodies) stimulation and the stem cell phenotypes are abrogated on a background null for the Tpo (show THPO Antibodies) receptor Mpl.

  7. OTT1 regulates the alternative splicing of Mpl-TR, a truncated isoform of c-Mpl, which modulates Thrombopoietin (show THPO Antibodies)-mediated signaling.

  8. Mpl expression, but not Tpo (show THPO Antibodies), is fundamental in the development of JAK2V617F(+) myeloproliferative neoplasms

  9. Thrombopoietin (show THPO Antibodies)/MPL signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 (show MECOM Antibodies) leukemia.

  10. These studies show the importance of the c-Mpl membrane-distal cytokine receptor (show LEPR Antibodies) homology module to thrombopoietin (show THPO Antibodies)-binding and suggest that mutations within this CRM that perturb TPO (show THPO Antibodies) binding could give rise to Congenital Amegakaryocytic Thrombocytopenia.

MPL Antigen Profile

Antigen Summary

In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.

Alternative names and synonyms associated with MPL

  • myeloproliferative leukemia virus oncogene (MPL) antibody
  • myeloproliferative leukemia virus oncogene (LOC100230798) antibody
  • myeloproliferative leukemia virus oncogene (LOC100355135) antibody
  • myeloproliferative leukemia virus oncogene (Mpl) antibody
  • C-MPL antibody
  • c-mpl-I antibody
  • c-mpl-II antibody
  • CD110 antibody
  • hlb219 antibody
  • MPL antibody
  • MPLV antibody
  • THCYT2 antibody
  • TPO-R antibody
  • TPOR antibody

Protein level used designations for MPL

thrombopoietin receptor , myeloproliferative leukemia virus oncogene , thrombopoietin receptor-like , TPO-R , myeloproliferative leukemia protein , proto-oncogene c-Mpl

GENE ID SPECIES
414804 Gallus gallus
528492 Bos taurus
723813 Macaca mulatta
747522 Pan troglodytes
100008643 Oryctolagus cuniculus
100066544 Equus caballus
100230798 Taeniopygia guttata
100355135 Oryctolagus cuniculus
100448006 Pongo abelii
100626347 Sus scrofa
4352 Homo sapiens
17480 Mus musculus
366455 Rattus norvegicus
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