You are viewing an incomplete version of our website. Please click to reload the website as full version.

Browse our PTPN11 Proteins (PTPN11)

Full name:
Protein tyrosine Phosphatase, Non-Receptor Type 11 Proteins (PTPN11)
On www.antibodies-online.com are 10 Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) Proteins from 7 different suppliers available. Additionally we are shipping PTPN11 Antibodies (353) and PTPN11 Kits (24) and many more products for this protein. A total of 401 PTPN11 products are currently listed.
Synonyms:
2700084A17Rik, AW536184, BPTP3, CFC, NS1, PTP-1D, PTP1D, PTP2C, SAP-2, SH-PTP2, SH-PTP3, SHP-2, Shp2, SYP
list all proteins Gene Name GeneID UniProt
PTPN11 5781 Q06124
PTPN11 19247 P35235
PTPN11 25622 P41499

Show all synonyms

PTPN11 Proteins (PTPN11) by Origin

Select your origin of interest

Top referenced PTPN11 Proteins

  1. Human PTPN11 Protein expressed in Wheat germ - ABIN1316822 : Jo, Park, Lee, Ahn, Kim, Park, Choi: SHP-2 binds to caveolin-1 and regulates Src activity via competitive inhibition of CSK in response to H2O2 in astrocytes. in PLoS ONE 2014 (PubMed)

More Proteins for PTPN11 Interaction Partners

Human Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) interaction partners

  1. SHP2, SOCS3 (show SOCS3 Proteins) and PIAS3 (show PIAS3 Proteins) levels are reduced in medulloblastomas in vivo and in vitro, of which PIAS3 (show PIAS3 Proteins) downregulation is more reversely correlated with STAT3 (show STAT3 Proteins) activation. In resveratrol-suppressed medulloblastoma cells with STAT3 (show STAT3 Proteins) downregulation and decreased incidence of STAT3 (show STAT3 Proteins) nuclear translocation, PIAS3 (show PIAS3 Proteins) is upregulated, the SHP2 level remains unchanged and SOCS3 (show SOCS3 Proteins) is downregulated.

  2. SHP2-ERK2 (show MAPK1 Proteins) signaling acts upstream of C/EBPalpha (show CEBPA Proteins) as a regulator of cell surface I antigen synthesis.

  3. could promote hepatocellular carcinoma cell dedifferentiation and liver cancer stem cell expansion by amplifying beta-catenin (show CTNNB1 Proteins) signaling

  4. The results revealed that although the expression levels of SOCS1 (show SOCS1 Proteins), SOCS3 (show SOCS3 Proteins) and, in particular, pSHP2, tend to decrease in the four types of astrocytomas, PIAS3 (show PIAS3 Proteins) downregulation is more negatively correlated with STAT3 (show STAT3 Proteins) activation in the stepwise progress of astrocytomas and would indicate an unfavorable outcome.

  5. In a retroviral transduction/transplantation mouse model, mice transplanted with MLL (show MLL Proteins)/AF10 (show MLLT10 Proteins)(OM-LZ) cells harboring PTPN11(wt) developed myelomonocytic leukemia. Those transplanted with cells harboring PTPN11(G503A) -induced monocytic leukemia (show KAT6B Proteins) in a shorter latency. Adding PTPN11(G503A) to MLL (show MLL Proteins)/AF10 (show MLLT10 Proteins) affected cell proliferation, chemo-resistance, differentiation, in vivo BM recruitment/clonal expansion and faster progression.

  6. Shp2 (Src (show SRC Proteins)-homology 2 domain-containing phosphatase 2) functions as a negative regulator for STAT3 (show STAT3 Proteins) transcription factor (Stat3 (show STAT3 Proteins)) activation in esophageal squamous cell cancer (ESCC).

  7. the phosphatase activity of Shp2 and its tyrosine phosphorylation, are necessary for the IL-6 (show IL6 Proteins)-induced downregulation of E-cadherin (show CDH1 Proteins) and the phosphorylation of Erk1/2. Our findings uncover an important function that links Shp2 to IL-6 (show IL6 Proteins)-promoted breast cancer progression.

  8. This study reveals the critical contribution of Ptpn11 mutations in the bone marrow microenvironment to leukaemogenesis and identifies CCL3 (show CCL3 Proteins) as a potential therapeutic target for controlling leukaemic progression in Noonan syndrome and for improving stem cell transplantation therapy in Noonan-syndrome-associated leukaemias.

  9. higher expression of SHP2 might be involved in the progression of pancreatic ductal adenocarcinoma, suggesting that SHP2 may be a potential prognostic marker and target for therapy

  10. Data indicate that the most prominent proteins associating with Gab2 (show GAB2 Proteins) are PTPN11, PIK3R1 and ARID3B (show ARID3B Proteins).

Cow (Bovine) Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) interaction partners

  1. SHP2 supports basal pulmonary endothelial barrier function by coordinating the tyrosine phosphorylation profile of VE-cadherin (show CDH5 Proteins), beta-catenin (show CTNNB1 Proteins), and p190RhoGAP (show GRLF1 Proteins) and the activity of RhoA (show RHOA Proteins).

Mouse (Murine) Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) interaction partners

  1. Data show aberrant neuronal activity-induced signaling and regulation of gene expression in protein tyrosine phosphatase (show ACP1 Proteins), non-receptor type 11 (Ptpn11D61Y) mutation and suggest that these deficits contribute to the pathophysiology of cognitive impairments in Noonan syndrome (NS).

  2. This study indicates that Shp2 is required to orchestrate macrophage function and regulate host innate immunity against pulmonary bacterial infection.

  3. In conclusion, our data suggest that SIRPalpha signaling through SHP-2-PI3K-Akt2 (show AKT2 Proteins) strongly influences osteoblast differentiation from bone marrow stromal cells.

  4. SHP-2 is functionally important for the maintenance of appropriate barrier function and host-microbiota homeostasis in the large intestine.

  5. This study reveals the critical contribution of Ptpn11 mutations in the bone marrow microenvironment to leukaemogenesis and identifies CCL3 (show CCL3 Proteins) as a potential therapeutic target for controlling leukaemic progression in Noonan syndrome and for improving stem cell transplantation therapy in Noonan-syndrome-associated leukaemias.

  6. SHP2 is a potential positive regulator of eosinophil differentiation, and inhibition of SHP2 specifically in myeloid cells eventually alleviates eosinophilic airway inflammation.

  7. lack of Shp2 in orofacial cartilage led to severe defects of ciliogenesis.

  8. results collectively suggest that Shp2 is a critical signaling protein that is required to maintain Sertoli cell function and could serve as a novel target for male infertility therapies

  9. PTPN11 is a central node in intrinsic and acquired resistance to targeted cancer drugs.

  10. SHP2 activity is elevated in astrocytes isolated from glioblastoma multiforme (GBM)-prone H-Ras (show HRAS Proteins)(12V) knock-in mice.

PTPN11 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with PTPN11

  • protein tyrosine phosphatase, non-receptor type 11 (PTPN11)
  • protein tyrosine phosphatase, non-receptor type 11 (Ptpn11)
  • 2700084A17Rik protein
  • AW536184 protein
  • BPTP3 protein
  • CFC protein
  • NS1 protein
  • PTP-1D protein
  • PTP1D protein
  • PTP2C protein
  • SAP-2 protein
  • SH-PTP2 protein
  • SH-PTP3 protein
  • SHP-2 protein
  • Shp2 protein
  • SYP protein

Protein level used designations for PTPN11

PTP-2C , protein-tyrosine phosphatase 1D , protein-tyrosine phosphatase 2C , tyrosine-protein phosphatase non-receptor type 11 , SH2 domain-containing protein tyrosine phosphatase-2 , protein-tyrosine phosphatase SYP , PTP-1D , SH-PTP2 protein tyrosine phosphatase non-receptor type 11 , SH-PTP2 protein tyrosine phosphatase, non-receptor type 11 , SHP-2 , encodes catalytic domain , protein tyrosine phosphatase SH-PTP2 , SH-PTP2 , cSH-PTP2 , protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) , non-receptor type protein tyrosine phosphatase SHP2

GENE ID SPECIES
5781 Homo sapiens
533590 Bos taurus
19247 Mus musculus
25622 Rattus norvegicus
395815 Gallus gallus
477488 Canis lupus familiaris
100170851 Sus scrofa
Selected quality suppliers for PTPN11 Proteins (PTPN11)
Did you look for something else?