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Browse our PTPN11 Proteins (PTPN11)

Full name:
Protein tyrosine Phosphatase, Non-Receptor Type 11 Proteins (PTPN11)
On are 10 Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) Proteins from 7 different suppliers available. Additionally we are shipping PTPN11 Antibodies (365) and PTPN11 Kits (21) and many more products for this protein. A total of 410 PTPN11 products are currently listed.
2700084A17Rik, AW536184, BPTP3, CFC, NS1, PTP-1D, PTP1D, PTP2C, SAP-2, SH-PTP2, SH-PTP3, SHP-2, Shp2, SYP
list all proteins Gene Name GeneID UniProt
PTPN11 5781 Q06124
PTPN11 19247 P35235
PTPN11 25622 P41499

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PTPN11 Proteins (PTPN11) by Origin

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Top referenced PTPN11 Proteins

  1. Human PTPN11 Protein expressed in Wheat germ - ABIN1316822 : Jo, Park, Lee, Ahn, Kim, Park, Choi: SHP-2 binds to caveolin-1 and regulates Src activity via competitive inhibition of CSK in response to H2O2 in astrocytes. in PLoS ONE 2014 (PubMed)

More Proteins for PTPN11 Interaction Partners

Human Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) interaction partners

  1. higher expression of SHP2 might be involved in the progression of pancreatic ductal adenocarcinoma, suggesting that SHP2 may be a potential prognostic marker and target for therapy

  2. Data indicate that the most prominent proteins associating with Gab2 (show GAB2 Proteins) are PTPN11, PIK3R1 and ARID3B (show ARID3B Proteins).

  3. Since rs2301756 polymorphism of PTPN11 was associated with reduced risk of gastric cancer and better effects of chemotherapy on gastric cancer, it can be considered as a predictor of gastric cancer prognosis and the treatment target for gastric cancer.

  4. SHP2 gain-of-function mutation enhances malignancy of breast carcinoma.

  5. mutation in PTPN11 is associated with co-occurrence of hypertrophic cardiomyopathy and myeloproliferative disorder in a neonate with Noonan syndrome.

  6. The existence of a tight association between SHP2 and EGFR (show EGFR Proteins) expression in tumors and cell lines further suggested the importance of SHP2 in EGFR (show EGFR Proteins) expression.

  7. patients with low Shp2 expression exhibited superior prognosis to sorafenib

  8. Combined X-ray crystallography, small-angle X-ray scattering, and biochemistry to elucidate structural and mechanistic features of three cancer-associated SHP2 variants with single point mutations within the N-SH2:PTP interdomain autoinhibitory interface.

  9. In vitro assays suggested that LEOPARD syndrome-associated SHP-2 mutations might enhance melanin synthesis in melanocytes, and that the activation of Akt (show AKT1 Proteins)/mTOR (show FRAP1 Proteins) signalling may contribute to this process.

  10. SHP2 may promote invadopodia formation through inhibition of Rho signaling in cancer cells.

Cow (Bovine) Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) interaction partners

  1. SHP2 supports basal pulmonary endothelial barrier function by coordinating the tyrosine phosphorylation profile of VE-cadherin (show CDH5 Proteins), beta-catenin (show CTNNB1 Proteins), and p190RhoGAP (show GRLF1 Proteins) and the activity of RhoA (show RHOA Proteins).

Mouse (Murine) Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) interaction partners

  1. SHP2 is a potential positive regulator of eosinophil differentiation, and inhibition of SHP2 specifically in myeloid cells eventually alleviates eosinophilic airway inflammation.

  2. lack of Shp2 in orofacial cartilage led to severe defects of ciliogenesis.

  3. results collectively suggest that Shp2 is a critical signaling protein that is required to maintain Sertoli cell function and could serve as a novel target for male infertility therapies

  4. PTPN11 is a central node in intrinsic and acquired resistance to targeted cancer drugs.

  5. SHP2 activity is elevated in astrocytes isolated from glioblastoma multiforme (GBM)-prone H-Ras (show HRAS Proteins)(12V) knock-in mice.

  6. find that Shp2 is distributed to the kinetochore, centrosome, spindle midzone, and midbody

  7. Mouse podocytes lacking Shp2 do not develop foot process spreading when subjected to podocyte injury in vivo using protamine sulfate or nephrotoxic serum.

  8. Shp2 and Pten have antagonistic roles in myeloproliferation but cooperate to promote erythropoiesis in mammals.

  9. Leukemogenic Ptpn11 allele causes defective erythropoiesis in mice.

  10. SHP2 silencing in P815 mouse mastocytoma cell line harboring KITD814Y mutation results in impaired signaling to ERK (show EPHB2 Proteins), Btk (show BTK Proteins), Lyn (show LYN Proteins) and STAT5 (show STAT5A Proteins) pathways, and reduced rates of cell growth and colony formation.

PTPN11 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with PTPN11

  • protein tyrosine phosphatase, non-receptor type 11 (PTPN11)
  • protein tyrosine phosphatase, non-receptor type 11 (Ptpn11)
  • 2700084A17Rik protein
  • AW536184 protein
  • BPTP3 protein
  • CFC protein
  • NS1 protein
  • PTP-1D protein
  • PTP1D protein
  • PTP2C protein
  • SAP-2 protein
  • SH-PTP2 protein
  • SH-PTP3 protein
  • SHP-2 protein
  • Shp2 protein
  • SYP protein

Protein level used designations for PTPN11

PTP-2C , protein-tyrosine phosphatase 1D , protein-tyrosine phosphatase 2C , tyrosine-protein phosphatase non-receptor type 11 , SH2 domain-containing protein tyrosine phosphatase-2 , protein-tyrosine phosphatase SYP , PTP-1D , SH-PTP2 protein tyrosine phosphatase non-receptor type 11 , SH-PTP2 protein tyrosine phosphatase, non-receptor type 11 , SHP-2 , encodes catalytic domain , protein tyrosine phosphatase SH-PTP2 , SH-PTP2 , cSH-PTP2 , protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) , non-receptor type protein tyrosine phosphatase SHP2

5781 Homo sapiens
533590 Bos taurus
19247 Mus musculus
25622 Rattus norvegicus
395815 Gallus gallus
477488 Canis lupus familiaris
100170851 Sus scrofa
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