Browse our PTPN11 Proteins (PTPN11)

Full name:
Protein tyrosine Phosphatase, Non-Receptor Type 11 Proteins (PTPN11)
On are 10 Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) Proteins from 7 different suppliers available. Additionally we are shipping PTPN11 Antibodies (378) and PTPN11 Kits (26) and many more products for this protein. A total of 428 PTPN11 products are currently listed.
2700084A17Rik, AW536184, BPTP3, CFC, NS1, PTP-1D, PTP1D, PTP2C, SAP-2, SH-PTP2, SH-PTP3, SHP-2, Shp2, SYP
list all proteins Gene Name GeneID UniProt
PTPN11 5781 Q06124
PTPN11 19247 P35235
PTPN11 25622 P41499

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PTPN11 Proteins (PTPN11) by Origin

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Top referenced PTPN11 Proteins

  1. Human PTPN11 Protein expressed in Wheat germ - ABIN1316822 : Jo, Park, Lee, Ahn, Kim, Park, Choi: SHP-2 binds to caveolin-1 and regulates Src activity via competitive inhibition of CSK in response to H2O2 in astrocytes. in PLoS ONE 2014 (PubMed)

More Proteins for PTPN11 Interaction Partners

Human Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) interaction partners

  1. High PTPN11 expression is associated with Pancreatic cancer.

  2. SHP-2 acts together with PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) to regulate a ZEB1-miR (show MLXIP Proteins)-200 feedback loop in PDGFRalpha-driven gliomas.

  3. Results provide evidence that repression of SHP-1 (show PTPN6 Proteins), SHP-2 and SOCS-1 (show SOCS1 Proteins) gene expression in patient plasma cells supports the constitutive activation of the JAK (show JAK3 Proteins)/STAT3 (show STAT3 Proteins) pathway and probably leads to higher degrees of bone marrow invasion.

  4. The data presented in the current study reveal that intestinal serotonin transporter (SERT (show SLC6A4 Proteins)) is a target of the tyrosine phosphatase SHP2 and show a novel mechanism by which a common diarrheagenic pathogen, EPEC, activates cellular SHP2 to inhibit SERT (show SLC6A4 Proteins) function.

  5. The effects of SHP2 overexpression and inhibition on fibroblast response to profibrotic stimuli were analyzed in in primary human fibroblasts. SHP2 was down-regulated and lung fibroblasts obtained from patients with IPF, revealing SHP2 was absent within fibroblastic foci sufficient to induce fibroblast-to-myofibroblast differentiation in primary human lung fibroblasts, resulting in reduced cell survival.

  6. PTPN11 variant was identified in a case with a lethal presentation of Noonan syndrome.

  7. our results provide strong evidence that CD244 (show CD244 Proteins) co-operates with c-Kit to regulate leukemogenesis through SHP-2/p27 (show PAK2 Proteins) signaling.

  8. SHP2, SOCS3 (show SOCS3 Proteins) and PIAS3 (show PIAS3 Proteins) levels are reduced in medulloblastomas in vivo and in vitro, of which PIAS3 (show PIAS3 Proteins) downregulation is more reversely correlated with STAT3 (show STAT3 Proteins) activation. In resveratrol-suppressed medulloblastoma cells with STAT3 (show STAT3 Proteins) downregulation and decreased incidence of STAT3 (show STAT3 Proteins) nuclear translocation, PIAS3 (show PIAS3 Proteins) is upregulated, the SHP2 level remains unchanged and SOCS3 (show SOCS3 Proteins) is downregulated.

  9. SHP2-ERK2 (show MAPK1 Proteins) signaling acts upstream of C/EBPalpha (show CEBPA Proteins) as a regulator of cell surface I antigen synthesis.

  10. could promote hepatocellular carcinoma cell dedifferentiation and liver cancer stem cell expansion by amplifying beta-catenin (show CTNNB1 Proteins) signaling

Cow (Bovine) Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) interaction partners

  1. SHP2 supports basal pulmonary endothelial barrier function by coordinating the tyrosine phosphorylation profile of VE-cadherin (show CDH5 Proteins), beta-catenin (show CTNNB1 Proteins), and p190RhoGAP (show GRLF1 Proteins) and the activity of RhoA (show RHOA Proteins).

Mouse (Murine) Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) interaction partners

  1. data suggested that deletion of Shp2 impaired IL-25 (show IL25 Proteins) production in bronchial epithelial cells in vitro, but might yet have minor influence on OVA-induced allergic reaction in vivo

  2. The effects of SHP2 overexpression and inhibition on fibroblast response to profibrotic stimuli were analyzed in in the bleomycin model of lung fibrosis by SHP2-lentiviral administration in transgenic mice carrying a constitutively active SHP2 mutation. Mice carrying the Noonan syndrome-associated SHP2 mutation were resistant bleomycin induced pulmonary fibrosis.

  3. Data show aberrant neuronal activity-induced signaling and regulation of gene expression in protein tyrosine phosphatase (show ACP1 Proteins), non-receptor type 11 (Ptpn11D61Y) mutation and suggest that these deficits contribute to the pathophysiology of cognitive impairments in Noonan syndrome (NS).

  4. This study indicates that Shp2 is required to orchestrate macrophage function and regulate host innate immunity against pulmonary bacterial infection.

  5. In conclusion, our data suggest that SIRPalpha signaling through SHP-2-PI3K-Akt2 (show AKT2 Proteins) strongly influences osteoblast differentiation from bone marrow stromal cells.

  6. SHP-2 is functionally important for the maintenance of appropriate barrier function and host-microbiota homeostasis in the large intestine.

  7. This study reveals the critical contribution of Ptpn11 mutations in the bone marrow microenvironment to leukaemogenesis and identifies CCL3 (show CCL3 Proteins) as a potential therapeutic target for controlling leukaemic progression in Noonan syndrome and for improving stem cell transplantation therapy in Noonan-syndrome-associated leukaemias.

  8. SHP2 is a potential positive regulator of eosinophil differentiation, and inhibition of SHP2 specifically in myeloid cells eventually alleviates eosinophilic airway inflammation.

  9. lack of Shp2 in orofacial cartilage led to severe defects of ciliogenesis.

  10. results collectively suggest that Shp2 is a critical signaling protein that is required to maintain Sertoli cell function and could serve as a novel target for male infertility therapies

PTPN11 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with PTPN11

  • protein tyrosine phosphatase, non-receptor type 11 (PTPN11)
  • protein tyrosine phosphatase, non-receptor type 11 (Ptpn11)
  • 2700084A17Rik protein
  • AW536184 protein
  • BPTP3 protein
  • CFC protein
  • NS1 protein
  • PTP-1D protein
  • PTP1D protein
  • PTP2C protein
  • SAP-2 protein
  • SH-PTP2 protein
  • SH-PTP3 protein
  • SHP-2 protein
  • Shp2 protein
  • SYP protein

Protein level used designations for PTPN11

PTP-2C , protein-tyrosine phosphatase 1D , protein-tyrosine phosphatase 2C , tyrosine-protein phosphatase non-receptor type 11 , SH2 domain-containing protein tyrosine phosphatase-2 , protein-tyrosine phosphatase SYP , PTP-1D , SH-PTP2 protein tyrosine phosphatase non-receptor type 11 , SH-PTP2 protein tyrosine phosphatase, non-receptor type 11 , SHP-2 , encodes catalytic domain , protein tyrosine phosphatase SH-PTP2 , SH-PTP2 , cSH-PTP2 , protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) , non-receptor type protein tyrosine phosphatase SHP2

5781 Homo sapiens
533590 Bos taurus
19247 Mus musculus
25622 Rattus norvegicus
395815 Gallus gallus
477488 Canis lupus familiaris
100170851 Sus scrofa
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