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Human Thrombopoietin Protein expressed in Escherichia coli (E. coli) - ABIN2667588
Avanzi, Lista, Giovinazzo, Miniero, Saglio, Benetton, Coda, Cattoretti, Pegoraro: Selective growth response to IL-3 of a human leukaemic cell line with megakaryoblastic features. in British journal of haematology 1988
Show all 6 references for ABIN2667588
Rat (Rattus) Thrombopoietin Protein expressed in Escherichia coli (E. coli) - ABIN2667589
Deutsch, Tomer: Megakaryocyte development and platelet production. in British journal of haematology 2006
Show all 6 references for ABIN2667589
Mouse (Murine) Thrombopoietin Protein expressed in HEK-293 - ABIN2666760
Kaushansky: The molecular mechanisms that control thrombopoiesis. in The Journal of clinical investigation 2005
Show all 6 references for ABIN2666760
Rat (Rattus) Thrombopoietin Protein expressed in Escherichia coli (E. coli) - ABIN2667587
Ehrenreich, Hasselblatt, Knerlich, von Ahsen, Jacob, Sperling, Woldt, Vehmeyer, Nave, Sirén: A hematopoietic growth factor, thrombopoietin, has a proapoptotic role in the brain. in Proceedings of the National Academy of Sciences of the United States of America 2005
Show all 6 references for ABIN2667587
Human Thrombopoietin Protein expressed in Escherichia coli (E. coli) - ABIN2667584
Kato, Oda, Inagaki, Ohashi, Matsumoto, Ozaki, Miyakawa, Watarai, Fuju, Kokubo, Kadoya, Ikeda, Miyazaki: Thrombin cleaves recombinant human thrombopoietin: one of the proteolytic events that generates truncated forms of thrombopoietin. in Proceedings of the National Academy of Sciences of the United States of America 1997
Show all 6 references for ABIN2667584
Mouse (Murine) Thrombopoietin Protein expressed in Escherichia coli (E. coli) - ABIN2667585
Beutler, Cerami: Tumor necrosis, cachexia, shock, and inflammation: a common mediator. in Annual review of biochemistry 1988
Show all 3 references for ABIN2667585
Human Thrombopoietin Protein expressed in CHO - ABIN804525
Vas, Wandhoff, Dörr, Niebel, Geiger: Contribution of an aged microenvironment to aging-associated myeloproliferative disease. in PLoS ONE 2012
These studies indicate that the functional role of Tpo in the differentiation of thrombocytes from hematopoietic stem and progenitor cells is well conserved among vertebrate organisms, positing the zebrafish as an excellent model to investigate diseases caused by dysregulated erythro- and thrombo-poietic differentiation.
Colorectal cancer tumor-initiating cells (TICs) expressing CD110 (show MPL Proteins), the thrombopoietin (TPO)-binding receptor, mediate liver metastasis. We show that TPO promotes metastasis of CD110 (show MPL Proteins)+ TICs to the liver by activating lysine degradation.
decreased TPO levels or decreased bone marrow production of platelets may not be a cause of thrombocytopenia in chronic hepatitis C
WASP (show WASL Proteins), RUNX1 (show RUNX1 Proteins), and ANKRD26 genes are important for normal TPO signaling and the network underlying thrombopoiesis.
Data suggest that elevated serum level of thrombopoietin may serve as unfavorable marker of stage of multiple myeloma.
The regulation of OCs by TPO highlights a novel therapeutic target for bone loss diseases and may be important to consider in the numerous hematologic disorders associated with alterations in TPO/c-mpl (show MPL Proteins) signaling
TPO was greatly enhanced in HPT in comparison with ITP (show ITPA Proteins) patients (958 +/- 659 and 11 +/- 27 pg/ml, p < 0.001). In the ITP (show ITPA Proteins) group a reverse correlation was detected between TPO and glycocalicin (r = -0.373, p = 0.006).
observations suggest that NRP-1 (show NELL1 Proteins) is involved in megakaryocytopoiesis through complex formation with PDGFRs, and that NRP-1 (show NELL1 Proteins)-PDGFR (show PDGFRB Proteins)-complexes may contribute to effective cellular functions mediated by TPO and PDGF (show PDGFA Proteins) in megakaryocytic cells
Endocytic AMR (show GPR182 Proteins) controls TPO expression through Janus kinase 2 (JAK2 (show JAK2 Proteins)) and the acute phase response signal transducer and activator of transcription 3 (STAT3 (show STAT3 Proteins)) in vivo and in vitro
An Arg->Cys (show DNAJC5 Proteins) substitution at residue 38 or residue 17 excluding the 21-AA signal peptide of the receptor binding domain was found in a family with aplastic anemia. Adding a 5th cysteine may disrupt normal disulfide bonding & receptor binding.
increased plasma thrombopoietin levels were associated with a favorable prognosis of bone marrow failure and could, therefore, represent a reliable marker for a benign subset of myelodysplastic syndrome.
The results demonstrate the possible involvement of locally produced TPO (show TPO Proteins)/c-MPL (show MPL Proteins) system as a 'physiological filter' in bovine ovary where they may promote cell selection by inducing proliferation of viable cells and scavenging non-viable cells.
Thrombopoietin-mediated phosphorylation of STAT5 (show STAT5A Proteins) triggers its genome-wide relocation to STAT (show STAT1 Proteins) consensus sites, resulting in loss of a uSTAT5 program that restrains megakaryocytic differentiation and activation of STAT5 (show STAT5A Proteins)-driven gene expression.
Furthermore, although the contribution of the TPO treated graft to long-term hematological engraftment was reduced, the TPO treated and untreated grafts both contributed significantly to long-term chimerism in vivo.
TPO treatment also promoted the peripheral induction of Foxp3 (show FOXP3 Proteins)(+) Tregs in conjunction with elevated circulating TGF-beta (show TGFB1 Proteins) levels.
novel findings about aspects of TPO action on stem cells
Mpl (show MPL Proteins) expression, but not Tpo, is fundamental in the development of JAK2V617F(+) myeloproliferative neoplasms
Thrombopoietin/MPL (show MPL Proteins) signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 (show MECOM Proteins) leukemia.
Megakaryocytes regulate cell cycle quiescence of hematopoietic stem cell through the production of thrombopoietin.
IEX-1 (show IER3 Proteins) has a role in activation of Erk (show EPHB2 Proteins) and NF-kB pathways, which affects thrombopoietin-promoted NHEJ DNA repair in hematopoietic stem cells
Findings establish that Clock regulates Thpo and Mpl (show MPL Proteins) expression in vivo, and demonstrate an important link between the body's circadian timing mechanisms and megakaryopoiesis.
Signal transduction pathway of ERK1/2 participates in the activation of thrombopoietin in inflammatory injury of BV2 cells.
Megakaryocytopoiesis is the cellular development process that leads to platelet production. The protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternate splicing results in multiple transcript variants of this gene.
thrombopoietin (myeloproliferative leukemia virus oncogene ligand, megakaryocyte growth and development factor)
, MPL ligand
, c-mpl ligand
, megakaryocyte colony-stimulating factor
, megakaryocyte growth and development factor
, megakaryocyte stimulating factor
, myeloproliferative leukemia virus oncogene ligand
, thrombopoietin nirs variant 1
, C-mpl ligand