Browse our Thrombopoietin Proteins (THPO)

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Thrombopoietin Proteins (THPO)
On are 70 Thrombopoietin (THPO) Proteins from 16 different suppliers available. Additionally we are shipping Thrombopoietin Antibodies (160) and Thrombopoietin Kits (69) and many more products for this protein. A total of 314 Thrombopoietin products are currently listed.
LOC100231762, Mgdf, MKCSF, Ml, Mpllg, THCYT1, Tpo, Tpo1, Tpo2, Tpo3, Tpo4
list all proteins Gene Name GeneID UniProt
THPO 7066 P40225
THPO 21832 P40226
THPO 81811 P49745

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Thrombopoietin Proteins (THPO) by Origin

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Top referenced Thrombopoietin Proteins

  1. Human Thrombopoietin Protein expressed in Escherichia coli (E. coli) - ABIN2667588 : Avanzi, Lista, Giovinazzo, Miniero, Saglio, Benetton, Coda, Cattoretti, Pegoraro: Selective growth response to IL-3 of a human leukaemic cell line with megakaryoblastic features. in British journal of haematology 1988 (PubMed)
    Show all 6 references for 2667588

  2. Rat (Rattus) Thrombopoietin Protein expressed in Escherichia coli (E. coli) - ABIN2667589 : Deutsch, Tomer: Megakaryocyte development and platelet production. in British journal of haematology 2006 (PubMed)
    Show all 6 references for 2667589

  3. Mouse (Murine) Thrombopoietin Protein expressed in HEK-293 - ABIN2666760 : Kaushansky: The molecular mechanisms that control thrombopoiesis. in The Journal of clinical investigation 2005 (PubMed)
    Show all 6 references for 2666760

  4. Human Thrombopoietin Protein expressed in Escherichia coli (E. coli) - ABIN2667584 : Ehrenreich, Hasselblatt, Knerlich, von Ahsen, Jacob, Sperling, Woldt, Vehmeyer, Nave, Sirén: A hematopoietic growth factor, thrombopoietin, has a proapoptotic role in the brain. in Proceedings of the National Academy of Sciences of the United States of America 2005 (PubMed)
    Show all 6 references for 2667584

  5. Rat (Rattus) Thrombopoietin Protein expressed in Escherichia coli (E. coli) - ABIN2667587 : Kato, Oda, Inagaki, Ohashi, Matsumoto, Ozaki, Miyakawa, Watarai, Fuju, Kokubo, Kadoya, Ikeda, Miyazaki: Thrombin cleaves recombinant human thrombopoietin: one of the proteolytic events that generates truncated forms of thrombopoietin. in Proceedings of the National Academy of Sciences of the United States of America 1997 (PubMed)
    Show all 6 references for 2667587

  6. Mouse (Murine) Thrombopoietin Protein expressed in Escherichia coli (E. coli) - ABIN2667585 : Beutler, Cerami: Tumor necrosis, cachexia, shock, and inflammation: a common mediator. in Annual review of biochemistry 1988 (PubMed)
    Show all 3 references for 2667585

More Proteins for Thrombopoietin Interaction Partners

Zebrafish Thrombopoietin (THPO) interaction partners

  1. These studies indicate that the functional role of Tpo in the differentiation of thrombocytes from hematopoietic stem and progenitor cells is well conserved among vertebrate organisms, positing the zebrafish as an excellent model to investigate diseases caused by dysregulated erythro- and thrombo-poietic differentiation.

Human Thrombopoietin (THPO) interaction partners

  1. bone marrow megakaryocytes possess a complete mechanism to synthesize the ECM (show MMRN1 Proteins) components, and that thrombopoietin is a pivotal regulator of this new function inducing transforming growth factor-b1 (TGF-beta1 (show TGFB1 Proteins)) release and consequent activation of the downstream pathways, both in vitro and in vivo

  2. High Thrombopoietin expression is associated with immune thrombocytopenia in pregnancy.

  3. Colorectal cancer tumor-initiating cells (TICs) expressing CD110 (show MPL Proteins), the thrombopoietin (TPO)-binding receptor, mediate liver metastasis. We show that TPO promotes metastasis of CD110 (show MPL Proteins)+ TICs to the liver by activating lysine degradation.

  4. decreased TPO levels or decreased bone marrow production of platelets may not be a cause of thrombocytopenia in chronic hepatitis C

  5. WASP (show WASL Proteins), RUNX1 (show RUNX1 Proteins), and ANKRD26 genes are important for normal TPO signaling and the network underlying thrombopoiesis.

  6. Data suggest that elevated serum level of thrombopoietin may serve as unfavorable marker of stage of multiple myeloma.

  7. The regulation of OCs by TPO highlights a novel therapeutic target for bone loss diseases and may be important to consider in the numerous hematologic disorders associated with alterations in TPO/c-mpl (show MPL Proteins) signaling

  8. TPO was greatly enhanced in HPT in comparison with ITP (show ITPA Proteins) patients (958 +/- 659 and 11 +/- 27 pg/ml, p < 0.001). In the ITP (show ITPA Proteins) group a reverse correlation was detected between TPO and glycocalicin (r = -0.373, p = 0.006).

  9. observations suggest that NRP-1 (show NELL1 Proteins) is involved in megakaryocytopoiesis through complex formation with PDGFRs, and that NRP-1 (show NELL1 Proteins)-PDGFR (show PDGFRB Proteins)-complexes may contribute to effective cellular functions mediated by TPO and PDGF (show PDGFA Proteins) in megakaryocytic cells

  10. Endocytic AMR (show GPR182 Proteins) controls TPO expression through Janus kinase 2 (JAK2 (show JAK2 Proteins)) and the acute phase response signal transducer and activator of transcription 3 (STAT3 (show STAT3 Proteins)) in vivo and in vitro

Cow (Bovine) Thrombopoietin (THPO) interaction partners

  1. The results demonstrate the possible involvement of locally produced TPO (show TPO Proteins)/c-MPL (show MPL Proteins) system as a 'physiological filter' in bovine ovary where they may promote cell selection by inducing proliferation of viable cells and scavenging non-viable cells.

Mouse (Murine) Thrombopoietin (THPO) interaction partners

  1. Thrombopoietin-mediated phosphorylation of STAT5 (show STAT5A Proteins) triggers its genome-wide relocation to STAT (show STAT1 Proteins) consensus sites, resulting in loss of a uSTAT5 program that restrains megakaryocytic differentiation and activation of STAT5 (show STAT5A Proteins)-driven gene expression.

  2. Furthermore, although the contribution of the TPO treated graft to long-term hematological engraftment was reduced, the TPO treated and untreated grafts both contributed significantly to long-term chimerism in vivo.

  3. TPO treatment also promoted the peripheral induction of Foxp3 (show FOXP3 Proteins)(+) Tregs in conjunction with elevated circulating TGF-beta (show TGFB1 Proteins) levels.

  4. novel findings about aspects of TPO action on stem cells

  5. Mpl (show MPL Proteins) expression, but not Tpo, is fundamental in the development of JAK2V617F(+) myeloproliferative neoplasms

  6. Thrombopoietin/MPL (show MPL Proteins) signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 (show MECOM Proteins) leukemia.

  7. Megakaryocytes regulate cell cycle quiescence of hematopoietic stem cell through the production of thrombopoietin.

  8. IEX-1 (show IER3 Proteins) has a role in activation of Erk (show EPHB2 Proteins) and NF-kB pathways, which affects thrombopoietin-promoted NHEJ DNA repair in hematopoietic stem cells

  9. Findings establish that Clock regulates Thpo and Mpl (show MPL Proteins) expression in vivo, and demonstrate an important link between the body's circadian timing mechanisms and megakaryopoiesis.

  10. Signal transduction pathway of ERK1/2 participates in the activation of thrombopoietin in inflammatory injury of BV2 cells.

Thrombopoietin (THPO) Protein Profile

Protein Summary

Megakaryocytopoiesis is the cellular development process that leads to platelet production. The protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternate splicing results in multiple transcript variants of this gene.

Alternative names and synonyms associated with Thrombopoietin (THPO)

  • thrombopoietin (THPO)
  • thrombopoietin (thpo)
  • thrombopoietin (LOC100231762)
  • thrombopoietin (Thpo)
  • thrombopoietin-like (LOC100620258)
  • thrombopoietin-like (LOC100357079)
  • thrombopoietin-like (LOC100855822)
  • LOC100231762 protein
  • Mgdf protein
  • MKCSF protein
  • Ml protein
  • Mpllg protein
  • THCYT1 protein
  • Tpo protein
  • Tpo1 protein
  • Tpo2 protein
  • Tpo3 protein
  • Tpo4 protein

Protein level used designations for Thrombopoietin Proteins (THPO)

thrombopoietin (myeloproliferative leukemia virus oncogene ligand, megakaryocyte growth and development factor) , thrombopoietin , MPL ligand , c-mpl ligand , megakaryocyte colony-stimulating factor , megakaryocyte growth and development factor , megakaryocyte stimulating factor , myeloproliferative leukemia virus oncogene ligand , thrombopoietin nirs variant 1 , C-mpl ligand

736549 Pan troglodytes
100189608 Danio rerio
100231762 Taeniopygia guttata
100302539 Felis catus
100582097 Nomascus leucogenys
7066 Homo sapiens
538672 Bos taurus
21832 Mus musculus
81811 Rattus norvegicus
414803 Gallus gallus
607489 Canis lupus familiaris
100726592 Cavia porcellus
101119601 Ovis aries
100620258 Sus scrofa
100357079 Oryctolagus cuniculus
100855822 Canis lupus familiaris
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