Thrombopoietin Protein (THPO) (AA 22-356)
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- Target See all Thrombopoietin (THPO) Proteins
- Thrombopoietin (THPO)
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 22-356
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Origin
- Mouse
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Source
- CHO Cells
- Characteristics
- ED50 < 2 ng /mL, measured in a proliferation assay using MO7e cells.
- Purity
- > 95 % as analyzed by SDS-PAGE.
- Endotoxin Level
- < 0.2 EU/μg, determined by LAL method.
- Top Product
- Discover our top product THPO Protein
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Thrombopoietin (THPO) (AA 22-195) protein (His-IF2DI Tag)
THPO Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Thrombopoietin (THPO) (AA 23-195) protein (His tag)THPO Origin: Mouse Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Thrombopoietin (THPO) protein (His tag)THPO Origin: Mouse Host: Human Cells Recombinant > 95 % as determined by SDS-PAGE
Thrombopoietin (THPO) (AA 1-349) protein (GST tag)THPO Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Thrombopoietin (THPO) (AA 22-356) protein (His tag)Crystallography grade THPO Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Thrombopoietin (THPO) proteinTHPO Origin: Mouse Host: Escherichia coli (E. coli) Recombinant
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Reconstituted in ddH2O or PBS at 100 μg/mL..
- Buffer
- Lyophilized after extensive dialysis against PBS.
- Storage
- -80 °C
- Storage Comment
- Lyophilized recombinant murine Thrombopoietin (TPO) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, murine Thrombopoietin (TPO) should be stable up to 1 week at 4 °C or up to 2 months at -20 °C.
- Expiry Date
- 6 months
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- Target
- Thrombopoietin (THPO)
- Alternative Name
- Thrombopoietin (TPO) (THPO Products)
- Synonyms
- MGDF Protein, MKCSF Protein, ML Protein, MPLLG Protein, THCYT1 Protein, TPO Protein, Mgdf Protein, Ml Protein, Mpllg Protein, Tpo Protein, Tpo1 Protein, Tpo2 Protein, Tpo3 Protein, Tpo4 Protein, tpo Protein, LOC100231762 Protein, thrombopoietin Protein, THPO Protein, Thpo Protein, thpo Protein
- Background
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Thrombopoietin (TPO), also known as C-mpl ligand, MGDF and Thpo, is a glycoprotein hormone belonging to the EPO/TPO family. It is expressed mainly in the liver, kidney and skeletal muscle. TPO binds and signals through MLP/C_MPL receptor. It stimulates the proliferation and maturation of megakaryocytes from their committed progenitor cells, and it regulates the production and circulation of platelets. TPO has also been reported to promote the apoptosis of hypoxia-sensitized neurons and to inhibit neuronal differentiation.
Synonyms: Thrombopoietin, Megakaryocyte colony-stimulating factor, c-MPL Ligand, MGDF - Molecular Weight
- 30-80 kDa, observed by reducing SDS-PAGE.
- UniProt
- P40226
- Pathways
- JAK-STAT Signaling, Hormone Activity
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