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anti-Human AKAP9 Antibodies:
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Human Monoclonal AKAP9 Primary Antibody for IF, WB - ABIN968571
Lin, Wyszynski, Madhavan, Sealock, Kim, Sheng: Yotiao, a novel protein of neuromuscular junction and brain that interacts with specific splice variants of NMDA receptor subunit NR1. in The Journal of neuroscience : the official journal of the Society for Neuroscience 1998
Show all 3 Pubmed References
Human Polyclonal AKAP9 Primary Antibody for ICC, IF - ABIN4278930
Oldenburger, Poppinga, Kos, de Bruin, Rijks, Heijink, Timens, Meurs, Maarsingh, Schmidt: A-kinase anchoring proteins contribute to loss of E-cadherin and bronchial epithelial barrier by cigarette smoke. in American journal of physiology. Cell physiology 2014
Show all 2 Pubmed References
Human Polyclonal AKAP9 Primary Antibody for IHC, ELISA - ABIN250389
Christian, Szaszák, Friedl, Drewianka, Lorenz, Goncalves, Furkert, Vargas, Schmieder, Götz, Zühlke, Moutty, Göttert, Joshi, Reif, Haase, Morano, Grossmann, Klukovits, Verli, Gáspár, Noack, Bergmann et al.: Small molecule AKAP-protein kinase A (PKA) interaction disruptors that activate PKA interfere with compartmentalized cAMP signaling in cardiac myocytes. ... in The Journal of biological chemistry 2011
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Dog (Canine) Polyclonal AKAP9 Primary Antibody for ELISA - ABIN4252975
Frank, Wiestler, Kropp, Hemminki, Spurdle, Sutter, Wappenschmidt, Chen, Beesley, Hopper, Meindl, Kiechle, Slanger, Bugert, Schmutzler, Bartram, Flesch-Janys, Mutschelknauss, Ashton, Salazar, Webb et al.: Association of a common AKAP9 variant with breast cancer risk: a collaborative analysis. ... in Journal of the National Cancer Institute 2008
Human Monoclonal AKAP9 Primary Antibody for ICC, IF - ABIN261462
Gorshkov, Mehta, Ramamurthy, Ronnett, Zhou, Zhang: AKAP-mediated feedback control of cAMP gradients in developing hippocampal neurons. in Nature chemical biology 2017
Data suggest that CDK5RAP2 and CEP170 both interact with microtubule nucleation-promoting region of AKAP350A; CEP68 interacts with distal C-terminal region of AKAP350A; AKAP350A spans the bridge between centrioles. (CDK5RAP2 = CDK5 regulatory subunit associated protein 2; CEP170 = centrosomal protein 170kDa; AKAP350A = A kinase (PRKA) anchor protein (yotiao) 9; CEP68 = centrosomal protein 68kDa)
Findings suggest MALAT1 increases AKAP-9 expression by promoting SRPK1 (show SRPK1 Antibodies)-catalyzed SRSF1 (show SRSF1 Antibodies) phosphorylation in CRC (show CALR Antibodies) cells. These results reveal a novel molecular mechanism by which MALAT1 regulates AKAP-9 expression in CRC (show CALR Antibodies) cells.
AKAP9 gene harbors not only somatic frameshift mutations but also mutational ITH.
results support a model in which AKAP350 recruits CIP4 to the centrosome, providing a centrosomal scaffold to integrate microtubule and actin dynamics, thus enabling centrosome polarization and ensuring cell migration directionality.
Study suggests a role of rare missense variants at NRXN1 (show NRXN1 Antibodies) and AKAP9 in schizophrenia susceptibility, probably related to alteration of the excitatory/inhibitory synaptic balance, deserving further investigation
This study demonstrated that two rare AKAP9 variants( rs144662445 and rs149979685) are associated with Alzheimer's disease in African Americans.
AKAP9 has been identified as a Long QT Syndrome Type 1 modifying gene
data indicate that MALAT1 may promote CRC (show CALR Antibodies) tumor development via its target protein AKAP-9
A590T mutation in KCNQ1 (show KCNQ1 Antibodies) C-terminal helix D decreases KCNE1 (show KCNE1 Antibodies) channel trafficking and function but not Yotiao interaction.
AKAP (show AKAP1 Antibodies) proteins, most likely AKAP9, maintain the bronchial epithelial barrier by regulating the E-cadherin (show CDH1 Antibodies) expression at the cell membrane.
AKAP9 and, by inference, the regulation of the microtubule network are critical for blood-testis barrier function and subsequent germ cell development during spermatogenesis
AKAP9 is dispensable for T cell priming and migration into tissues and lymph nodes, but is required for T cell retention in tissues.
We postulate that this novel interaction linking MVI with the PKA pathway could be important for targeting AKAP9-PKA complex within cells and/or providing PKA to phosphorylate MVI tail domain.
Overexpression of an AKAP450 fragment containing the CK1delta-binding site inhibits Golgi-derived microtubule nucleation, Golgi distribution of intraflagellar transport protein 20 homologue, and ciliogenesis.
Mutations in Akap9 disrupt Sertoli cell maturation, gap and tight junctions and localization of zona occluden-1 and connexin43 (show GJA1 Antibodies).
in heart, Yotiao brings together PKA, PP1 (show PPP1CC Antibodies), PDE4D3, AC9 (show ADCY9 Antibodies), and the I(Ks) channel to achieve localized temporal regulation of beta-adrenergic stimulation.
Expression of Akap9 in the mouse striatum is modulated by a sequence variant (B2 SINE indel) in the 3' UTR (show UTS2R Antibodies) of Comt (catechol-O-methyltransferase (show COMT Antibodies)).
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternate splicing of this gene results in at least two isoforms that localize to the centrosome and the Golgi apparatus, and interact with numerous signaling proteins from multiple signal transduction pathways. These signaling proteins include type II protein kinase A, serine/threonine kinase protein kinase N, protein phosphatase 1, protein phosphatase 2a, protein kinase C-epsilon and phosphodiesterase 4D3.
A-kinase anchor protein 350 kDa
, A-kinase anchor protein 450 kDa
, A-kinase anchor protein 9
, AKAP 120-like protein
, AKAP9-BRAF fusion protein
, centrosome- and Golgi-localized PKN-associated protein
, kinase N-associated protein
, protein hyperion
, protein kinase A anchoring protein 9
, protein phosphatase 1, regulatory subunit 45
, protein yotiao
, protein kinase A-anchoring protein 9
, GABA-B receptor-interacting scaffolding protein
, hyperion protein, 419 kD isoform
, A kinase (PRKA) anchor protein (yotiao) 9
, a-kinase anchor protein 9
, a-kinase anchor protein 9-like
, A kinase (PRKA) anchor protein 9
, A-kinase anchoring protein AKAP120
, A-kinase anchor protein 120 kDa
, AKAP 120
, myocyte A kinase anchor protein