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anti-Mouse (Murine) Cep76 Antibodies:
anti-Rat (Rattus) Cep76 Antibodies:
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Human Polyclonal Cep76 Primary Antibody for ELISA, WB - ABIN1534756
Andersen, Wilkinson, Mayor, Mortensen, Nigg, Mann: Proteomic characterization of the human centrosome by protein correlation profiling. in Nature 2003
Here, we found that centrosomal protein of 76 kDa (Cep76), previously shown to restrain centriole amplification, interacts with cyclin-dependent kinase 2 (CDK2 (show CDK2 Antibodies)) and is a bona fide substrate of this kinase. Cep76 is preferentially phosphorylated by cyclin A (show CCNA2 Antibodies)/CDK2 (show CDK2 Antibodies) at a single site S83, and this event is crucial to suppress centriole amplification in S phase
Enforced Cep76 expression specifically inhibits centriole amplification in cells undergoing multiple rounds of duplication without preventing the formation of extra procentrioles from a parental template.
This gene encodes a centrosomal protein which regulates centriole amplification by limiting centriole duplication to once per cell cycle. Alternative splicing results in multiple transcript variants.
centrosomal protein 76kDa
, centrosomal protein of 76 kDa
, centrosomal protein of 76 kDa-like