Browse our Cullin 3 Proteins (CUL3)

On are 6 Cullin 3 (CUL3) Proteins from 4 different suppliers available. Additionally we are shipping Cullin 3 Antibodies (96) and many more products for this protein. A total of 107 Cullin 3 products are currently listed.
AI467304, ATCUL3, ATCUL3A, AW146203, CUL-3, CUL-3-A, CUL-3-B, CUL3, CUL3A, cul3b, Cullin-3, Cullin-3-A, Cullin-3-B, cullin 3, cullin 3A, mKIAA0617, PHA2E, T24P13.25, wu:fc37e01
list all proteins Gene Name GeneID UniProt
CUL3 8452 Q13618
CUL3 26554 Q9JLV5
CUL3 301555  

Cullin 3 Proteins (CUL3) by Origin

More Proteins for Cullin 3 Interaction Partners

Arabidopsis thaliana Cullin 3 (CUL3) interaction partners

  1. Data show that CUL3 and BPM proteins assemble in planta with WRI1.

  2. The plasma membrane-associated phototropic receptor phot1 is ubiquitinated in response to blue light activation. Ubiquitination of phot1 is dependent upon both the phot1-interacting proteins NPH3 and CUL3.

  3. AtCUL3a and AtCUL3b can assemble in Arabidopsis with BTB/POZ-MATH and AtRBX1 proteins to form functional E3 ligases. [AtCUL3a]

  4. CUL3A is ubiquitously expressed in plants and is able to interact with the ring-finger protein (show TRIM31 Proteins) RBX1 (show RBX1 Proteins). [CUL3A]

  5. Arabidopsis CUL3A gene is essential for normal embryogenesis.

  6. work highlights that CUL3 is essential for the normal division and organisation of the root stem cell niche and columella root cap cells

  7. CUL3a and CUL3b are essential for plant development [CUL3a]

Human Cullin 3 (CUL3) interaction partners

  1. p97 (show EIF4G2 Proteins) negatively regulates NRF2 (show GABPA Proteins) through the canonical pathway by extracting ubiquitylated NRF2 (show GABPA Proteins) from the KEAP1 (show KEAP1 Proteins)-CUL3 E3 complex.

  2. CUL3 interacts with ACLY (show ACLY Proteins) through its adaptor protein, KLHL25 (Kelch-like family member 25), to ubiquitinate and degrade ACLY (show ACLY Proteins) in cells

  3. this work identifies both calcium and CUL3 co-adaptors as important regulators of ubiquitylation events that control human development.

  4. Together, the data indicate that a CUL3-SPOPL (show SPOPL Proteins) E3 ubiquitin ligase (show MUL1 Proteins) complex regulates endocytic trafficking and formation of multivesicular bodies by ubiquitinating and degrading EPS15 (show EPS15 Proteins) at endosomes.

  5. Data show that Cullin3 exerts its function through promoting breast-cancer metastasis suppressor 1 (BRMS1 (show BRMS1 Proteins)) protein degradation, which was associated with epithelial-mesenchymal transition (EMT (show ITK Proteins)), migration and invasion.

  6. CUL3 acts as a tumor suppressor by regulating oxidative stress

  7. The authors find that the KCTD proteins 5, 6, 9 and 17 bind to Cul3 with high affinity, while the KCTD proteins 1 and 16 do not have detectable binding.

  8. Study identifies a key role of Cul3-KLHL20 (show KLHL20 Proteins) in autophagy termination by controlling autophagy-dependent turnover of ULK1 (show ULK1 Proteins) and VPS34 (show PIK3C3 Proteins) complex subunits and reveals the pathophysiological functions of this autophagy termination mechanism.

  9. Data show that the differentiation of LiSa-2 preadipocytes is associated with an increase of cullin-associated and neddylation-dissociated 1 (CAND1 (show CAND1 Proteins)), COP9 (show COPS8 Proteins) signalosome (CSN), neddylated cullin 3 (Cul3) and the BTB protein Keap1 (show KEAP1 Proteins).

  10. Heterodimeric CUL3 proteinubiquitylates TIAM1.CUL3 regulates TIAM1 abundance and subsequent RAC1 signaling.

Mouse (Murine) Cullin 3 (CUL3) interaction partners

  1. Data (including data from studies using cells cultured from knockout mice) suggest that Sccro (show DCUN1D1 Proteins) neddylates Cul3 with Nedd8 (show NEDD8 Proteins), promoting Cul3/Klhl21 (show KLHL21 Proteins) complex formation and localization of Cul3 during telophase. (Sccro (show DCUN1D1 Proteins) = squamous cell carcinoma-related oncogene (show DCUN1D2 Proteins); Cul3 = cullin 3; Nedd8 (show NEDD8 Proteins) = neural precursor cell expressed, developmentally down-regulated protein 8; Klhl21 (show KLHL21 Proteins) = kelch-like protein 21 (show KLHL21 Proteins))

  2. Myeloid deletion of Cul3 led to defective STAT3 (show STAT3 Proteins) phosphorylation in colon macrophages, which was accompanied by exacerbated colonic inflammation and inflammation-driven tumorigenesis.

  3. Results showed that in the basal state, the amount of Keap1 (show KEAP1 Proteins) and Cul3 proteins were maintained at higher levels than that of Nrf2 (show NFE2L2 Proteins), and remained the same even under oxidative and electrophilic stimuli.

  4. Suggest that the hyperkalemia in knock-in mouse with the CUL3(Delta403-459) mutation is not caused by reduced ROMK (show KCNJ1 Proteins) expression in the distal nephron.

  5. Study identifies a key role of Cul3-KLHL20 (show KLHL20 Proteins) in autophagy termination by controlling autophagy-dependent turnover of ULK1 (show ULK1 Proteins) and VPS34 (show PIK3C3 Proteins) complex subunits and reveals the pathophysiological functions of this autophagy termination mechanism.

  6. These results suggest that KLHL2 (show KLHL2 Proteins) likely plays a role in the pathogenesis of FHHt, and aggravates the phenotype caused by mutations in CUL3 and WNK4 (show WNK4 Proteins).

  7. Hypoxia-responsive miR (show MLXIP Proteins)-101 stimulates angiogenesis by activating the HO-1 (show HMOX1 Proteins)/VEGF (show VEGFA Proteins)/eNOS (show NOS3 Proteins) axis via Cul3 targeting

  8. Mutation of cul3 protein is involved in the development of renal hypertension and chronic kidney diseases.

  9. Data show that Bcl6 (show BCL6 Proteins) (B cell lymphoma 6)-cullin 3 complexes provide essential negative feedback regulation during both thymocyte development and T cell activation to restrain excessive T follicular helper (Tfh) responses.

  10. Knockdown of Cullin-3 or inhibition of cullin-RING ligase activity in aortic smooth muscle cells increased RhoA (show RHOA Proteins).

Caenorhabditis elegans (C. elegans) Cullin 3 (CUL3) interaction partners

  1. KEL-8 is a substrate receptor for Cullin 3 ubiquitin ligases that is required for the proteolysis of GLR-1 receptors and suggest a novel postmitotic role in neurons for Kelch/CUL3 ubiquitin ligases.

  2. The BTB-containing protein MEL-26 is a component required for degradation of MEI-1 (show MEI1 Proteins) in vivo; importantly, MEL-26 specifically interacts with CUL-3 and MEI-1 (show MEI1 Proteins) in vivo and in vitro, and displays properties of a substrate-specific adaptor

  3. the identification of a large family of BTB-domain proteins as substrate-specific adaptors for C. elegans CUL-3

  4. FIGL-1 by the CUL-3MEL-26 E3 ligase spatially restricts FIGL-1 function to mitotic cells, where it is required for correct progression through mitosis.

  5. cullin (CUL)-3 as a component of E3 ligase and KEL-8 as the substrate adaptor of RPY-1.

Cullin 3 (CUL3) Protein Profile

Protein Summary

This gene encodes a member of the cullin protein family. The encoded protein plays a critical role in the polyubiquitination and subsequent degradation of specific protein substrates as the core component and scaffold protein of an E3 ubiquitin ligase complex. Complexes including the encoded protein may also play a role in late endosome maturation. Mutations in this gene are a cause of type 2E pseudohypoaldosteronism. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Alternative names and synonyms associated with Cullin 3 (CUL3)

  • cullin 3 (CUL3)
  • cullin 3 (cul3)
  • cullin 3 (cul3-a)
  • cullin 3 (cul3-b)
  • cullin-3 (PTRG_11586)
  • Cullin-3 (CUL-3) (Smp_117580)
  • cullin 3a (cul3a)
  • cullin 3 (Cul3)
  • Protein CUL-3 (cul-3)
  • AI467304 protein
  • ATCUL3 protein
  • ATCUL3A protein
  • AW146203 protein
  • CUL-3 protein
  • CUL-3-A protein
  • CUL-3-B protein
  • CUL3 protein
  • CUL3A protein
  • cul3b protein
  • Cullin-3 protein
  • Cullin-3-A protein
  • Cullin-3-B protein
  • cullin 3 protein
  • cullin 3A protein
  • mKIAA0617 protein
  • PHA2E protein
  • T24P13.25 protein
  • wu:fc37e01 protein

Protein level used designations for Cullin 3 Proteins (CUL3)

cullin-3 , cullin-3-A , cullin-3-B , Cullin-3 (CUL-3) , cullin 3 , CUL-3

100061420 Equus caballus
548729 Xenopus (Silurana) tropicalis
446487 Xenopus laevis
444103 Xenopus laevis
6349903 Pyrenophora tritici-repentis Pt-1C-BFP
8349090 Schistosoma mansoni
324655 Danio rerio
744812 Pan troglodytes
839226 Arabidopsis thaliana
8452 Homo sapiens
26554 Mus musculus
301555 Rattus norvegicus
424804 Gallus gallus
477392 Canis lupus familiaris
534325 Bos taurus
178547 Caenorhabditis elegans
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