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Study found that in peripheral blood mononuclear cells the median expression of KIFC3, KIF1B, and KIF5C (show KIF5C Proteins) was much lower than the expression of dynactin (show DCTN1 Proteins) subunits DCTN1 (show DCTN1 Proteins) and DCTN3, in both sporadic amyotrophic lateral sclerosis and healthy cases
This gene encodes the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex. It is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin. Alternative splicing of this gene generates 2 transcript variants.
dynactin subunit 3
, dynactin 3 (p22)
, dynactin light chain (P24)
, dynactin light chain p24
, p24 dynactin light chain
, dynactin complex subunit 22 kDa subunit
, dynactin light chain