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Browse our anti-Optineurin (OPTN) Antibodies

Full name:
anti-Optineurin Antibodies (OPTN)
On www.antibodies-online.com are 92 Optineurin (OPTN) Antibodies from 22 different suppliers available. Additionally we are shipping Optineurin Kits (11) and Optineurin Proteins (8) and many more products for this protein. A total of 125 Optineurin products are currently listed.
Synonyms:
4930441O07Rik, ALS12, Fip2, fj52f04, GLC1E, HIP7, HYPL, NRP, si:ch211-240l19.3, TFIIIA-INTP, wu:fj52f04, zgc:66386, zgc:77868

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Top referenced anti-Optineurin Antibodies

  1. Cow (Bovine) Polyclonal OPTN Primary Antibody for WB - ABIN2781486 : Morton, Hesson, Peggie, Cohen: Enhanced binding of TBK1 by an optineurin mutant that causes a familial form of primary open angle glaucoma. in FEBS letters 2008 (PubMed)

  2. Human Polyclonal OPTN Primary Antibody for ICC, IF - ABIN4341482 : Smith, Sewell, Levine, Chew, Dunne, OShea, Smith, Harrison, Macdonald, Bloom, Segal: Disruption of macrophage pro-inflammatory cytokine release in Crohn's disease is associated with reduced optineurin expression in a subset of patients. in Immunology 2014 (PubMed)

More Antibodies against Optineurin Interaction Partners

Human Optineurin (OPTN) interaction partners

  1. The present study provides insight into the genetic or haplotype variants of MYOC (show MYOC Antibodies) and OPTN genes contributing to primary glaucoma. Haplotype variants identified in the present study may be regarded as potential contributing factors of primary glaucoma in Korea.

  2. the E50K OPTN mutation markedly reduced the levels of miR (show MLXIP Antibodies)-9, which led to alterations in REST and reduced expression levels of BDNF (show BDNF Antibodies) in RGC-5 cells.

  3. ALS (show IGFALS Antibodies)-linked mutations in OPTN and TBK1 (show TBK1 Antibodies) can interfere with mitophagy, suggesting that inefficient turnover of damaged mitochondria may represent a key pathophysiological mechanism contributing to neurodegenerative disease.

  4. We conclude that OPTN mutations are associated with Amyotrophic lateral sclerosis

  5. In combination with phosphorylation of S177 and S513, this posttranslational modification promotes recruitment and retention of OPTN/TBK1 (show TBK1 Antibodies) on ubiquitinated, damaged mitochondria

  6. Familial linkage studies for primary angle-closure glaucoma have been performed and identified OPTN causative primary angle-closure glaucoma disease

  7. Nine OPTN variants were identified in Chinese sporadic ALS patients, including 5 known SNPs and four novel missense mutations: c.407C > T (p.A136V), c.1184A > G (p.K395R), c.1352T > C (p.I451T), and c.1546G > C (p.E516Q) (all heterozygous).

  8. OPTN 691_692insAG is a founder mutation in Moroccan and Ashkenazi Jews with ALS.

  9. A polymorphism of optineurin, M98K, associated with glaucoma, causes enhanced autophagy leading to transferrin receptor degradation and apoptotic death of retinal cells.

  10. Optineurin can also mediate the removal of protein aggregates through an ubiquitin-independent mechanism. This protein in addition can induce autophagy upon overexpression or mutation.

Mouse (Murine) Optineurin (OPTN) interaction partners

  1. Report establishes optineurin as a positive regulator TBK1 (show TBK1 Antibodies) via a bipartite interaction between these molecules.

  2. OPTN-deficient mice were more susceptible to infection with Salmonella, confirming in vivo the importance of OPTN in bacterial clearance.

  3. Optineurin knockdown enhances osteoclast differentiation. Optineurin inhibits osteoclast formation by modulating NF-kappaB (show NFKB1 Antibodies) and IFN-beta (show IFNB1 Antibodies) signaling.

  4. Mutation in Optineurin gene is associated with Glaucoma.

  5. Disruption in optineurin and myosin VI (show MYO6 Antibodies)-mediated cellular trafficking is associated with amyotrophic lateral sclerosis.

  6. OPTN plays a role in acute inflammation and neutrophil recruitment, potentially via defective macrophage proinflammatory cytokine secretion.

  7. that ubiquitin (Ub)-binding domain mutants compromise the maturation of autophagosomes, which in turn interfered with optineurin-mediated autophagy and clearance of inclusion bodies

  8. results indicated that optineurin trimers may be the basic unit of these oligomers. The oligomeric state can be affected by many factors that induce covalent bonds, such as H2O2 or E50K

  9. Loss of optineurin in vivo results in elevated cell death and alters axonal trafficking dynamics

  10. HACE1 (show HACE1 Antibodies)-OPTN axis synergistically suppresses growth and tumorigenicity of lung cancer cells.

Zebrafish Optineurin (OPTN) interaction partners

  1. Loss of optineurin in vivo results in elevated cell death and alters axonal trafficking dynamics

Rhesus Monkey Optineurin (OPTN) interaction partners

  1. The optineurin gene and protein are evolutionary conserved between humans and the rhesus monkey. High similarity of ocular expression and tissue distribution between the two optineurin proteins.

Optineurin (OPTN) Antigen Profile

Antigen Summary

This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.

Alternative names and synonyms associated with Optineurin (OPTN)

  • optineurin (OPTN) antibody
  • optineurin (optn) antibody
  • optineurin (LOC100219034) antibody
  • optineurin (Optn) antibody
  • 4930441O07Rik antibody
  • ALS12 antibody
  • Fip2 antibody
  • fj52f04 antibody
  • GLC1E antibody
  • HIP7 antibody
  • HYPL antibody
  • NRP antibody
  • si:ch211-240l19.3 antibody
  • TFIIIA-INTP antibody
  • wu:fj52f04 antibody
  • zgc:66386 antibody
  • zgc:77868 antibody

Protein level used designations for anti-Optineurin (OPTN) Antibodies

optineurin , optineurin-like , E3-14.7K-interacting protein , FIP-2 , HIP-7 , Huntingtin interacting protein L , huntingtin yeast partner L , huntingtin-interacting protein 7 , huntingtin-interacting protein L , nemo-related protein , optic neuropathy-inducing protein , transcription factor IIIA-interacting protein , transcrption factor IIIA-interacting protein , tumor necrosis factor alpha-inducible cellular protein containing leucine zipper domains , 14.7K-interacting protein 2 , FIP-2-like protein , TFIIIA-INTP , ag9-C5

GENE ID SPECIES
736417 Pan troglodytes
100144665 Xenopus (Silurana) tropicalis
100195260 Salmo salar
100219034 Taeniopygia guttata
100398129 Callithrix jacchus
100597487 Nomascus leucogenys
10133 Homo sapiens
246294 Rattus norvegicus
478003 Canis lupus familiaris
397011 Sus scrofa
534150 Bos taurus
71648 Mus musculus
336159 Danio rerio
496250 Xenopus laevis
374079 Gallus gallus
100172952 Pongo abelii
574252 Macaca mulatta
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