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Browse our SPAG5 Proteins (SPAG5)

Full name:
Sperm Associated Antigen 5 Proteins (SPAG5)
On www.antibodies-online.com are 4 Sperm Associated Antigen 5 (SPAG5) Proteins from 3 different suppliers available. Additionally we are shipping SPAG5 Antibodies (33) and SPAG5 Kits (3) and many more products for this protein. A total of 42 SPAG5 products are currently listed.
Synonyms:
AI874642, D11Bhm180e, Deepest, hMAP126, MAP126, Mastrin, S17, SPAG5
list all proteins Gene Name GeneID UniProt
SPAG5 10615 Q96R06
SPAG5 54141 Q7TME2
Rat SPAG5 SPAG5 252918  

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SPAG5 Proteins (SPAG5) by Origin

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Human Sperm Associated Antigen 5 (SPAG5) interaction partners

  1. findings reveal a direct physical link between two important regulators of mitotic progression and demonstrate the critical role of the NuMA-Astrin interaction for accurate cell division.

  2. Mechanistically, Plk1 acts as an upstream kinase for Astrin phosphorylation by Cdk1 (show CDK1 Proteins) and targeting phospho-Astrin to KTs, leading to the recruitment of outer KT components, such as Cenp-E (show CENPE Proteins), and the stable attachment of spindles to KTs.

  3. Results showed a progression-driving role of SPAG5 in prostate cancer which can be regulated by miR (show MLXIP Proteins)-539.

  4. Molecular requirements for the inter-subunit interaction and kinetochore recruitment of SKAP (show KNSTRN Proteins) and Astrin have been reported.

  5. SPAG5 upregulation relates to poor prognosis in cervical cancer patients, and SPAG5 is a regulator of mTOR (show FRAP1 Proteins) activity during taxol treatment in cervical cancer.

  6. Astrin acts as a mitotic phosphoprotein during the regulation of mitosis.

  7. Study identifies astrin as an essential negative mTORC1 regulator in the cellular stress response. Upon stress, astrin inhibits mTORC1 association and recruits the mTORC1 component raptor (show RPTOR Proteins) to stress granules, thereby preventing mTORC1-hyperactivation-induced apoptosis.

  8. Data show that CLASP1 (show CLASP1 Proteins)-astrin-Kif2b (show KIF2B Proteins) complex acts as a central switch at kinetochores that defines mitotic progression and promotes fidelity by temporally regulating kinetochore-microtuble attachments.

  9. These findings suggest that the silencing of astrin induce a p53 (show TP53 Proteins)-dependent apoptosis and has an additive effect on paclitaxel treatment.

  10. a model is proposed wherein hNinein (show NIN Proteins) regulates the dynamic movement of Astrin throughout the cell cycle and this interaction, in turn, is required for maintenance of centrosome/spindle pole integrity.

Mouse (Murine) Sperm Associated Antigen 5 (SPAG5) interaction partners

  1. cloning and genomic structure of mastrin; mastrin protein was demonstrated to localize to mitotic spindles during mitosis[masatrin]

  2. Loss-of-function of Astrin by RNAi and overexpression of the coiled-coil domain results in spindle disorganization, chromosome misalignment and meiosis progression arrest.

SPAG5 Protein Profile

Protein Summary

This gene encodes a protein associated with the mitotic spindle apparatus. The encoded protein may be involved in the functional and dynamic regulation of mitotic spindles.

Alternative names and synonyms associated with SPAG5

  • sperm associated antigen 5 (SPAG5)
  • sperm associated antigen 5 (Spag5)
  • AI874642 protein
  • D11Bhm180e protein
  • Deepest protein
  • hMAP126 protein
  • MAP126 protein
  • Mastrin protein
  • S17 protein
  • SPAG5 protein

Protein level used designations for SPAG5

sperm associated antigen 5 , sperm-associated antigen 5-like , astrin , mitotic spindle associated protein p126 , mitotic spindle coiled-coil related protein , mitotic spindle-associated protein p126 , sperm-associated antigen 5 , microtubule-associated protein

GENE ID SPECIES
709400 Macaca mulatta
739263 Pan troglodytes
100059272 Equus caballus
100286810 Sus scrofa
100466628 Ailuropoda melanoleuca
100602580 Nomascus leucogenys
10615 Homo sapiens
54141 Mus musculus
252918 Rattus norvegicus
480623 Canis lupus familiaris
504585 Bos taurus
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