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anti-Mouse (Murine) DAP Kinase 1 Antibodies:
anti-Rat (Rattus) DAP Kinase 1 Antibodies:
anti-Human DAP Kinase 1 Antibodies:
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Human Polyclonal DAP Kinase 1 Primary Antibody for EIA, IHC (p) - ABIN359411
Shohat, Spivak-Kroizman, Cohen, Bialik, Shani, Berrisi, Eisenstein, Kimchi: The pro-apoptotic function of death-associated protein kinase is controlled by a unique inhibitory autophosphorylation-based mechanism. in The Journal of biological chemistry 2001
Show all 3 references for ABIN359411
Human Monoclonal DAP Kinase 1 Primary Antibody for IF, IP - ABIN967884
Cohen, Feinstein, Kimchi: DAP-kinase is a Ca2+/calmodulin-dependent, cytoskeletal-associated protein kinase, with cell death-inducing functions that depend on its catalytic activity. in The EMBO journal 1997
Show all 2 references for ABIN967884
Human Polyclonal DAP Kinase 1 Primary Antibody for IF (p), IHC (p) - ABIN732983
Liu, Ao, Zhou, Cui, Zhou, Yuan, Xiang, Cao, Liu: CpG island hypermethylation of multiple tumor suppressor genes associated with loss of their protein expression during rat lung carcinogenesis induced by 3-methylcholanthrene and diethylnitrosamine. in Biochemical and biophysical research communications 2010
This study demonstrate that phosphorylation of Tau at Serine 262 by the kinase domain of DAPK1 mediates spine damage and the subsequent neuronal death in ischemic stroke.
DAPK1-p53 (show TP53 Antibodies) interaction is a preferred target for therapeutic intervention of stroke.
Suggest that DAPK1 is a novel regulator of tau protein abundance, and that DAPK1 upregulation might contribute to tau-related pathologies in Alzheimer disease.
the DAPK1-p53 (show TP53 Antibodies) interaction is a signaling point of convergence of necrotic and apoptotic pathways
a new function of DAPK in suppressing TNF (show TNF Antibodies)-induced STAT3 (show STAT3 Antibodies) activation, was identified.
TSC2 (show TSC2 Antibodies) binds to the death domain of DAPK. This interaction is required for TSC2 (show TSC2 Antibodies) to reduce DAPK protein levels and half-life. DAPK is regulated by the lysosome pathway. Lysosome inhibition blocks TSC2 (show TSC2 Antibodies)-mediated degradation of DAPK.
Results identify DAPK as a molecule required for full production of IL-1beta (show IL1B Antibodies) and functional assembly of the NLRP3 (show NLRP3 Antibodies) inflammasome.
Study reports that cerebral ischemia recruits death-associated protein kinase 1 (DAPK1) into the NMDA receptor NR2B (show GRIN2B Antibodies) protein complex in the cortex of adult mice.
Death-associated protein kinase (DAPK) is regulated by DANGER which binds directly to DAPK and inhibits catalytic activity.
cellular activities of DAPK are critical for antagonizing caspase (show CASP3 Antibodies)-dependent apoptosis to promote cell survival under normal cell growth conditions.
Our meta-analysis results reveal that DAPK promoter methylation might be associated with tumor metastasis and poor prognosis in NSCLC patients, although no correlation with histological types and TNM (show ODZ1 Antibodies) stage in NSCLC patients were found.
Results identified MGMT (show MGMT Antibodies) and DAPK1 as predictors of nodal metastasis in oral and oropharyngeal squamous cell carcinoma with a high predictive value and specificity and sensitivity.
Viral infection induced DAPK1-IRF7 (show IRF7 Antibodies) and DAPK1-IRF3 (show IRF3 Antibodies) interactions and overexpression of DAPK1 enhanced virus-induced activation of the interferon (show IFNA Antibodies)-stimulated response element (ISRE) and IFN-beta (show IFNB1 Antibodies) promoters and the expression of the IFNB1 (show IFNB1 Antibodies) gene.
DAPK1 is highly expressed in the peritumoral region of glioblastoma multiforme brain neoplasms.
A significant strong association between DAPK1 promoter methylation and CC was shown and confirmed independently by histological tumor type, method used to evaluate methylation and source of control samples.
miR (show MLXIP Antibodies)-191-DAPK1 axis may play an important role modulating the response of ovarian endometriosis and endometrioid carcinoma cells to TNF-alpha (show TNF Antibodies).
The authors discuss evidence suggesting potential contributions of DAPK in the regulation of gut (show GUSB Antibodies) inflammation and intestinal homeostasis. [review]
Besides mediating the anticancer effect, pDAPK(S308) may serve as a predictive biomarker for Raf (show RAF1 Antibodies) inhibitors combination therapy, suggesting an ideal preclinical model that is worthy of clinical translation.
These data define a novel link between DAPK and HSF1 (show HSF1 Antibodies) and highlight a positive-feedback loop in DAPK regulation under mild inflammatory stress conditions in colorectal tumors.
high DAPK1 expression causes increased cancer cell growth and enhanced signaling via the mTOR (show FRAP1 Antibodies)/S6K (show RPS6KB1 Antibodies) pathway; evaluation of breast cancer patient data sets revealed that high DAPK1 expression associates with worse outcomes in women with p53 (show TP53 Antibodies)-mutant cancers
Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate.
death-associated protein kinase 1
, death-associated protein kinase 1-like
, DAP kinase 1