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anti-Mouse (Murine) DAP Kinase 1 Antibodies:
anti-Rat (Rattus) DAP Kinase 1 Antibodies:
anti-Human DAP Kinase 1 Antibodies:
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Human Polyclonal DAP Kinase 1 Primary Antibody for EIA, IHC (p) - ABIN359411
Shohat, Spivak-Kroizman, Cohen, Bialik, Shani, Berrisi, Eisenstein, Kimchi: The pro-apoptotic function of death-associated protein kinase is controlled by a unique inhibitory autophosphorylation-based mechanism. in The Journal of biological chemistry 2001
Show all 3 references for ABIN359411
Human Monoclonal DAP Kinase 1 Primary Antibody for IF, IP - ABIN967884
Cohen, Feinstein, Kimchi: DAP-kinase is a Ca2+/calmodulin-dependent, cytoskeletal-associated protein kinase, with cell death-inducing functions that depend on its catalytic activity. in The EMBO journal 1997
Show all 2 references for ABIN967884
Human Monoclonal DAP Kinase 1 Primary Antibody for IP, MA - ABIN265776
Hearnden, Powers, Elmogassabi, Lowe, Murdoch: Methyl-donor depletion of head and neck cancer cells in vitro establishes a less aggressive tumour cell phenotype. in European journal of nutrition 2017
Human Polyclonal DAP Kinase 1 Primary Antibody for IF (p), IHC (p) - ABIN732983
Liu, Ao, Zhou, Cui, Zhou, Yuan, Xiang, Cao, Liu: CpG island hypermethylation of multiple tumor suppressor genes associated with loss of their protein expression during rat lung carcinogenesis induced by 3-methylcholanthrene and diethylnitrosamine. in Biochemical and biophysical research communications 2010
This study demonstrate that phosphorylation of Tau at Serine 262 by the kinase domain of DAPK1 mediates spine damage and the subsequent neuronal death in ischemic stroke.
DAPK1-p53 (show TP53 Antibodies) interaction is a preferred target for therapeutic intervention of stroke.
Suggest that DAPK1 is a novel regulator of tau protein abundance, and that DAPK1 upregulation might contribute to tau-related pathologies in Alzheimer disease.
the DAPK1-p53 (show TP53 Antibodies) interaction is a signaling point of convergence of necrotic and apoptotic pathways
a new function of DAPK in suppressing TNF (show TNF Antibodies)-induced STAT3 (show STAT3 Antibodies) activation, was identified.
TSC2 (show TSC2 Antibodies) binds to the death domain of DAPK. This interaction is required for TSC2 (show TSC2 Antibodies) to reduce DAPK protein levels and half-life. DAPK is regulated by the lysosome pathway. Lysosome inhibition blocks TSC2 (show TSC2 Antibodies)-mediated degradation of DAPK.
Results identify DAPK as a molecule required for full production of IL-1beta (show IL1B Antibodies) and functional assembly of the NLRP3 (show NLRP3 Antibodies) inflammasome.
Study reports that cerebral ischemia recruits death-associated protein kinase 1 (DAPK1) into the NMDA receptor NR2B (show GRIN2B Antibodies) protein complex in the cortex of adult mice.
Death-associated protein kinase (DAPK) is regulated by DANGER which binds directly to DAPK and inhibits catalytic activity.
cellular activities of DAPK are critical for antagonizing caspase (show CASP3 Antibodies)-dependent apoptosis to promote cell survival under normal cell growth conditions.
The result suggests that DAPK promoter methylation is significantly increased in bladder cancer patients compared to normal controls. DAPK promoter methylation could serve as a biomarker for bladder cancer detection and management.
Down-regulation of mRNA expression was found in cases in which CASP8 (show CASP8 Antibodies), TMS1 (show SERINC3 Antibodies) and DAPK were hypermethylated.
A transcription factor complex consisting of ATF6 (show ATF6 Antibodies) (an endoplasmic reticulum-resident factor) and C/EBP-beta (show CEBPB Antibodies) is required for the IFN-gamma-induced (show SAMHD1 Antibodies) expression of DAPK1 IFN-gamma-induced (show SAMHD1 Antibodies) proteolytic processing of ATF6 (show ATF6 Antibodies) and phosphorylation of C/EBP-beta (show CEBPB Antibodies) are obligatory for the formation of this transcriptional complex
the present study demonstrated that DAPK contributed to the Hcyinduced endothelial apoptosis via modulation of Bcl2 (show BCL2 Antibodies)/Bax (show BAX Antibodies) expression levels and activation of caspase 3 (show CASP3 Antibodies)
DAPK seems to be a major player that influences the migratory capability of disseminating tumor cells and possibly affects the dynamic interface between pro- and anti-survival factors at the invasion front of colorectal cancer.
The sensitivity was found to be 62% and 83% for DAPK1 and SOX1 (show SOX1 Antibodies), respectively, when analyzed separately in the singleplex assay, but increased to 90% in the multiplex assay when either or both of the SOX1 (show SOX1 Antibodies) and the DAPK1 gene promoters showed methylation.
Authors observed the cleavage of ATF6 (show ATF6 Antibodies), the phosphorylation of MRLC, and the expression of death-associated protein kinase (DAPK1) by western blotting; the transcription of DAPK1 by RT-PCR; and the subcellular localization of ATF6 (show ATF6 Antibodies) and mAtg9 (show ATG9A Antibodies) by immunofluorescence.
testing for DNA methylations of MGMT (show MGMT Antibodies) plus DAPK1 genes holds some promise for high grade cervical disease screening
DAPK-1 and MLH1 (show MLH1 Antibodies) methylation correlated inversely in tumors in the middle-third of the stomach
Results show that CYP1B1 (show CYP1B1 Antibodies) may promote renal cell carcinoma (show MOK Antibodies) development by inducing CDC20 (show CDC20 Antibodies) expression and inhibiting apoptosis through the down-regulation of DAPK1.
Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate.
death-associated protein kinase 1
, death-associated protein kinase 1-like
, DAP kinase 1