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This study demonstrate that phosphorylation of Tau at Serine 262 by the kinase domain of DAPK1 mediates spine damage and the subsequent neuronal death in ischemic stroke.
DAPK1-p53 (show TP53 Proteins) interaction is a preferred target for therapeutic intervention of stroke.
Suggest that DAPK1 is a novel regulator of tau protein abundance, and that DAPK1 upregulation might contribute to tau-related pathologies in Alzheimer disease.
the DAPK1-p53 (show TP53 Proteins) interaction is a signaling point of convergence of necrotic and apoptotic pathways
a new function of DAPK in suppressing TNF (show TNF Proteins)-induced STAT3 (show STAT3 Proteins) activation, was identified.
TSC2 binds to the death domain of DAPK. This interaction is required for TSC2 to reduce DAPK protein levels and half-life. DAPK is regulated by the lysosome pathway. Lysosome inhibition blocks TSC2-mediated degradation of DAPK.
Results identify DAPK as a molecule required for full production of IL-1beta (show IL1B Proteins) and functional assembly of the NLRP3 (show NLRP3 Proteins) inflammasome.
Study reports that cerebral ischemia recruits death-associated protein kinase 1 (DAPK1) into the NMDA receptor NR2B (show GRIN2B Proteins) protein complex in the cortex of adult mice.
Death-associated protein kinase (DAPK) is regulated by DANGER which binds directly to DAPK and inhibits catalytic activity.
cellular activities of DAPK are critical for antagonizing caspase (show CASP3 Proteins)-dependent apoptosis to promote cell survival under normal cell growth conditions.
The result suggests that DAPK promoter methylation is significantly increased in bladder cancer patients compared to normal controls. DAPK promoter methylation could serve as a biomarker for bladder cancer detection and management.
Down-regulation of mRNA expression was found in cases in which CASP8 (show CASP8 Proteins), TMS1 (show SERINC3 Proteins) and DAPK were hypermethylated.
A transcription factor complex consisting of ATF6 (show ATF6 Proteins) (an endoplasmic reticulum-resident factor) and C/EBP-beta (show CEBPB Proteins) is required for the IFN-gamma-induced (show SAMHD1 Proteins) expression of DAPK1 IFN-gamma-induced (show SAMHD1 Proteins) proteolytic processing of ATF6 (show ATF6 Proteins) and phosphorylation of C/EBP-beta (show CEBPB Proteins) are obligatory for the formation of this transcriptional complex
the present study demonstrated that DAPK contributed to the Hcyinduced endothelial apoptosis via modulation of Bcl2 (show BCL2 Proteins)/Bax (show BAX Proteins) expression levels and activation of caspase 3 (show CASP3 Proteins)
DAPK seems to be a major player that influences the migratory capability of disseminating tumor cells and possibly affects the dynamic interface between pro- and anti-survival factors at the invasion front of colorectal cancer.
The sensitivity was found to be 62% and 83% for DAPK1 and SOX1 (show SOX1 Proteins), respectively, when analyzed separately in the singleplex assay, but increased to 90% in the multiplex assay when either or both of the SOX1 (show SOX1 Proteins) and the DAPK1 gene promoters showed methylation.
Authors observed the cleavage of ATF6 (show ATF6 Proteins), the phosphorylation of MRLC, and the expression of death-associated protein kinase (DAPK1) by western blotting; the transcription of DAPK1 by RT-PCR; and the subcellular localization of ATF6 (show ATF6 Proteins) and mAtg9 (show ATG9A Proteins) by immunofluorescence.
testing for DNA methylations of MGMT (show MGMT Proteins) plus DAPK1 genes holds some promise for high grade cervical disease screening
DAPK-1 and MLH1 (show MLH1 Proteins) methylation correlated inversely in tumors in the middle-third of the stomach
Results show that CYP1B1 (show CYP1B1 Proteins) may promote renal cell carcinoma (show MOK Proteins) development by inducing CDC20 (show CDC20 Proteins) expression and inhibiting apoptosis through the down-regulation of DAPK1.
Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate.
death-associated protein kinase 1
, death-associated protein kinase 1-like
, DAP kinase 1