Browse our DAP Kinase 1 Proteins (DAPK1)

Full name:
Death-Associated Protein Kinase 1 Proteins (DAPK1)
On www.antibodies-online.com are 10 Death-Associated Protein Kinase 1 (DAPK1) Proteins from 6 different suppliers available. Additionally we are shipping DAP Kinase 1 Antibodies (95) and DAP Kinase 1 Kits (11) and many more products for this protein. A total of 122 DAP Kinase 1 products are currently listed.
Synonyms:
2310039H24Rik, 2810425C21Rik, AI642003, D13Ucla1, DAP-Kinase, DAPK, DAPK1, MGC81366, MGC83745, si:ch211-66i11.1, wu:fj09c03
list all proteins Gene Name GeneID UniProt
DAPK1 69635 Q80YE7
Rat DAPK1 DAPK1 306722  
DAPK1 1612 P53355

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DAP Kinase 1 Proteins (DAPK1) by Origin

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More Proteins for DAP Kinase 1 Interaction Partners

Mouse (Murine) Death-Associated Protein Kinase 1 (DAPK1) interaction partners

  1. Inhibition of DAPK1 by deleting a catalytic domain or a death domain of DAPK1 rescues the Excitatory pyramidal neurons in the entorhinal cortical layer II region synaptic loss

  2. in Alzheimer's disease (AD) brains, elevated DAPK1 levels showed co-relation with the increase of APP (show APP Proteins) phosphorylation. Combined together, these results suggest that DAPK1 promotes the phosphorylation and amyloidogenic processing of APP (show APP Proteins), and that may serve a potential therapeutic target for AD.

  3. This study demonstrate that phosphorylation of Tau at Serine 262 by the kinase domain of DAPK1 mediates spine damage and the subsequent neuronal death in ischemic stroke.

  4. DAPK1-p53 (show TP53 Proteins) interaction is a preferred target for therapeutic intervention of stroke.

  5. Suggest that DAPK1 is a novel regulator of tau protein abundance, and that DAPK1 upregulation might contribute to tau-related pathologies in Alzheimer disease.

  6. the DAPK1-p53 (show TP53 Proteins) interaction is a signaling point of convergence of necrotic and apoptotic pathways

  7. a new function of DAPK in suppressing TNF (show TNF Proteins)-induced STAT3 (show STAT3 Proteins) activation, was identified.

  8. TSC2 binds to the death domain of DAPK. This interaction is required for TSC2 to reduce DAPK protein levels and half-life. DAPK is regulated by the lysosome pathway. Lysosome inhibition blocks TSC2-mediated degradation of DAPK.

  9. Results identify DAPK as a molecule required for full production of IL-1beta (show IL1B Proteins) and functional assembly of the NLRP3 (show NLRP3 Proteins) inflammasome.

  10. Study reports that cerebral ischemia recruits death-associated protein kinase 1 (DAPK1) into the NMDA receptor NR2B (show GRIN2B Proteins) protein complex in the cortex of adult mice.

Human Death-Associated Protein Kinase 1 (DAPK1) interaction partners

  1. results suggest that DAPK1 is an important prognostic marker and therapeutic target for bladder cancer and have identified possible therapeutic agents for future testing in bladder cancer models with low DAPK1 expression

  2. Study provides evidence that DAPK1 is a negative-feedback regulator of the RIG-I (show DDX58 Proteins) pathway. RIG-I (show DDX58 Proteins)-mediated antiviral signaling activates DAPK1 kinase activity and DAPK1 inactivates RIG-I (show DDX58 Proteins) RNA sensing by direct phosphorylation of RIG-I (show DDX58 Proteins).

  3. Meta-analysis suggested that aberrant methylation of DAPK promoter was associated with head and neck squamous cell carcinoma.

  4. our study characterized DAPK1 as a novel transcriptional target of BRMS1 (show BRMS1 Proteins). Transcriptional activation of DAPK1 might be another important mechanism accounting for the metastasis suppressive activity of BRMS1 (show BRMS1 Proteins).

  5. in Alzheimer's disease (AD) brains, elevated DAPK1 levels showed co-relation with the increase of APP (show APP Proteins) phosphorylation. Combined together, these results suggest that DAPK1 promotes the phosphorylation and amyloidogenic processing of APP (show APP Proteins), and that may serve a potential therapeutic target for AD.

  6. The result suggests that DAPK promoter methylation is significantly increased in bladder cancer patients compared to normal controls. DAPK promoter methylation could serve as a biomarker for bladder cancer detection and management.

  7. Down-regulation of mRNA expression was found in cases in which CASP8 (show CASP8 Proteins), TMS1 (show SERINC3 Proteins) and DAPK were hypermethylated.

  8. A transcription factor complex consisting of ATF6 (show ATF6 Proteins) (an endoplasmic reticulum-resident factor) and C/EBP-beta (show CEBPB Proteins) is required for the IFN-gamma-induced (show SAMHD1 Proteins) expression of DAPK1 IFN-gamma-induced (show SAMHD1 Proteins) proteolytic processing of ATF6 (show ATF6 Proteins) and phosphorylation of C/EBP-beta (show CEBPB Proteins) are obligatory for the formation of this transcriptional complex

  9. the present study demonstrated that DAPK contributed to the Hcyinduced endothelial apoptosis via modulation of Bcl2 (show BCL2 Proteins)/Bax (show BAX Proteins) expression levels and activation of caspase 3 (show CASP3 Proteins)

  10. DAPK seems to be a major player that influences the migratory capability of disseminating tumor cells and possibly affects the dynamic interface between pro- and anti-survival factors at the invasion front of colorectal cancer.

DAP Kinase 1 (DAPK1) Protein Profile

Protein Summary

Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate.

Alternative names and synonyms associated with DAP Kinase 1 (DAPK1)

  • death-associated protein kinase 1 (LOC427465)
  • death-associated protein kinase 1 (dapk1)
  • death-associated protein kinase 1 (DAPK1)
  • death-associated protein kinase 1 (LOC100343775)
  • death-associated protein kinase 1 (dapk1-b)
  • death-associated protein kinase 1 (RCJMB04_1b10)
  • death associated protein kinase 1 (Dapk1)
  • 2310039H24Rik protein
  • 2810425C21Rik protein
  • AI642003 protein
  • D13Ucla1 protein
  • DAP-Kinase protein
  • DAPK protein
  • DAPK1 protein
  • MGC81366 protein
  • MGC83745 protein
  • si:ch211-66i11.1 protein
  • wu:fj09c03 protein

Protein level used designations for DAPK1

death-associated protein kinase 1 , death-associated protein kinase 1-like , DAP kinase 1

GENE ID SPECIES
427465 Gallus gallus
446562 Xenopus laevis
464571 Pan troglodytes
484142 Canis lupus familiaris
540873 Bos taurus
558314 Danio rerio
694315 Macaca mulatta
100144678 Xenopus (Silurana) tropicalis
100231489 Taeniopygia guttata
100343775 Oryctolagus cuniculus
100448934 Pongo abelii
431807 Xenopus laevis
100389223 Callithrix jacchus
100603623 Nomascus leucogenys
431670 Gallus gallus
100012765 Monodelphis domestica
100061567 Equus caballus
100516103 Sus scrofa
100556297 Anolis carolinensis
69635 Mus musculus
306722 Rattus norvegicus
1612 Homo sapiens
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