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GCN2 and ATF4 are important regulators of 4E-BP transcription during normal drosophila development and aging.
longevity assurance mutants of chico, the Drosophila insulin receptor (show INSR ELISA Kits) substrate homolog, require Drosophila d4eBP to slow aging.
These results indicate that the Ccr4-Not complex controls expression of 4E-BP at multiple levels and adjusts the magnitude of the total effect.
eIF4E-binding protein requires non-canonical 4E-binding motifs and a lateral surface of eIF4E (show EIF4E ELISA Kits) to repress translation.
PcG proteins can directly modulate cell growth in Drosophila, in part by regulating Thor expression
These findings reveal an organism-wide regulation of proteostasis in response to muscle aging and a key role of FOXO/4E-BP signaling in the coordination of organismal and tissue aging.
Induction of 4EBP likely leads to growth inhibition by Dfoxo, whereas activation of InR (show INSR ELISA Kits) provides a novel transcriptionally induced feedback control mechanism.
S6 kinase (dS6K) and a single 4E-BP (d4E-BP) are phosphorylated via the insulin and target of rapamycin (TOR) signaling pathways.
Drosophila 4E-BP activity becomes critical for survival under dietary restriction and oxidative stress, and is linked to life span.
Analysis of Drosophila 4E-BP(null) mutant survival upon infection with C. albicans showed that 4E-BP plays an important role in host defense.
Arg, Leu, and Gln act coordinately to stimulate proliferation of pTr cells through activation of the MTOR (show FRAP1 ELISA Kits)-RPS6K-RPS6 (show RPS6 ELISA Kits)-EIF4EBP1 signal transduction pathway.
There were significantly higher expressions of p-eIF4E (show EIF4E ELISA Kits) and p-4EBP-1 proteins in the cases with lymph node metastasis than in those without lymph node metastasis.
4E-BP1 has tumor suppressor activity by inhibiting eIF4E (show EIF4E ELISA Kits) and, thus, blocking mRNA translation and proliferation. This is corroborated by elevated levels of phosphorylated and hence inactive 4E-BP1, which are detected in various cancers
Rotterlin inhibits mTORC1 and 4EBP1 activity in melanoma cells, inhibiting protein synthesis and promoting cell death.
Inhibition of mTORC1-mediated 4EBP1 phosphorylation leads to decreased expression of c-MYC (show MYC ELISA Kits) and subsequent upregulation of the proapoptotic BCL2 (show BCL2 ELISA Kits) family member PUMA (show BBC3 ELISA Kits), whereas inhibition of mTORC2 (show CRTC2 ELISA Kits) results in nuclear factor-kappaB-mediated expression of the Early Growth Response 1 (EGR1 (show EGR1 ELISA Kits)) gene, which encodes a transcription factor that binds and transactivates the proapoptotic BCL2L11 (show BCL2L11 ELISA Kits) locus encoding BIM (show BCL2L11 ELISA Kits).
p-4E-BP1 is more highly expressed in early gastric cancers than in advanced ones, and has limited potential as an independent prognostic biomarker in patients with gastric cancer.
this study shows that anticancer activity of perillyl alcohol is mediated via inhibition of 4E-BP1 signaling
4EBP1 may serve as a funnel factor that converge the upstream proliferative oncogenic signals.
Increased expression of miR (show MLXIP ELISA Kits)-125a is associated with invasion and migration in ovarian cancer.
4E-BP1 was shown to be phosphorylated by other kinases besides mTOR (show FRAP1 ELISA Kits), and overexpression of 4E-BP1 was found in different human carcinomas. (Review)
Twist1 (show TWIST1 ELISA Kits) is correlated with p-4E-BP1 in predicting the prognostic outcome of NSCLC.
The authors now show that West Nile virus growth and protein expression are dependent on mTORC1 mediated-regulation of the eukaryotic translation initiation factor 4E-binding protein/eukaryotic translation initiation factor 4E-binding protein (4EBP/eIF4E (show EIF4E ELISA Kits)) interaction and eukaryotic initiation factor (show EIF4G1 ELISA Kits) 4F (eIF4F (show EIF4A2 ELISA Kits)) complex formation to support viral growth and viral protein expression.
p-mTOR, p-4EBP1, HIF-1alpha and VEGF together are involved in the pathogenesis of asthma.
Thus, translational control by 4E-BP1 downstream of mTOR (show FRAP1 ELISA Kits) effects the expression of neuroligin 1 (show NLGN1 ELISA Kits) and excitatory synaptic transmission in the spinal cord, and thereby contributes to enhanced mechanical nociception.
The findings support a model whereby elevated 4E-BP1 expression observed in the retina of diabetic rodents is the result of O-GlcNAcylation of 4E-BP1 within its PEST motif.
The mTORC1 effectors S6K1 and 4E-BP play different roles in CNS axon regeneration.
Oxidative stress-induced (show SQSTM1 ELISA Kits) premature senescence occurred due to impaired autophagy function through 4EBP1 phosphorylation.
Data show that deletion of eukaryotic translation initiation factor 4E-binding protein 1/2 (4E-BP1/2) in erythroid cells rendered them resistant to mammalian target of rapamycin complex 1 (TORC1) inhibition and restored hemoglobin production.
Rotenone induction of hydrogen peroxide inhibits mTOR (show FRAP1 ELISA Kits)-mediated S6K1 (show RPS6KB1 ELISA Kits) and 4E-BP1/eIF4E (show EIF4E ELISA Kits) pathways, resulting in caspase (show CASP3 ELISA Kits)-dependent and -independent apoptosis in neuronal cells.
These findings indicate that regulation of 4E-BP1 in skeletal muscle may serve as an important conduit through which mTORC1 controls metabolism.
Disruption of genes encoding Eif4ebp1 and Eif4ebp2 (show EIF4EBP2 ELISA Kits) does not alter basal or sepsis-induced changes in skeletal muscle protein synthesis in male or female mice.
This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.
, Eif4e-binding protein
, eIF-4E-binding protein
, eif4e-binding protein 4EBP
, eukaryotic initiation factor 4E binding protein
, eukaryotic initiation factor 4E-binding protein
, eukaryotic translation initiation factor 4E binding protein
, eukaryotic translation initiation factor 4E-binding protein
, insulin-stimulated eIF-4E binding protein
, lethal (2) 06270
, eukaryotic translation initiation factor 4E binding protein 1
, translation initiation factor 4E binding protein 1
, eukaryotic translation initiation factor 4E-binding protein 1
, eIF4E-binding protein 1
, phosphorylated heat- and acid-stable protein regulated by insulin 1